AU2016353547B9 - Cyclic peptides targeting α4β7 integrin - Google Patents
Cyclic peptides targeting α4β7 integrin Download PDFInfo
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- AU2016353547B9 AU2016353547B9 AU2016353547A AU2016353547A AU2016353547B9 AU 2016353547 B9 AU2016353547 B9 AU 2016353547B9 AU 2016353547 A AU2016353547 A AU 2016353547A AU 2016353547 A AU2016353547 A AU 2016353547A AU 2016353547 B9 AU2016353547 B9 AU 2016353547B9
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
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- Diabetes (AREA)
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- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Analytical Chemistry (AREA)
- Transplantation (AREA)
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- Obesity (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562254003P | 2015-11-11 | 2015-11-11 | |
| US62/254,003 | 2015-11-11 | ||
| PCT/CA2016/000274 WO2017079820A1 (en) | 2015-11-11 | 2016-11-14 | CYCLIC PEPTIDES TARGETING α4β7 INTEGRIN |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2016353547A1 AU2016353547A1 (en) | 2018-06-28 |
| AU2016353547B2 AU2016353547B2 (en) | 2020-08-06 |
| AU2016353547B9 true AU2016353547B9 (en) | 2020-12-03 |
Family
ID=58694457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016353547A Active AU2016353547B9 (en) | 2015-11-11 | 2016-11-14 | Cyclic peptides targeting α4β7 integrin |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US11072616B2 (enExample) |
| EP (2) | EP3377471A4 (enExample) |
| JP (1) | JP6961586B2 (enExample) |
| KR (1) | KR102867019B1 (enExample) |
| CN (2) | CN109071602B (enExample) |
| AU (1) | AU2016353547B9 (enExample) |
| CA (2) | CA3004641A1 (enExample) |
| WO (2) | WO2017079821A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3004641A1 (en) | 2015-11-11 | 2017-05-18 | Encycle Therapeutics, Inc. | Cyclic peptides targeting .alpha.4.beta.7 integrin |
| JP7035044B2 (ja) | 2016-11-11 | 2022-03-14 | ジーランド ファーマ エー/エス | α4β7インテグリンを標的とする環状ペプチド多量体 |
| EP3621980A4 (en) * | 2017-05-10 | 2021-06-30 | Zealand Pharma A/S | HOMODETIC CYCLIC PEPTIDES TARGETING INTEGRIN ALPHA4 BETA7 |
| CN110551178B (zh) * | 2018-06-01 | 2020-07-21 | 深圳翰宇药业股份有限公司 | 一种含脯氨酸的首尾环肽合成方法 |
| WO2020185999A1 (en) * | 2019-03-14 | 2020-09-17 | Genentech, Inc. | Cyclic peptide antibiotics |
| EP4101929A4 (en) * | 2019-12-27 | 2024-05-22 | The University of Tokyo | BANK CONSTRUCTION METHOD, CYCLIC PEPTIDE, FXIIA BINDER AND IFNGR1 BINDER |
| JP2021106565A (ja) * | 2019-12-27 | 2021-07-29 | 国立大学法人 東京大学 | ライブラリーの製造方法、環状ペプチド、FXIIa結合剤、及びIFNGR1結合剤 |
| US20230295235A1 (en) | 2020-06-29 | 2023-09-21 | Zealand Pharma A/S | Compounds targeting alpha4-beta7 integrin |
| IL313590A (en) | 2021-12-20 | 2024-08-01 | Zealand Pharma As | Compounds |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140193465A1 (en) * | 2012-10-11 | 2014-07-10 | Protagonist Therapeutics, Inc. | NOVEL a4B7 PEPTIDE DIMER ANTAGONISTS |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3219113A1 (de) * | 1982-05-21 | 1983-11-24 | Bayer Ag, 5090 Leverkusen | Verwendung von n-substituierten 2,3-diaminocarbonsaeuren in arzneimitteln und ihre herstellung |
| AU638264B2 (en) | 1989-08-10 | 1993-06-24 | Aventis Inc. | Cyclic neurokinin a antagonists |
| US5296604A (en) | 1992-05-15 | 1994-03-22 | Miles Inc. | Proline derivatives and compositions for their use as inhibitors of HIV protease |
| US5705481A (en) | 1992-11-06 | 1998-01-06 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Cyclopeptides |
| AU681119B2 (en) | 1993-05-17 | 1997-08-21 | Fujisawa Pharmaceutical Co., Ltd. | New polypeptide compound and a process for preparation thereof |
| US5693325A (en) | 1994-03-15 | 1997-12-02 | Molecumetics, Ltd. | Peptide vaccines and methods relating thereto |
| DE4415310A1 (de) | 1994-04-30 | 1995-11-02 | Merck Patent Gmbh | Cyclopeptide |
| GB9524630D0 (en) * | 1994-12-24 | 1996-01-31 | Zeneca Ltd | Chemical compounds |
| US5696084A (en) | 1996-08-16 | 1997-12-09 | Abbott Laboratories | Amino-lipopetide antifungal agents |
| US6492553B1 (en) | 1998-01-29 | 2002-12-10 | Aventis Pharamaceuticals Inc. | Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds |
| DE10107707A1 (de) * | 2001-02-19 | 2002-08-29 | Wilex Biotechnology Gmbh | Antagonisten für alpha¶4¶beta¶7¶-Integrin |
| US6667407B2 (en) | 2002-05-03 | 2003-12-23 | Bayer Polymers Llc | Process of making polyaziridines |
| CA2562411A1 (en) | 2004-04-15 | 2005-11-10 | Proteolix, Inc. | Compounds for enzyme inhibition |
| CA2702605C (en) | 2006-10-20 | 2015-03-24 | Ryan Hili | Unprotected amino aldehydes and applications for same |
| EP1961759A1 (en) * | 2007-02-21 | 2008-08-27 | Universita'degli Studi Di Milano | Integrin targeted cyclopeptide ligands, their preparation and use |
| EP2291390B1 (en) * | 2008-05-22 | 2014-11-05 | Centre National de la Recherche Scientifique (CNRS) | New optically pure compounds for improved therapeutic efficiency |
| CN102498124B (zh) | 2009-03-16 | 2015-05-13 | 多伦多大学管理委员会 | 环状氨基酸分子及其制备方法 |
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| US10301371B2 (en) | 2014-10-01 | 2019-05-28 | Protagonist Therapeutics, Inc. | Cyclic monomer and dimer peptides having integrin antagonist activity |
| US10281407B2 (en) | 2015-11-02 | 2019-05-07 | Jon A. Petty | Multi-fluid strip test |
| CA3004641A1 (en) | 2015-11-11 | 2017-05-18 | Encycle Therapeutics, Inc. | Cyclic peptides targeting .alpha.4.beta.7 integrin |
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2016
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2021
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| US20140193465A1 (en) * | 2012-10-11 | 2014-07-10 | Protagonist Therapeutics, Inc. | NOVEL a4B7 PEPTIDE DIMER ANTAGONISTS |
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| CN109071602A (zh) | 2018-12-21 |
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| AU2016353547B2 (en) | 2020-08-06 |
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| US20200165300A1 (en) | 2020-05-28 |
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| CN109071430A (zh) | 2018-12-21 |
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| EP3387004B1 (en) | 2021-10-06 |
| EP3377471A1 (en) | 2018-09-26 |
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| WO2017079820A1 (en) | 2017-05-18 |
| EP3387004A1 (en) | 2018-10-17 |
| CA3004641A1 (en) | 2017-05-18 |
| US11072616B2 (en) | 2021-07-27 |
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