AU2015355226B2 - Compositions comprising 2-((1-(2(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia - Google Patents

Compositions comprising 2-((1-(2(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia Download PDF

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AU2015355226B2
AU2015355226B2 AU2015355226A AU2015355226A AU2015355226B2 AU 2015355226 B2 AU2015355226 B2 AU 2015355226B2 AU 2015355226 A AU2015355226 A AU 2015355226A AU 2015355226 A AU2015355226 A AU 2015355226A AU 2015355226 B2 AU2015355226 B2 AU 2015355226B2
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compound
tablet
pharmaceutical formulation
formulation
administered
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AU2015355226A1 (en
Inventor
Remy LUTHRINGER
Nadine Noel
Masahiro Okuyama
Sandra Werner
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Minerva Neurosciences Inc
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Minerva Neurosciences Inc
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Priority to AU2020204286A priority Critical patent/AU2020204286B2/en
Priority to AU2021229240A priority patent/AU2021229240B2/en
Priority to AU2023258386A priority patent/AU2023258386B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2015355226A 2014-12-02 2015-11-30 Compositions comprising 2-((1-(2(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia Active AU2015355226B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2020204286A AU2020204286B2 (en) 2014-12-02 2020-06-26 Compositions comprising 2-((1-(2(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia
AU2021229240A AU2021229240B2 (en) 2014-12-02 2021-09-10 Compositions comprising 2-((1-(2(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia
AU2023258386A AU2023258386B2 (en) 2014-12-02 2023-11-01 Compositions comprising 2-((1-(2(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462086691P 2014-12-02 2014-12-02
US62/086,691 2014-12-02
US201562248071P 2015-10-29 2015-10-29
US62/248,071 2015-10-29
PCT/US2015/062985 WO2016089766A1 (en) 2014-12-02 2015-11-30 Compositions comprising 2-((1-(2(4-fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia

Related Child Applications (1)

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AU2020204286A Division AU2020204286B2 (en) 2014-12-02 2020-06-26 Compositions comprising 2-((1-(2(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia

Publications (2)

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AU2015355226A1 AU2015355226A1 (en) 2017-06-08
AU2015355226B2 true AU2015355226B2 (en) 2020-04-02

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AU2015355226A Active AU2015355226B2 (en) 2014-12-02 2015-11-30 Compositions comprising 2-((1-(2(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia
AU2020204286A Active AU2020204286B2 (en) 2014-12-02 2020-06-26 Compositions comprising 2-((1-(2(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia
AU2021229240A Active AU2021229240B2 (en) 2014-12-02 2021-09-10 Compositions comprising 2-((1-(2(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia
AU2023258386A Active AU2023258386B2 (en) 2014-12-02 2023-11-01 Compositions comprising 2-((1-(2(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia

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AU2020204286A Active AU2020204286B2 (en) 2014-12-02 2020-06-26 Compositions comprising 2-((1-(2(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia
AU2021229240A Active AU2021229240B2 (en) 2014-12-02 2021-09-10 Compositions comprising 2-((1-(2(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia
AU2023258386A Active AU2023258386B2 (en) 2014-12-02 2023-11-01 Compositions comprising 2-((1-(2(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia

Country Status (26)

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US (7) US9458130B2 (enExample)
EP (2) EP4063357B1 (enExample)
JP (4) JP2018501217A (enExample)
KR (1) KR102620681B1 (enExample)
CN (2) CN111110677A (enExample)
AU (4) AU2015355226B2 (enExample)
BR (1) BR112017011555B1 (enExample)
CA (1) CA2968977A1 (enExample)
CL (2) CL2017001376A1 (enExample)
CO (1) CO2017005498A2 (enExample)
DK (1) DK3227273T3 (enExample)
EA (1) EA201791226A1 (enExample)
ES (2) ES2910528T3 (enExample)
HU (1) HUE058212T2 (enExample)
IL (4) IL301320B2 (enExample)
MX (1) MX385586B (enExample)
MY (1) MY185516A (enExample)
PE (1) PE20171646A1 (enExample)
PH (1) PH12017501007B1 (enExample)
PL (1) PL3227273T3 (enExample)
PT (1) PT3227273T (enExample)
SG (1) SG11201704332YA (enExample)
TW (1) TWI694069B (enExample)
UA (1) UA122780C2 (enExample)
WO (1) WO2016089766A1 (enExample)
ZA (1) ZA201703481B (enExample)

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IL301320B2 (en) 2014-12-02 2024-11-01 Minerva Neurosciences Inc Compositions comprising 2-((1-(2(4-fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia
CN113694065A (zh) * 2016-05-25 2021-11-26 田边三菱制药株式会社 用于治疗非精神分裂症患者中的阴性症状的组合物和方法
JP2020525436A (ja) 2017-06-21 2020-08-27 ミネルバ・ニューロサイエンシズ・インコーポレイテッド 胃耐性制御放出経口剤形
MX2020002271A (es) 2017-09-01 2020-10-05 Ptc Therapeutics Mp Inc Composiciones farmaceuticas que comprenden sepiapterina y sus usos de las mismas.
CN107721988A (zh) * 2017-10-31 2018-02-23 无锡福祈制药有限公司 具有抗炎活性的异吲哚‑1‑酮类化合物
EP3840835A1 (en) 2018-08-21 2021-06-30 Minerva Neurosciences, Inc. Use of roluperidone to treat negative symptoms and disorders, increase neuroplasticity, and promote neuroprotection
TWI841545B (zh) * 2018-12-12 2024-05-11 日商田邊三菱製藥股份有限公司 耐胃性控制釋放經口劑型
US12441701B2 (en) * 2019-06-28 2025-10-14 Tapi Czech Industries S.R.O. Solid state forms of roluperidone and salts thereof
IL298323B2 (en) 2020-05-20 2023-10-01 Univ Illinois A method for treating lysosomal storage disease using histatin peptides
CN116251078B (zh) * 2021-12-09 2025-12-19 河北以岭医药研究院有限公司 一种盐酸度洛西汀肠溶胶囊及其制备方法
EP4479049B1 (en) 2022-02-14 2025-12-17 Minerva Neurosciences, Inc. Use of roluperidone in preventing relapse in schizophrenia patients
WO2025090588A1 (en) 2023-10-24 2025-05-01 Minerva Neurosciences, Inc. Roluperidone for the treatment of lysosomal storage disorders and their symptoms
WO2026035878A1 (en) * 2024-08-07 2026-02-12 Nimbus Saturn, Inc. Hpk1 inhibitor formulations and methods of making the same
WO2026035872A1 (en) * 2024-08-07 2026-02-12 Nimbus Saturn, Inc. Hpk1 inhibitor formulations and methods of making the same

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WO2012012542A1 (en) * 2010-07-20 2012-01-26 Cyrenaic Pharmaceuticals, Inc. Methods of use of cyclic amide derivatives to treat schizophrenia

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DK3227273T3 (da) 2022-05-02
AU2020204286A1 (en) 2020-07-16
US20170042877A1 (en) 2017-02-16
PH12017501007B1 (en) 2024-07-03
EP4063357B1 (en) 2025-12-31
JP2018501217A (ja) 2018-01-18
US9730920B2 (en) 2017-08-15
IL252347B (en) 2021-01-31
MX385586B (es) 2025-03-18
PH12017501007A1 (en) 2017-12-18
US20210228561A1 (en) 2021-07-29
IL280052B1 (en) 2023-05-01
MX2017007065A (es) 2017-12-18
AU2021229240B2 (en) 2023-08-24
IL313572A (en) 2024-08-01
US20250195494A1 (en) 2025-06-19
PT3227273T (pt) 2022-04-06
EP3227273A1 (en) 2017-10-11
IL301320A (en) 2023-05-01
NZ770365A (en) 2023-10-27
EA201791226A1 (ru) 2017-09-29
IL301320B1 (en) 2024-07-01
PL3227273T3 (pl) 2022-05-30
IL280052A (en) 2021-03-01
ZA201703481B (en) 2023-12-20
TWI694069B (zh) 2020-05-21
AU2015355226A1 (en) 2017-06-08
US10799493B2 (en) 2020-10-13
CO2017005498A2 (es) 2017-09-20
CN111110677A (zh) 2020-05-08
US20200022968A1 (en) 2020-01-23
US9458130B2 (en) 2016-10-04
BR112017011555A2 (pt) 2018-01-09
IL280052B2 (en) 2023-09-01
EP4063357A1 (en) 2022-09-28
WO2016089766A1 (en) 2016-06-09
IL252347A0 (en) 2017-07-31
ES3065087T3 (en) 2026-05-04
BR112017011555B1 (pt) 2023-10-03
US10258614B2 (en) 2019-04-16
AU2020204286B2 (en) 2021-06-17
HUE058212T2 (hu) 2022-07-28
MY185516A (en) 2021-05-19
UA122780C2 (uk) 2021-01-06
JP2020172531A (ja) 2020-10-22
CL2017001376A1 (es) 2018-02-16
TW201632511A (zh) 2016-09-16
KR20170106310A (ko) 2017-09-20
AU2021229240A1 (en) 2021-10-07
PE20171646A1 (es) 2017-11-13
CA2968977A1 (en) 2016-06-09
ES2910528T3 (es) 2022-05-12
CN107567444A (zh) 2018-01-09
US20180153871A1 (en) 2018-06-07
KR102620681B1 (ko) 2024-01-04
US20230201184A1 (en) 2023-06-29
AU2023258386A1 (en) 2023-11-23
CL2021000044A1 (es) 2021-06-04
NZ732033A (en) 2023-10-27
JP2022105159A (ja) 2022-07-12
SG11201704332YA (en) 2017-06-29
AU2023258386B2 (en) 2025-10-23
IL301320B2 (en) 2024-11-01
JP7069253B2 (ja) 2022-05-17
JP2025004090A (ja) 2025-01-14
EP3227273B1 (en) 2022-02-09
US20160152597A1 (en) 2016-06-02

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