AU2017278329B2 - Methods for the use of CD32B x CD79B-binding molecules in the treatment of inflammatory diseases and disorders - Google Patents

Methods for the use of CD32B x CD79B-binding molecules in the treatment of inflammatory diseases and disorders Download PDF

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AU2017278329B2
AU2017278329B2 AU2017278329A AU2017278329A AU2017278329B2 AU 2017278329 B2 AU2017278329 B2 AU 2017278329B2 AU 2017278329 A AU2017278329 A AU 2017278329A AU 2017278329 A AU2017278329 A AU 2017278329A AU 2017278329 B2 AU2017278329 B2 AU 2017278329B2
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cd32b
cd79b
ser
val
dose
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AU2017278329A1 (en
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Ezio Bonvini
Wei Chen
Paul A. Moore
Naimish Bharat Pandya
Jon Marc Wigginton
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Macrogenics Inc
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Macrogenics Inc
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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  • Health & Medical Sciences (AREA)
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  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2017278329A 2016-06-07 2017-06-06 Methods for the use of CD32B x CD79B-binding molecules in the treatment of inflammatory diseases and disorders Active AU2017278329B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662346717P 2016-06-07 2016-06-07
US62/346,717 2016-06-07
US201662432328P 2016-12-09 2016-12-09
US62/432,328 2016-12-09
PCT/US2017/036079 WO2017214096A1 (en) 2016-06-07 2017-06-06 Methods for the use of cd32b x cd79b-binding molecules in the treatment of inflammatory diseases and disorders

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AU2017278329A1 AU2017278329A1 (en) 2019-01-03
AU2017278329B2 true AU2017278329B2 (en) 2024-08-08

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AU2017278329A Active AU2017278329B2 (en) 2016-06-07 2017-06-06 Methods for the use of CD32B x CD79B-binding molecules in the treatment of inflammatory diseases and disorders

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US (1) US20190322741A1 (cg-RX-API-DMAC10.html)
EP (1) EP3464378A4 (cg-RX-API-DMAC10.html)
JP (3) JP2019521103A (cg-RX-API-DMAC10.html)
KR (3) KR20250021614A (cg-RX-API-DMAC10.html)
CN (1) CN109311990A (cg-RX-API-DMAC10.html)
AU (1) AU2017278329B2 (cg-RX-API-DMAC10.html)
BR (1) BR112018075303A2 (cg-RX-API-DMAC10.html)
MX (2) MX2018015265A (cg-RX-API-DMAC10.html)
RU (1) RU2022101891A (cg-RX-API-DMAC10.html)
TW (1) TW201742633A (cg-RX-API-DMAC10.html)
WO (1) WO2017214096A1 (cg-RX-API-DMAC10.html)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
EA201790719A1 (ru) * 2014-09-26 2017-07-31 Макродженикс, Инк. Биспецифические моновалентные диатела, которые способны связывать cd19 и cd3, а также их применения
EP3532497B1 (en) * 2016-10-26 2024-07-24 The Board of Trustees of the Leland Stanford Junior University Modified immunoglobulin hinge regions to reduce hemagglutination
JP2022513338A (ja) * 2018-10-03 2022-02-07 ネペンザ・バイオサイエンシズ・エルエルシー 抗ｃｄ７９抗体およびその使用
CN114502587A (zh) * 2019-07-30 2022-05-13 普瑞文森生物有限公司 通过非耗竭性b细胞抑制剂降低免疫原性的方法和组合物
KR20220091458A (ko) * 2019-07-30 2022-06-30 프로벤션 바이오, 인코포레이티드 비-고갈성 b 세포 억제제에 의한 면역원성을 감소시키기 위한 방법 및 조성물
WO2021207681A1 (en) * 2020-04-10 2021-10-14 The Board Of Trustees Of The Leland Stanford Junior University Targeted reduction of activated immune cells
KR20230113312A (ko) * 2020-11-01 2023-07-28 프로벤션 바이오, 인코포레이티드 루푸스 치료 방법 및 조성물
CA3231174A1 (en) * 2021-08-02 2023-02-09 Innovent Biologics (Suzhou) Co., Ltd. Anti-cd79bxcd3 bispecific antibody and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015021089A1 (en) * 2013-08-09 2015-02-12 Macrogenics, Inc. Bi-specific monovalent fc diabodies that are capable of binding cd32b and cd79b and uses thereof

Family Cites Families (4)

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US9963510B2 (en) * 2005-04-15 2018-05-08 Macrogenics, Inc. Covalent diabodies and uses thereof
US9284375B2 (en) * 2005-04-15 2016-03-15 Macrogenics, Inc. Covalent diabodies and uses thereof
US11384149B2 (en) * 2013-08-09 2022-07-12 Macrogenics, Inc. Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof
AU2016207758C1 (en) * 2015-01-13 2020-05-28 New Zealand Institute For Bioeconomy Science Limited Agricultural composition

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015021089A1 (en) * 2013-08-09 2015-02-12 Macrogenics, Inc. Bi-specific monovalent fc diabodies that are capable of binding cd32b and cd79b and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WEI CHEN ET AL: "Development of human B-lymphocyte targeted bi-specific DART molecules for the treatment of autoimmune disorders", 1 May 2014 (2014-05-01), XP055691801, Retrieved from the Internet [retrieved on 20200505] *

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Publication number Publication date
US20190322741A1 (en) 2019-10-24
JP2019521103A (ja) 2019-07-25
RU2022101891A (ru) 2022-02-07
BR112018075303A2 (pt) 2019-04-30
RU2018145971A3 (cg-RX-API-DMAC10.html) 2020-09-03
MX2018015265A (es) 2019-09-06
KR20220143769A (ko) 2022-10-25
KR20190016079A (ko) 2019-02-15
WO2017214096A1 (en) 2017-12-14
RU2018145971A (ru) 2020-07-10
KR20250021614A (ko) 2025-02-13
CN109311990A (zh) 2019-02-05
JP2022120061A (ja) 2022-08-17
TW201742633A (zh) 2017-12-16
EP3464378A1 (en) 2019-04-10
JP2024102146A (ja) 2024-07-30
EP3464378A4 (en) 2020-06-17
MX2024005841A (es) 2024-05-27
AU2017278329A1 (en) 2019-01-03

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