AU2016252382A1 - Formulations of L-ornithine phenylacetate - Google Patents
Formulations of L-ornithine phenylacetate Download PDFInfo
- Publication number
- AU2016252382A1 AU2016252382A1 AU2016252382A AU2016252382A AU2016252382A1 AU 2016252382 A1 AU2016252382 A1 AU 2016252382A1 AU 2016252382 A AU2016252382 A AU 2016252382A AU 2016252382 A AU2016252382 A AU 2016252382A AU 2016252382 A1 AU2016252382 A1 AU 2016252382A1
- Authority
- AU
- Australia
- Prior art keywords
- pharmaceutical formulation
- phenylacetate
- omithine
- oral pharmaceutical
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- Neurology (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| AU2021200740A AU2021200740A1 (en) | 2015-04-20 | 2021-02-05 | Formulations of L-ornithine phenylacetate |
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| PCT/US2016/028298 WO2016172112A1 (en) | 2015-04-20 | 2016-04-19 | Formulations of l-ornithine phenylacetate |
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| PT2319581E (pt) | 2004-11-26 | 2015-06-30 | Ucl Business Plc | Composições compreendendo ornitina e fenilacetato ou fenilbutirato para tratamento de encefalopatia hepática |
| ES2791524T3 (es) | 2009-04-03 | 2020-11-04 | Ocera Therapeutics Inc | Fenilacetato de L-ornitina y métodos de elaboración del mismo |
| EP3517110A1 (en) | 2009-06-08 | 2019-07-31 | UCL Business PLC | Treatment of inflammation using l-ornithine phenylacetate |
| BR112017010761B1 (pt) | 2014-11-24 | 2022-10-18 | Ucl Business Plc | Tratamento de doenças associadas à ativação de célula estrelada hepática com o uso de terapias de redução de amônia |
| CA2995823A1 (en) | 2015-08-18 | 2017-02-23 | Ocera Therapeutics, Inc. | Treatment and prevention of muscle loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
| KR20180086431A (ko) * | 2015-11-13 | 2018-07-31 | 오세라 테라퓨틱스, 아이엔씨. | L-오르니틴 페닐아세테이트의 제제 |
| US11219611B2 (en) | 2015-11-13 | 2022-01-11 | Ocera Therapeutics, Inc. | Formulations of L-ornithine phenylacetate |
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| EP3621947A4 (en) | 2017-05-11 | 2021-03-10 | Ocera Therapeutics, Inc. | L-ORNITHINE PHENYLACETATE MANUFACTURING PROCESSES |
| BR112020002419A2 (pt) | 2017-08-14 | 2020-07-28 | Axcella Health Inc. | aminoácido para o tratamento de doença do fígado |
| EP3810123A1 (en) | 2018-06-20 | 2021-04-28 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
| KR102852068B1 (ko) | 2019-05-09 | 2025-08-28 | 오세라 테라퓨틱스, 아이엔씨. | 간성 뇌증의 평가 및 치료 방법 |
| BR112022007268A2 (pt) * | 2019-10-16 | 2022-07-05 | Ocera Therapeutics Inc | Dosagens e usos do fenilacetato de ornitina para o tratamento da hiperamonemia |
| EP4096647A1 (en) | 2020-01-30 | 2022-12-07 | Yeda Research and Development Co. Ltd | Treating acute liver disease with tlr-mik inhibitors |
| WO2024261477A1 (en) | 2023-06-20 | 2024-12-26 | Yaqrit Limited | Combination of tlr4 antagonist, ornithine and phenylacetate or phenylbutyrate |
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| US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
| IL116674A (en) * | 1995-01-09 | 2003-05-29 | Mendell Co Inc Edward | Microcrystalline cellulose-based excipient having improved compressibility, pharmaceutical compositions containing the same and methods for the preparation of said excipient and of solid dosage form thereof |
| PT2319581E (pt) * | 2004-11-26 | 2015-06-30 | Ucl Business Plc | Composições compreendendo ornitina e fenilacetato ou fenilbutirato para tratamento de encefalopatia hepática |
| ES2791524T3 (es) | 2009-04-03 | 2020-11-04 | Ocera Therapeutics Inc | Fenilacetato de L-ornitina y métodos de elaboración del mismo |
| AU2015221466B2 (en) * | 2009-04-03 | 2017-02-02 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| AU2014250643B2 (en) * | 2009-06-08 | 2016-07-14 | Ocera Therapeutics, Inc. | Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate |
| EP3517110A1 (en) * | 2009-06-08 | 2019-07-31 | UCL Business PLC | Treatment of inflammation using l-ornithine phenylacetate |
| EP2625162B1 (en) | 2010-10-06 | 2019-03-13 | Ocera Therapeutics, Inc. | Methods of making l-ornithine phenyl acetate |
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2016
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2021
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| EP4205735A1 (en) | 2023-07-05 |
| RU2017137643A3 (OSRAM) | 2019-09-17 |
| CA2983146A1 (en) | 2016-10-27 |
| KR20180006904A (ko) | 2018-01-19 |
| HK1251149A1 (zh) | 2019-01-25 |
| RU2755904C2 (ru) | 2021-09-22 |
| RU2017137643A (ru) | 2019-05-20 |
| AU2021200740A1 (en) | 2021-03-04 |
| CA2983146C (en) | 2023-09-12 |
| EP3285756A4 (en) | 2019-01-23 |
| EP3285756B1 (en) | 2023-02-22 |
| CN113599350A (zh) | 2021-11-05 |
| ES2944311T3 (es) | 2023-06-20 |
| DK3285756T3 (da) | 2023-05-08 |
| MX2017013170A (es) | 2018-04-11 |
| JP2018513171A (ja) | 2018-05-24 |
| US20220184014A1 (en) | 2022-06-16 |
| US20160338982A1 (en) | 2016-11-24 |
| MX391167B (es) | 2025-03-11 |
| EP3285756A1 (en) | 2018-02-28 |
| JP2022101549A (ja) | 2022-07-06 |
| CN107708684A (zh) | 2018-02-16 |
| WO2016172112A1 (en) | 2016-10-27 |
| MX2022003855A (es) | 2023-03-02 |
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