AU2015387481B2 - Detection of brain injury - Google Patents

Detection of brain injury Download PDF

Info

Publication number
AU2015387481B2
AU2015387481B2 AU2015387481A AU2015387481A AU2015387481B2 AU 2015387481 B2 AU2015387481 B2 AU 2015387481B2 AU 2015387481 A AU2015387481 A AU 2015387481A AU 2015387481 A AU2015387481 A AU 2015387481A AU 2015387481 B2 AU2015387481 B2 AU 2015387481B2
Authority
AU
Australia
Prior art keywords
mir
dna
patient
seq
brain injury
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2015387481A
Other languages
English (en)
Other versions
AU2015387481A1 (en
Inventor
Sarjubhai A. Patel
Thomas F. Rau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Montana Missoula
Original Assignee
University of Montana Missoula
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Montana Missoula filed Critical University of Montana Missoula
Publication of AU2015387481A1 publication Critical patent/AU2015387481A1/en
Application granted granted Critical
Publication of AU2015387481B2 publication Critical patent/AU2015387481B2/en
Priority to AU2021258088A priority Critical patent/AU2021258088B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2015387481A 2014-03-26 2015-09-22 Detection of brain injury Active AU2015387481B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021258088A AU2021258088B2 (en) 2014-03-26 2021-10-29 Detection of brain injury

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201461970613P 2014-03-26 2014-03-26
US14/669,454 2015-03-26
US14/669,454 US9605315B2 (en) 2014-03-26 2015-03-26 Detection of traumatic brain injury
PCT/US2015/051518 WO2016153549A1 (en) 2015-03-26 2015-09-22 Detection of brain injury

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021258088A Division AU2021258088B2 (en) 2014-03-26 2021-10-29 Detection of brain injury

Publications (2)

Publication Number Publication Date
AU2015387481A1 AU2015387481A1 (en) 2017-08-03
AU2015387481B2 true AU2015387481B2 (en) 2021-08-05

Family

ID=56979279

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2015387481A Active AU2015387481B2 (en) 2014-03-26 2015-09-22 Detection of brain injury
AU2021258088A Active AU2021258088B2 (en) 2014-03-26 2021-10-29 Detection of brain injury

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2021258088A Active AU2021258088B2 (en) 2014-03-26 2021-10-29 Detection of brain injury

Country Status (11)

Country Link
US (3) US9605315B2 (enExample)
EP (1) EP3274008B1 (enExample)
JP (1) JP2018518147A (enExample)
CN (1) CN107427614B (enExample)
AU (2) AU2015387481B2 (enExample)
CA (1) CA2976347A1 (enExample)
CL (1) CL2017002420A1 (enExample)
ES (1) ES3014311T3 (enExample)
IL (1) IL253889A0 (enExample)
SG (1) SG11201707332XA (enExample)
WO (1) WO2016153549A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2833375A1 (en) 2011-04-18 2012-10-26 Diamir, Llc Methods of using mirna from bodily fluids for early detection and monitoring of mild cognitive impairment (mci) and alzheimer's disease (ad)
CA2931082C (en) 2013-11-18 2024-01-23 Diamir, Llc Methods of using mirnas from bodily fluids for detection and monitoring of parkinson's disease (pd)
EP3377074B1 (en) * 2015-11-18 2024-01-03 Dignity Health Methods of diagnosing post traumatic epilepsy
US10975436B2 (en) 2016-01-05 2021-04-13 Diamir, Llc Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders
GB201603967D0 (en) * 2016-03-08 2016-04-20 Univ Birmingham Biomarkers of traumatic brain injury
ES2993025T3 (en) 2016-03-21 2024-12-20 Diamir Llc Methods of using mirnas from bodily fluids for detection and differentiation of neurodegenerative diseases
CN108300788B (zh) * 2017-01-13 2021-07-09 中国人民解放军南京军区南京总医院 一种用于检测轻型脑外伤的微小核糖核酸组合及其应用
EP3600472B1 (en) * 2017-03-23 2024-04-17 Quadrant Biosciences Inc. Analysis and prediction of traumatic brain injury and concusion symptoms
US10781487B2 (en) 2017-07-24 2020-09-22 Diamir, Llc miRNA-based methods for detecting and monitoring aging
CN119985995A (zh) 2018-05-31 2025-05-13 阿米达斯公司 用于检测创伤性脑损伤的组合物和方法
WO2025039033A1 (en) * 2023-08-21 2025-02-27 Glia Diagnostics Pty Ltd Methods and reagents for diagnosis and/or prognosis of traumatic brain injury
CN118314963B (zh) * 2023-11-13 2024-10-29 中国人民解放军空军特色医学中心 一种基于lasso回归的血小板储存损伤风险预测模型及其构建方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011032155A2 (en) * 2009-09-14 2011-03-17 Banyan Biomarkers, Inc. Micro-rna, autoantibody and protein markers for diagnosis of neuronal injury
WO2011149354A1 (en) * 2010-05-28 2011-12-01 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Mirnas involved in the blood brain barrier function
US20120196293A1 (en) * 2011-01-28 2012-08-02 Kaohsiung Medical University Method and kit for in vitro diagnosis of atherosclerosis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL145209A0 (en) * 2000-09-06 2002-06-30 Pfizer Prod Inc Pharmaceutical combinations for the treatment of stroke and traumatic brain injury
EP1549301A2 (en) * 2002-06-10 2005-07-06 Oklahoma Medical Research Foundation A method for using tethered bis(polyhydroxyphenyls) and o-alkyl derivatives thereof in treating inflammatory conditions of the central nervous system
EP2271931A4 (en) * 2008-04-25 2011-10-12 Merck Sharp & Dohme MICRO-RNA BIOMARKERS FOR TISSUE INJURIES
WO2013032962A2 (en) 2011-08-28 2013-03-07 The Board Of Trustees Of The Leland Stanford Junior University Micro rnas to treat stroke, ischemic brain injury, traumatic brain injury, and neurodegenerative disease
AU2012308092A1 (en) * 2011-09-13 2014-04-17 Commonwealth Scientific And Industrial Research Organisation Detection of viral infection
AU2013219799C1 (en) * 2012-02-15 2017-12-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of treating and preventing diseases and disorders of the central nervous system
US9101580B2 (en) * 2012-12-18 2015-08-11 Matthew Bennett Compositions and methods for treating traumatic brain injury

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011032155A2 (en) * 2009-09-14 2011-03-17 Banyan Biomarkers, Inc. Micro-rna, autoantibody and protein markers for diagnosis of neuronal injury
WO2011149354A1 (en) * 2010-05-28 2011-12-01 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Mirnas involved in the blood brain barrier function
US20120196293A1 (en) * 2011-01-28 2012-08-02 Kaohsiung Medical University Method and kit for in vitro diagnosis of atherosclerosis

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ANDREW G. HOSS ET AL, "MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington's Disease Pathogenesis", PLOS GENETICS, (2014-02-27), vol. 10, no. 2, doi:10.1371/journal.pgen.1004188, page e1004188 *
ANUJ SHARMA ET AL, "Identification of Serum MicroRNA Signatures for Diagnosis of Mild Traumatic Brain Injury in a Closed Head Injury Model", PLOS ONE, (2014-11-07), vol. 9, no. 11, doi:10.1371/journal.pone.0112019, page e112019 *
BIRKS, D.K., et al. 'Survey of MicroRNA expression in pediatric brain tumors', Pediatric Blood and Cancer. 2011, v. 56, n. 2, pp. 211-216 *
FU JIA LIU ET AL, "microRNAs Involved in Regulating Spontaneous Recovery in Embolic Stroke Model", PLOS ONE, (2013-06-18), vol. 8, no. 6, doi:10.1371/ journal.pone.0066393, page e66393 *
HU K ET AL, "Expression profile of microRNAs in rat hippocampus following lithium-pilocarpine-induced status epilepticus", NEUROSCIENCE LETTERS, vol. 488, (2011-01-25), pages 252 - 257 *
LEI, P et al., 'Microarray Based Analysis of microRNA Expression In Rat Cerebral Cortex After Traumatic Brain Injury', Brain Research. 2009, v. 1284, pp 191 - 201 *
NAGARAJA BALAKATHIRESAN ET AL, "MicroRNA Let-7i Is a Promising Serum Biomarker for Blast-Induced Traumatic Brain Injury", JOURNAL OF NEUROTRAUMA., US, (2012-05-01), vol. 29, pages 1379 - 1387 *
TING-YI SUN ET AL, "Expression profiling of MicroRNAs in hippocampus of rats following traumatic brain injury", HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY. (2014-08-01), vol. 34, pages 548 - 553 *
WANG-XIA WANG ET AL, 'Mitochondria-associated microRNAs in rat hippocampus following traumatic brain injury', Experimental Neurology. 2015, v. 265, pp. 84-93 *

Also Published As

Publication number Publication date
US10815529B2 (en) 2020-10-27
SG11201707332XA (en) 2017-10-30
US20170268058A1 (en) 2017-09-21
EP3274008C0 (en) 2024-12-04
AU2015387481A1 (en) 2017-08-03
IL253889A0 (en) 2017-10-31
ES3014311T3 (en) 2025-04-21
EP3274008A1 (en) 2018-01-31
JP2018518147A (ja) 2018-07-12
US20190352716A1 (en) 2019-11-21
AU2021258088B2 (en) 2024-11-28
CN107427614A (zh) 2017-12-01
EP3274008A4 (en) 2018-10-24
EP3274008B1 (en) 2024-12-04
US10202649B2 (en) 2019-02-12
WO2016153549A1 (en) 2016-09-29
US9605315B2 (en) 2017-03-28
CN107427614B (zh) 2021-10-15
AU2021258088A1 (en) 2021-11-25
CL2017002420A1 (es) 2018-07-13
US20150344954A1 (en) 2015-12-03
CA2976347A1 (en) 2016-09-29

Similar Documents

Publication Publication Date Title
AU2021258088B2 (en) Detection of brain injury
EP3071712B1 (en) Methods of using mirnas from bodily fluids for detection and monitoring of parkinson's disease (pd)
CN105861712B (zh) 使用来自体液的miRNA来早期检测和监控轻度认知障碍(MCI)和阿尔茨海默病(AD)的方法
EP2406402B1 (en) Method to assess human allograft status from microrna expression levels
KR20140074997A (ko) 신경병성 질환에서 마이크로rna
US20160199399A1 (en) Methods for predicting drug responsiveness in cancer patients
US20170114410A1 (en) System and method for diagnosis and treatment of neuropsychiatric disorders
AU2019270336B2 (en) Methods for predicting drug responsiveness in cancer patients
EP2561096A2 (en) Means and methods for determining risk of cardiovascular disease
Traina et al. Cytoprotective effect of acetyl-L-carnitine evidenced by analysis of gene expression in the rat brain
KR102208777B1 (ko) 마이크로 RNA miR-210 억제제를 유효성분으로 포함하는 노화 관련 대사질환 방지용 조성물 및 miR-210 억제제의 스크리닝 방법
IT201800004359A1 (it) IDENTIFICAZIONE DI miRNA MUSCOLARI COME BIOMARCATORI E TRATTAMENTO CO-ADIUVANTE PER L’ATROFIA MUSCOLARE SPINALE
WO2014183110A1 (en) Methods for the detection of brain injury
US20220096431A1 (en) Pharmaceutical composition and method for preventing, treating and diagnosing a neurodegenerative disease
Li et al. Effects of Bisphenol a on the Proliferation and Tumor Growth of Human Uterine Leiomyoma Cell: In Vitro and in Vivo Evaluation with Mechanistic Insights Related to Xbp1
Sachs et al. Acid Stress Increases Gene Expression of Pro-inflammatory Cytokines in 6 Madin Darby Canine Kidney Cells 7

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)