AU2017291842A1 - Human-enzyme mediated depletion of cystine - Google Patents
Human-enzyme mediated depletion of cystine Download PDFInfo
- Publication number
- AU2017291842A1 AU2017291842A1 AU2017291842A AU2017291842A AU2017291842A1 AU 2017291842 A1 AU2017291842 A1 AU 2017291842A1 AU 2017291842 A AU2017291842 A AU 2017291842A AU 2017291842 A AU2017291842 A AU 2017291842A AU 2017291842 A1 AU2017291842 A1 AU 2017291842A1
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- Prior art keywords
- cystine
- cgl
- protein
- enzyme
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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Landscapes
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| PCT/US2017/040897 WO2018009663A1 (en) | 2016-07-06 | 2017-07-06 | Human-enzyme mediated depletion of cystine for treating patients with cystinuria |
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| WO2011097381A2 (en) | 2010-02-04 | 2011-08-11 | The Board Of Regents Of Use University Of Texas System | Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations therof |
| US10363311B2 (en) | 2013-08-29 | 2019-07-30 | Board Of Regents, The University Of Texas System | Engineered primate cystine/cysteine degrading enzymes as antineogenic agents |
| WO2015031726A2 (en) | 2013-08-29 | 2015-03-05 | Board Of Regents, The University Of Texas System | Engineered primate l-methioninase for therapeutic purposes |
| US10865403B2 (en) | 2017-05-12 | 2020-12-15 | Board Of Regents, The University Of Texas System | Engineered primate cystine/cysteine degrading enzymes for therapeutic uses |
| CN110603324A (zh) | 2017-05-12 | 2019-12-20 | 得克萨斯大学体系董事会 | 用于治疗高同型半胱氨酸血症和同型胱胺酸尿症患者的人类酶介导的同型半胱氨酸耗竭 |
| EP3870081A4 (en) | 2018-10-26 | 2023-01-18 | Board of Regents, The University of Texas System | GENETIC CYSTINE/CYSTEIN DEGRADING PRIMATE ENZYMES FOR THERAPEUTIC USES |
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| US5824311A (en) | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
| US4870287A (en) | 1988-03-03 | 1989-09-26 | Loma Linda University Medical Center | Multi-station proton beam therapy system |
| US5329028A (en) | 1992-08-05 | 1994-07-12 | Genentech, Inc. | Carbohydrate-directed cross-linking reagents |
| US5801029A (en) | 1993-02-16 | 1998-09-01 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| US5801005A (en) | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
| GB9506466D0 (en) | 1994-08-26 | 1995-05-17 | Prolifix Ltd | Cell cycle regulated repressor and dna element |
| US5760395A (en) | 1996-04-18 | 1998-06-02 | Universities Research Assoc., Inc. | Method and apparatus for laser-controlled proton beam radiology |
| US5739169A (en) | 1996-05-31 | 1998-04-14 | Procept, Incorporated | Aromatic compounds for inhibiting immune response |
| US20070207158A1 (en) | 2003-06-17 | 2007-09-06 | Harrison Roger G | Conjugate for the specific targeting of anticancer agents to tumor cells or tumor vasculature and production thereof |
| US20060275279A1 (en) * | 2005-06-06 | 2006-12-07 | Rozzell J D | Methods for dissolving cystine stones and reducing cystine in urine |
| EP1749822B1 (en) * | 2005-08-05 | 2008-10-15 | Hybrigenics S.A. | Novel cysteine protease inhibitors and their therapeutic applications |
| RS58405B1 (sr) * | 2009-12-01 | 2019-04-30 | Translate Bio Inc | Stereoidni derivati za isporuku irnk u humanim genetskim oboljenjima |
| WO2015031726A2 (en) | 2013-08-29 | 2015-03-05 | Board Of Regents, The University Of Texas System | Engineered primate l-methioninase for therapeutic purposes |
| US10363311B2 (en) | 2013-08-29 | 2019-07-30 | Board Of Regents, The University Of Texas System | Engineered primate cystine/cysteine degrading enzymes as antineogenic agents |
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2017
- 2017-07-06 KR KR1020197003180A patent/KR20190026813A/ko not_active Withdrawn
- 2017-07-06 BR BR112019000215-4A patent/BR112019000215A2/pt not_active Application Discontinuation
- 2017-07-06 CA CA3028771A patent/CA3028771A1/en not_active Abandoned
- 2017-07-06 AU AU2017291842A patent/AU2017291842A1/en not_active Abandoned
- 2017-07-06 WO PCT/US2017/040897 patent/WO2018009663A1/en not_active Ceased
- 2017-07-06 JP JP2019500316A patent/JP2019520392A/ja not_active Ceased
- 2017-07-06 EP EP17824888.6A patent/EP3481425A4/en not_active Withdrawn
- 2017-07-06 CN CN201780041950.0A patent/CN109562178A/zh active Pending
- 2017-07-06 MX MX2019000235A patent/MX383505B/es unknown
- 2017-07-06 US US15/643,436 patent/US20180008681A1/en not_active Abandoned
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2018
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| US20180008681A1 (en) | 2018-01-11 |
| CA3028771A1 (en) | 2018-01-11 |
| EP3481425A1 (en) | 2019-05-15 |
| CN109562178A (zh) | 2019-04-02 |
| WO2018009663A1 (en) | 2018-01-11 |
| EP3481425A4 (en) | 2020-02-26 |
| JP2019520392A (ja) | 2019-07-18 |
| MX383505B (es) | 2025-03-14 |
| BR112019000215A2 (pt) | 2019-04-24 |
| IL263997A (en) | 2019-02-03 |
| MX2019000235A (es) | 2019-05-30 |
| KR20190026813A (ko) | 2019-03-13 |
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| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |