AU2016318595B2 - Methods and compositions for soft anticholinergic esters - Google Patents

Methods and compositions for soft anticholinergic esters Download PDF

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Publication number
AU2016318595B2
AU2016318595B2 AU2016318595A AU2016318595A AU2016318595B2 AU 2016318595 B2 AU2016318595 B2 AU 2016318595B2 AU 2016318595 A AU2016318595 A AU 2016318595A AU 2016318595 A AU2016318595 A AU 2016318595A AU 2016318595 B2 AU2016318595 B2 AU 2016318595B2
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AU
Australia
Prior art keywords
hydroxyacetoxy
cyclopentyl
phenyl
methylpyrrolidinium bromide
compound
Prior art date
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Application number
AU2016318595A
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English (en)
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AU2016318595A1 (en
Inventor
Nicholas S. Bodor
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Bodor Laboratories Inc
Original Assignee
Bodor Laboratories Inc
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Publication date
Application filed by Bodor Laboratories Inc filed Critical Bodor Laboratories Inc
Publication of AU2016318595A1 publication Critical patent/AU2016318595A1/en
Priority to AU2021204306A priority Critical patent/AU2021204306B2/en
Application granted granted Critical
Publication of AU2016318595B2 publication Critical patent/AU2016318595B2/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007Drug-containing films, membranes or sheets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12Oxygen or sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2016318595A 2015-09-11 2016-09-06 Methods and compositions for soft anticholinergic esters Active AU2016318595B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021204306A AU2021204306B2 (en) 2015-09-11 2021-06-24 Methods and compositions for soft anticholinergic esters

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562217362P 2015-09-11 2015-09-11
US62/217,362 2015-09-11
PCT/US2016/050385 WO2017044412A1 (en) 2015-09-11 2016-09-06 Methods and compositions for soft anticholinergic esters

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021204306A Division AU2021204306B2 (en) 2015-09-11 2021-06-24 Methods and compositions for soft anticholinergic esters

Publications (2)

Publication Number Publication Date
AU2016318595A1 AU2016318595A1 (en) 2018-04-26
AU2016318595B2 true AU2016318595B2 (en) 2021-07-08

Family

ID=58239861

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2016318595A Active AU2016318595B2 (en) 2015-09-11 2016-09-06 Methods and compositions for soft anticholinergic esters
AU2021204306A Active AU2021204306B2 (en) 2015-09-11 2021-06-24 Methods and compositions for soft anticholinergic esters

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2021204306A Active AU2021204306B2 (en) 2015-09-11 2021-06-24 Methods and compositions for soft anticholinergic esters

Country Status (13)

Country Link
US (3) US11534422B2 (enExample)
EP (1) EP3347007B1 (enExample)
JP (4) JP7270958B2 (enExample)
KR (1) KR102889909B1 (enExample)
CN (4) CN118045082A (enExample)
AU (2) AU2016318595B2 (enExample)
CA (1) CA2998357A1 (enExample)
ES (1) ES2942361T3 (enExample)
IL (1) IL257970B (enExample)
MX (1) MX388831B (enExample)
MY (1) MY197265A (enExample)
WO (1) WO2017044412A1 (enExample)
ZA (1) ZA201801685B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109044965A (zh) * 2018-10-17 2018-12-21 广州大光制药有限公司 格隆溴铵的眼用药物组合物及医药用途
US20230149349A1 (en) * 2020-03-03 2023-05-18 Kaken Pharmaceutical Co., Ltd. Medicament containing sofpironium bromide
KR20240088983A (ko) 2021-11-01 2024-06-20 유타대학연구재단 침흘림증 치료를 위한 조성물 및 방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080102102A1 (en) * 2005-01-19 2008-05-01 Neurohealing Pharmaceuticals, Inc. Methods And Compositions For Decreasing Saliva Production
US20080260823A1 (en) * 2007-04-20 2008-10-23 Sciele Pharma, Inc. Orally disintegrating tablet comprising glycopyrrolate for treating sialorrhea
US20140275204A1 (en) * 2013-03-15 2014-09-18 Bodor Laboratories, Inc. Method of dosing and use of soft anticholinergic esters

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2879100A (en) * 1999-02-12 2000-08-29 Miles A. Libbey Iii Formulation and system for intra-oral delivery of pharmaceutical agents
WO2001008681A1 (en) 1999-08-02 2001-02-08 First Horizon Pharmaceutical Corporation Methods of administration of glycopyrrolate compositions
CA2627982C (en) 2005-11-10 2013-09-10 Nicholas S. Bodor Soft anticholinergic esters
US7399861B2 (en) 2005-11-10 2008-07-15 Bodor Nicholas S Soft anticholinergic esters
US8071693B2 (en) 2006-06-22 2011-12-06 Sabic Innovative Plastics Ip B.V. Polysiloxane/polyimide copolymers and blends thereof
JP2010530902A (ja) 2007-06-22 2010-09-16 サイエル ファーマ,インコーポレイティド 流涎症治療のためのグリコピロレートを含む経皮送達システム
US8628729B2 (en) 2008-03-27 2014-01-14 President And Fellows Of Harvard College Three-dimensional microfluidic devices

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080102102A1 (en) * 2005-01-19 2008-05-01 Neurohealing Pharmaceuticals, Inc. Methods And Compositions For Decreasing Saliva Production
US20080260823A1 (en) * 2007-04-20 2008-10-23 Sciele Pharma, Inc. Orally disintegrating tablet comprising glycopyrrolate for treating sialorrhea
US20140275204A1 (en) * 2013-03-15 2014-09-18 Bodor Laboratories, Inc. Method of dosing and use of soft anticholinergic esters

Also Published As

Publication number Publication date
JP2023164671A (ja) 2023-11-10
KR20180061220A (ko) 2018-06-07
WO2017044412A1 (en) 2017-03-16
JP2018526420A (ja) 2018-09-13
JP7270958B2 (ja) 2023-05-11
US11534422B2 (en) 2022-12-27
MY197265A (en) 2023-06-08
MX388831B (es) 2025-03-20
AU2021204306B2 (en) 2023-11-09
JP7723417B2 (ja) 2025-08-14
ES2942361T3 (es) 2023-05-31
AU2021204306A1 (en) 2021-07-22
JP2022132446A (ja) 2022-09-08
CN108348502A (zh) 2018-07-31
EP3347007B1 (en) 2023-03-29
IL257970B (en) 2021-04-29
ZA201801685B (en) 2023-12-20
MX2018003002A (es) 2018-08-01
US12458625B2 (en) 2025-11-04
CN118021770A (zh) 2024-05-14
IL257970A (en) 2018-05-31
CN118021797A (zh) 2024-05-14
EP3347007A4 (en) 2019-05-08
CA2998357A1 (en) 2017-03-16
US20220401410A1 (en) 2022-12-22
JP2021001238A (ja) 2021-01-07
KR102889909B1 (ko) 2025-11-24
CN118045082A (zh) 2024-05-17
EP3347007A1 (en) 2018-07-18
HK1255558A1 (en) 2019-08-23
US20180250265A1 (en) 2018-09-06
US20240261262A1 (en) 2024-08-08
US11951093B2 (en) 2024-04-09
AU2016318595A1 (en) 2018-04-26

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