CN107427614B - 脑损伤的检测 - Google Patents

脑损伤的检测 Download PDF

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CN107427614B
CN107427614B CN201580077882.4A CN201580077882A CN107427614B CN 107427614 B CN107427614 B CN 107427614B CN 201580077882 A CN201580077882 A CN 201580077882A CN 107427614 B CN107427614 B CN 107427614B
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mir
dna
patient
brain injury
seq
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CN107427614A (zh
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萨乔巴哈·A·帕特尔
托马斯·F·劳
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University of Montana Missoula
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580077882.4A 2015-03-26 2015-09-22 脑损伤的检测 Active CN107427614B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/669,454 US9605315B2 (en) 2014-03-26 2015-03-26 Detection of traumatic brain injury
US14/669,454 2015-03-26
PCT/US2015/051518 WO2016153549A1 (en) 2015-03-26 2015-09-22 Detection of brain injury

Publications (2)

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CN107427614A CN107427614A (zh) 2017-12-01
CN107427614B true CN107427614B (zh) 2021-10-15

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CN201580077882.4A Active CN107427614B (zh) 2015-03-26 2015-09-22 脑损伤的检测

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US (3) US9605315B2 (enExample)
EP (1) EP3274008B1 (enExample)
JP (1) JP2018518147A (enExample)
CN (1) CN107427614B (enExample)
AU (2) AU2015387481B2 (enExample)
CA (1) CA2976347A1 (enExample)
CL (1) CL2017002420A1 (enExample)
ES (1) ES3014311T3 (enExample)
IL (1) IL253889A0 (enExample)
SG (1) SG11201707332XA (enExample)
WO (1) WO2016153549A1 (enExample)

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JP6211511B2 (ja) 2011-04-18 2017-10-11 ディアミール, エルエルシーDiamir, Llc ｍｉＲＮＡに基づくユニバーサルスクリーニングテスト（ＵＳＴ）
WO2015073972A1 (en) 2013-11-18 2015-05-21 Diamir, Llc METHODS OF USING mIRNAs FROM BODILY FLUIDS FOR DETECTION AND MONITORING OF PARKINSON'S DISEASE (PD)
EP3377074B1 (en) * 2015-11-18 2024-01-03 Dignity Health Methods of diagnosing post traumatic epilepsy
US10975436B2 (en) 2016-01-05 2021-04-13 Diamir, Llc Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders
GB201603967D0 (en) * 2016-03-08 2016-04-20 Univ Birmingham Biomarkers of traumatic brain injury
US11149313B2 (en) 2016-03-21 2021-10-19 Diamir, Llc Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases
CN108300788B (zh) * 2017-01-13 2021-07-09 中国人民解放军南京军区南京总医院 一种用于检测轻型脑外伤的微小核糖核酸组合及其应用
WO2018175941A1 (en) * 2017-03-23 2018-09-27 Quadrant Biosciences Inc. Analysis and prediction of traumatic brain injury and concusion symptoms
US10781487B2 (en) 2017-07-24 2020-09-22 Diamir, Llc miRNA-based methods for detecting and monitoring aging
EP3803416A4 (en) * 2018-05-31 2022-05-18 Amydis, Inc. COMPOSITIONS AND METHODS FOR DETECTING BRAIN TRAUMA
WO2025039033A1 (en) * 2023-08-21 2025-02-27 Glia Diagnostics Pty Ltd Methods and reagents for diagnosis and/or prognosis of traumatic brain injury
CN118314963B (zh) * 2023-11-13 2024-10-29 中国人民解放军空军特色医学中心 一种基于lasso回归的血小板储存损伤风险预测模型及其构建方法和应用

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
IL145209A0 (en) * 2000-09-06 2002-06-30 Pfizer Prod Inc Pharmaceutical combinations for the treatment of stroke and traumatic brain injury
WO2003103583A2 (en) 2002-06-10 2003-12-18 Oklahoma Medical Research Foundation A method for using tethered bis(polyhydroxyphenyls) and o-alkyl derivatives thereof in treating inflammatory conditions of the central nervous system
WO2009132273A2 (en) * 2008-04-25 2009-10-29 Merck & Co., Inc. Microrna biomarkers of tissue injury
HUE040281T2 (hu) * 2009-09-14 2019-03-28 Banyan Biomarkers Inc Autoantitest markerek traumás agysérülés diagnózisára
WO2011149354A1 (en) * 2010-05-28 2011-12-01 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Mirnas involved in the blood brain barrier function
TW201231671A (en) * 2011-01-28 2012-08-01 Univ Kaohsiung Medical Method and kit for in vitro diagnosis of atherosclerosis
WO2013032962A2 (en) 2011-08-28 2013-03-07 The Board Of Trustees Of The Leland Stanford Junior University Micro rnas to treat stroke, ischemic brain injury, traumatic brain injury, and neurodegenerative disease
AU2012308092A1 (en) * 2011-09-13 2014-04-17 Commonwealth Scientific And Industrial Research Organisation Detection of viral infection
CA2864606C (en) * 2012-02-15 2021-06-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of treating and preventing diseases and disorders of the central nervous system
US9101580B2 (en) * 2012-12-18 2015-08-11 Matthew Bennett Compositions and methods for treating traumatic brain injury

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Publication number Publication date
AU2021258088A1 (en) 2021-11-25
EP3274008B1 (en) 2024-12-04
US10815529B2 (en) 2020-10-27
US20170268058A1 (en) 2017-09-21
SG11201707332XA (en) 2017-10-30
EP3274008C0 (en) 2024-12-04
ES3014311T3 (en) 2025-04-21
JP2018518147A (ja) 2018-07-12
IL253889A0 (en) 2017-10-31
AU2021258088B2 (en) 2024-11-28
WO2016153549A1 (en) 2016-09-29
US9605315B2 (en) 2017-03-28
US20150344954A1 (en) 2015-12-03
EP3274008A1 (en) 2018-01-31
US20190352716A1 (en) 2019-11-21
EP3274008A4 (en) 2018-10-24
US10202649B2 (en) 2019-02-12
CL2017002420A1 (es) 2018-07-13
CA2976347A1 (en) 2016-09-29
CN107427614A (zh) 2017-12-01
AU2015387481B2 (en) 2021-08-05
AU2015387481A1 (en) 2017-08-03

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