AU2014348457B2 - Neurodegenerative disorders and methods of treatment and diagnosis thereof - Google Patents
Neurodegenerative disorders and methods of treatment and diagnosis thereof Download PDFInfo
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- AU2014348457B2 AU2014348457B2 AU2014348457A AU2014348457A AU2014348457B2 AU 2014348457 B2 AU2014348457 B2 AU 2014348457B2 AU 2014348457 A AU2014348457 A AU 2014348457A AU 2014348457 A AU2014348457 A AU 2014348457A AU 2014348457 B2 AU2014348457 B2 AU 2014348457B2
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- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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Landscapes
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| PCT/US2014/065670 WO2015073803A1 (en) | 2013-11-14 | 2014-11-14 | Neurodegenerative disorders and methods of treatment and diagnosis thereof |
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| ES2728727T3 (es) | 2012-12-13 | 2019-10-28 | Baylor Res Institute At Dallas | Triheptanoína para el tratamiento de la deficiencia del transportador de glucosa 1 |
| US9833430B2 (en) | 2013-11-14 | 2017-12-05 | The University Of Queensland | Neurodegenerative disorders and methods of treatment and diagnosis thereof |
| US12521378B2 (en) | 2016-04-19 | 2026-01-13 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate salt blend and related compounds in humans |
| US12533346B2 (en) | 2016-04-19 | 2026-01-27 | Axcess Global Sciences, Llc | Administration of berberine metabolites |
| US12496283B2 (en) | 2016-04-19 | 2025-12-16 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US10925843B2 (en) | 2018-04-18 | 2021-02-23 | Axcess Global Sciences, Llc | Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate |
| US12599579B2 (en) | 2016-04-19 | 2026-04-14 | Axcess Global Sciences, Llc | Compositions and compounds containing ketone bodies and/or ketone body precursors and one or more amino acids |
| US12329734B2 (en) | 2017-12-19 | 2025-06-17 | Axcess Global Sciences, Llc | Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow |
| US12109182B2 (en) | 2016-04-19 | 2024-10-08 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
| US20230346721A1 (en) | 2018-04-18 | 2023-11-02 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for delivery of ketone bodies |
| WO2017208217A2 (en) * | 2016-06-01 | 2017-12-07 | Aspi Ip Holder Llc | C5 ketone compositions, and related methods, for therapeutic and performance supplementation |
| US11406616B2 (en) | 2016-06-08 | 2022-08-09 | Sunregen Healthcare Ag | Lipids with odd number of carbon atoms and their use as pharmaceutical composition or nutritional supplement |
| WO2019052629A1 (en) * | 2017-09-12 | 2019-03-21 | Sunregen Healthcare Ag | LIPIDS HAVING AN IMPERATIVE NUMBER OF CARBON ATOMS AND THEIR USE AS A PHARMACEUTICAL COMPOSITION OR FOOD SUPPLEMENT |
| US12090129B2 (en) | 2017-11-22 | 2024-09-17 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US12472200B2 (en) | 2019-05-15 | 2025-11-18 | Axcess Global Sciences, Llc | Autobiotic compositions and method for promoting healthy gut microbiome |
| US12167993B2 (en) | 2019-06-21 | 2024-12-17 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US11969430B1 (en) | 2023-03-10 | 2024-04-30 | Axcess Global Sciences, Llc | Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance |
| US12186297B2 (en) | 2020-08-26 | 2025-01-07 | Axcess Global Sciences, Llc | Compositions and methods for increasing lean-to-fat mass ratio |
| CN113917034A (zh) * | 2021-10-19 | 2022-01-11 | 北京豪思生物科技有限公司 | 用于评估阿尔茨海默症的生物标记组合及其应用和试剂盒 |
| WO2024155950A2 (en) * | 2023-01-20 | 2024-07-25 | Keto Innovations, Llc | C5 ketone compositions and related methods for therapeutic and performance supplementation |
| WO2025184834A1 (zh) * | 2024-03-06 | 2025-09-12 | 中国科学院昆明动物研究所 | 一种庚酸酯化合物及其用于制备预防和/或治疗神经退行性疾病的药物或功能食品中的用途 |
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| US20100063147A1 (en) * | 2006-12-04 | 2010-03-11 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Anaplerotic Therapy of Huntington Disease and Other Polyglutamine Diseases |
| EP2599482A1 (en) * | 2011-11-30 | 2013-06-05 | Lunamed AG | Low dose therapeutic use of glyceryl tri-(4-phenylbutyrate) |
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| US4025649A (en) | 1974-08-19 | 1977-05-24 | Labaz | Acetic acid derivatives having pharmacological activity and compositions containing the same |
| DE3032300A1 (de) | 1980-08-27 | 1982-04-01 | Alfred Ing. Wien Lohninger | Mittel zur parenteralen ernaehrung |
| GB2104079B (en) | 1981-08-14 | 1985-08-21 | London Polytech | New aminoacid isomers, their production and their medicinal use |
| US4753963A (en) | 1985-09-26 | 1988-06-28 | The Procter & Gamble Company | Nutritional fat suitable for enteral and parenteral products |
| JP3486778B2 (ja) | 1993-04-02 | 2004-01-13 | 三菱ウェルファーマ株式会社 | アルツハイマー病予防治療剤 |
| US20090253781A1 (en) | 2002-05-24 | 2009-10-08 | Btg International Limited | Therapeutic compositions |
| US6740679B1 (en) | 1999-02-05 | 2004-05-25 | Baylor University Medical Center | Nutritional supplement or pharmaceutical preparation comprising triglycerides with seven-carbon fatty acid |
| EP1150579B1 (en) | 1999-02-05 | 2005-08-31 | Baylor Research Institute | Nutritional supplement or pharmaceutical preparation comprising triglycerides with seven carbon fatty acid |
| CA2389623A1 (en) | 1999-11-03 | 2001-05-10 | Juvenon, Inc. | Method of treating benign forgetfulness |
| WO2007115282A2 (en) | 2006-04-03 | 2007-10-11 | Accera, Inc. | Use of ketogenic compounds for treatment of age-associated memory impairment |
| US6835750B1 (en) | 2000-05-01 | 2004-12-28 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II |
| AU2001257451A1 (en) | 2000-05-01 | 2001-11-12 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism |
| US20060189545A1 (en) | 2003-03-06 | 2006-08-24 | Henderson Samuel T | Novel chemical entities and methods for their use in treatment of metabolic disorders |
| US8399515B2 (en) | 2003-05-20 | 2013-03-19 | Baylor Research Institute | Five and fifteen carbon fatty acids for treating metabolic disorders and as nutritional supplements |
| US8106093B2 (en) | 2004-07-02 | 2012-01-31 | Baylor Research Institute | Glycogen or polysaccharide storage disease treatment method |
| US7884115B2 (en) | 2004-09-28 | 2011-02-08 | Allergan, Inc. | Methods and compositions for the treatment of pain and other neurological conditions |
| WO2008039855A2 (en) | 2006-09-26 | 2008-04-03 | Baylor Research Institute | Nutrient sensor |
| CA2853992C (en) | 2007-07-31 | 2020-06-23 | Cerecin Inc. | Use of genomic testing and ketogenic compounds for treatment of reduced cognitive function |
| WO2009124250A1 (en) | 2008-04-03 | 2009-10-08 | The Trustees Of The University Of Pennsylvania | Compositions and methods for detecting tricarboxylic acid (tca) metabolic flux |
| CA2785714C (en) | 2009-12-30 | 2016-01-26 | Baylor Research Institute | Anaplerotic therapy for alzheimer's disease and the aging brain |
| US20110301238A1 (en) * | 2010-06-02 | 2011-12-08 | Borges Karin | Seizure related disorders and therapeutic methods thereof |
| CN103079555A (zh) * | 2010-06-14 | 2013-05-01 | 贝勒研究院 | 用于成人葡萄糖多聚体病（apbd）治疗的三庚酸甘油酯膳食 |
| JP6054301B2 (ja) | 2010-12-23 | 2017-01-11 | アマゼンティス エスアーＡｍａｚｅｎｔｉｓ Ｓａ | ミトコンドリア機能向上と、神経変性疾患および認知障害治療とのための組成物および方法 |
| ES2728727T3 (es) | 2012-12-13 | 2019-10-28 | Baylor Res Institute At Dallas | Triheptanoína para el tratamiento de la deficiencia del transportador de glucosa 1 |
| US9833430B2 (en) | 2013-11-14 | 2017-12-05 | The University Of Queensland | Neurodegenerative disorders and methods of treatment and diagnosis thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100063147A1 (en) * | 2006-12-04 | 2010-03-11 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Anaplerotic Therapy of Huntington Disease and Other Polyglutamine Diseases |
| EP2599482A1 (en) * | 2011-11-30 | 2013-06-05 | Lunamed AG | Low dose therapeutic use of glyceryl tri-(4-phenylbutyrate) |
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| Title |
|---|
| STAFSTROM, C.E. and RHO, J.M., "The ketogenic diet as a treatment paradigm for diverse neurological disorders", Frontiers in Pharmacology, April 2012, vol. 3, 59, pages 1-8 * |
| ZHAO, WEI et al., PLOS ONE, (2012-11-07), vol. 7, no. 11, e49191, pages 1-8 * |
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| ES2774321T3 (es) | 2020-07-20 |
| JP6588903B2 (ja) | 2019-10-09 |
| US20160263071A1 (en) | 2016-09-15 |
| US9833430B2 (en) | 2017-12-05 |
| CA2929601A1 (en) | 2015-05-21 |
| JP2016539935A (ja) | 2016-12-22 |
| US20190255008A1 (en) | 2019-08-22 |
| AU2014348457A1 (en) | 2016-05-26 |
| JP2020063233A (ja) | 2020-04-23 |
| EP3689343A1 (en) | 2020-08-05 |
| WO2015073803A1 (en) | 2015-05-21 |
| EP3068492A1 (en) | 2016-09-21 |
| US20180207121A1 (en) | 2018-07-26 |
| EP3068492B1 (en) | 2020-01-08 |
| EP3068492A4 (en) | 2017-07-05 |
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