AU2014367150C1 - Systems and methods for subretinal delivery of therapeutic agents - Google Patents

Systems and methods for subretinal delivery of therapeutic agents Download PDF

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Publication number
AU2014367150C1
AU2014367150C1 AU2014367150A AU2014367150A AU2014367150C1 AU 2014367150 C1 AU2014367150 C1 AU 2014367150C1 AU 2014367150 A AU2014367150 A AU 2014367150A AU 2014367150 A AU2014367150 A AU 2014367150A AU 2014367150 C1 AU2014367150 C1 AU 2014367150C1
Authority
AU
Australia
Prior art keywords
treatment device
inner tube
retinal
retina
retinal treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2014367150A
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English (en)
Other versions
AU2014367150B2 (en
AU2014367150A1 (en
Inventor
Pooria S. Kashani
Michael Papac
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
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Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of AU2014367150A1 publication Critical patent/AU2014367150A1/en
Publication of AU2014367150B2 publication Critical patent/AU2014367150B2/en
Application granted granted Critical
Publication of AU2014367150C1 publication Critical patent/AU2014367150C1/en
Assigned to ALCON INC. reassignment ALCON INC. Request for Assignment Assignors: NOVARTIS AG
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/00491Surgical glue applicators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
AU2014367150A 2013-12-18 2014-11-06 Systems and methods for subretinal delivery of therapeutic agents Ceased AU2014367150C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/132,859 2013-12-18
US14/132,859 US10010447B2 (en) 2013-12-18 2013-12-18 Systems and methods for subretinal delivery of therapeutic agents
PCT/US2014/064407 WO2015094507A1 (en) 2013-12-18 2014-11-06 Systems and methods for subretinal delivery of therapeutic agents

Publications (3)

Publication Number Publication Date
AU2014367150A1 AU2014367150A1 (en) 2016-07-28
AU2014367150B2 AU2014367150B2 (en) 2017-08-24
AU2014367150C1 true AU2014367150C1 (en) 2018-04-12

Family

ID=53367065

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014367150A Ceased AU2014367150C1 (en) 2013-12-18 2014-11-06 Systems and methods for subretinal delivery of therapeutic agents

Country Status (8)

Country Link
US (1) US10010447B2 (cg-RX-API-DMAC7.html)
EP (1) EP3068353B1 (cg-RX-API-DMAC7.html)
JP (1) JP6438030B2 (cg-RX-API-DMAC7.html)
CN (1) CN105979914B (cg-RX-API-DMAC7.html)
AU (1) AU2014367150C1 (cg-RX-API-DMAC7.html)
CA (1) CA2932912C (cg-RX-API-DMAC7.html)
ES (1) ES2733398T3 (cg-RX-API-DMAC7.html)
WO (1) WO2015094507A1 (cg-RX-API-DMAC7.html)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9730834B2 (en) * 2013-12-20 2017-08-15 Novartis Ag Variable stiffness cannula and methods for a surgical system
US9925088B2 (en) * 2014-06-06 2018-03-27 Janssen Biotech, Inc. Sub-retinal tangential needle catheter guide and introducer
US20160331584A1 (en) * 2015-05-14 2016-11-17 Novartis Ag Surgical tool tracking to control surgical system
US10507134B2 (en) 2015-05-27 2019-12-17 Novartis Ag Systems and methods for pulsed posterior vitreous detachment creation
AU2016372824B2 (en) 2015-12-14 2021-05-20 Alcon Inc. Uni-port hybrid gauge surgical apparatuses and methods
WO2017103744A1 (en) * 2015-12-14 2017-06-22 Novartis Ag Patch for sealing retinal breaks and associated devices, systems, and methods
TW201722377A (zh) 2015-12-16 2017-07-01 諾華公司 用於插管遞送式治療材料施加裝置之裝置及方法
US10478553B2 (en) * 2016-03-09 2019-11-19 Orbit Biomedical Limited Apparatus for subretinal administration of therapeutic agent via a curved needle
US10646374B2 (en) * 2016-06-17 2020-05-12 Orbit Biomedical Limited Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent
US11033427B2 (en) 2017-04-13 2021-06-15 Alcon Inc. Vitreoretinal instruments for fluid aspiration
WO2019082082A1 (en) * 2017-10-27 2019-05-02 Novartis Ag OCT DISPLAY CONTROLLED BY LEVER OF FOOT CONTROL FOR VITREO-RETINAL SURGERY
US11433174B2 (en) * 2018-12-12 2022-09-06 Alcon Inc. Retractable backflush instrument
US12318343B2 (en) 2019-05-29 2025-06-03 Alcon Inc. Retina massage and smoothing device
DE102020115346A1 (de) * 2020-06-09 2021-12-09 Carl Zeiss Meditec Ag Kontrollierte Injektion zwischen zwei Gewebeschichten des menschlichen Auges
TWI757205B (zh) * 2020-06-30 2022-03-01 財團法人工業技術研究院 微針電轉染裝置
AU2021360288A1 (en) * 2020-10-15 2023-05-11 Alcon Inc. Wireless injector
CA3201659A1 (en) * 2020-12-17 2022-06-23 Reto GRUEEBLER A retractable backflush instrument
CA3204137A1 (en) 2021-01-25 2022-07-28 Niels Alexander Abt Method and apparatus for subretinal injection
JP6964912B1 (ja) * 2021-05-28 2021-11-10 株式会社中京メディカル 眼球装着管
US20240350312A1 (en) * 2021-08-10 2024-10-24 Nallakrishnan Family Trust Surgical Instrument And Method For Goniotomy Procedure
WO2024013559A1 (en) * 2022-07-11 2024-01-18 Gyroscope Therapeutics Limited Transvitreal subretinal injector
CN119770839B (zh) * 2025-03-11 2025-07-04 瑞安市人民医院(瑞安市人民医院医疗服务集团瑞安市红十字医院) 一种食道精准上药器

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120271272A1 (en) * 2010-10-15 2012-10-25 Iscience Interventional Corporation Device for ocular access

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4830877B1 (cg-RX-API-DMAC7.html) * 1966-11-25 1973-09-25
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5084009A (en) * 1990-04-18 1992-01-28 Mackool Richard J Fluid infusion sleeve for use during eye surgery
US5273530A (en) 1990-11-14 1993-12-28 The University Of Rochester Intraretinal delivery and withdrawal instruments
US5767079A (en) 1992-07-08 1998-06-16 Celtrix Pharmaceuticals, Inc. Method of treating ophthalmic disorders using TGF -β
CA2150554A1 (en) 1992-12-02 1994-06-09 Sheng-Wan Tsao Cyclodextrin and polymer based drug delivery system
US5399352A (en) 1993-04-14 1995-03-21 Emory University Device for local drug delivery and methods for using the same
US5985307A (en) 1993-04-14 1999-11-16 Emory University Device and method for non-occlusive localized drug delivery
WO1995003009A1 (en) 1993-07-22 1995-02-02 Oculex Pharmaceuticals, Inc. Method of treatment of macular degeneration
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
WO1995017673A1 (en) 1993-12-21 1995-06-29 Ocutech, Inc. Ocular diagnostics and therapies
SE9402816D0 (sv) 1994-08-24 1994-08-24 Pharmacia Ab Method and meams for drug administration
AU3584895A (en) 1994-09-28 1996-04-19 Celtrix Pharmaceuticals, Inc. Method of treating macular degeneration using tgf-beta
US5899882A (en) 1994-10-27 1999-05-04 Novoste Corporation Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient
CN1177919A (zh) * 1995-03-10 1998-04-01 托马斯·J·钱伯斯 柔性眼内晶状体插入系统
US5755700A (en) * 1995-07-27 1998-05-26 Michiel S. Kritzinger Corneal irrigation cannula and method of using
US6015403A (en) 1996-02-26 2000-01-18 Alcon Laboratories, Inc. Ophthalmic surgery probe with soft tip
US5948427A (en) 1996-04-25 1999-09-07 Point Medical Corporation Microparticulate surgical adhesive
US5941250A (en) * 1996-11-21 1999-08-24 University Of Louisville Research Foundation Inc. Retinal tissue implantation method
HUP0003393A3 (en) 1997-05-16 2001-03-28 Amgen Inc Thousand Oaks Ustained-release delayed gels
AU743819B2 (en) 1997-10-27 2002-02-07 California Institute Of Technology Methods and pharmaceutical compositions for the closure of retinal breaks
US6764461B2 (en) * 1997-12-01 2004-07-20 Scimed Life Systems, Inc. Catheter system for the delivery of a low volume bolus
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6936053B1 (en) 1998-07-02 2005-08-30 Jeffrey N. Weiss Ocular implant needle
US6378526B1 (en) 1998-08-03 2002-04-30 Insite Vision, Incorporated Methods of ophthalmic administration
US6309374B1 (en) 1998-08-03 2001-10-30 Insite Vision Incorporated Injection apparatus and method of using same
US6219575B1 (en) 1998-10-23 2001-04-17 Babak Nemati Method and apparatus to enhance optical transparency of biological tissues
JP2002534139A (ja) 1999-01-05 2002-10-15 マサチューセッツ・アイ・アンド・イア・インファーマリー 網膜と脈絡膜への経強膜徐放性薬剤標的送達
JP2003515359A (ja) 1999-02-17 2003-05-07 ボシュ・アンド・ロム・インコーポレイテッド 哺乳類の眼から水晶体を切除する方法、装置およびシステム
EP1178791A2 (en) 1999-05-07 2002-02-13 Johns Hopkins University School of Medicine The use of a protein tyrosine kinase pathway inhibitor in the treatment of ocular disorders
US6159218A (en) * 1999-05-19 2000-12-12 Aramant; Robert B. Retinal tissue implantation tool
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
JP2003509349A (ja) 1999-09-15 2003-03-11 エラン ファーマシューティカルズ,インコーポレイテッド ヘテロアリールメタンスルホンアミドを使用するニューロパシー性疼痛を処置するための方法。
DE60018777T2 (de) 1999-10-21 2006-02-02 Alcon Inc. Medikamentenversorgung der sub-tenon
WO2001037767A1 (de) * 1999-11-24 2001-05-31 Grieshaber & Co. Ag Einrichtung zum verbessern des kammerwasserabflusses im auge eines lebewesens
KR100855740B1 (ko) 1999-12-10 2008-09-03 아이싸이언스 인터벤셔날 코포레이션 안 질환의 치료방법
US20030211166A1 (en) 2001-07-31 2003-11-13 Yamamoto Ronald K Microparticulate biomaterial composition for medical use
US6491670B1 (en) 2000-04-04 2002-12-10 Duke University Miniaturized surgical instruments especially useful for the opthalmologic surgical procedures and methods of making the same
AU2001259085A1 (en) 2000-04-17 2001-10-30 Childrens Hospital Research Foundation Treatment of ocular neovascularization and related diseases
ATE363902T1 (de) 2000-06-14 2007-06-15 Us Health Isoflavonen gegen strahlungsinduzierte mortalität
US7331944B2 (en) * 2000-10-23 2008-02-19 Medical Instill Technologies, Inc. Ophthalmic dispenser and associated method
US20030171722A1 (en) 2001-01-04 2003-09-11 Michel Paques Microsurgical injection and/or distending instruments and surgical method and apparatus utilizing same
AU2002240004A1 (en) 2001-01-25 2002-08-06 Philip J. Ferrone Infusion cannula
US6827738B2 (en) * 2001-01-30 2004-12-07 Timothy R. Willis Refractive intraocular implant lens and method
US6945984B2 (en) 2001-08-23 2005-09-20 Alcon Grieshaber Ag Micro surgical instrument
JP4303116B2 (ja) 2001-11-21 2009-07-29 アイサイエンス コーポレイション 眼科マイクロサージャリー装置
US20050089545A1 (en) 2002-02-22 2005-04-28 Mitsuaki Kuwano Drug delivery system for the subconjunctival administration of fine grains
US20050165413A1 (en) 2002-03-22 2005-07-28 Conston Stanley R. Ophthalmic microfiducial device and method for use
CA2492140A1 (en) 2002-07-12 2004-01-22 Iscience Surgical Corporation Ultrasound interfacing device for tissue imaging
WO2004026347A2 (en) 2002-09-17 2004-04-01 Iscience Surgical Corporation Apparatus and method for surgical bypass of aqueous humor
US6899717B2 (en) 2002-09-18 2005-05-31 Allergan, Inc. Methods and apparatus for delivery of ocular implants
CA2498191C (en) 2002-09-18 2012-04-10 Trustees Of The University Of Pennsylvania Method of inhibiting choroidal neovascularization
US20040221855A1 (en) 2002-10-17 2004-11-11 Paul Ashton Methods for monitoring treatment of disease
US7141048B1 (en) 2002-10-17 2006-11-28 Alcon, Inc. Vitreoretinal instrument
US7285107B1 (en) 2002-10-17 2007-10-23 Alcon, Inc. Vitreoretinal instrument
US20060167435A1 (en) 2003-02-18 2006-07-27 Adamis Anthony P Transscleral drug delivery device and related methods
AU2004231968B2 (en) 2003-04-16 2011-02-24 Iscience Surgical Corporation Opthalmic microsurgical instruments
US20050009910A1 (en) 2003-07-10 2005-01-13 Allergan, Inc. Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug
JP4180993B2 (ja) 2003-08-06 2008-11-12 日本化薬株式会社 ガス発生器
JP2007520276A (ja) 2004-01-12 2007-07-26 アイサイエンス・インターベンショナル・コーポレーション 粘性材料のための注入器
AU2011221361A1 (en) 2004-01-23 2011-09-29 Iscience Surgical Corporation Composite Ophthalmic Microcannula
AU2011218623B2 (en) 2004-01-23 2014-01-23 Nova Eye, Inc. Composite Ophthalmic Microcannula
PL1715827T3 (pl) 2004-01-23 2011-07-29 Iscience Interventional Corp Złożona okulistyczna mikrokaniula
US20100173866A1 (en) 2004-04-29 2010-07-08 Iscience Interventional Corporation Apparatus and method for ocular treatment
CA2564840A1 (en) 2004-04-29 2005-11-17 Michael Hee Apparatus and method for ocular treatment
US20080058704A1 (en) 2004-04-29 2008-03-06 Michael Hee Apparatus and Method for Ocular Treatment
EP1740239A4 (en) 2004-04-29 2008-12-03 Iscience Interventional Corp DEVICE AND METHOD FOR THE SURGICAL REINFORCEMENT OF THE DRAINAGE OF AQUEOUS HUMOR
US20050244462A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Devices and methods for treating a mammalian eye
US9138228B2 (en) 2004-08-11 2015-09-22 Emory University Vascular conduit device and system for implanting
WO2006042252A2 (en) 2004-10-08 2006-04-20 Potentia Pharmeceuticals, Inc. Viral complement control proteins for eye disorders
ATE448826T1 (de) * 2004-12-07 2009-12-15 Cook Inc Einführvorrichtung
EP2215996B1 (en) 2004-12-16 2013-04-03 Iscience Interventional Corporation Ophthalmic implant for treatment of glaucoma
AU2012200785A1 (en) 2004-12-16 2012-03-01 Iscience Interventional Corporation Ophthalmic implant for treatment of glaucoma
JP5388582B2 (ja) 2006-01-17 2014-01-15 トランセンド・メディカル・インコーポレイテッド 薬剤投与処置装置
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US7918814B2 (en) 2006-05-02 2011-04-05 Georgia Tech Research Corporation Method for drug delivery to ocular tissue using microneedle
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
US20080097335A1 (en) 2006-08-04 2008-04-24 Allergan, Inc. Ocular implant delivery assemblies
US9681947B2 (en) * 2006-10-23 2017-06-20 Novartis Ag Intraocular lens delivery system with temperature control
EP2124857B1 (en) * 2007-01-09 2017-03-29 Fovea Pharmaceuticals Apparatus for intra-ocular injection
EP2111821A4 (en) 2007-02-08 2013-10-23 Kaneka Corp INJECTOR FOR EYES
US20080195135A1 (en) 2007-02-12 2008-08-14 Alcon, Inc. Surgical Probe
US7846123B2 (en) 2007-04-24 2010-12-07 Emory University Conduit device and system for implanting a conduit device in a tissue wall
US8147512B1 (en) 2007-06-06 2012-04-03 Scanlan International, Inc. Dual closing guide for a surgical instrument
US20090036827A1 (en) 2007-07-31 2009-02-05 Karl Cazzini Juxtascleral Drug Delivery and Ocular Implant System
WO2009089409A2 (en) 2008-01-10 2009-07-16 Bausch & Lomb Incorporated Intravitreal injection system having coaxial cannulae and use thereof
WO2009105690A2 (en) * 2008-02-21 2009-08-27 Targeted Genetics Corporation Devices and methods for delivering polynucleotides into retinal cells of the macula and fovea
WO2009120960A2 (en) 2008-03-27 2009-10-01 Iscience Interventional Corporation Microliter injector
US8425473B2 (en) 2009-01-23 2013-04-23 Iscience Interventional Corporation Subretinal access device
US20100191177A1 (en) 2009-01-23 2010-07-29 Iscience Interventional Corporation Device for aspirating fluids
US8057483B2 (en) 2009-02-14 2011-11-15 Ocular Transplantation Llc Subretinal implantation instrument
EP2429607A4 (en) 2009-05-15 2014-01-08 Iscience Interventional Corp METHOD AND DEVICE FOR SUBRETINAL CATHETERIZATION
US8419673B2 (en) * 2009-09-21 2013-04-16 Alcon Research, Ltd. Glaucoma drainage device with pump
WO2011057283A1 (en) 2009-11-09 2011-05-12 Iscience Interventional Corporation Expandable cannula for infusion of fluids
US8177747B2 (en) 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
WO2011106781A1 (en) 2010-02-26 2011-09-01 Iscience Interventional Corporation Apparatus for enhancement of aqueous humor drainage from the eye
JP5931847B2 (ja) 2010-03-31 2016-06-08 オキュジェクト, エルエルシー 眼内薬剤送達のためのデバイスおよび方法
US9408746B2 (en) 2010-03-31 2016-08-09 Ocuject, Llc Device and method for intraocular drug delivery
US8702644B2 (en) * 2010-05-13 2014-04-22 Ethicon Endo-Surgery, Inc. Instrument for debriding tissue and applying therapeutic cells
JP2013526969A (ja) 2010-05-27 2013-06-27 アイサイエンス・インターベンショナル・コーポレーション シュレム管内に管状インプラントを配置するための装置
EP2588011B1 (en) * 2010-06-30 2015-08-12 Laurimed, Llc Devices for cutting and evacuating tissue
ES2626182T3 (es) 2010-07-21 2017-07-24 Eastern Virginia Medical School Compuestos peptídicos para regular el sistema del complemento
US8821135B2 (en) 2010-08-25 2014-09-02 Emory University Devices and systems for medical fluid treatment
US8535268B2 (en) 2010-12-22 2013-09-17 Alcon Research, Ltd. Device for at least one of injection or aspiration
EP2670346A2 (en) 2011-02-01 2013-12-11 Georgia Tech Research Corporation Systems for implanting and using a conduit within a tissue wall
US20120322144A1 (en) 2011-06-14 2012-12-20 Emory University Microfluidic devices and systems
US20130149214A1 (en) 2011-12-12 2013-06-13 Emory University Microvascular fluidic devices, systems and methods related thereto
US9101444B2 (en) * 2012-01-12 2015-08-11 Innfocus, Inc. Method, surgical kit and device for treating glaucoma
JOP20200175A1 (ar) 2012-07-03 2017-06-16 Novartis Ag حقنة
US9757536B2 (en) 2012-07-17 2017-09-12 Novartis Ag Soft tip cannula
WO2014036009A1 (en) 2012-08-27 2014-03-06 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using microneedles
CN110893188A (zh) 2012-11-08 2020-03-20 克莱尔塞德生物医学股份有限公司 用于在人类受试者中治疗眼部疾病的方法和装置
CN105246529B (zh) 2013-05-03 2019-06-14 科尼尔赛德生物医学公司 用于眼部注射的设备和方法
US10188550B2 (en) 2013-06-03 2019-01-29 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using multiple reservoirs
US20150148838A1 (en) 2013-11-26 2015-05-28 Novartis Ag Systems and Methods for a Surgical Tissue Manipulator
US9730834B2 (en) 2013-12-20 2017-08-15 Novartis Ag Variable stiffness cannula and methods for a surgical system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120271272A1 (en) * 2010-10-15 2012-10-25 Iscience Interventional Corporation Device for ocular access

Also Published As

Publication number Publication date
CN105979914A (zh) 2016-09-28
EP3068353A1 (en) 2016-09-21
ES2733398T3 (es) 2019-11-28
EP3068353B1 (en) 2019-05-08
AU2014367150B2 (en) 2017-08-24
WO2015094507A1 (en) 2015-06-25
CN105979914B (zh) 2018-03-27
JP2017500123A (ja) 2017-01-05
CA2932912A1 (en) 2015-06-25
JP6438030B2 (ja) 2018-12-12
US10010447B2 (en) 2018-07-03
CA2932912C (en) 2019-04-09
AU2014367150A1 (en) 2016-07-28
EP3068353A4 (en) 2017-08-02
US20150164687A1 (en) 2015-06-18

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