AU2016369520B2 - Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine - Google Patents

Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine Download PDF

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Publication number
AU2016369520B2
AU2016369520B2 AU2016369520A AU2016369520A AU2016369520B2 AU 2016369520 B2 AU2016369520 B2 AU 2016369520B2 AU 2016369520 A AU2016369520 A AU 2016369520A AU 2016369520 A AU2016369520 A AU 2016369520A AU 2016369520 B2 AU2016369520 B2 AU 2016369520B2
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AU2016369520A1 (en
Inventor
Craig Bates
Jianmin Mao
David P. Reed
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Arqule Inc
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Arqule Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
AU2016369520A 2015-12-17 2016-12-16 Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine Active AU2016369520B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021202610A AU2021202610B2 (en) 2015-12-17 2021-04-28 Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562268758P 2015-12-17 2015-12-17
US62/268,758 2015-12-17
PCT/US2016/067161 WO2017106639A1 (fr) 2015-12-17 2016-12-16 Procédés de préparation de 5,6-dihydro-6-phénylbenzo[f]isoquinoléine-2-amine substituée

Related Child Applications (1)

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AU2021202610A Division AU2021202610B2 (en) 2015-12-17 2021-04-28 Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine

Publications (2)

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AU2016369520A1 AU2016369520A1 (en) 2018-06-07
AU2016369520B2 true AU2016369520B2 (en) 2021-02-18

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AU2016369520A Active AU2016369520B2 (en) 2015-12-17 2016-12-16 Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine
AU2021202610A Active AU2021202610B2 (en) 2015-12-17 2021-04-28 Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine

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AU2021202610A Active AU2021202610B2 (en) 2015-12-17 2021-04-28 Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine

Country Status (16)

Country Link
US (4) US9834519B2 (fr)
EP (2) EP4015508A1 (fr)
JP (2) JP6940504B2 (fr)
KR (1) KR20180085814A (fr)
CN (2) CN108602779A (fr)
AU (2) AU2016369520B2 (fr)
BR (1) BR112018012325A2 (fr)
CA (1) CA3006077A1 (fr)
EA (1) EA201891431A1 (fr)
HK (1) HK1255014A1 (fr)
IL (1) IL259557A (fr)
MX (2) MX2020012771A (fr)
NZ (1) NZ742785A (fr)
SG (1) SG11201804601TA (fr)
TW (1) TWI748972B (fr)
WO (1) WO2017106639A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018537499A (ja) 2015-12-17 2018-12-20 アークル インコーポレイテッド 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミン化合物の固体形態
EP4015508A1 (fr) 2015-12-17 2022-06-22 ArQule, Inc. Procédés de préparation de 5,6-dihydro-6-phénylbenzo[f]isoquinoléine-2-amine substituée
CN110669015A (zh) * 2018-07-03 2020-01-10 上海喀露蓝科技有限公司 一种fgfr抑制剂的制备方法
WO2022053708A1 (fr) 2020-09-14 2022-03-17 Basilea Pharmaceutica International AG Combinaisons pharmaceutiques destinées à être utilisées pour le traitement d'un adénocarcinome gastrique

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028281A1 (fr) * 1996-12-23 1998-07-02 Celltech Therapeutics Limited Derives polycyclique fondus de 2-aminopyrimidine, leur preparation et leur utilisation comme inhibiteurs de proteine tyrosine-kinase
US6133257A (en) * 1997-06-20 2000-10-17 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives
WO2010078421A1 (fr) * 2008-12-30 2010-07-08 Arqule, Inc. Composés de 5,6-dihydro-6-phénylbenzo[f]isoquinoléine-2-amines substituées

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
CN101115749B (zh) * 2004-12-17 2011-06-22 安姆根有限公司 氨基嘧啶化合物和使用方法
US8906922B2 (en) 2006-12-29 2014-12-09 Rigel Pharmaceuticals, Inc. Substituted triazoles useful as AXl inhibitors
GB2449293A (en) * 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
EA024026B1 (ru) 2010-11-25 2016-08-31 Рациофарм Гмбх Новые соли и полиморфные формы афатиниба
US8815854B2 (en) * 2011-06-24 2014-08-26 Arqule, Inc. Substituted imidazopyridinyl compounds
KR20160138494A (ko) * 2014-03-31 2016-12-05 데비오팜 인터네셔날 에스 에이 Fgfr 융합물
JP2018537499A (ja) 2015-12-17 2018-12-20 アークル インコーポレイテッド 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミン化合物の固体形態
EP4015508A1 (fr) 2015-12-17 2022-06-22 ArQule, Inc. Procédés de préparation de 5,6-dihydro-6-phénylbenzo[f]isoquinoléine-2-amine substituée

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028281A1 (fr) * 1996-12-23 1998-07-02 Celltech Therapeutics Limited Derives polycyclique fondus de 2-aminopyrimidine, leur preparation et leur utilisation comme inhibiteurs de proteine tyrosine-kinase
US6133257A (en) * 1997-06-20 2000-10-17 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives
WO2010078421A1 (fr) * 2008-12-30 2010-07-08 Arqule, Inc. Composés de 5,6-dihydro-6-phénylbenzo[f]isoquinoléine-2-amines substituées

Also Published As

Publication number Publication date
EP3390368A4 (fr) 2019-07-03
US9834519B2 (en) 2017-12-05
EP3390368A1 (fr) 2018-10-24
US10766868B2 (en) 2020-09-08
AU2021202610A1 (en) 2021-05-27
US20200102276A1 (en) 2020-04-02
NZ742785A (en) 2023-06-30
KR20180085814A (ko) 2018-07-27
TWI748972B (zh) 2021-12-11
WO2017106639A1 (fr) 2017-06-22
SG11201804601TA (en) 2018-07-30
US20170174637A1 (en) 2017-06-22
US11279679B2 (en) 2022-03-22
MX2020012771A (es) 2022-10-04
BR112018012325A2 (pt) 2018-12-04
EA201891431A1 (ru) 2018-11-30
JP2018537495A (ja) 2018-12-20
US20190241527A1 (en) 2019-08-08
MX2018007415A (es) 2018-11-09
HK1255014A1 (zh) 2019-08-02
TW201733992A (zh) 2017-10-01
JP6940504B2 (ja) 2021-09-29
US20180065937A1 (en) 2018-03-08
JP2021191782A (ja) 2021-12-16
CA3006077A1 (fr) 2017-06-22
IL259557A (en) 2018-07-31
CN108602779A (zh) 2018-09-28
AU2016369520A1 (en) 2018-06-07
EP4015508A1 (fr) 2022-06-22
CN114874149A (zh) 2022-08-09
AU2021202610B2 (en) 2022-06-02
US10093632B2 (en) 2018-10-09

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