AU2017238644B2 - Methods for treating and preventing C. difficile infection - Google Patents

Methods for treating and preventing C. difficile infection Download PDF

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Publication number
AU2017238644B2
AU2017238644B2 AU2017238644A AU2017238644A AU2017238644B2 AU 2017238644 B2 AU2017238644 B2 AU 2017238644B2 AU 2017238644 A AU2017238644 A AU 2017238644A AU 2017238644 A AU2017238644 A AU 2017238644A AU 2017238644 B2 AU2017238644 B2 AU 2017238644B2
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subject
compound
infection
difficile
developing
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AU2017238644A
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AU2017238644A1 (en
Inventor
Michael P. Draper
S. Ken Tanaka
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Paratek Pharmaceuticals Inc
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Paratek Pharmaceuticals Inc
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Priority to AU2023200798A priority Critical patent/AU2023200798A1/en
Priority to AU2025202020A priority patent/AU2025202020A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
AU2017238644A 2016-03-24 2017-03-24 Methods for treating and preventing C. difficile infection Active AU2017238644B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2023200798A AU2023200798A1 (en) 2016-03-24 2023-02-14 Methods for treating and preventing C. difficile infection
AU2025202020A AU2025202020A1 (en) 2016-03-24 2025-03-20 Methods for treating and preventing C. difficile infection

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662312996P 2016-03-24 2016-03-24
US62/312,996 2016-03-24
US201662320053P 2016-04-08 2016-04-08
US62/320,053 2016-04-08
PCT/US2017/023958 WO2017165729A1 (en) 2016-03-24 2017-03-24 Methods for treating and preventing c. difficile infection

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2023200798A Division AU2023200798A1 (en) 2016-03-24 2023-02-14 Methods for treating and preventing C. difficile infection

Publications (2)

Publication Number Publication Date
AU2017238644A1 AU2017238644A1 (en) 2018-10-25
AU2017238644B2 true AU2017238644B2 (en) 2022-12-15

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
AU2017238644A Active AU2017238644B2 (en) 2016-03-24 2017-03-24 Methods for treating and preventing C. difficile infection
AU2023200798A Abandoned AU2023200798A1 (en) 2016-03-24 2023-02-14 Methods for treating and preventing C. difficile infection
AU2025202020A Pending AU2025202020A1 (en) 2016-03-24 2025-03-20 Methods for treating and preventing C. difficile infection

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2023200798A Abandoned AU2023200798A1 (en) 2016-03-24 2023-02-14 Methods for treating and preventing C. difficile infection
AU2025202020A Pending AU2025202020A1 (en) 2016-03-24 2025-03-20 Methods for treating and preventing C. difficile infection

Country Status (13)

Country Link
US (3) US20170319603A1 (enExample)
EP (1) EP3432891A4 (enExample)
JP (3) JP7458706B2 (enExample)
CN (2) CN119454720A (enExample)
AU (3) AU2017238644B2 (enExample)
BR (2) BR122024000249A2 (enExample)
CA (1) CA3018872A1 (enExample)
MX (2) MX2018011413A (enExample)
MY (1) MY197627A (enExample)
PH (1) PH12018502020A1 (enExample)
RU (1) RU2751509C1 (enExample)
SG (2) SG10201913559VA (enExample)
WO (1) WO2017165729A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119454720A (zh) * 2016-03-24 2025-02-18 帕拉特克Spv2有限责任公司 用于治疗和预防艰难梭菌感染的方法
TWI746610B (zh) * 2016-08-03 2021-11-21 美商派瑞泰Ｓｐｖ２有限公司 9-胺甲基米諾四環素化合物及其用途
SG11201903846TA (en) * 2016-11-01 2019-05-30 Paratek Pharm Innc 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)
JP7110560B2 (ja) * 2017-09-06 2022-08-02 株式会社三洋物産 遊技機
JP7110562B2 (ja) * 2017-09-06 2022-08-02 株式会社三洋物産 遊技機
JP7110563B2 (ja) * 2017-09-06 2022-08-02 株式会社三洋物産 遊技機
JP2019136430A (ja) * 2018-02-15 2019-08-22 株式会社三洋物産 遊技機
JP2019136431A (ja) * 2018-02-15 2019-08-22 株式会社三洋物産 遊技機
JP2019136429A (ja) * 2018-02-15 2019-08-22 株式会社三洋物産 遊技機
WO2020051151A1 (en) * 2018-09-04 2020-03-12 Paratek Pharmaceuticals, Inc. Methods of treating mycobacterial infections using tetracycline compounds
CN112823014A (zh) * 2018-10-10 2021-05-18 营养株式会社 艰难梭菌感染的预防和/或治疗剂
US20230357135A1 (en) * 2020-06-11 2023-11-09 Paratek Pharmaceuticals, Inc. Crystalline forms of omadacycline, methods of synthesis thereof and methods of use thereof
PT117254B (pt) 2021-05-26 2024-04-18 Hovione Farm S A Método de síntese de compostos 9-aminometil tetraciclinas
JP2023105293A (ja) * 2022-07-21 2023-07-28 株式会社三洋物産 遊技機
JP2023105292A (ja) * 2022-07-21 2023-07-28 株式会社三洋物産 遊技機

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100113399A1 (en) * 2008-05-19 2010-05-06 Paratek Pharmaceuticals, Inc. Salts and Polymorphs of a Tetracycline Compound

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BR9206300A (pt) * 1991-07-24 1994-08-02 Procter & Gamble Processos e composições de tratamento antimicrobiano
CZ2003344A3 (cs) * 2000-07-07 2003-05-14 Trustees Of Tufts College 9-Substituované minocyklinové sloučeniny
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP1408987B1 (en) * 2001-07-13 2013-04-10 Paratek Pharmaceuticals, Inc. Tetracycline compounds having target therapeutic activities
WO2007075792A1 (en) * 2005-12-22 2007-07-05 Wyeth Methods of treating gastrointestinal tract infections with tigecycline
EP1991236A2 (en) * 2006-01-24 2008-11-19 Paratek Pharmaceuticals, Inc. Methods of increasing oral bioavailability of tetracyclines
EP2144870A2 (en) 2007-04-27 2010-01-20 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
US20110294726A1 (en) * 2009-02-11 2011-12-01 Cedars-Sinai Medical Center Antibiotic therapy to reduce the likelihood of developing post-infectious irritable bowel syndrome
AU2011239470B2 (en) * 2010-04-15 2015-09-10 Progenics Pharmaceuticals, Inc. Antibodies for the treatment of Clostridium difficile-associated infection and disease
WO2012050826A1 (en) * 2010-09-29 2012-04-19 St. Jude Children's Research Hostpital Methods for treating clostridium difficile infections
WO2012065028A2 (en) * 2010-11-11 2012-05-18 Concert Pharmaceuticals Inc. Substituted tetracyclines
MX369877B (es) * 2013-02-04 2019-11-25 Seres Therapeutics Inc Composiciones y metodos.
US20140274800A1 (en) * 2013-03-13 2014-09-18 Procarta Biosystems Ltd. Transcription factor decoys for the treatment and prevention of infections caused by bacteria including clostridium difficile
CN119454720A (zh) * 2016-03-24 2025-02-18 帕拉特克Spv2有限责任公司 用于治疗和预防艰难梭菌感染的方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100113399A1 (en) * 2008-05-19 2010-05-06 Paratek Pharmaceuticals, Inc. Salts and Polymorphs of a Tetracycline Compound

Non-Patent Citations (2)

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LARSON K.C. et al.: Annals of Pharmacotherapy, 2011, vol. 45, no. 7-8, pp. 1005-1010 *
MACONE A.B. et al.: Antimicrobial Agents & Chemotherapy, 2014, vol. 58, no. 2, pp. 1127-1135 *

Also Published As

Publication number Publication date
EP3432891A1 (en) 2019-01-30
MY197627A (en) 2023-06-29
CN109152789A (zh) 2019-01-04
EP3432891A4 (en) 2019-10-30
CA3018872A1 (en) 2017-09-28
MX2018011413A (es) 2019-01-10
MX2023004969A (es) 2023-05-24
RU2751509C1 (ru) 2021-07-14
JP2022115985A (ja) 2022-08-09
BR122024000249A2 (pt) 2024-02-27
JP7458706B2 (ja) 2024-04-01
CN119454720A (zh) 2025-02-18
JP2019509318A (ja) 2019-04-04
SG10201913559VA (en) 2020-02-27
JP2024023187A (ja) 2024-02-21
AU2017238644A1 (en) 2018-10-25
AU2023200798A1 (en) 2023-03-09
PH12018502020A1 (en) 2019-07-15
SG11201808246SA (en) 2018-10-30
US20250049819A1 (en) 2025-02-13
US20170319603A1 (en) 2017-11-09
BR112018069303A2 (pt) 2019-01-22
WO2017165729A1 (en) 2017-09-28
AU2025202020A1 (en) 2025-04-10
US20200281948A1 (en) 2020-09-10

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