AU2015301809A1 - Mannose-6-phosphate bearing peptides fused to lysosomal enzymes - Google Patents
Mannose-6-phosphate bearing peptides fused to lysosomal enzymes Download PDFInfo
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- AU2015301809A1 AU2015301809A1 AU2015301809A AU2015301809A AU2015301809A1 AU 2015301809 A1 AU2015301809 A1 AU 2015301809A1 AU 2015301809 A AU2015301809 A AU 2015301809A AU 2015301809 A AU2015301809 A AU 2015301809A AU 2015301809 A1 AU2015301809 A1 AU 2015301809A1
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- naglu
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- protein
- lysosomal
- targeted therapeutic
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- Molecular Biology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Marine Sciences & Fisheries (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201462036082P | 2014-08-11 | 2014-08-11 | |
| US62/036,082 | 2014-08-11 | ||
| PCT/US2015/044713 WO2016025519A1 (en) | 2014-08-11 | 2015-08-11 | Mannose-6-phosphate bearing peptides fused to lysosomal enzymes |
Publications (1)
| Publication Number | Publication Date |
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| AU2015301809A1 true AU2015301809A1 (en) | 2017-02-02 |
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| AU2015301809A Abandoned AU2015301809A1 (en) | 2014-08-11 | 2015-08-11 | Mannose-6-phosphate bearing peptides fused to lysosomal enzymes |
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| US (2) | US10722559B2 (enExample) |
| EP (1) | EP3185889B1 (enExample) |
| JP (1) | JP6623213B2 (enExample) |
| CN (1) | CN106573039A (enExample) |
| AU (1) | AU2015301809A1 (enExample) |
| BR (1) | BR112017002741A2 (enExample) |
| CA (1) | CA2956469A1 (enExample) |
| EA (1) | EA201790178A1 (enExample) |
| MX (1) | MX2017001898A (enExample) |
| WO (1) | WO2016025519A1 (enExample) |
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| PT3626258T (pt) | 2010-06-25 | 2021-10-19 | Shire Human Genetic Therapies | Métodos e composições para fornecimento ao snc de iduronato-2-sulfatase |
| US20220133863A1 (en) * | 2010-06-25 | 2022-05-05 | Shire Human Genetic Therapies, Inc. | Treatment of sanfilippo syndrome type b |
| BR112020005271A2 (pt) | 2017-10-02 | 2020-09-15 | Denali Therapeutics Inc. | proteína, polipeptídeo, polinucleotídeo, vetor, célula hospedeira, método para produção de um polipeptídeo, métodos de tratamento de um distúrbio, de diminuição do acúmulo, de monitoramento, de transporte de um agente e de tratamento de um lsd e composição farmacêutica |
| JP2021533200A (ja) | 2018-08-02 | 2021-12-02 | ダイン セラピューティクス, インコーポレーテッドDyne Therapeutics, Inc. | 顔面・肩甲・上腕筋ジストロフィーを処置するための筋標的化複合体およびそれらの使用 |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| MX2021007376A (es) * | 2018-12-19 | 2021-09-21 | Univ Leland Stanford Junior | Moléculas bifuncionales para el direccionamiento lisosómico y composiciones y métodos relacionados. |
| EP3994253A1 (en) * | 2019-07-02 | 2022-05-11 | M6P Therapeutics (Switzerland) LLC | Vector compositions and methods of using same for treatment of lysosomal storage disorders |
| CN111455004B (zh) * | 2020-02-29 | 2023-05-05 | 浙江农林大学 | 一种脂肪酶催化在线合成香豆素-3-羧酸-6’-o-d-甘露糖酯的方法 |
| WO2022026906A2 (en) * | 2020-07-30 | 2022-02-03 | The Board Of Trustees Of The Leland Stanford Junior University | Lysosomal targeting molecules comprising knottin peptides and related compositions and methods |
| WO2023288033A1 (en) | 2021-07-14 | 2023-01-19 | Lycia Therapeutics, Inc. | Asgpr cell surface receptor binding compounds and conjugates |
| US20250134967A1 (en) * | 2022-02-07 | 2025-05-01 | M6P Therapeutics, Inc. | Compositions comprising acid alpha glucosidase and methods of use thereof |
| KR20250004770A (ko) | 2022-04-15 | 2025-01-08 | 다인 세라퓨틱스, 인크. | 근긴장성 이영양증을 치료하기 위한 근육 표적화 복합체 및 제제 |
| WO2025238106A1 (en) * | 2024-05-15 | 2025-11-20 | M6P Therapeutics (Switzerland) GmbH | Lysosome-targeting degradation fusion design |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040142474A1 (en) * | 2000-09-14 | 2004-07-22 | Expression Genetics, Inc. | Novel cationic lipopolymer as a biocompatible gene delivery agent |
| US7560424B2 (en) * | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| EP1463512B1 (en) * | 2002-01-11 | 2014-05-28 | biOasis Technologies Inc. | Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes |
| WO2009062195A2 (en) * | 2007-11-09 | 2009-05-14 | Anaphore, Inc. | Fusion proteins of mannose binding lectins for treatment of disease |
| US20110223147A1 (en) * | 2008-05-07 | 2011-09-15 | Zystor Therapeutics, Inc. | Lysosomal targeting peptides and uses thereof |
| DK2588130T3 (en) * | 2010-06-25 | 2016-10-24 | Shire Human Genetic Therapies | Cns delivery of therapeutic agents |
| US20110318327A1 (en) | 2010-06-25 | 2011-12-29 | Shire Human Genetic Therapies, Inc. | Treatment of sanfilippo syndrome type b |
| EP2975134A3 (en) | 2010-07-22 | 2016-02-24 | Shire Human Genetic Therapies, Inc. | Crystal structure of human alpha-n-acetylglucosaminidase |
| WO2012157136A1 (ja) | 2011-05-19 | 2012-11-22 | 財団法人東京都医学総合研究所 | リン酸化糖鎖を含有する組換えヒトサポシンｂタンパク質及びその用途 |
| PL2714752T3 (pl) * | 2011-05-27 | 2018-04-30 | Amicus Therapeutics, Inc. | Sposoby sprzęgania peptydów nakierowanych na rekombinowane enzymy lizosomalne dla poprawy leczenia lizosomalnych chorób spichrzeniowych |
| JP6329483B2 (ja) * | 2011-10-12 | 2018-05-23 | シナジェバ・バイオファーマ・コーポレイションＳｙｎａｇｅｖａ Ｂｉｏｐｈａｒｍａ Ｃｏｒｐ． | 組換えヒトｎａｇｌｕタンパク質およびその利用 |
| RU2680581C2 (ru) | 2012-11-27 | 2019-02-22 | Байомарин Фармасьютикал Инк. | Направленные терапевтические химерные белки лизосомальных ферментов и их применение |
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2015
- 2015-08-11 AU AU2015301809A patent/AU2015301809A1/en not_active Abandoned
- 2015-08-11 EP EP15757368.4A patent/EP3185889B1/en active Active
- 2015-08-11 CN CN201580043154.1A patent/CN106573039A/zh active Pending
- 2015-08-11 WO PCT/US2015/044713 patent/WO2016025519A1/en not_active Ceased
- 2015-08-11 CA CA2956469A patent/CA2956469A1/en not_active Abandoned
- 2015-08-11 EA EA201790178A patent/EA201790178A1/ru unknown
- 2015-08-11 JP JP2017507791A patent/JP6623213B2/ja active Active
- 2015-08-11 BR BR112017002741-0A patent/BR112017002741A2/pt not_active Application Discontinuation
- 2015-08-11 US US15/503,223 patent/US10722559B2/en active Active
- 2015-08-11 MX MX2017001898A patent/MX2017001898A/es unknown
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2020
- 2020-06-18 US US16/904,943 patent/US20200376095A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017529326A (ja) | 2017-10-05 |
| EP3185889A1 (en) | 2017-07-05 |
| CA2956469A1 (en) | 2016-02-18 |
| WO2016025519A1 (en) | 2016-02-18 |
| US10722559B2 (en) | 2020-07-28 |
| BR112017002741A2 (pt) | 2018-02-27 |
| US20200376095A1 (en) | 2020-12-03 |
| EA201790178A1 (ru) | 2017-07-31 |
| EP3185889B1 (en) | 2020-07-15 |
| US20170232076A1 (en) | 2017-08-17 |
| JP6623213B2 (ja) | 2019-12-18 |
| CN106573039A (zh) | 2017-04-19 |
| MX2017001898A (es) | 2017-04-11 |
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| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |