CN107530417A - H1n1流感的计算优化的广泛反应性抗原的协同共同给药 - Google Patents

H1n1流感的计算优化的广泛反应性抗原的协同共同给药 Download PDF

Info

Publication number
CN107530417A
CN107530417A CN201580076587.7A CN201580076587A CN107530417A CN 107530417 A CN107530417 A CN 107530417A CN 201580076587 A CN201580076587 A CN 201580076587A CN 107530417 A CN107530417 A CN 107530417A
Authority
CN
China
Prior art keywords
influenza
seq
amino acid
polypeptides
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580076587.7A
Other languages
English (en)
Chinese (zh)
Inventor
T.M.罗斯
T.阿勒芬蒂斯
D.M.小卡特
C.A.达比
H.克利恩索斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oregon Health and Science University
Sanofi Pasteur Inc
Original Assignee
Oregon Health and Science University
Sanofi Pasteur Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oregon Health and Science University, Sanofi Pasteur Inc filed Critical Oregon Health and Science University
Publication of CN107530417A publication Critical patent/CN107530417A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16123Virus like particles [VLP]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201580076587.7A 2014-12-19 2015-12-18 H1n1流感的计算优化的广泛反应性抗原的协同共同给药 Pending CN107530417A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462094772P 2014-12-19 2014-12-19
US62/094772 2014-12-19
PCT/US2015/066882 WO2016100922A1 (en) 2014-12-19 2015-12-18 Synergistic co-administration of computationally optimized broadly reactive antigens for h1n1 influenza

Publications (1)

Publication Number Publication Date
CN107530417A true CN107530417A (zh) 2018-01-02

Family

ID=56127736

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580076587.7A Pending CN107530417A (zh) 2014-12-19 2015-12-18 H1n1流感的计算优化的广泛反应性抗原的协同共同给药

Country Status (7)

Country Link
US (2) US10220086B2 (enExample)
EP (1) EP3233116A4 (enExample)
JP (2) JP6764408B2 (enExample)
CN (1) CN107530417A (enExample)
AU (1) AU2015364253B2 (enExample)
CA (1) CA2970158A1 (enExample)
WO (1) WO2016100922A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3233116A4 (en) * 2014-12-19 2018-05-30 Oregon Health & Science University Synergistic co-administration of computationally optimized broadly reactive antigens for h1n1 influenza
WO2019086463A1 (en) 2017-10-30 2019-05-09 Baxalta GmbH Environmentally compatible detergents for inactivation of lipid-enveloped viruses
US20190167738A1 (en) * 2017-12-01 2019-06-06 Kemin Industries, Inc. Compositions containing euglena gracilis for viral protection and related methods
US12521430B2 (en) 2018-03-28 2026-01-13 Sanofi Pasteur Inc. Methods of generating broadly protective vaccine compositions comprising neuraminidase
WO2020092207A1 (en) * 2018-10-28 2020-05-07 University Of Georgia Research Foundation Broadly reactive immunogens of influenza virus, compositions, and methods of use thereof
EP4351637A4 (en) * 2021-06-10 2025-09-24 Univ Georgia BROAD-SPECTRUM VIRAL ANTIGENS AS IMMUNOGENS, THEIR COMPOSITIONS AND METHODS OF USE

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013148164A1 (en) * 2012-03-30 2013-10-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Computationally optimized broadly reactive antigens for h5n1 and h1n1 influenza viruses
US20140147459A1 (en) * 2012-11-27 2014-05-29 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Computationally optimized broadly reactive antigens for h1n1 influenza

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100221284A1 (en) * 2001-05-30 2010-09-02 Saech-Sisches Serumwerk Dresden Novel vaccine composition
CA2763816A1 (en) 2009-04-27 2010-11-04 Novartis Ag Adjuvanted vaccines for protecting against influenza
US20140227309A1 (en) 2013-02-11 2014-08-14 Novavax, Inc. Combination vaccine for respiratory syncytial virus and influenza
EP3233116A4 (en) * 2014-12-19 2018-05-30 Oregon Health & Science University Synergistic co-administration of computationally optimized broadly reactive antigens for h1n1 influenza
WO2016201127A1 (en) * 2015-06-09 2016-12-15 Sanofi Pasteur, Inc. Methods of optimizing nucleotide sequences encoding engineered influenza proteins
WO2017053413A1 (en) * 2015-09-21 2017-03-30 Oregon Health & Science University Vaccines intelligently produced by epitope recombination (viper) for influenza

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013148164A1 (en) * 2012-03-30 2013-10-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Computationally optimized broadly reactive antigens for h5n1 and h1n1 influenza viruses
US20140147459A1 (en) * 2012-11-27 2014-05-29 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Computationally optimized broadly reactive antigens for h1n1 influenza

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BRENDAN M. GILES ET AL.: "Antibody Breadth and Protective Efficacy Are Increased by Vaccination with Computationally Optimized Hemagglutinin but Not with Polyvalent Hemagglutinin-Based H5N1 Virus-Like Particle Vaccines", 《CLINICAL AND VACCINE IMMUNOLOGY》 *

Also Published As

Publication number Publication date
US20170368164A1 (en) 2017-12-28
AU2015364253A1 (en) 2017-06-29
CA2970158A1 (en) 2016-06-23
EP3233116A4 (en) 2018-05-30
US10220086B2 (en) 2019-03-05
WO2016100922A1 (en) 2016-06-23
JP2020186252A (ja) 2020-11-19
US20190175721A1 (en) 2019-06-13
JP6764408B2 (ja) 2020-09-30
JP2018501258A (ja) 2018-01-18
EP3233116A1 (en) 2017-10-25
US10925957B2 (en) 2021-02-23
AU2015364253B2 (en) 2020-01-23

Similar Documents

Publication Publication Date Title
US10925957B2 (en) Synergistic co-administration of computationally optimized broadly reactive antigens for H1N1 influenza
US10548965B2 (en) Synergistic co-administration of computationally optimized broadly reactive antigens for human and avian H5N1 influenza
US11542527B2 (en) Parainfluenza virus 5 based vaccines
Krammer et al. Advances in the development of influenza virus vaccines
Brazzoli et al. Induction of broad-based immunity and protective efficacy by self-amplifying mRNA vaccines encoding influenza virus hemagglutinin
Kang et al. Virus-like particles as universal influenza vaccines
US11389523B2 (en) Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (HA) protein
Giles et al. Antibody breadth and protective efficacy are increased by vaccination with computationally optimized hemagglutinin but not with polyvalent hemagglutinin-based H5N1 virus-like particle vaccines
Jang et al. Cross-protective immune responses elicited by live attenuated influenza vaccines
Li et al. Mucosally administered Lactobacillus surface-displayed influenza antigens (sM2 and HA2) with cholera toxin subunit A1 (CTA1) Induce broadly protective immune responses against divergent influenza subtypes
Allen et al. Broadened immunity and protective responses with emulsion-adjuvanted H5 COBRA-VLP vaccines
EP2015774A1 (en) Influenza virus vaccine
Lofano et al. B cells and functional antibody responses to combat influenza
Fox et al. Extending the breadth of influenza vaccines: status and prospects for a universal vaccine
EP2822585B1 (en) Improved vaccination against influenza
JP7479424B2 (ja) 改変インフルエンザヘマグルチニンポリペプチドの修飾
JP2024540290A (ja) ヘマグルチニン及びノイラミニダーゼを含むハイブリッド多価インフルエンザワクチン及びそれを使用する方法
US20130236494A1 (en) Vaccination against influenza
US8685409B2 (en) Influenza T-cell immunization against diverse influenza A viruses
KR20190137385A (ko) 저온 적응된 약독화 바이러스를 이용한 유니버설 독감 백신
Wittwer et al. Non-neutralizing antibody responses to vesicular stomatitis virus-vectored influenza A virus vaccines correlate with protection
Kotey et al. Influenza Management Prospects of Passive Immunotherapy
Roose Design and validation of novel cross-reactive Influenza B vaccines

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination