AU2017205343A1 - Self-crosslinking antibodies - Google Patents
Self-crosslinking antibodies Download PDFInfo
- Publication number
- AU2017205343A1 AU2017205343A1 AU2017205343A AU2017205343A AU2017205343A1 AU 2017205343 A1 AU2017205343 A1 AU 2017205343A1 AU 2017205343 A AU2017205343 A AU 2017205343A AU 2017205343 A AU2017205343 A AU 2017205343A AU 2017205343 A1 AU2017205343 A1 AU 2017205343A1
- Authority
- AU
- Australia
- Prior art keywords
- ser
- leu
- gly
- thr
- val
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 238000004132 cross linking Methods 0.000 title claims abstract 18
- 101710160107 Outer membrane protein A Proteins 0.000 claims abstract 21
- 238000000034 method Methods 0.000 claims abstract 14
- 230000001225 therapeutic effect Effects 0.000 claims abstract 4
- 238000009826 distribution Methods 0.000 claims abstract 3
- 241000880493 Leptailurus serval Species 0.000 claims 113
- 108090000765 processed proteins & peptides Proteins 0.000 claims 75
- 229920001184 polypeptide Polymers 0.000 claims 74
- 102000004196 processed proteins & peptides Human genes 0.000 claims 74
- 239000000427 antigen Substances 0.000 claims 55
- 102000036639 antigens Human genes 0.000 claims 55
- 108091007433 antigens Proteins 0.000 claims 55
- 239000012634 fragment Substances 0.000 claims 52
- 108010031719 prolyl-serine Proteins 0.000 claims 50
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- XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Chemical compound NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 claims 42
- 108010089804 glycyl-threonine Proteins 0.000 claims 42
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- 108010049041 glutamylalanine Proteins 0.000 claims 36
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- XYEXCEPTALHNEV-RCWTZXSCSA-N Thr-Arg-Arg Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O XYEXCEPTALHNEV-RCWTZXSCSA-N 0.000 claims 26
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- BMKNXTJLHFIAAH-CIUDSAMLSA-N Ser-Ser-Leu Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O BMKNXTJLHFIAAH-CIUDSAMLSA-N 0.000 claims 24
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- MNYNCKZAEIAONY-XGEHTFHBSA-N Thr-Val-Ser Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(O)=O MNYNCKZAEIAONY-XGEHTFHBSA-N 0.000 claims 23
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- 108010071635 tyrosyl-prolyl-arginine Proteins 0.000 claims 23
- HSWYMWGDMPLTTH-FXQIFTODSA-N Asp-Glu-Gln Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O HSWYMWGDMPLTTH-FXQIFTODSA-N 0.000 claims 22
- BYYNJRSNDARRBX-YFKPBYRVSA-N Gly-Gln-Gly Chemical compound NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(O)=O BYYNJRSNDARRBX-YFKPBYRVSA-N 0.000 claims 22
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- 108010051110 tyrosyl-lysine Proteins 0.000 claims 22
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- VCHVSKNMTXWIIP-SRVKXCTJSA-N Leu-Lys-Ser Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O VCHVSKNMTXWIIP-SRVKXCTJSA-N 0.000 claims 20
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US201662276803P | 2016-01-08 | 2016-01-08 | |
| US62/276,803 | 2016-01-08 | ||
| US201662317342P | 2016-04-01 | 2016-04-01 | |
| US62/317,342 | 2016-04-01 | ||
| PCT/US2017/012754 WO2017120599A1 (en) | 2016-01-08 | 2017-01-09 | Self-crosslinking antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2017205343A1 true AU2017205343A1 (en) | 2018-07-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017205343A Abandoned AU2017205343A1 (en) | 2016-01-08 | 2017-01-09 | Self-crosslinking antibodies |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11459397B2 (enExample) |
| EP (1) | EP3399992A4 (enExample) |
| JP (1) | JP6983808B2 (enExample) |
| KR (1) | KR20180098672A (enExample) |
| CN (1) | CN108712908A (enExample) |
| AU (1) | AU2017205343A1 (enExample) |
| CA (1) | CA3010632A1 (enExample) |
| WO (1) | WO2017120599A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2017215350A1 (en) * | 2016-02-02 | 2018-08-09 | Meditope Biosciences, Inc. | Anti-EGFR antibody drug conjugate |
| EP3765523A1 (en) * | 2018-03-12 | 2021-01-20 | Memorial Sloan Kettering Cancer Center | Bispecific binding agents and uses thereof |
| CN109521192B (zh) * | 2018-11-27 | 2021-07-13 | 柏荣诊断产品（上海）有限公司 | 一种提高胶乳比浊试剂检测灵敏度的方法 |
| KR20220078665A (ko) * | 2019-10-10 | 2022-06-10 | 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 | 다중특이적 면역 세포 인게이저를 발현하는 종양용해 바이러스 |
| EP4025250A4 (en) * | 2019-10-12 | 2024-01-17 | Bio-Thera Solutions, Ltd. | FORMULATION OF ANTI-CD20 ANTIBODIES AND USE OF ANTI-CD20 ANTIBODIES FOR THE TREATMENT OF CD20-POSITIVE DISEASES |
| JPWO2021112249A1 (enExample) * | 2019-12-06 | 2021-06-10 | ||
| MX2022011701A (es) * | 2020-03-23 | 2022-10-07 | Bristol Myers Squibb Co | Anticuerpos anti-receptor de quimiocina 8 con motivo c-c (ccr8) para el tratamiento del cancer. |
| WO2022068141A1 (zh) * | 2020-09-29 | 2022-04-07 | 昆明赛诺制药股份有限公司 | 人源化抗-cd22重组免疫毒素及其应用 |
| CN112661828B (zh) * | 2021-01-15 | 2022-04-01 | 武汉大学 | 一种突触素的抗原肽及其抗体与应用 |
| WO2022158554A1 (ja) * | 2021-01-22 | 2022-07-28 | 味の素株式会社 | 二量体化した環状ペプチドをスクリーニングする方法 |
| CA3212386A1 (en) * | 2021-03-18 | 2022-09-22 | Alessandro ARCOVITO | Ferritin variants with increased stability and complexation ability |
| CN115677856B (zh) * | 2021-07-29 | 2023-11-28 | 东莞市朋志生物科技有限公司 | 抗人IgM抗体及其应用 |
| JP2024025400A (ja) * | 2022-08-12 | 2024-02-26 | 浜松ホトニクス株式会社 | 膜貫通タンパク質を標的オルガネラに局在化させるためのペプチドリンカー及び局在化方法並びに局在化する融合タンパク質 |
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| EP1293514B1 (en) * | 2001-09-14 | 2006-11-29 | Affimed Therapeutics AG | Multimeric single chain tandem Fv-antibodies |
| AU2005266184A1 (en) * | 2004-07-26 | 2006-02-02 | Asterion Limited | Linkers |
| US20140127200A1 (en) * | 2008-01-03 | 2014-05-08 | The Scripps Research Institute | Multispecific Antibody Targeting and Multivalency Through Modular Recognition Domains |
| US8962804B2 (en) * | 2010-10-08 | 2015-02-24 | City Of Hope | Meditopes and meditope-binding antibodies and uses thereof |
| SG189313A1 (en) * | 2010-10-08 | 2013-05-31 | John C Williams | A monoclonal antibody framework binding interface for meditopes, meditope delivery systems and methods for their use |
| CN114634572A (zh) * | 2011-10-10 | 2022-06-17 | 希望之城公司 | 中间位和中间位结合抗体及其用途 |
| US9428553B2 (en) * | 2012-02-10 | 2016-08-30 | City Of Hope | Meditopes and meditope-binding antibodies and uses thereof |
| CN117442748A (zh) * | 2014-10-02 | 2024-01-26 | 希望之城公司 | 多价中间表位、中间表位结合抗体及其用途 |
| ES2852973T3 (es) * | 2015-05-15 | 2021-09-14 | Hope City | Composiciones de receptores de antígeno quimérico |
| AU2017215350A1 (en) * | 2016-02-02 | 2018-08-09 | Meditope Biosciences, Inc. | Anti-EGFR antibody drug conjugate |
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2017
- 2017-01-09 EP EP17736526.9A patent/EP3399992A4/en not_active Withdrawn
- 2017-01-09 JP JP2018554653A patent/JP6983808B2/ja not_active Expired - Fee Related
- 2017-01-09 CN CN201780016120.2A patent/CN108712908A/zh active Pending
- 2017-01-09 WO PCT/US2017/012754 patent/WO2017120599A1/en not_active Ceased
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- 2017-01-09 US US16/068,892 patent/US11459397B2/en active Active
- 2017-01-09 KR KR1020187022826A patent/KR20180098672A/ko not_active Ceased
- 2017-01-09 AU AU2017205343A patent/AU2017205343A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP6983808B2 (ja) | 2021-12-17 |
| KR20180098672A (ko) | 2018-09-04 |
| US11459397B2 (en) | 2022-10-04 |
| WO2017120599A1 (en) | 2017-07-13 |
| JP2019509054A (ja) | 2019-04-04 |
| EP3399992A4 (en) | 2019-07-31 |
| US20190016822A1 (en) | 2019-01-17 |
| CA3010632A1 (en) | 2017-07-13 |
| CN108712908A (zh) | 2018-10-26 |
| EP3399992A1 (en) | 2018-11-14 |
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| Date | Code | Title | Description |
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| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |