IL257970B - Methods and compositions for soft anticholinergic esters - Google Patents

Methods and compositions for soft anticholinergic esters

Info

Publication number
IL257970B
IL257970B IL257970A IL25797018A IL257970B IL 257970 B IL257970 B IL 257970B IL 257970 A IL257970 A IL 257970A IL 25797018 A IL25797018 A IL 25797018A IL 257970 B IL257970 B IL 257970B
Authority
IL
Israel
Prior art keywords
compositions
methods
soft anticholinergic
anticholinergic esters
esters
Prior art date
Application number
IL257970A
Other languages
English (en)
Hebrew (he)
Other versions
IL257970A (en
Original Assignee
Bodor Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bodor Laboratories Inc filed Critical Bodor Laboratories Inc
Publication of IL257970A publication Critical patent/IL257970A/en
Publication of IL257970B publication Critical patent/IL257970B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007Drug-containing films, membranes or sheets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12Oxygen or sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL257970A 2015-09-11 2018-03-08 Methods and compositions for soft anticholinergic esters IL257970B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562217362P 2015-09-11 2015-09-11
PCT/US2016/050385 WO2017044412A1 (en) 2015-09-11 2016-09-06 Methods and compositions for soft anticholinergic esters

Publications (2)

Publication Number Publication Date
IL257970A IL257970A (en) 2018-05-31
IL257970B true IL257970B (en) 2021-04-29

Family

ID=58239861

Family Applications (1)

Application Number Title Priority Date Filing Date
IL257970A IL257970B (en) 2015-09-11 2018-03-08 Methods and compositions for soft anticholinergic esters

Country Status (12)

Country Link
US (3) US11534422B2 (enExample)
EP (1) EP3347007B1 (enExample)
JP (4) JP7270958B2 (enExample)
KR (1) KR102889909B1 (enExample)
CN (4) CN118021797A (enExample)
AU (2) AU2016318595B2 (enExample)
ES (1) ES2942361T3 (enExample)
IL (1) IL257970B (enExample)
MX (1) MX388831B (enExample)
MY (1) MY197265A (enExample)
WO (1) WO2017044412A1 (enExample)
ZA (1) ZA201801685B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109044965A (zh) * 2018-10-17 2018-12-21 广州大光制药有限公司 格隆溴铵的眼用药物组合物及医药用途
WO2021177256A1 (ja) * 2020-03-03 2021-09-10 科研製薬株式会社 ソフピロニウム臭化物を含有する医薬
KR20240088983A (ko) 2021-11-01 2024-06-20 유타대학연구재단 침흘림증 치료를 위한 조성물 및 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000047203A1 (en) 1999-02-12 2000-08-17 Mqs, Inc. Formulation and system for intra-oral delivery of pharmaceutical agents
WO2001008681A1 (en) 1999-08-02 2001-02-08 First Horizon Pharmaceutical Corporation Methods of administration of glycopyrrolate compositions
CA2593492C (en) 2005-01-19 2011-12-13 Neurohealing Pharmaceuticals, Inc. Methods and compositions for decreasing saliva production
ATE529400T1 (de) 2005-11-10 2011-11-15 Nicholas S Bodor Weiche anticholinerge zwitterionen
JP5257073B2 (ja) 2005-11-10 2013-08-07 ボーダー、ニコラス・エス ソフト型抗コリン作動性エステル
US8071693B2 (en) 2006-06-22 2011-12-06 Sabic Innovative Plastics Ip B.V. Polysiloxane/polyimide copolymers and blends thereof
US20080260823A1 (en) * 2007-04-20 2008-10-23 Sciele Pharma, Inc. Orally disintegrating tablet comprising glycopyrrolate for treating sialorrhea
AU2008268465A1 (en) 2007-06-22 2008-12-31 Sciele Pharma, Inc. Transdermal delivery system comprising glycopyrrolate to treat sialorrhea
EP2257819A4 (en) 2008-03-27 2017-10-11 President and Fellows of Harvard College Three-dimensional microfluidic devices
MY192033A (en) * 2013-03-15 2022-07-24 Bodor Laboratories Inc Method of dosing and use of soft anticholinergic esters

Also Published As

Publication number Publication date
US12458625B2 (en) 2025-11-04
AU2021204306A1 (en) 2021-07-22
HK1255558A1 (en) 2019-08-23
CA2998357A1 (en) 2017-03-16
US11951093B2 (en) 2024-04-09
CN118021797A (zh) 2024-05-14
KR20180061220A (ko) 2018-06-07
EP3347007A4 (en) 2019-05-08
JP7723417B2 (ja) 2025-08-14
US20240261262A1 (en) 2024-08-08
MX388831B (es) 2025-03-20
EP3347007B1 (en) 2023-03-29
ZA201801685B (en) 2023-12-20
US20220401410A1 (en) 2022-12-22
KR102889909B1 (ko) 2025-11-24
CN118021770A (zh) 2024-05-14
AU2016318595B2 (en) 2021-07-08
AU2021204306B2 (en) 2023-11-09
JP2022132446A (ja) 2022-09-08
CN108348502A (zh) 2018-07-31
WO2017044412A1 (en) 2017-03-16
MY197265A (en) 2023-06-08
JP2018526420A (ja) 2018-09-13
US11534422B2 (en) 2022-12-27
MX2018003002A (es) 2018-08-01
US20180250265A1 (en) 2018-09-06
JP2023164671A (ja) 2023-11-10
IL257970A (en) 2018-05-31
JP2021001238A (ja) 2021-01-07
JP7270958B2 (ja) 2023-05-11
ES2942361T3 (es) 2023-05-31
EP3347007A1 (en) 2018-07-18
CN118045082A (zh) 2024-05-17
AU2016318595A1 (en) 2018-04-26

Similar Documents

Publication Publication Date Title
IL259576A (en) Preparations and methods for immuno-oncology
GB2546350B (en) Compositions and methods
IL256295A (en) Anti-ntb-a antibodies and related compositions and methods
GB2535253B (en) Compositions and methods
SG11201708524VA (en) Self-foaming compositions and methods
PT3204413T (pt) Composições de anticorpos portadores e métodos de produção e utilização dos mesmos
IL260124A (en) Compounds and methods for reducing tau expression
GB201718876D0 (en) Antithrombin-heparin compositions and methods
IL246879B (en) Preparations of Epilimod and methods of using them
ZA201707896B (en) Compositions and methods for reducing visual loss
IL274524A (en) Preparations and methods for aquaculture
IL257895A (en) Preparations and methods against malaria
GB2550632B (en) Compositions and uses and methods relating thereto
PT3113774T (pt) Composições de grapiprant e métodos de utilização das mesmas
IL257167A (en) Antitussive compositions and methods
GB201715820D0 (en) Compositions and methods
GB201705626D0 (en) Compositions and methods
IL257970B (en) Methods and compositions for soft anticholinergic esters
PL3223846T3 (pl) Kompozycje adiuwantowe i powiązane sposoby
ZA201807665B (en) Methods and compositions
GB201512996D0 (en) Compositions and methods
GB201514413D0 (en) Compositions and methods
GB201402915D0 (en) Compositions and methods
ZA201807782B (en) Methods and compositions
IL256261B (en) Hide1 compositions and methods

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed