AU2017281533B2 - Automated adjustment of light sheet geometry in a microscope - Google Patents
Automated adjustment of light sheet geometry in a microscope Download PDFInfo
- Publication number
- AU2017281533B2 AU2017281533B2 AU2017281533A AU2017281533A AU2017281533B2 AU 2017281533 B2 AU2017281533 B2 AU 2017281533B2 AU 2017281533 A AU2017281533 A AU 2017281533A AU 2017281533 A AU2017281533 A AU 2017281533A AU 2017281533 B2 AU2017281533 B2 AU 2017281533B2
- Authority
- AU
- Australia
- Prior art keywords
- light
- sheet
- sample
- imaging
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/32—Micromanipulators structurally combined with microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/06—Means for illuminating specimens
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/365—Control or image processing arrangements for digital or video microscopes
- G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/0025—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00 for optical correction, e.g. distorsion, aberration
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Multimedia (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Microscoopes, Condenser (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662354384P | 2016-06-24 | 2016-06-24 | |
| US62/354,384 | 2016-06-24 | ||
| US201762447154P | 2017-01-17 | 2017-01-17 | |
| US62/447,154 | 2017-01-17 | ||
| PCT/US2017/038970 WO2017223426A1 (en) | 2016-06-24 | 2017-06-23 | Automated adjustment of light sheet geometry in a microscope |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2017281533A1 AU2017281533A1 (en) | 2018-12-20 |
| AU2017281533B2 true AU2017281533B2 (en) | 2019-06-27 |
Family
ID=60783949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017281533A Active AU2017281533B2 (en) | 2016-06-24 | 2017-06-23 | Automated adjustment of light sheet geometry in a microscope |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11320640B2 (https=) |
| EP (1) | EP3475753B1 (https=) |
| JP (2) | JP6906550B2 (https=) |
| AU (1) | AU2017281533B2 (https=) |
| WO (1) | WO2017223426A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102017106984B4 (de) * | 2017-03-31 | 2022-02-10 | Carl Zeiss Microscopy Gmbh | Lichtmikroskop und Verfahren zum Betreiben eines Lichtmikroskops mit optimierter Beleuchtungsgeometrie |
| EP3695263B1 (en) * | 2017-10-12 | 2025-01-15 | Howard Hughes Medical Institute | High-resolution, real-time imaging with adaptive optics and lattice light sheets |
| US11169368B2 (en) * | 2018-01-02 | 2021-11-09 | King's College London | Method and system for localisation microscopy |
| CN108226120B (zh) * | 2018-01-23 | 2020-10-16 | 哈尔滨工业大学 | 一种测量片状激光光束尺寸和能量分布的装置及方法 |
| US20210239955A1 (en) * | 2018-06-08 | 2021-08-05 | The Board Of Trustees Of The Leland Stanford Junior University | Near infra-red light sheet microscopy through scattering tissues |
| CN108956562B (zh) * | 2018-06-11 | 2020-05-22 | 浙江大学 | 一种基于重定位的光切片荧光显微成像方法和装置 |
| US11965775B2 (en) * | 2018-07-20 | 2024-04-23 | Ophir Optronics Solutions, Ltd. | Method and apparatus for focus correction of multi-image laser beam quality measurements |
| EP3633414B1 (en) * | 2018-10-02 | 2022-03-02 | Vaisala, OYJ | A forward scatter sensor |
| EP3751326B1 (en) * | 2019-06-14 | 2025-04-09 | Leica Microsystems CMS GmbH | Method and microscope for imaging a sample |
| US11322343B2 (en) * | 2019-07-09 | 2022-05-03 | IonQ, Inc. | Optical alignment using reflective dove prisms |
| KR102073712B1 (ko) * | 2019-10-29 | 2020-02-05 | 한국기초과학지원연구원 | 센서리스 적응광학 시스템, 이를 적용한 이미지 장치 및 통신 장치 |
| CN115380203B (zh) * | 2020-02-12 | 2025-07-22 | 深圳华大智造科技股份有限公司 | 光学成像系统及应用所述光学成像系统的生化物质检测系统 |
| CN111521608A (zh) * | 2020-04-27 | 2020-08-11 | 中国科学院广州生物医药与健康研究院 | 一种超分辨率显微成像方法及显微镜 |
| EP4211508B1 (en) * | 2020-09-14 | 2025-11-26 | Singular Genomics Systems, Inc. | Methods and systems for multidimensional imaging |
| EP4214562B1 (en) * | 2020-09-20 | 2026-04-08 | The Regents Of The University Of California | Transverse sheet illumination microscopy (transim) |
| DE102020128524A1 (de) * | 2020-10-29 | 2022-05-05 | Carl Zeiss Microscopy Gmbh | Lichtblattmikroskop und Verfahren der Lichtblattmikroskopie |
| CN117043655A (zh) * | 2021-01-22 | 2023-11-10 | 维微恩提斯显微镜有限责任公司 | 用于对样品进行成像的显微镜 |
| DE102021114307A1 (de) * | 2021-06-02 | 2022-12-08 | Carl Zeiss Microscopy Gmbh | Digitale kontrastnachbearbeitung von mikroskopiebildern |
| WO2024068447A1 (en) | 2022-09-26 | 2024-04-04 | Consiglio Nazionale Delle Ricerche | System and method for adjusting the alignment of a light sheet microscope |
| CN118414566A (zh) * | 2022-11-30 | 2024-07-30 | 锘海生物科学仪器(上海)有限公司 | 一种平铺光片显微镜、其成像方法、显微镜系统和检测相机 |
| EP4664180A1 (en) * | 2024-06-12 | 2025-12-17 | Viventis Microscopy Sàrl | Method for acquiring images and related microscope |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110115895A1 (en) * | 2008-07-30 | 2011-05-19 | Jan Huisken | Multidirectional selective plane illumination microscopy |
| US20150098126A1 (en) * | 2013-10-09 | 2015-04-09 | Howard Hughes Medical Institute | Multiview Light-Sheet Microscopy |
| US20150362713A1 (en) * | 2014-03-17 | 2015-12-17 | Howard Hughes Medical Institute | Rapid adaptive optical microscopy over large multicellular volumes |
| US20160124201A1 (en) * | 2014-11-04 | 2016-05-05 | Olympus Corporation | Light sheet illumination microscope and light sheet illumination method |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001289914A1 (en) * | 2000-09-25 | 2002-04-02 | Sensovation Ag | Image sensor device, apparatus and method for optical measurements |
| JP2003185927A (ja) | 2001-12-13 | 2003-07-03 | Olympus Optical Co Ltd | 走査型レーザー顕微鏡 |
| US20040109586A1 (en) * | 2002-12-04 | 2004-06-10 | Scott Samson | Shadowed image particle profiling and evaluation recorder |
| DE10257423A1 (de) * | 2002-12-09 | 2004-06-24 | Europäisches Laboratorium für Molekularbiologie (EMBL) | Mikroskop |
| EP1683074A1 (en) * | 2003-11-10 | 2006-07-26 | Technology Innovations, LLC | Digital imaging assembly and methods thereof |
| WO2009002225A2 (ru) | 2007-06-25 | 2008-12-31 | Closed Company 'molecular-Medicine Technologies' | Многофункциональное устройство для диагностики и способ тестирования биологических объектов |
| DE102007045897A1 (de) | 2007-09-26 | 2009-04-09 | Carl Zeiss Microimaging Gmbh | Verfahren zur mikroskopischen dreidimensionalen Abbildung einer Probe |
| US8537461B2 (en) | 2007-11-26 | 2013-09-17 | Carl Zeiss Microimaging Gmbh | Method and configuration for the optical detection of an illuminated specimen |
| DE102007063274B8 (de) | 2007-12-20 | 2022-12-15 | Albert-Ludwigs-Universität Freiburg | Mikroskop |
| DE102008009216A1 (de) | 2008-02-13 | 2009-08-20 | Carl Zeiss Microimaging Gmbh | Vorrichtung und Verfahren zum räumlich hochauflösenden Abbilden einer Struktur einer Probe |
| GB0814039D0 (en) * | 2008-07-31 | 2008-09-10 | Imp Innovations Ltd | Optical arrangement for oblique plane microscopy |
| US20100249562A1 (en) * | 2009-03-17 | 2010-09-30 | Zhang Hao F | Ultrasonic imaging device |
| US8063385B2 (en) * | 2009-05-29 | 2011-11-22 | General Electric Company | Method and apparatus for ultraviolet scan planning |
| DE102009044987A1 (de) * | 2009-09-24 | 2011-03-31 | Carl Zeiss Microimaging Gmbh | Mikroskop |
| DE102009044984A1 (de) * | 2009-09-24 | 2011-03-31 | Carl Zeiss Microimaging Gmbh | Mikroskop |
| DE102009044983A1 (de) | 2009-09-24 | 2011-03-31 | Carl Zeiss Microimaging Gmbh | Mikroskop |
| WO2011059833A2 (en) | 2009-10-29 | 2011-05-19 | California Institute Of Technology | Dual-mode raster point scanning/light sheet illumination microscope |
| US8582208B2 (en) * | 2009-12-18 | 2013-11-12 | Sagem Identification Bv | Method and apparatus for manufacturing a security document comprising a lenticular array and blurred pixel tracks |
| US8711211B2 (en) | 2010-06-14 | 2014-04-29 | Howard Hughes Medical Institute | Bessel beam plane illumination microscope |
| US10051240B2 (en) | 2010-06-14 | 2018-08-14 | Howard Hughes Medical Institute | Structured plane illumination microscopy |
| WO2012027542A2 (en) | 2010-08-25 | 2012-03-01 | California Institute Of Technology | Simultaneous orthogonal light sheet microscopy and computed optical tomography |
| DE102010060121C5 (de) * | 2010-10-22 | 2023-09-28 | Leica Microsystems Cms Gmbh | SPIM-Mikroskop mit sequenziellem Lightsheet |
| KR20140039151A (ko) * | 2011-01-06 | 2014-04-01 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 무렌즈 단층 촬영 이미징 장치들 및 방법들 |
| US10908403B2 (en) | 2011-02-14 | 2021-02-02 | European Molecular Biology Laboratory (Embl) | Light-pad microscope for high-resolution 3D fluorescence imaging and 2D fluctuation spectroscopy |
| US9316824B2 (en) | 2011-03-04 | 2016-04-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Optomechanical module for converting a microscope to provide selective plane illumination microscopy |
| JP6037623B2 (ja) | 2012-02-24 | 2016-12-07 | オリンパス株式会社 | レーザ走査型共焦点顕微鏡、及び、レーザ走査型共焦点顕微鏡の光学系のアライメント調整方法 |
| WO2013150273A1 (en) | 2012-04-03 | 2013-10-10 | University Court Of The University Of St Andrews | High resolution imaging of extended volumes |
| CN104487821A (zh) * | 2012-05-14 | 2015-04-01 | 微流控光学公司 | 使用近场光学力的方法 |
| DE102012013163B4 (de) | 2012-07-02 | 2022-08-25 | Carl Zeiss Microscopy Gmbh | Mikroskop und Verfahren zur Lichtscheibenmikroskopie |
| GB201217171D0 (en) * | 2012-08-23 | 2012-11-07 | Isis Innovation | Stimulated emission depletion microscopy |
| US9404869B2 (en) * | 2012-10-09 | 2016-08-02 | Howard Hughes Medical Institute | Multiview light-sheet microscopy |
| DE102012020240A1 (de) * | 2012-10-12 | 2014-04-17 | Carl Zeiss Microscopy Gmbh | Mikroskop und Verfahren zur SPIM Mikroskopie |
| US20160004058A1 (en) * | 2013-03-15 | 2016-01-07 | Leonard Rodenhausen Wayne | Lightsheet microscopy with rotational-shear interferometry |
| US9581798B2 (en) * | 2013-07-22 | 2017-02-28 | Fundacio Institut De Ciencies Fotoniques | Light sheet-based imaging device with extended depth of field |
| DE102013021542A1 (de) | 2013-12-18 | 2015-06-18 | Carl Zeiss Microscopy Gmbh | Mikroskop und Verfahren zur SPIM Mikroskopie |
| JP2017517761A (ja) * | 2014-05-30 | 2017-06-29 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 大きなインタクトな組織試料を撮像するための方法及び装置 |
| US20160187633A1 (en) * | 2014-12-24 | 2016-06-30 | Applied Scientific Instrumentation Inc. | Dual oblique view single plane illumination microscope |
-
2017
- 2017-06-23 AU AU2017281533A patent/AU2017281533B2/en active Active
- 2017-06-23 US US16/309,057 patent/US11320640B2/en active Active
- 2017-06-23 EP EP17816281.4A patent/EP3475753B1/en active Active
- 2017-06-23 WO PCT/US2017/038970 patent/WO2017223426A1/en not_active Ceased
- 2017-06-23 JP JP2018562259A patent/JP6906550B2/ja active Active
-
2021
- 2021-01-27 JP JP2021010726A patent/JP2021092575A/ja active Pending
-
2022
- 2022-04-01 US US17/711,128 patent/US12360353B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110115895A1 (en) * | 2008-07-30 | 2011-05-19 | Jan Huisken | Multidirectional selective plane illumination microscopy |
| US20150098126A1 (en) * | 2013-10-09 | 2015-04-09 | Howard Hughes Medical Institute | Multiview Light-Sheet Microscopy |
| US20150362713A1 (en) * | 2014-03-17 | 2015-12-17 | Howard Hughes Medical Institute | Rapid adaptive optical microscopy over large multicellular volumes |
| US20160124201A1 (en) * | 2014-11-04 | 2016-05-05 | Olympus Corporation | Light sheet illumination microscope and light sheet illumination method |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3475753B1 (en) | 2025-04-09 |
| JP6906550B2 (ja) | 2021-07-21 |
| US20220236550A1 (en) | 2022-07-28 |
| EP3475753A4 (en) | 2020-04-15 |
| EP3475753A1 (en) | 2019-05-01 |
| WO2017223426A1 (en) | 2017-12-28 |
| US20190219811A1 (en) | 2019-07-18 |
| US11320640B2 (en) | 2022-05-03 |
| JP2019525216A (ja) | 2019-09-05 |
| AU2017281533A1 (en) | 2018-12-20 |
| JP2021092575A (ja) | 2021-06-17 |
| US12360353B2 (en) | 2025-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |