AU2016222902A1 - Methods and compositions for treating dry eye disease and other eye disorders - Google Patents

Methods and compositions for treating dry eye disease and other eye disorders Download PDF

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Publication number
AU2016222902A1
AU2016222902A1 AU2016222902A AU2016222902A AU2016222902A1 AU 2016222902 A1 AU2016222902 A1 AU 2016222902A1 AU 2016222902 A AU2016222902 A AU 2016222902A AU 2016222902 A AU2016222902 A AU 2016222902A AU 2016222902 A1 AU2016222902 A1 AU 2016222902A1
Authority
AU
Australia
Prior art keywords
eye
alpha
dry eye
brimonidine
adrenergic agonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2016222902A
Other languages
English (en)
Inventor
Sandeep Jain
Uday Bhaskar Kompella
Shankar Musunuri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ocugen Inc
University of Illinois System
Original Assignee
University of Illinois at Urbana Champaign
Ocugen Inc
University of Illinois System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Illinois at Urbana Champaign, Ocugen Inc, University of Illinois System filed Critical University of Illinois at Urbana Champaign
Publication of AU2016222902A1 publication Critical patent/AU2016222902A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/04Artificial tears; Irrigation solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2016222902A 2015-02-24 2016-02-23 Methods and compositions for treating dry eye disease and other eye disorders Abandoned AU2016222902A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562119857P 2015-02-24 2015-02-24
US62/119,857 2015-02-24
PCT/US2016/019207 WO2016138049A1 (en) 2015-02-24 2016-02-23 Methods and compositions for treating dry eye disease and other eye disorders

Publications (1)

Publication Number Publication Date
AU2016222902A1 true AU2016222902A1 (en) 2017-08-31

Family

ID=56692824

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016222902A Abandoned AU2016222902A1 (en) 2015-02-24 2016-02-23 Methods and compositions for treating dry eye disease and other eye disorders

Country Status (12)

Country Link
US (1) US9597328B2 (enExample)
EP (1) EP3261620B1 (enExample)
JP (1) JP2018506570A (enExample)
KR (1) KR20170132725A (enExample)
CN (1) CN107427459A (enExample)
AU (1) AU2016222902A1 (enExample)
BR (1) BR112017017448A2 (enExample)
CA (1) CA2976120A1 (enExample)
ES (1) ES2936394T3 (enExample)
MX (1) MX2017010544A (enExample)
RU (1) RU2691412C2 (enExample)
WO (1) WO2016138049A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
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US20070016256A1 (en) 2005-07-18 2007-01-18 Korb Donald R Method and apparatus for treating gland dysfunction
US7981145B2 (en) 2005-07-18 2011-07-19 Tearscience Inc. Treatment of meibomian glands
US20070060988A1 (en) 2005-07-18 2007-03-15 Grenon Stephen M Melting meibomian gland obstructions
US20080114423A1 (en) 2006-05-15 2008-05-15 Grenon Stephen M Apparatus for inner eyelid treatment of meibomian gland dysfunction
WO2016022066A1 (en) 2014-08-04 2016-02-11 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
US11478437B2 (en) * 2016-07-05 2022-10-25 Jenivision Inc. Formulations for hair growth
JP2020523406A (ja) * 2017-05-19 2020-08-06 オクジェン アイエヌシー. 眼科用組成物および使用方法
US11759472B2 (en) * 2017-11-21 2023-09-19 Cs Pharmaceuticals Limited Compositions and methods of use for treating aberrant inflammation in peri-ocular secretory glands or at the ocular surface
MX2020005155A (es) * 2017-11-21 2020-08-20 Axerovision Inc Composiciones y metodos de uso para tratar inflamacion aberrante en glandulas secretoras perioculares o en la superficie ocular.
AU2018385766B2 (en) 2017-12-15 2022-12-01 Tarsus Pharmaceuticals, Inc. Isoxazoline parasiticide formulations and methods for treating blepharitis
WO2019189721A1 (ja) * 2018-03-30 2019-10-03 千寿製薬株式会社 水性液剤
WO2019189720A1 (ja) * 2018-03-30 2019-10-03 千寿製薬株式会社 水性液剤
US11077053B2 (en) 2018-08-21 2021-08-03 Allergan, Inc. Alpha-2-adrenergic receptor agonists for treatment of presbyopia, visual glare, visual starbursts, visual halos and night myopia
WO2020047197A1 (en) * 2018-08-29 2020-03-05 Ocugen, Inc. Ophthalmic compositions and methods of use
US12502377B2 (en) 2019-04-04 2025-12-23 Tarsus Pharmaceuticals, Inc. Method of eradicating ticks that attach to humans using lotilaner formulations
AU2020400389B2 (en) * 2019-12-10 2024-02-15 Alcon Inc. Dissolvable polymeric eye inserts with a biodegradable polymer
WO2022031830A1 (en) * 2020-08-04 2022-02-10 Harrow Ip Llc Antibacterial compositions and methods for fabricating thereof
CN116710087A (zh) * 2020-11-23 2023-09-05 美国商业眼科医疗器械公司 用于治疗眼部病症的制剂和方法
JP2023550632A (ja) 2020-11-23 2023-12-04 サイト サイエンシーズ, インコーポレイテッド 眼の症状を処置するための製剤および方法
CN115645356A (zh) * 2022-11-21 2023-01-31 山东诺明康药物研究院有限公司 一种酒石酸溴莫尼定原位凝胶及其制备方法和应用
WO2025174723A1 (en) * 2024-02-12 2025-08-21 Selagine Inc. Ophthalmic composition comprising cethromycin

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK3412U (sk) * 2002-07-01 2003-01-09 Unimed Pharma Spol Sro Očná inštalácia so zlepšenou stabilitou účinnej látky na báze brimomidínu
US20040088199A1 (en) * 2002-10-31 2004-05-06 Childress Allen B. Method of forming a business rule
US20050196370A1 (en) * 2003-03-18 2005-09-08 Zhi-Jian Yu Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye
JP2007528897A (ja) * 2004-03-12 2007-10-18 メルビ ホールディングス, エルエルシー 眼表面用の潤滑剤
EP2070518A2 (en) * 2006-07-25 2009-06-17 Osmotica Corp. Ophthalmic solutions
US9125807B2 (en) * 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
CN101352441A (zh) * 2007-07-27 2009-01-28 肖正连 一种酒石酸溴莫尼定眼用即型凝胶
US20120003296A1 (en) * 2010-07-01 2012-01-05 Shantha Totada R New methods of treating dry eye syndrome
RU2599495C2 (ru) 2010-08-16 2016-10-10 Аллерган, Инк. Способ активации регуляторных т-клеток агонистами альфа-2в адренергических рецепторов
US20120082625A1 (en) * 2010-09-28 2012-04-05 Michael Graeber Combination treatment for rosacea
US20120076738A1 (en) * 2010-09-28 2012-03-29 Michael Graeber Combination treatment for dermatological conditions
US20120093876A1 (en) * 2010-10-13 2012-04-19 Aciex, Inc. Ophthalmic Formulations, Methods Of Manufacture And Methods of Normalizing Meibomian Gland Secretions
CN107982211A (zh) * 2011-04-05 2018-05-04 奥普托索夫研究与发展有限公司 眼科治疗
EP2630952A1 (en) * 2012-02-23 2013-08-28 Novagali Pharma S.A. Self-preserved oil dispersions comprising boric acid

Also Published As

Publication number Publication date
CA2976120A1 (en) 2016-09-01
EP3261620B1 (en) 2022-11-09
CN107427459A (zh) 2017-12-01
RU2017129247A (ru) 2019-03-25
US9597328B2 (en) 2017-03-21
KR20170132725A (ko) 2017-12-04
EP3261620A4 (en) 2018-10-31
JP2018506570A (ja) 2018-03-08
ES2936394T3 (es) 2023-03-16
RU2017129247A3 (enExample) 2019-03-25
BR112017017448A2 (pt) 2018-04-03
MX2017010544A (es) 2018-06-18
RU2691412C2 (ru) 2019-06-13
WO2016138049A1 (en) 2016-09-01
EP3261620A1 (en) 2018-01-03
US20160243116A1 (en) 2016-08-25

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Legal Events

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MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application