AU2017278329B2 - Methods for the use of CD32B x CD79B-binding molecules in the treatment of inflammatory diseases and disorders - Google Patents

Methods for the use of CD32B x CD79B-binding molecules in the treatment of inflammatory diseases and disorders Download PDF

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AU2017278329B2
AU2017278329B2 AU2017278329A AU2017278329A AU2017278329B2 AU 2017278329 B2 AU2017278329 B2 AU 2017278329B2 AU 2017278329 A AU2017278329 A AU 2017278329A AU 2017278329 A AU2017278329 A AU 2017278329A AU 2017278329 B2 AU2017278329 B2 AU 2017278329B2
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cd32b
cd79b
ser
val
dose
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AU2017278329A1 (en
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Ezio Bonvini
Wei Chen
Paul A. Moore
Naimish Bharat Pandya
Jon Marc Wigginton
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Macrogenics Inc
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Macrogenics Inc
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07—ORGANIC CHEMISTRY
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
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  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2017278329A 2016-06-07 2017-06-06 Methods for the use of CD32B x CD79B-binding molecules in the treatment of inflammatory diseases and disorders Active AU2017278329B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662346717P 2016-06-07 2016-06-07
US62/346,717 2016-06-07
US201662432328P 2016-12-09 2016-12-09
US62/432,328 2016-12-09
PCT/US2017/036079 WO2017214096A1 (en) 2016-06-07 2017-06-06 Methods for the use of cd32b x cd79b-binding molecules in the treatment of inflammatory diseases and disorders

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AU2017278329A1 AU2017278329A1 (en) 2019-01-03
AU2017278329B2 true AU2017278329B2 (en) 2024-08-08

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AU2017278329A Active AU2017278329B2 (en) 2016-06-07 2017-06-06 Methods for the use of CD32B x CD79B-binding molecules in the treatment of inflammatory diseases and disorders

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US (1) US20190322741A1 (enExample)
EP (1) EP3464378A4 (enExample)
JP (3) JP2019521103A (enExample)
KR (3) KR20190016079A (enExample)
CN (1) CN109311990A (enExample)
AU (1) AU2017278329B2 (enExample)
BR (1) BR112018075303A2 (enExample)
MX (2) MX2018015265A (enExample)
RU (1) RU2022101891A (enExample)
TW (1) TW201742633A (enExample)
WO (1) WO2017214096A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR101997A1 (es) * 2014-09-26 2017-01-25 Macrogenics Inc Diacuerpos monovalentes biespecíficos que son capaces de unir cd19 y cd3, y usos de los mismos
ES2987333T3 (es) 2016-10-26 2024-11-14 Univ Leland Stanford Junior Regiones bisagra de inmunoglobulina modificadas para reducir la hemaglutinación
CN120022359A (zh) * 2018-10-03 2025-05-23 柰裴斯生命科学公司 抗cd79抗体及其应用
WO2021022072A1 (en) * 2019-07-30 2021-02-04 Provention Bio, Inc. Methods and compositions for reducing immunogenicity by non-depletional b cell inhibitors
EP4004052A4 (en) * 2019-07-30 2023-11-01 Provention Bio, Inc. METHODS AND COMPOSITIONS FOR REDUCING IMMUNOGENICITY BY NON-DEPLETED B CELL INHIBITORS
EP4132582A4 (en) * 2020-04-10 2024-07-24 The Board of Trustees of the Leland Stanford Junior University TARGETED REDUCTION OF ACTIVATED IMMUNE CELLS
CA3196540A1 (en) * 2020-11-01 2022-05-05 Francisco Leon Methods and compositions for treatment of lupus
CA3231174A1 (en) * 2021-08-02 2023-02-09 Innovent Biologics (Suzhou) Co., Ltd. Anti-cd79bxcd3 bispecific antibody and use thereof

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2015021089A1 (en) * 2013-08-09 2015-02-12 Macrogenics, Inc. Bi-specific monovalent fc diabodies that are capable of binding cd32b and cd79b and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9963510B2 (en) * 2005-04-15 2018-05-08 Macrogenics, Inc. Covalent diabodies and uses thereof
US9284375B2 (en) * 2005-04-15 2016-03-15 Macrogenics, Inc. Covalent diabodies and uses thereof
US11384149B2 (en) * 2013-08-09 2022-07-12 Macrogenics, Inc. Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof
AU2016207758C1 (en) * 2015-01-13 2020-05-28 Agresearch Limited Agricultural composition

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015021089A1 (en) * 2013-08-09 2015-02-12 Macrogenics, Inc. Bi-specific monovalent fc diabodies that are capable of binding cd32b and cd79b and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WEI CHEN ET AL: "Development of human B-lymphocyte targeted bi-specific DART molecules for the treatment of autoimmune disorders", 1 May 2014 (2014-05-01), XP055691801, Retrieved from the Internet [retrieved on 20200505] *

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Publication number Publication date
KR20220143769A (ko) 2022-10-25
BR112018075303A2 (pt) 2019-04-30
EP3464378A1 (en) 2019-04-10
KR20190016079A (ko) 2019-02-15
CN109311990A (zh) 2019-02-05
JP2019521103A (ja) 2019-07-25
US20190322741A1 (en) 2019-10-24
MX2024005841A (es) 2024-05-27
WO2017214096A1 (en) 2017-12-14
JP2024102146A (ja) 2024-07-30
RU2022101891A (ru) 2022-02-07
KR20250021614A (ko) 2025-02-13
RU2018145971A3 (enExample) 2020-09-03
TW201742633A (zh) 2017-12-16
EP3464378A4 (en) 2020-06-17
RU2018145971A (ru) 2020-07-10
MX2018015265A (es) 2019-09-06
JP2022120061A (ja) 2022-08-17
AU2017278329A1 (en) 2019-01-03

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