AU2016287587B2 - Aryl sulfonamide compounds as carbonic anhydrase inhibitors and their therapeutic use - Google Patents
Aryl sulfonamide compounds as carbonic anhydrase inhibitors and their therapeutic use Download PDFInfo
- Publication number
- AU2016287587B2 AU2016287587B2 AU2016287587A AU2016287587A AU2016287587B2 AU 2016287587 B2 AU2016287587 B2 AU 2016287587B2 AU 2016287587 A AU2016287587 A AU 2016287587A AU 2016287587 A AU2016287587 A AU 2016287587A AU 2016287587 B2 AU2016287587 B2 AU 2016287587B2
- Authority
- AU
- Australia
- Prior art keywords
- benzenesulfonamide
- cancer
- oxoimidazolidin
- amino
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CC(*)C(*)(C(C)(C)C(C)(*)N(c(c(*)c1*)c(*)c(C)c1S(N)(=O)=O)C1=O)N1I* Chemical compound CC(*)C(*)(C(C)(C)C(C)(*)N(c(c(*)c1*)c(*)c(C)c1S(N)(=O)=O)C1=O)N1I* 0.000 description 5
- XUEAHCLDIMPUPE-UHFFFAOYSA-N C=S(c(cc1)ccc1N(CCN1c(cc2)ccc2F)C1=O)(N)=O Chemical compound C=S(c(cc1)ccc1N(CCN1c(cc2)ccc2F)C1=O)(N)=O XUEAHCLDIMPUPE-UHFFFAOYSA-N 0.000 description 1
- DLHFXQMERYWNCD-UHFFFAOYSA-N Cc(cc1)ccc1N(CCN1c(cc2)ccc2S(C)(=C)=O)C1=O Chemical compound Cc(cc1)ccc1N(CCN1c(cc2)ccc2S(C)(=C)=O)C1=O DLHFXQMERYWNCD-UHFFFAOYSA-N 0.000 description 1
- RDFDSMIDOOCACZ-UHFFFAOYSA-N Cc1cc(F)cc(NCC(Nc(cc2)ccc2S(N)(=O)=O)=O)c1 Chemical compound Cc1cc(F)cc(NCC(Nc(cc2)ccc2S(N)(=O)=O)=O)c1 RDFDSMIDOOCACZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562187636P | 2015-07-01 | 2015-07-01 | |
| US62/187,636 | 2015-07-01 | ||
| PCT/US2016/040736 WO2017004543A1 (en) | 2015-07-01 | 2016-07-01 | Aryl sulfonamide compounds as carbonic anhydrase inhibitors and their therapeutic use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2016287587A1 AU2016287587A1 (en) | 2018-01-25 |
| AU2016287587B2 true AU2016287587B2 (en) | 2020-04-30 |
Family
ID=56411955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016287587A Active AU2016287587B2 (en) | 2015-07-01 | 2016-07-01 | Aryl sulfonamide compounds as carbonic anhydrase inhibitors and their therapeutic use |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10562859B2 (enExample) |
| EP (1) | EP3317255B1 (enExample) |
| JP (1) | JP6795525B2 (enExample) |
| KR (1) | KR102637759B1 (enExample) |
| CN (1) | CN107922345B (enExample) |
| AU (1) | AU2016287587B2 (enExample) |
| BR (1) | BR112018000065B1 (enExample) |
| CA (1) | CA2991168C (enExample) |
| IL (1) | IL256527B (enExample) |
| MX (1) | MX387267B (enExample) |
| WO (1) | WO2017004543A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3606928T1 (sl) * | 2017-04-05 | 2023-02-28 | President And Fellows Of Harvard College | Makrociklična spojina in njene uporabe |
| KR20210000564A (ko) | 2019-06-25 | 2021-01-05 | 공주대학교 산학협력단 | 신규 아만타딘 유도체 화합물 및 이의 용도 |
| CN111233786B (zh) * | 2020-02-04 | 2021-11-26 | 中国人民解放军军事科学院军事医学研究院 | 含五元杂环的苯磺酰胺类化合物及其制备方法和用途 |
| EP4161910B1 (en) * | 2020-06-02 | 2025-01-08 | Yeditepe Universitesi | 2-(3-(2-methyl-6-(p-tolyl) pyridine-3-yl) ureido) benzenesulfonamide and derivatives as inhibitor of carbonic anhydrase ix for the treatment of cancer |
| TR202014185A2 (tr) * | 2020-09-08 | 2022-03-21 | Anadolu Ueniversitesi | BAZI YENİ 4-(2-((5-(SÜBSTİTÜEAMİNO)-1,3,4-TİYADİAZOL-2-İL)TİYO)ASETİL)BENZENSÜLFONAMİD TÜREVLERİ ve SÖZ KONUSU TÜREVLERİN SENTEZİ İÇİN BİR YÖNTEM |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130012485A1 (en) * | 2006-12-22 | 2013-01-10 | Baeschlin Daniel Kaspar | Organic compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2456939A1 (en) * | 2001-08-10 | 2003-02-20 | Pharmacia Corporation | Carbonic anhydrase inhibitors |
| CN103221388B (zh) | 2010-07-09 | 2016-09-28 | 维理生物技术公司 | 用于抑制转移性肿瘤生长的新型磺酰胺化合物 |
| WO2013023274A1 (en) * | 2011-08-16 | 2013-02-21 | Universite Laval | Substituted 2-imidazolidinones and 2-imidazolones and their use in the treatment of cancer |
-
2016
- 2016-07-01 CA CA2991168A patent/CA2991168C/en active Active
- 2016-07-01 CN CN201680046227.7A patent/CN107922345B/zh active Active
- 2016-07-01 BR BR112018000065-5A patent/BR112018000065B1/pt active IP Right Grant
- 2016-07-01 EP EP16738988.1A patent/EP3317255B1/en active Active
- 2016-07-01 JP JP2017568244A patent/JP6795525B2/ja active Active
- 2016-07-01 WO PCT/US2016/040736 patent/WO2017004543A1/en not_active Ceased
- 2016-07-01 US US15/743,601 patent/US10562859B2/en active Active
- 2016-07-01 KR KR1020187003119A patent/KR102637759B1/ko active Active
- 2016-07-01 MX MX2018000175A patent/MX387267B/es unknown
- 2016-07-01 AU AU2016287587A patent/AU2016287587B2/en active Active
-
2017
- 2017-12-24 IL IL256527A patent/IL256527B/en active IP Right Grant
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130012485A1 (en) * | 2006-12-22 | 2013-01-10 | Baeschlin Daniel Kaspar | Organic compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180023990A (ko) | 2018-03-07 |
| CN107922345A (zh) | 2018-04-17 |
| EP3317255A1 (en) | 2018-05-09 |
| KR102637759B1 (ko) | 2024-02-19 |
| JP6795525B2 (ja) | 2020-12-02 |
| BR112018000065B1 (pt) | 2023-11-07 |
| CN107922345B (zh) | 2021-03-23 |
| AU2016287587A1 (en) | 2018-01-25 |
| EP3317255B1 (en) | 2021-09-01 |
| CA2991168C (en) | 2022-04-26 |
| IL256527B (en) | 2021-04-29 |
| US20180201584A1 (en) | 2018-07-19 |
| BR112018000065A2 (pt) | 2018-09-11 |
| IL256527A (en) | 2018-02-28 |
| JP2018519332A (ja) | 2018-07-19 |
| US10562859B2 (en) | 2020-02-18 |
| HK1248228A1 (en) | 2018-10-12 |
| MX2018000175A (es) | 2018-03-26 |
| MX387267B (es) | 2025-03-18 |
| WO2017004543A1 (en) | 2017-01-05 |
| CA2991168A1 (en) | 2017-01-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |