AU2015246656B2 - Use of APC analogue for wound healing - Google Patents
Use of APC analogue for wound healing Download PDFInfo
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- AU2015246656B2 AU2015246656B2 AU2015246656A AU2015246656A AU2015246656B2 AU 2015246656 B2 AU2015246656 B2 AU 2015246656B2 AU 2015246656 A AU2015246656 A AU 2015246656A AU 2015246656 A AU2015246656 A AU 2015246656A AU 2015246656 B2 AU2015246656 B2 AU 2015246656B2
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- apc
- wound
- dermal
- repair
- wound healing
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- 125000001424 substituent group Chemical group 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- PIEPQKCYPFFYMG-UHFFFAOYSA-N tris acetate Chemical compound CC(O)=O.OCC(N)(CO)CO PIEPQKCYPFFYMG-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000003041 virtual screening Methods 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4866—Protein C (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0076—Sprayable compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Materials Engineering (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2014901397A AU2014901397A0 (en) | 2014-04-16 | Treatment of abnormal cutaneous scarring | |
| AU2014901397 | 2014-04-16 | ||
| AU2014902900 | 2014-07-25 | ||
| AU2014902900A AU2014902900A0 (en) | 2014-07-25 | Use of APC analogue for wound healing | |
| PCT/AU2015/050177 WO2015157822A1 (en) | 2014-04-16 | 2015-04-16 | Use of apc analogue for wound healing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015246656A1 AU2015246656A1 (en) | 2016-11-03 |
| AU2015246656B2 true AU2015246656B2 (en) | 2020-06-18 |
Family
ID=54323284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015246656A Active AU2015246656B2 (en) | 2014-04-16 | 2015-04-16 | Use of APC analogue for wound healing |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20170035862A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3131572B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6873387B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN106488773B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015246656B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2946032C (cg-RX-API-DMAC7.html) |
| DK (1) | DK3131572T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2890623T3 (cg-RX-API-DMAC7.html) |
| PL (1) | PL3131572T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT3131572T (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015157822A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6273272B2 (ja) | 2012-07-04 | 2018-01-31 | ジージー バイオテック エルエルシー | 炎症性皮膚障害の治療 |
| US20170042982A1 (en) | 2014-04-16 | 2017-02-16 | Zz Biotech Llc | Treatment of abnormal cutaneous scarring |
| CN107619437B (zh) * | 2017-11-07 | 2019-08-13 | 昆明医科大学 | 一种皮肤创伤修复肽whpp-oa1及其提纯方法与应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005007820A2 (en) * | 2003-07-08 | 2005-01-27 | The Scripps Research Institute | Activated protein c variants with normal cytoprotective activity but reduced anticoagulant activity |
| WO2008073603A2 (en) * | 2006-10-31 | 2008-06-19 | The Scripps Research Institute | Dosing regimen of activated protein c and variants having reduced anticoagulant activity |
| US20130280234A1 (en) * | 2001-06-13 | 2013-10-24 | The University Of Sydney | Treatment and Composition for Wound Healing |
| WO2014005183A1 (en) * | 2012-07-04 | 2014-01-09 | The University Of Sydney | Treatment of inflammatory skin disorders |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4775624A (en) | 1985-02-08 | 1988-10-04 | Eli Lilly And Company | Vectors and compounds for expression of human protein C |
| US5516650A (en) | 1985-06-27 | 1996-05-14 | Zymogenetics, Inc. | Production of activated protein C |
| US4959318A (en) | 1985-06-27 | 1990-09-25 | Zymogenetics, Inc. | Expression of protein C |
| WO1989012685A1 (en) | 1987-05-18 | 1989-12-28 | Integrated Genetics, Inc. | Improved protein c molecules and method for making and activating same |
| US5084274A (en) | 1987-11-17 | 1992-01-28 | Scripps Clinic And Research Foundation | Inhibition of arterial thrombotic occlusion or thromboembolism |
| US4981952A (en) | 1988-10-04 | 1991-01-01 | Eli Lilly And Company | Method for the purification of vitamin K-dependent proteins |
| US5093117A (en) | 1989-01-24 | 1992-03-03 | Baxter International Inc. | Compositions and method for the treatment or prophylaxis of sepsis or septic shock |
| US5571786A (en) | 1990-08-16 | 1996-11-05 | Immuno Aktiengesellschaft | Use of protein C or the activation peptide of protein C for preparing a pharmaceutical preparation |
| AT402260B (de) | 1990-08-16 | 1997-03-25 | Immuno Ag | Protein c-hältige pharmazeutische präparation |
| AT397615B (de) | 1991-05-14 | 1994-05-25 | Immuno Ag | Arzneimittel enthaltend protein c |
| WO1993009807A1 (en) | 1991-11-18 | 1993-05-27 | The Scripps Research Institute | Methods of inhibiting thrombosis via elevation of circulating endogenous activated protein c levels |
| MY110664A (en) | 1992-05-21 | 1999-01-30 | Lilly Co Eli | Protein c derivatives |
| DE4239150A1 (de) | 1992-11-20 | 1994-05-26 | Thomae Gmbh Dr K | O-Acyl-4-phenyl-cyclohexanole, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| JP3043558B2 (ja) | 1993-10-29 | 2000-05-22 | 財団法人化学及血清療法研究所 | ヒト活性化プロテインｃ調製物及びその製法 |
| AU2467395A (en) | 1994-05-04 | 1995-11-29 | Board Of Trustees Of The University Of Arkansas, The | Novel ophthalmologic uses of protein c |
| PL195642B1 (pl) | 1997-04-28 | 2007-10-31 | Lilly Co Eli | Sposób przetwarzania wodnego roztworu aktywowanego białka C |
| HUP0001237A3 (en) | 1997-10-20 | 2002-01-28 | Lilly Co Eli | Methods for treating vascular disorders |
| CA2398929C (en) | 2000-02-04 | 2011-05-31 | The Scripps Research Institute | Neuroprotective, antithrombotic and anti-flammatory uses of activated protein c (apc) |
| CA2400187A1 (en) | 2000-02-11 | 2001-08-16 | Eli Lilly And Company | Protein c derivatives |
| DE60111620T2 (de) | 2000-03-28 | 2006-05-18 | Eli Lilly And Co., Indianapolis | Aktiviertes protein c zur behandlung von pankreatitis |
| EP1328622A2 (en) | 2000-10-18 | 2003-07-23 | Maxygen Aps | Protein c or activated protein c-like molecules |
| AU2003275948A1 (en) | 2002-11-06 | 2004-06-07 | Novo Nordisk A/S | Pharmaceutical composition comprising a tissue factor antagonist and protein c polypeptides |
| SI1477166T1 (sl) | 2003-04-28 | 2006-12-31 | Biofrontera Bioscience Gmbh | Uporaba riluzola, kombiniranega s primernimi pomoznimi in dodatnimi snovmi, za zdravljenje bolezni,za katere je znacilna hiperproliferacija keratinocitov, se zlasti nevrodermitisa in psoriaze |
| US9192657B2 (en) | 2003-07-08 | 2015-11-24 | The Scripps Research Institute | Activated protein C variants with normal cytoprotective activity but reduced anticoagulant activity |
| US20070224150A1 (en) | 2005-03-24 | 2007-09-27 | Yongji Chung | Growth factor for hair and skin treatment |
| CA2612597C (en) | 2005-06-24 | 2015-03-31 | Drugrecure Aps | Airway administration of activated protein c in inflammatory conditions affecting the respiratory tract |
| GR1005700B (el) | 2006-09-01 | 2007-10-22 | (40%) ����� �������� | Τροπος αντιμετωπισης της 1ης φασης του εγκαυματοσσε μη σηπτικους ασθενεις με συνεχη ενδοφλεβια χορηγηση ενεργοποιημενης πρωτεινης-c για 48 ωρες με στοχο τη μειωση της τελικης εγκαυματικης βλαβης καιαυξηση της ταχυτητας επουλωσης κατα τα πρωτα επτα μετεγκαυματικα 24ωρα |
| GB0724231D0 (en) | 2007-12-12 | 2008-01-30 | Renono Ltd | Methods for inhibiting scarring |
| ES2316312B1 (es) | 2008-06-20 | 2010-02-08 | Ignacio Umbert Millet | Composicion farmaceutica dermatologica para el tratamiento de patologias de inflamacion de la piel, tales como por ejemplo dermatitis, dermatitis atopica, vitiligo, alopecia areata, acne, psoriasis y prurito,y combinaciones de las mismas. |
| EP2157176A1 (en) | 2008-08-20 | 2010-02-24 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Protein C Variants |
| CN101912450A (zh) | 2010-09-01 | 2010-12-15 | 吴业刚 | 一种治疗脚气皮炎的中西药组合物及其制备方法 |
| US20170042982A1 (en) | 2014-04-16 | 2017-02-16 | Zz Biotech Llc | Treatment of abnormal cutaneous scarring |
-
2015
- 2015-04-16 PT PT157795733T patent/PT3131572T/pt unknown
- 2015-04-16 DK DK15779573.3T patent/DK3131572T3/da active
- 2015-04-16 EP EP15779573.3A patent/EP3131572B1/en active Active
- 2015-04-16 CA CA2946032A patent/CA2946032C/en active Active
- 2015-04-16 US US15/304,433 patent/US20170035862A1/en not_active Abandoned
- 2015-04-16 WO PCT/AU2015/050177 patent/WO2015157822A1/en not_active Ceased
- 2015-04-16 ES ES15779573T patent/ES2890623T3/es active Active
- 2015-04-16 PL PL15779573T patent/PL3131572T3/pl unknown
- 2015-04-16 JP JP2017505687A patent/JP6873387B2/ja active Active
- 2015-04-16 AU AU2015246656A patent/AU2015246656B2/en active Active
- 2015-04-16 CN CN201580025422.7A patent/CN106488773B/zh active Active
-
2018
- 2018-02-15 US US15/897,801 patent/US20180243383A1/en not_active Abandoned
-
2019
- 2019-09-13 US US16/569,975 patent/US12214024B2/en active Active
-
2020
- 2020-02-27 JP JP2020031999A patent/JP2020100648A/ja not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130280234A1 (en) * | 2001-06-13 | 2013-10-24 | The University Of Sydney | Treatment and Composition for Wound Healing |
| WO2005007820A2 (en) * | 2003-07-08 | 2005-01-27 | The Scripps Research Institute | Activated protein c variants with normal cytoprotective activity but reduced anticoagulant activity |
| WO2008073603A2 (en) * | 2006-10-31 | 2008-06-19 | The Scripps Research Institute | Dosing regimen of activated protein c and variants having reduced anticoagulant activity |
| WO2014005183A1 (en) * | 2012-07-04 | 2014-01-09 | The University Of Sydney | Treatment of inflammatory skin disorders |
Non-Patent Citations (3)
| Title |
|---|
| MC KELVEY K et al., "Activated Protein C: A regulator of numan epidermal keratinocyte function", World J Biol Chem, (2014-05-26), vol. 5, no. 2, pages 169 179 * |
| WALKER CT et al., "Activated protein C with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impact", Brain Res, (2010), vol. 1347, ISSN 0006-8993, pages 125 - 131 * |
| WILLIAMS PD et al., "Preclinical Safety and Pharmacokinetic Profile of 3K3-APC, a Novel, Modified Activated Protein C for Ischemic Stroke", Curr Pharm Des., (2012), vol. 18, no. 27, pages 4215 - 4222 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20200000890A1 (en) | 2020-01-02 |
| JP2020100648A (ja) | 2020-07-02 |
| CN106488773A (zh) | 2017-03-08 |
| CA2946032A1 (en) | 2015-10-22 |
| WO2015157822A1 (en) | 2015-10-22 |
| JP6873387B2 (ja) | 2021-05-19 |
| DK3131572T3 (da) | 2021-10-11 |
| CA2946032C (en) | 2022-06-14 |
| EP3131572A4 (en) | 2017-12-20 |
| US20170035862A1 (en) | 2017-02-09 |
| CN106488773B (zh) | 2020-02-11 |
| PL3131572T3 (pl) | 2022-02-07 |
| AU2015246656A1 (en) | 2016-11-03 |
| US12214024B2 (en) | 2025-02-04 |
| US20180243383A1 (en) | 2018-08-30 |
| EP3131572A1 (en) | 2017-02-22 |
| PT3131572T (pt) | 2021-09-24 |
| EP3131572B1 (en) | 2021-07-14 |
| JP2017513945A (ja) | 2017-06-01 |
| ES2890623T3 (es) | 2022-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |