AU2015364253B2 - Synergistic co-administration of computationally optimized broadly reactive antigens for H1N1 influenza - Google Patents
Synergistic co-administration of computationally optimized broadly reactive antigens for H1N1 influenza Download PDFInfo
- Publication number
- AU2015364253B2 AU2015364253B2 AU2015364253A AU2015364253A AU2015364253B2 AU 2015364253 B2 AU2015364253 B2 AU 2015364253B2 AU 2015364253 A AU2015364253 A AU 2015364253A AU 2015364253 A AU2015364253 A AU 2015364253A AU 2015364253 B2 AU2015364253 B2 AU 2015364253B2
- Authority
- AU
- Australia
- Prior art keywords
- administration
- influenza
- synergistic
- reactive antigens
- computationally optimized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 206010069767 H1N1 influenza Diseases 0.000 title abstract 4
- 201000010740 swine influenza Diseases 0.000 title abstract 4
- 238000011260 co-administration Methods 0.000 title abstract 3
- 230000002195 synergetic effect Effects 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 101710154606 Hemagglutinin Proteins 0.000 abstract 4
- 101710093908 Outer capsid protein VP4 Proteins 0.000 abstract 4
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 abstract 4
- 101710176177 Protein A56 Proteins 0.000 abstract 4
- 239000000185 hemagglutinin Substances 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 230000001932 seasonal effect Effects 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16123—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462094772P | 2014-12-19 | 2014-12-19 | |
| US62/094,772 | 2014-12-19 | ||
| PCT/US2015/066882 WO2016100922A1 (en) | 2014-12-19 | 2015-12-18 | Synergistic co-administration of computationally optimized broadly reactive antigens for h1n1 influenza |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015364253A1 AU2015364253A1 (en) | 2017-06-29 |
| AU2015364253B2 true AU2015364253B2 (en) | 2020-01-23 |
Family
ID=56127736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015364253A Ceased AU2015364253B2 (en) | 2014-12-19 | 2015-12-18 | Synergistic co-administration of computationally optimized broadly reactive antigens for H1N1 influenza |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10220086B2 (enExample) |
| EP (1) | EP3233116A4 (enExample) |
| JP (2) | JP6764408B2 (enExample) |
| CN (1) | CN107530417A (enExample) |
| AU (1) | AU2015364253B2 (enExample) |
| CA (1) | CA2970158A1 (enExample) |
| WO (1) | WO2016100922A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016100922A1 (en) * | 2014-12-19 | 2016-06-23 | Oregon Health & Science University | Synergistic co-administration of computationally optimized broadly reactive antigens for h1n1 influenza |
| ES2991988T3 (es) | 2017-10-30 | 2024-12-05 | Takeda Pharmaceuticals Co | Detergentes compatibles con el medio ambiente para la inactivación de virus con envoltura lipídica |
| WO2019108319A1 (en) * | 2017-12-01 | 2019-06-06 | Kemin Industries, Inc. | Compositions containing euglena gracilis for viral protection and related methods |
| WO2019191261A1 (en) * | 2018-03-28 | 2019-10-03 | Sanofi Pasteur Inc. | Methods of generating broadly protective vaccine compositions comprising neuraminidase |
| WO2020092207A1 (en) * | 2018-10-28 | 2020-05-07 | University Of Georgia Research Foundation | Broadly reactive immunogens of influenza virus, compositions, and methods of use thereof |
| CA3221953A1 (en) * | 2021-06-10 | 2022-12-15 | University Of Georgia Research Foundation, Inc. | Broadly reactive viral antigens as immunogens, compositions and methods of use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100221284A1 (en) | 2001-05-30 | 2010-09-02 | Saech-Sisches Serumwerk Dresden | Novel vaccine composition |
| JP2012525370A (ja) * | 2009-04-27 | 2012-10-22 | ノバルティス アーゲー | インフルエンザに対して防御するためのアジュバント添加ワクチン |
| IN2014DN07399A (enExample) * | 2012-03-30 | 2015-04-24 | Univ Pittsburgh | |
| MX2015005056A (es) * | 2012-11-27 | 2015-07-23 | Univ Pittsburgh | Antigenos ampliamente reactivos computacionalmente optimizados para influenza h1n1. |
| RU2015138530A (ru) * | 2013-02-11 | 2017-03-20 | Новавакс, Инк. | Комбинированная вакцина против респираторно-синцитиального вируса и вируса гриппа |
| WO2016100922A1 (en) * | 2014-12-19 | 2016-06-23 | Oregon Health & Science University | Synergistic co-administration of computationally optimized broadly reactive antigens for h1n1 influenza |
| CN108290932A (zh) | 2015-06-09 | 2018-07-17 | 圣诺菲·帕斯图尔公司 | 优化编码工程改造的流感蛋白的核苷酸序列的方法 |
| US20200237898A1 (en) | 2015-09-21 | 2020-07-30 | Oregon Health & Science University | Vaccines intelligently produced by epitope recombination (viper) for influenza |
-
2015
- 2015-12-18 WO PCT/US2015/066882 patent/WO2016100922A1/en not_active Ceased
- 2015-12-18 CA CA2970158A patent/CA2970158A1/en not_active Abandoned
- 2015-12-18 JP JP2017533485A patent/JP6764408B2/ja not_active Expired - Fee Related
- 2015-12-18 CN CN201580076587.7A patent/CN107530417A/zh active Pending
- 2015-12-18 US US15/537,081 patent/US10220086B2/en active Active
- 2015-12-18 AU AU2015364253A patent/AU2015364253B2/en not_active Ceased
- 2015-12-18 EP EP15871236.4A patent/EP3233116A4/en not_active Withdrawn
-
2019
- 2019-01-25 US US16/258,094 patent/US10925957B2/en not_active Expired - Fee Related
-
2020
- 2020-08-03 JP JP2020131336A patent/JP2020186252A/ja active Pending
Non-Patent Citations (1)
| Title |
|---|
| B. M. GILES ET AL, A Computationally Optimized Hemagglutinin Virus-Like Particle Vaccine Elicits Broadly Reactive Antibodies that Protect Nonhuman Primates from H5N1 Infection, THE JOURNAL OF INFECTIOUS DISEASES, 2012, vol. 205(10), pg 1562 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018501258A (ja) | 2018-01-18 |
| US10925957B2 (en) | 2021-02-23 |
| US20170368164A1 (en) | 2017-12-28 |
| EP3233116A1 (en) | 2017-10-25 |
| CA2970158A1 (en) | 2016-06-23 |
| US20190175721A1 (en) | 2019-06-13 |
| WO2016100922A1 (en) | 2016-06-23 |
| JP6764408B2 (ja) | 2020-09-30 |
| JP2020186252A (ja) | 2020-11-19 |
| CN107530417A (zh) | 2018-01-02 |
| EP3233116A4 (en) | 2018-05-30 |
| US10220086B2 (en) | 2019-03-05 |
| AU2015364253A1 (en) | 2017-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |