AU2014346807B2 - Compositions and methods comprising bupropion or related compounds and dextromethorphan - Google Patents

Compositions and methods comprising bupropion or related compounds and dextromethorphan Download PDF

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Publication number
AU2014346807B2
AU2014346807B2 AU2014346807A AU2014346807A AU2014346807B2 AU 2014346807 B2 AU2014346807 B2 AU 2014346807B2 AU 2014346807 A AU2014346807 A AU 2014346807A AU 2014346807 A AU2014346807 A AU 2014346807A AU 2014346807 B2 AU2014346807 B2 AU 2014346807B2
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dextromethorphan
bupropion
day
pain
human
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AU2014346807A1 (en
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Herriot TABUTEAU
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Antecip Bioventures II LLC
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Antecip Bioventures II LLC
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Priority to AU2018203638A priority Critical patent/AU2018203638C1/en
Priority to AU2019236614A priority patent/AU2019236614C1/en
Priority to AU2019275593A priority patent/AU2019275593B2/en
Priority to AU2021202497A priority patent/AU2021202497B2/en
Priority to AU2023203438A priority patent/AU2023203438B2/en
Priority to AU2025230795A priority patent/AU2025230795A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2014346807A 2013-11-05 2014-11-05 Compositions and methods comprising bupropion or related compounds and dextromethorphan Active AU2014346807B2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2018203638A AU2018203638C1 (en) 2013-11-05 2018-05-23 Compositions and methods comprising bupropion or related compounds and dextromethorphan
AU2019236614A AU2019236614C1 (en) 2013-11-05 2019-09-23 Compositions and methods comprising bupropion or related compounds and dextromethorphan
AU2019275593A AU2019275593B2 (en) 2013-11-05 2019-12-04 Compositions and methods comprising bupropion or related compounds and dextromethorphan
AU2021202497A AU2021202497B2 (en) 2013-11-05 2021-04-23 Compositions and methods comprising bupropion or related compounds and dextromethorphan
AU2023203438A AU2023203438B2 (en) 2013-11-05 2023-06-01 Compositions and methods comprising bupropion or related compounds and dextromethorphan
AU2025230795A AU2025230795A1 (en) 2013-11-05 2025-09-12 Compositions and methods comprising bupropion or related compounds and dextromethorphan

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361900354P 2013-11-05 2013-11-05
US61/900,354 2013-11-05
PCT/US2014/064184 WO2015069809A1 (en) 2013-11-05 2014-11-05 Compositions and methods comprising bupropion or related compounds and dextromethorphan

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018203638A Division AU2018203638C1 (en) 2013-11-05 2018-05-23 Compositions and methods comprising bupropion or related compounds and dextromethorphan

Publications (2)

Publication Number Publication Date
AU2014346807A1 AU2014346807A1 (en) 2016-05-19
AU2014346807B2 true AU2014346807B2 (en) 2018-03-22

Family

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Family Applications (7)

Application Number Title Priority Date Filing Date
AU2014346807A Active AU2014346807B2 (en) 2013-11-05 2014-11-05 Compositions and methods comprising bupropion or related compounds and dextromethorphan
AU2018203638A Active AU2018203638C1 (en) 2013-11-05 2018-05-23 Compositions and methods comprising bupropion or related compounds and dextromethorphan
AU2019236614A Active AU2019236614C1 (en) 2013-11-05 2019-09-23 Compositions and methods comprising bupropion or related compounds and dextromethorphan
AU2019275593A Active AU2019275593B2 (en) 2013-11-05 2019-12-04 Compositions and methods comprising bupropion or related compounds and dextromethorphan
AU2021202497A Active AU2021202497B2 (en) 2013-11-05 2021-04-23 Compositions and methods comprising bupropion or related compounds and dextromethorphan
AU2023203438A Active AU2023203438B2 (en) 2013-11-05 2023-06-01 Compositions and methods comprising bupropion or related compounds and dextromethorphan
AU2025230795A Pending AU2025230795A1 (en) 2013-11-05 2025-09-12 Compositions and methods comprising bupropion or related compounds and dextromethorphan

Family Applications After (6)

Application Number Title Priority Date Filing Date
AU2018203638A Active AU2018203638C1 (en) 2013-11-05 2018-05-23 Compositions and methods comprising bupropion or related compounds and dextromethorphan
AU2019236614A Active AU2019236614C1 (en) 2013-11-05 2019-09-23 Compositions and methods comprising bupropion or related compounds and dextromethorphan
AU2019275593A Active AU2019275593B2 (en) 2013-11-05 2019-12-04 Compositions and methods comprising bupropion or related compounds and dextromethorphan
AU2021202497A Active AU2021202497B2 (en) 2013-11-05 2021-04-23 Compositions and methods comprising bupropion or related compounds and dextromethorphan
AU2023203438A Active AU2023203438B2 (en) 2013-11-05 2023-06-01 Compositions and methods comprising bupropion or related compounds and dextromethorphan
AU2025230795A Pending AU2025230795A1 (en) 2013-11-05 2025-09-12 Compositions and methods comprising bupropion or related compounds and dextromethorphan

Country Status (12)

Country Link
EP (3) EP3065742A4 (enExample)
JP (5) JP6605485B2 (enExample)
KR (4) KR102264179B1 (enExample)
CN (7) CN113750098A (enExample)
AU (7) AU2014346807B2 (enExample)
CA (4) CA3175703C (enExample)
IL (3) IL298972A (enExample)
MX (3) MX373330B (enExample)
MY (1) MY179696A (enExample)
NZ (1) NZ758428A (enExample)
SG (4) SG10201810888XA (enExample)
WO (1) WO2015069809A1 (enExample)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
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US11617747B2 (en) 2013-11-05 2023-04-04 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11311534B2 (en) 2013-11-05 2022-04-26 Antecip Bio Ventures Ii Llc Bupropion as a modulator of drug activity
US11253491B2 (en) 2013-11-05 2022-02-22 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11298351B2 (en) 2013-11-05 2022-04-12 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
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US11524007B2 (en) 2013-11-05 2022-12-13 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11426370B2 (en) 2013-11-05 2022-08-30 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11147808B2 (en) 2013-11-05 2021-10-19 Antecip Bioventures Ii Llc Method of decreasing the fluctuation index of dextromethorphan
US11433067B2 (en) 2013-11-05 2022-09-06 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
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US11576909B2 (en) 2013-11-05 2023-02-14 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11541048B2 (en) 2013-11-05 2023-01-03 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
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JP6605485B2 (ja) * 2013-11-05 2019-11-13 アンテシップ バイオベンチャーズ トゥー エルエルシー ブプロピオンまたは関連組成物およびデキストロメトルファンを含む組成物
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US11129826B2 (en) 2013-11-05 2021-09-28 Axsome Therapeutics, Inc. Bupropion as a modulator of drug activity
US20220233470A1 (en) 2013-11-05 2022-07-28 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
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US11234946B2 (en) 2013-11-05 2022-02-01 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
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US11298352B2 (en) 2013-11-05 2022-04-12 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
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US12109178B2 (en) 2013-11-05 2024-10-08 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
KR20170052684A (ko) * 2014-09-14 2017-05-12 아바니르 파마슈티컬스, 인코포레이티드 치매에서의 초조함을 치료하기 위한 덱스트로메토르판 화합물 및 퀴니딘을 포함하는 약제학적 조성물
JP6602863B2 (ja) * 2014-11-21 2019-11-06 アンテシップ バイオベンチャーズ トゥー エルエルシー ブプロピオンまたは関連組成物およびデキストロメトルファンを含む医薬組成物
WO2017165845A1 (en) * 2016-03-24 2017-09-28 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
TWI795446B (zh) * 2017-10-04 2023-03-11 美商神經治療股份有限公司 右旋美索芬(dextromethorphan)經皮輸送裝置
US20230225995A1 (en) * 2019-01-07 2023-07-20 Antecip Bioventures Ii Llc Combination of dextromethorphan and bupropion for treating depression
CN114712357A (zh) * 2019-01-07 2022-07-08 安泰赛普生物风投二代有限责任公司 用于治疗抑郁症的右美沙芬和安非他酮的组合
JP7637150B2 (ja) * 2020-03-30 2025-02-27 アンテシップ バイオベンチャーズ トゥー エルエルシー 神経疾患を治療するためのブプロピオンおよびデキストロメトルファンの組み合わせの使用
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CN117100750A (zh) * 2020-07-20 2023-11-24 深圳信立泰药业股份有限公司 一种药物组合物及其应用
JP2023553393A (ja) 2020-12-01 2023-12-21 アンテシップ バイオベンチャーズ トゥー エルエルシー うつ病患者の自殺リスク低減のためのブプロピオンおよびデキストロメトルファン
JP2024503114A (ja) * 2021-01-18 2024-01-24 アンテシップ バイオベンチャーズ トゥー エルエルシー 神経精神疾患に対する抗うつ剤とデキストロメトルファンとの組み合わせ
CN112999350A (zh) * 2021-02-23 2021-06-22 北京斯利安药业有限公司 一种药物组合物、复方制剂及其制备方法与应用
US12036191B1 (en) 2022-06-30 2024-07-16 Antecip Bioventures Ii Llc Treatment of poor metabolizers of dextromethorphan with a combination of bupropion and dextromethorphan
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CN118785900A (zh) * 2022-06-30 2024-10-15 艾克萨姆治疗公司 包含安非他酮和半胱氨酸的药物组合物
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