AU2016269848B2 - Formulation and process for limiting nerve trauma - Google Patents

Formulation and process for limiting nerve trauma Download PDF

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Publication number
AU2016269848B2
AU2016269848B2 AU2016269848A AU2016269848A AU2016269848B2 AU 2016269848 B2 AU2016269848 B2 AU 2016269848B2 AU 2016269848 A AU2016269848 A AU 2016269848A AU 2016269848 A AU2016269848 A AU 2016269848A AU 2016269848 B2 AU2016269848 B2 AU 2016269848B2
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nerve
formulation
forms
carrier
exposed
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AU2016269848A1 (en
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Timothy J. EVISTON
Arun Krishnan
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Intravital Pty Ltd
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Intravital Pty Ltd
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AU2015902089A AU2015902089A0 (en) 2015-06-02 Formulation and device for limiting nerve trauma
AU2015902669A AU2015902669A0 (en) 2015-07-07 Method and system for delivering a therapeutic substance during surgery
AU2015902669 2015-07-07
AU2015903087 2015-08-03
AU2015903087A AU2015903087A0 (en) 2015-08-03 Delivery Device
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Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107921237A (zh) 2015-04-27 2018-04-17 反射医学公司 交感神经心肺神经调节系统和方法
WO2017139487A1 (en) 2016-02-09 2017-08-17 Northwind Medical, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
CN110035754A (zh) 2016-06-29 2019-07-19 图拉维治疗股份有限公司 通过自主神经系统的局部神经调节治疗败血症及相关炎性病况
US20210315587A1 (en) 2018-07-02 2021-10-14 Tulavi Therapeutics, Inc. Methods and devices for in situ formed nerve cap with rapid release
AU2019299519B2 (en) 2018-07-02 2025-03-06 Incept Llc Methods and devices for in situ formed nerve cap
KR102501175B1 (ko) * 2020-02-03 2023-02-16 엠앤에이치바이오 주식회사 난청 치료용 제어 방출형 제제 및 이의 제조방법

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6238702B1 (en) * 1992-09-10 2001-05-29 Children's Medical Center Corp. High load formulations and methods for providing prolonged local anesthesia
WO2002043785A2 (en) * 2000-11-29 2002-06-06 Oculex Pharmaceuticals, Inc. Intraocular implants for preventing transplant rejection in the eye
WO2008157057A2 (en) * 2007-06-19 2008-12-24 Warsaw Orthopedic, Inc. Locally administrated low doses of corticosteroids
US20090263456A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Methods and Compositions for Reducing Preventing and Treating Adhesives
US8190271B2 (en) * 2007-08-29 2012-05-29 Advanced Bionics, Llc Minimizing trauma during and after insertion of a cochlear lead
WO2014116876A1 (en) * 2013-01-23 2014-07-31 Semnur Pharmaceuticals, Inc. Pharmaceutical formulation comprising an insoluble corticosteroid and a soluble corticosteroid
WO2016118649A1 (en) * 2015-01-21 2016-07-28 Semnur Pharmaceuticals, Inc. Pharmaceutical formulation

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2221739A (en) 1939-10-16 1940-11-12 Reiter David Hypodermic syringe
US2669230A (en) 1947-07-30 1954-02-16 Becton Dickinson Co Injection apparatus
US3496937A (en) * 1967-05-18 1970-02-24 John E Balson Hypodermic syringe
DE3270634D1 (en) 1981-11-12 1986-05-22 John Joseph Jacklich A dental syringe
US4641766A (en) * 1984-11-02 1987-02-10 Alcon Laboratories, Inc. Metering dispenser for high viscosity compositions
US4659327A (en) 1985-11-26 1987-04-21 Dentsply Research & Development Corp. Multiple dosage syringe
US5700485A (en) * 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
GB2369996B (en) * 2000-12-18 2004-06-23 S T D Pharmaceutical Products Method and apparatus for producing an injectable foam
EP2210634A1 (en) 2009-01-22 2010-07-28 Sanofi-Aventis Deutschland GmbH Drug delivery device dose setting mechanism
US8574199B2 (en) 2006-07-03 2013-11-05 Novo Nordisk A/S Coupling for injection devices
CN201033195Y (zh) * 2007-01-29 2008-03-12 吴同顺 注射器的自动扎针装置
BRPI0918297A2 (pt) * 2008-09-10 2016-05-03 Hoffmann La Roche "dispositivo de distribuição de droga para bombear a medicação para dentro do corpo de um usuário"
WO2010086273A1 (en) 2009-01-30 2010-08-05 Sanofi-Aventis Deutschland Gmbh Cartridge and medication delivery device
AU2011224884B2 (en) 2010-03-09 2013-08-15 Shl Medical Ag Medicament delivery device
WO2012021762A1 (en) 2010-08-12 2012-02-16 Tyco Healthcare Group Lp Single use device for delivery of cartridge drugs
CN103153367A (zh) 2010-08-13 2013-06-12 赛诺菲-安万特德国有限公司 用于药物输送装置贮液器的连接器
AU2011290668B2 (en) * 2010-08-19 2014-08-14 Novo Nordisk A/S Medical auto-injection device for manual needle insertion having needle shield, damping mechanism and audible and tactile feedback
JP6106666B2 (ja) 2011-07-07 2017-04-05 ノボ・ノルデイスク・エー／エス アドオン式の投薬取得／表示モジュールを備える薬剤送出注射ペン
CN103239780A (zh) * 2012-02-14 2013-08-14 上海双鸽实业有限公司 安全注射针
EP2656865A1 (en) 2012-04-24 2013-10-30 Sanofi-Aventis Deutschland GmbH Syringe carrier with needle shield and data storage device for use in a medical auto-injection device
EP2682142A1 (en) 2012-07-06 2014-01-08 Sanofi-Aventis Deutschland GmbH Autoinjector
CN103894970A (zh) * 2012-12-24 2014-07-02 健康机器人技术有限公司 用于移除注射器的针的设备

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6238702B1 (en) * 1992-09-10 2001-05-29 Children's Medical Center Corp. High load formulations and methods for providing prolonged local anesthesia
WO2002043785A2 (en) * 2000-11-29 2002-06-06 Oculex Pharmaceuticals, Inc. Intraocular implants for preventing transplant rejection in the eye
WO2008157057A2 (en) * 2007-06-19 2008-12-24 Warsaw Orthopedic, Inc. Locally administrated low doses of corticosteroids
US8190271B2 (en) * 2007-08-29 2012-05-29 Advanced Bionics, Llc Minimizing trauma during and after insertion of a cochlear lead
US20090263456A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Methods and Compositions for Reducing Preventing and Treating Adhesives
WO2014116876A1 (en) * 2013-01-23 2014-07-31 Semnur Pharmaceuticals, Inc. Pharmaceutical formulation comprising an insoluble corticosteroid and a soluble corticosteroid
WO2016118649A1 (en) * 2015-01-21 2016-07-28 Semnur Pharmaceuticals, Inc. Pharmaceutical formulation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ITO, T. et al., "Anti-inflammatory function of an in situ cross-linkable conjugate hydrogel of hyaluronic acid and dexamethasone'.", Biomaterials, vol. 28, no. issue 10, pages 1778 - 1786 *
K. IKEDA ET AL, "Hyaluronic acid prevents peripheral nerve adhesion", BRITISH JOURNAL OF PLASTIC SURGERY., GB, (2003-06-01), vol. 56, no. 4, doi:10.1016/S0007-1226(03)00197-8, ISSN 0007-1226, pages 342 - 347 *
OZSOY, Z. et al., "The effect of methylprednisolone and tenoxicam on the protection of damage of the nerve physiomorphology caused by prolene mesh", International Journal of Surgery., (2015), vol. 22, pages 159 - 163 *

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