AU2016218635B2 - Molecular design of recombinant protein drug - Google Patents

Molecular design of recombinant protein drug Download PDF

Info

Publication number
AU2016218635B2
AU2016218635B2 AU2016218635A AU2016218635A AU2016218635B2 AU 2016218635 B2 AU2016218635 B2 AU 2016218635B2 AU 2016218635 A AU2016218635 A AU 2016218635A AU 2016218635 A AU2016218635 A AU 2016218635A AU 2016218635 B2 AU2016218635 B2 AU 2016218635B2
Authority
AU
Australia
Prior art keywords
seq
motif
mutant
endostatin
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2016218635A
Other languages
English (en)
Other versions
AU2016218635A1 (en
Inventor
Peng Liu
Xinan Lu
Yongzhang Luo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tsinghua University
Protgen Ltd
Original Assignee
Tsinghua University
Protgen Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tsinghua University, Protgen Ltd filed Critical Tsinghua University
Publication of AU2016218635A1 publication Critical patent/AU2016218635A1/en
Application granted granted Critical
Publication of AU2016218635B2 publication Critical patent/AU2016218635B2/en
Priority to AU2020256316A priority Critical patent/AU2020256316B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1891—Angiogenesic factors; Angiogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2016218635A 2015-02-13 2016-02-14 Molecular design of recombinant protein drug Active AU2016218635B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020256316A AU2020256316B2 (en) 2015-02-13 2020-10-13 Molecular design of recombinant protein drug

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201510079486 2015-02-13
CN201510079486.7 2015-02-13
CN201510736184 2015-11-02
CN201510736184.2 2015-11-02
PCT/CN2016/073773 WO2016127948A1 (zh) 2015-02-13 2016-02-14 一种重组蛋白质药物的分子设计

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020256316A Division AU2020256316B2 (en) 2015-02-13 2020-10-13 Molecular design of recombinant protein drug

Publications (2)

Publication Number Publication Date
AU2016218635A1 AU2016218635A1 (en) 2017-10-05
AU2016218635B2 true AU2016218635B2 (en) 2020-07-23

Family

ID=56614147

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2016218635A Active AU2016218635B2 (en) 2015-02-13 2016-02-14 Molecular design of recombinant protein drug
AU2020256316A Active AU2020256316B2 (en) 2015-02-13 2020-10-13 Molecular design of recombinant protein drug

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2020256316A Active AU2020256316B2 (en) 2015-02-13 2020-10-13 Molecular design of recombinant protein drug

Country Status (8)

Country Link
US (2) US10869910B2 (enExample)
EP (1) EP3269731B1 (enExample)
JP (1) JP6896636B2 (enExample)
CN (2) CN114249816B (enExample)
AU (2) AU2016218635B2 (enExample)
CA (1) CA3014538A1 (enExample)
DK (1) DK3269731T5 (enExample)
WO (1) WO2016127948A1 (enExample)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101890155A (zh) * 2010-05-25 2010-11-24 江苏先声药物研究有限公司 一种药物组合物及其应用
EP2754718A1 (en) * 2011-09-09 2014-07-16 Tsinghua University Vascular endothelial myostatin mutant that mutates at atp binding sites

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107148277B (zh) * 2014-11-03 2022-03-22 清华大学 一种抑制脂肪细胞分化和胰岛素耐受的药物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101890155A (zh) * 2010-05-25 2010-11-24 江苏先声药物研究有限公司 一种药物组合物及其应用
EP2754718A1 (en) * 2011-09-09 2014-07-16 Tsinghua University Vascular endothelial myostatin mutant that mutates at atp binding sites

Also Published As

Publication number Publication date
EP3269731A4 (en) 2018-08-15
JP6896636B2 (ja) 2021-06-30
EP3269731B1 (en) 2023-10-04
AU2020256316A1 (en) 2020-11-12
CA3014538A1 (en) 2016-08-18
AU2016218635A1 (en) 2017-10-05
CN114249816A (zh) 2022-03-29
CN114249816B (zh) 2024-09-06
CN107428809A (zh) 2017-12-01
WO2016127948A1 (zh) 2016-08-18
US20180200337A1 (en) 2018-07-19
US20210085754A1 (en) 2021-03-25
JP2018507854A (ja) 2018-03-22
DK3269731T5 (da) 2024-10-14
AU2020256316B2 (en) 2021-10-07
US10869910B2 (en) 2020-12-22
DK3269731T3 (da) 2023-10-30
EP3269731A1 (en) 2018-01-17
CN107428809B (zh) 2021-10-01

Similar Documents

Publication Publication Date Title
JPH01501283A (ja) 新規な型のコロニー刺激因子―１
Terzyan et al. The three-dimensional structure of human RNase 4, unliganded and complexed with d (Up), reveals the basis for its uridine selectivity
EA036064B1 (ru) Гибридный белок альбумин-связывающей молекулы и аргининдезиминазы для лечения рака и аргинин-зависимых болезней
US20070293660A1 (en) Method for purifying granulocyte-colony stimulating factor
CN114796525B (zh) 细胞周期调控蛋白抑制剂在肿瘤治疗中的应用
US7078485B2 (en) N-terminal modified recombinant human endostatin and its production
AU2020256316B2 (en) Molecular design of recombinant protein drug
CN106432483B (zh) 沼水蛙皮肤丝氨酸蛋白酶抑制肽及其基因和制药应用
CN112851791B (zh) 一种新型抗代谢紊乱的fgf类似物及其应用
JP4445466B2 (ja) 大腸菌で発現させるためのヒト顆粒球コロニー刺激因子をコードする合成遺伝子
US20190315820A1 (en) A Composition Containing SMAD Protein for Treatment of Autoimmune Diseases, a Fusion Protein Comprising SMAD Protein, an Expression Vector and a Method for Preparing the Same
JPH03297388A (ja) 新規なｔｎｆ変異体、その製造法及びそれを有効成分とする抗腫瘍剤
HK1240943B (zh) 一种重组蛋白质药物的分子设计
EP3500284A1 (en) Bovine fibroblast growth factor 21 and ketosis in dairy cattle
HK1240943A1 (en) Molecular design of recombinant protein drug
JP2548204B2 (ja) 新生理活性ポリペプチド
WO2004091650A1 (fr) Utilisation de la troponine i cardiaque pour preparer des medicaments antitumoraux
CN104511028A (zh) Klf9基因在抑制肝癌中的应用
CN1188151A (zh) 一种重组人碱性成纤维细胞生长因子的制备方法及应用
CN100487118C (zh) 一种重组人角质细胞生长因子-2的生产方法
JP5422832B2 (ja) 不活化遺伝子再活性化ペプチド
WO2010095422A1 (ja) 悪性腫瘍治療剤
JPWO2006057389A1 (ja) Ａｍｐプロテインキナーゼによってリン酸化される新規転写因子とその遺伝子
JPH02156884A (ja) ポリペプチド及びその製造方法
JPWO2001092332A1 (ja) ネコ肝細胞増殖因子

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)