AU2016305092B2 - Method for differentially diagnosing ACTH-dependent Cushing's syndrome - Google Patents

Method for differentially diagnosing ACTH-dependent Cushing's syndrome Download PDF

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Publication number
AU2016305092B2
AU2016305092B2 AU2016305092A AU2016305092A AU2016305092B2 AU 2016305092 B2 AU2016305092 B2 AU 2016305092B2 AU 2016305092 A AU2016305092 A AU 2016305092A AU 2016305092 A AU2016305092 A AU 2016305092A AU 2016305092 B2 AU2016305092 B2 AU 2016305092B2
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Prior art keywords
acth
cushing
syndrome
patient
venous
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AU2016305092A
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AU2016305092A1 (en
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Andreas G. MORAITIS
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Corcept Therapeutics Inc
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Corcept Therapeutics Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/665—Assays involving proteins derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • G01N2333/695—Corticotropin [ACTH]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/048—Pituitary or hypothalamic - pituitary relationships, e.g. vasopressin or ADH related

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2016305092A 2015-08-13 2016-08-12 Method for differentially diagnosing ACTH-dependent Cushing's syndrome Ceased AU2016305092B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562204723P 2015-08-13 2015-08-13
US62/204,723 2015-08-13
PCT/US2016/046904 WO2017027851A1 (en) 2015-08-13 2016-08-12 Method for differentially diagnosing acth-dependent cushing's syndrome

Publications (2)

Publication Number Publication Date
AU2016305092A1 AU2016305092A1 (en) 2018-04-05
AU2016305092B2 true AU2016305092B2 (en) 2022-01-27

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AU2016305092A Ceased AU2016305092B2 (en) 2015-08-13 2016-08-12 Method for differentially diagnosing ACTH-dependent Cushing's syndrome

Country Status (10)

Country Link
US (6) US9829495B2 (https=)
EP (1) EP3335043B1 (https=)
JP (1) JP6768789B2 (https=)
KR (1) KR20180052120A (https=)
AU (1) AU2016305092B2 (https=)
CA (1) CA2994422A1 (https=)
ES (1) ES2865334T3 (https=)
IL (1) IL257439B (https=)
MX (1) MX383318B (https=)
WO (1) WO2017027851A1 (https=)

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MX2019011543A (es) 2017-03-31 2019-12-16 Corcept Therapeutics Inc Moduladores del receptor de glucocorticoides para el tratamiento de cancer cervical.
US11234971B2 (en) 2018-12-19 2022-02-01 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
US11464764B2 (en) 2018-12-19 2022-10-11 Corcept Therapeutics Incorporated Pharmaceutical formulations containing relacorilant, a heteroaryl-ketone fused azadecalin compound
US11389432B2 (en) 2018-12-19 2022-07-19 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
CN113194957A (zh) 2018-12-21 2021-07-30 科塞普特治疗公司 通过施用糖皮质激素受体调节剂治疗库欣综合征中的高凝血病
JP7789561B2 (ja) 2019-02-22 2025-12-22 コーセプト セラピューティクス， インコーポレイテッド レラコリラント、ヘテロアリール－ケトン縮合アザデカリングルココルチコイド受容体調節物質の治療用途
WO2021007512A1 (en) 2019-07-11 2021-01-14 Emory University Platinum-based chemotherapy, mast binding agents, glucocorticoid receptor (gr) binding agents, and/or hsp90 binding agents for uses in treating cancer
ES3060361T3 (en) * 2019-12-21 2026-03-26 Corcept Therapeutics Inc Treatment of, and differential diagnosis between, acth-dependent cushing's syndrome and acth-independent cushing's syndrome
AT18182U1 (de) * 2020-05-04 2024-04-15 Nordic Group Bv Mifepriston in oraler Form zur Verwendung bei der Zervixreifung und Geburtseinleitung
WO2021242912A1 (en) 2020-05-27 2021-12-02 Corcept Therapeutics Incorporated Concomitant administration of glucocorticoid receptor modulator relacorilant and paclitaxel, a dual substrate of cyp2c8 and cyp3a4
WO2022134033A1 (en) 2020-12-25 2022-06-30 Corcept Therapeutics Incorporated Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
CN119585268A (zh) * 2022-06-28 2025-03-07 科赛普特治疗公司 制备杂芳基-酮稠合的氮杂萘烷糖皮质激素受体调节剂的方法
KR20250073629A (ko) 2022-10-06 2025-05-27 코어셉트 쎄라퓨틱스 인코포레이티드 글루코코르티코이드 수용체 조절제의 제형
US12433882B2 (en) 2022-10-28 2025-10-07 Corcept Therapeutics Incorporated Treatments for amyotrophic lateral sclerosis using dazucorilant

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Also Published As

Publication number Publication date
ES2865334T3 (es) 2021-10-15
IL257439B (en) 2020-08-31
US20200088745A1 (en) 2020-03-19
US20180267064A1 (en) 2018-09-20
EP3335043A4 (en) 2019-01-16
MX383318B (es) 2025-03-13
AU2016305092A1 (en) 2018-04-05
MX2018001803A (es) 2018-05-16
CA2994422A1 (en) 2017-02-16
US10495650B2 (en) 2019-12-03
WO2017027851A1 (en) 2017-02-16
US20230324415A1 (en) 2023-10-12
US20180052178A1 (en) 2018-02-22
JP6768789B2 (ja) 2020-10-14
US20170045535A1 (en) 2017-02-16
JP2018529941A (ja) 2018-10-11
US11073523B2 (en) 2021-07-27
KR20180052120A (ko) 2018-05-17
US9829495B2 (en) 2017-11-28
EP3335043A1 (en) 2018-06-20
US20210311079A1 (en) 2021-10-07
HK1255714A1 (en) 2019-08-23
US10006924B2 (en) 2018-06-26
EP3335043B1 (en) 2021-03-31
IL257439A (en) 2018-04-30

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