CA2956469A1 - Mannose-6-phosphate bearing peptides fused to lysosomal enzymes - Google Patents
Mannose-6-phosphate bearing peptides fused to lysosomal enzymes Download PDFInfo
- Publication number
- CA2956469A1 CA2956469A1 CA2956469A CA2956469A CA2956469A1 CA 2956469 A1 CA2956469 A1 CA 2956469A1 CA 2956469 A CA2956469 A CA 2956469A CA 2956469 A CA2956469 A CA 2956469A CA 2956469 A1 CA2956469 A1 CA 2956469A1
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- Prior art keywords
- naglu
- seq
- protein
- lysosomal
- targeted therapeutic
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- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N9/1288—Transferases for other substituted phosphate groups (2.7.8)
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- C12Y—ENZYMES
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- C12Y207/08—Transferases for other substituted phosphate groups (2.7.8)
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462036082P | 2014-08-11 | 2014-08-11 | |
| US62/036,082 | 2014-08-11 | ||
| PCT/US2015/044713 WO2016025519A1 (en) | 2014-08-11 | 2015-08-11 | Mannose-6-phosphate bearing peptides fused to lysosomal enzymes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2956469A1 true CA2956469A1 (en) | 2016-02-18 |
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| US20220133863A1 (en) * | 2010-06-25 | 2022-05-05 | Shire Human Genetic Therapies, Inc. | Treatment of sanfilippo syndrome type b |
| BR112012033214B1 (pt) | 2010-06-25 | 2020-11-03 | Shire Human Genetic Therapies, Inc. | uso de uma formulação estável compreendendo uma proteína de iduronato-2-sulfatase (i2s), formulação compreendendo a mesma e recipiente |
| CR20200129A (es) | 2017-10-02 | 2020-08-22 | Denali Therapeutics Inc | Proteínas de fusión que comprenden enzimas de terapia de reemplazo de enzimas |
| WO2020028864A1 (en) | 2018-08-02 | 2020-02-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| CN113301925A (zh) * | 2018-12-19 | 2021-08-24 | 小利兰·斯坦福大学理事会 | 用于溶酶体靶向的双官能分子以及相关的组合物和方法 |
| WO2021003442A1 (en) * | 2019-07-02 | 2021-01-07 | M6P Therapeutics | Vector compositions and methods of using same for treatment of lysosomal storage disorders |
| CN111455004B (zh) * | 2020-02-29 | 2023-05-05 | 浙江农林大学 | 一种脂肪酶催化在线合成香豆素-3-羧酸-6’-o-d-甘露糖酯的方法 |
| WO2022026906A2 (en) * | 2020-07-30 | 2022-02-03 | The Board Of Trustees Of The Leland Stanford Junior University | Lysosomal targeting molecules comprising knottin peptides and related compositions and methods |
| WO2023288033A1 (en) | 2021-07-14 | 2023-01-19 | Lycia Therapeutics, Inc. | Asgpr cell surface receptor binding compounds and conjugates |
| US20250134967A1 (en) * | 2022-02-07 | 2025-05-01 | M6P Therapeutics, Inc. | Compositions comprising acid alpha glucosidase and methods of use thereof |
| CN119183457A (zh) | 2022-04-15 | 2024-12-24 | 达因疗法公司 | 用于治疗强直性肌营养不良的肌肉靶向复合物和制剂 |
| WO2025238106A1 (en) * | 2024-05-15 | 2025-11-20 | M6P Therapeutics (Switzerland) GmbH | Lysosome-targeting degradation fusion design |
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| US20040142474A1 (en) * | 2000-09-14 | 2004-07-22 | Expression Genetics, Inc. | Novel cationic lipopolymer as a biocompatible gene delivery agent |
| US7560424B2 (en) * | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| EP2399586A1 (en) | 2002-01-11 | 2011-12-28 | Jefferies, Dr., Wilfred | Use of P97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes |
| WO2009062195A2 (en) * | 2007-11-09 | 2009-05-14 | Anaphore, Inc. | Fusion proteins of mannose binding lectins for treatment of disease |
| BRPI0912225A2 (pt) * | 2008-05-07 | 2018-03-20 | Zystor Therapeutics, Inc. | peptídeos de direcionamento lisossomais e usos dos mesmos |
| UA115648C2 (uk) * | 2010-06-25 | 2017-12-11 | Шае Хюмен Дженетік Терапіс, Інк. | Доставка терапевтичних агентів до цнс |
| US20110318327A1 (en) | 2010-06-25 | 2011-12-29 | Shire Human Genetic Therapies, Inc. | Treatment of sanfilippo syndrome type b |
| US8775146B2 (en) * | 2010-07-22 | 2014-07-08 | Shire Human Genetic Therapies, Inc. | Crystal structure of human alpha-N-acetylglucosaminidase |
| WO2012157136A1 (ja) | 2011-05-19 | 2012-11-22 | 財団法人東京都医学総合研究所 | リン酸化糖鎖を含有する組換えヒトサポシンｂタンパク質及びその用途 |
| WO2012166653A2 (en) * | 2011-05-27 | 2012-12-06 | Callidus Biopharma, Inc. | Methods for coupling targeting peptides onto recombinant lysosomal enzymes for improved treatments of lysosomal storage diseases |
| WO2013055888A2 (en) | 2011-10-12 | 2013-04-18 | Synageva Biopharma Corp. | Recombinant human naglu protein and uses thereof |
| KR102262882B1 (ko) * | 2012-11-27 | 2021-06-10 | 바이오마린 파머수티컬 인크. | 표적화된 치료적 리소좀 효소 융합 단백질들 및 그들의 용도들 |
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| US20200376095A1 (en) | 2020-12-03 |
| MX2017001898A (es) | 2017-04-11 |
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| JP6623213B2 (ja) | 2019-12-18 |
| WO2016025519A1 (en) | 2016-02-18 |
| EP3185889A1 (en) | 2017-07-05 |
| US20170232076A1 (en) | 2017-08-17 |
| US10722559B2 (en) | 2020-07-28 |
| EA201790178A1 (ru) | 2017-07-31 |
| JP2017529326A (ja) | 2017-10-05 |
| CN106573039A (zh) | 2017-04-19 |
| EP3185889B1 (en) | 2020-07-15 |
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| FZDE | Discontinued |
Effective date: 20230116 |