AU2014341866B2 - Methods of removing alpha-galactose - Google Patents

Methods of removing alpha-galactose Download PDF

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Publication number
AU2014341866B2
AU2014341866B2 AU2014341866A AU2014341866A AU2014341866B2 AU 2014341866 B2 AU2014341866 B2 AU 2014341866B2 AU 2014341866 A AU2014341866 A AU 2014341866A AU 2014341866 A AU2014341866 A AU 2014341866A AU 2014341866 B2 AU2014341866 B2 AU 2014341866B2
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AU
Australia
Prior art keywords
tissue
alpha
galactose
collagen
matrix
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AU2014341866A
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English (en)
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AU2014341866A1 (en
Inventor
Nathaniel Bachrach
Li Ting Huang
Rick Owens
Hua Wan
Hui Xu
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LifeCell Corp
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LifeCell Corp
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Priority to AU2018236910A priority Critical patent/AU2018236910A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/362—Skin, e.g. dermal papillae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3695—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the function or physical properties of the final product, where no specific conditions are defined to achieve this
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
AU2014341866A 2013-11-04 2014-11-04 Methods of removing alpha-galactose Active AU2014341866B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2018236910A AU2018236910A1 (en) 2013-11-04 2018-10-02 Methods of removing alpha-galactose

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361899647P 2013-11-04 2013-11-04
US61/899,647 2013-11-04
PCT/US2014/063796 WO2015066668A1 (en) 2013-11-04 2014-11-04 Methods of removing alpha-galactose

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018236910A Division AU2018236910A1 (en) 2013-11-04 2018-10-02 Methods of removing alpha-galactose

Publications (2)

Publication Number Publication Date
AU2014341866A1 AU2014341866A1 (en) 2016-04-07
AU2014341866B2 true AU2014341866B2 (en) 2018-07-05

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AU2018236910A Abandoned AU2018236910A1 (en) 2013-11-04 2018-10-02 Methods of removing alpha-galactose

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US (2) US10307510B2 (enExample)
EP (2) EP3799893A1 (enExample)
JP (1) JP6524597B2 (enExample)
CN (1) CN105682697B (enExample)
AU (2) AU2014341866B2 (enExample)
BR (1) BR112016009178B1 (enExample)
CA (1) CA2925332C (enExample)
DK (1) DK3065790T3 (enExample)
ES (1) ES2846758T3 (enExample)
WO (1) WO2015066668A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3509541B1 (en) 2016-09-12 2021-09-01 Gebauer-Klopotek Patent Verwaltungs-UG (haftungsbeschränkt) Lenticules for intrastromal corneal implantation
CN106860861B (zh) * 2017-03-03 2020-11-03 北京博辉瑞进生物科技有限公司 一种免疫增强组合物、制备方法及其应用
EP3592397A4 (en) 2017-03-06 2020-12-30 Tei Biosciences, Inc. PERFORATED FABRIC GRAFT
US12350144B2 (en) 2018-07-02 2025-07-08 Gebauer-Klopotek Patent Verw Altungs-Ug Stabilization of collagen scaffolds
WO2020008258A2 (en) * 2018-07-02 2020-01-09 Gebauer-Klopotek Patent Verwaltungs-Ug Stabilization of collagen scaffolds
WO2021034928A1 (en) * 2019-08-20 2021-02-25 Lifecell Corporation Method of manufacturing particulate tissue products
CN111632196A (zh) * 2020-06-01 2020-09-08 内蒙古自治区中医药研究所 一种去α-半乳糖基抗原脱细胞基质的制备方法
CN115591020A (zh) * 2021-06-28 2023-01-13 金佩奇生物科技（南京）有限公司（Cn） 疝修复真皮补片材料的制备及应用
CN115591019A (zh) * 2021-06-28 2023-01-13 金佩奇生物科技（南京）有限公司（Cn） 脱细胞材料制备方法及其应用
CN114276974A (zh) * 2021-12-24 2022-04-05 上海理工大学 封装细胞的间质材料及其制备方法和应用
CN114377206B (zh) * 2021-12-24 2022-09-30 杭州华迈医疗科技有限公司 一种脱细胞基质生物材料的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000047131A1 (en) * 1999-02-11 2000-08-17 Crosscart, Inc. Proteoglycan-reduced soft tissue xenografts
WO2006095342A2 (en) * 2005-03-07 2006-09-14 Technion Research & Development Foundation Ltd. Natural tissue-derived decellularized matrix and methods of generating and using same
US20120276213A1 (en) * 2011-04-28 2012-11-01 Lifecell Corporation Method for enzymatic treatment of tissue products
US20130236439A1 (en) * 2012-03-08 2013-09-12 Lifecell Corporation Enzyme-activated collagen and tissue matrices

Family Cites Families (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5230097A (en) 1975-09-02 1977-03-07 Kaneyasu Miyata Method of mounting different substitute blood vessel
US4801299A (en) 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US5116615A (en) 1989-01-27 1992-05-26 Immunolytics, Inc. Method for treating benign prostatic hypertrophy
CN1122719C (zh) 1989-10-12 2003-10-01 艾姆特兰有限公司 经修饰的生物材料
US6482404B1 (en) 1989-10-12 2002-11-19 David James White Transplantation of tissue comprising a DNA sequence encoding a homologous complement restriction factor
US5846715A (en) 1990-05-11 1998-12-08 The Austin Research Institute CD46 variants
US8067149B2 (en) 1990-09-12 2011-11-29 Lifecell Corporation Acellular dermal matrix and method of use thereof for grafting
US5336616A (en) 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
CA2051092C (en) 1990-09-12 2002-07-23 Stephen A. Livesey Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions
US5374539A (en) 1991-06-17 1994-12-20 Nimni; Marcel E. Process for purifying collagen and generating bioprosthesis
WO1994021799A1 (en) 1993-03-16 1994-09-29 Austin Research Institute USE OF PORCINE GAL α(1,3) GALACTOSYL TRANSFERASE IN XENOGRAFT THERAPIES
US6331658B1 (en) 1993-04-20 2001-12-18 Integris Baptist Medical Center, Inc. Genetically engineered mammals for use as organ donors
US5460962A (en) 1994-01-04 1995-10-24 Organogenesis Inc. Peracetic acid sterilization of collagen or collagenous tissue
US5849991A (en) 1994-01-27 1998-12-15 Bresatch Limited Mice homozygous for an inactivated α 1,3-galactosyl transferase gene
WO1995020661A1 (en) 1994-01-27 1995-08-03 Bresatec Ltd. Materials and methods for management of hyperacute rejection in human xenotransplantation
DE69535752D1 (de) 1994-04-13 2008-06-26 Biotransplant Inc Alpha(1,3)galactosyltransferase-negatives schwein
AU2828595A (en) 1994-06-15 1996-01-05 Alexion Pharmaceuticals, Inc. Methods for reducing hyperacute rejection of xenografts
US5547681A (en) 1994-07-14 1996-08-20 Union Carbide Chemicals & Plastics Technology Corporation Dermal patch
AUPM772494A0 (en) 1994-08-30 1994-09-22 Austin Research Institute, The Improvements in production of proteins in host cells
WO1996032905A1 (en) 1995-04-19 1996-10-24 St. Jude Medical, Inc. Matrix substrate for a viable body tissue-derived prosthesis and method for making the same
US5782915A (en) 1995-09-15 1998-07-21 Stone; Kevin R. Articular cartilage heterografts
US6166288A (en) 1995-09-27 2000-12-26 Nextran Inc. Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor
WO1998005768A1 (en) 1996-08-02 1998-02-12 The Austin Research Institute Improved nucleic acids encoding a chimeric glycosyltransferase
US6455037B1 (en) 1996-11-01 2002-09-24 Mount Sinai School Of Medicine Of The City University Of New York Cells expressing an αgala nucleic acid and methods of xenotransplantation
CA2267449C (en) 1996-11-05 2008-10-14 Purdue Research Foundation Myocardial graft constructs
CA2274033C (en) 1996-12-10 2010-05-11 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue
WO1998025636A1 (en) 1996-12-10 1998-06-18 Purdue Research Foundation Stomach submucosa derived tissue graft
ES2513043T3 (es) 1997-03-26 2014-10-24 Imperial Innovations Limited Proteína de fusión anticoagulante anclada a membrana de la célula
EP0987998B1 (en) 1997-04-11 2004-10-13 CryoLife, Inc. Tissue decellularization
WO1999000152A2 (de) 1997-06-27 1999-01-07 Augustinus Bader Bioartifizielles transplantat und verfahren zu seiner herstellung
US6613278B1 (en) 1998-11-13 2003-09-02 Regeneration Technologies, Inc. Tissue pooling process
US6482584B1 (en) 1998-11-13 2002-11-19 Regeneration Technologies, Inc. Cyclic implant perfusion cleaning and passivation process
US6652818B1 (en) 1998-11-13 2003-11-25 Regeneration Technologies, Inc. Implant sterilization apparatus
US6371992B1 (en) 1997-12-19 2002-04-16 The Regents Of The University Of California Acellular matrix grafts: preparation and use
AU759086B2 (en) 1998-03-06 2003-04-03 Crosscart, Inc. Soft tissue xenografts
US6383732B1 (en) 1999-02-11 2002-05-07 Crosscart, Inc. Method of preparing xenograft heart valves
ES2374290T3 (es) 1998-03-20 2012-02-15 Commonwealth Scientific And Industrial Research Organisation Genes sintéticos y constructos genéticos que comprenden los mismos.
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
GB9809280D0 (en) 1998-04-30 1998-07-01 Rpms Technology Ltd Immunosupression
US6432710B1 (en) 1998-05-22 2002-08-13 Isolagen Technologies, Inc. Compositions for regenerating tissue that has deteriorated, and methods for using such compositions
EP1082006B1 (en) 1998-05-26 2006-02-01 Lifecell Corporation Cryopreservation of human red blood cells
DE69941216D1 (de) 1998-06-19 2009-09-17 Lifecell Corp Teilchenförmige zellfreie gewebematrix
US6933326B1 (en) 1998-06-19 2005-08-23 Lifecell Coporation Particulate acellular tissue matrix
US8563232B2 (en) 2000-09-12 2013-10-22 Lifenet Health Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced
US6743574B1 (en) 2000-09-12 2004-06-01 Lifenet Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced
US6734018B2 (en) 1999-06-07 2004-05-11 Lifenet Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced
GB2345638A (en) 1998-09-11 2000-07-19 Tissue Science Lab Limited Injectable collagen compositions
US20020110609A1 (en) 1998-12-28 2002-08-15 David Hung Increasing retrievable fluid from a breast duct
CA2360549C (en) 1999-01-13 2013-04-09 Ppl Therapeutics (Scotland) Limited Double nuclear transfer method and results thereof
US20030068815A1 (en) 1999-02-11 2003-04-10 Stone Kevin R. Sterilized xenograft tissue
US20020012660A1 (en) 1999-03-04 2002-01-31 Alan Colman Method of preparing a somatic cells for nuclear transfer
CN1266716A (zh) 1999-03-12 2000-09-20 中国人民解放军第四军医大学第一附属医院 交联型猪脱细胞真皮片
US6381026B1 (en) 1999-03-15 2002-04-30 Lifecell Corp. Method of measuring the contour of a biological surface
US8232320B2 (en) 1999-04-28 2012-07-31 The Regents Of The University Of Michigan Antimicrobial nanoemulsion compositions and methods
CA2426669A1 (en) 1999-10-22 2001-05-03 University Of Pittsburgh Of The Commonwealth System Of Higher Education .alpha.1-3 galactosyltransferase gene and promoter
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US6866686B2 (en) 2000-01-28 2005-03-15 Cryolife, Inc. Tissue graft
WO2001078798A1 (en) 2000-02-10 2001-10-25 Regeneration Technologies, Inc. Assembled implant
US20070009586A1 (en) 2000-02-29 2007-01-11 Cohen Kelman I Wound dressings containing complexes of transition metals and alginate for elastase sequestering
WO2001088096A2 (en) 2000-05-15 2001-11-22 Geron Corporation Ovine tissue for xenotransplantation
AU2001284968B2 (en) 2000-08-16 2006-12-21 Duke University Decellularized tissue engineered constructs and tissues
AU2001288458A1 (en) 2000-08-28 2002-03-13 Collagenesis, Inc. Methods for processing animal tissues
US20020077697A1 (en) 2000-12-15 2002-06-20 Ranieri John Paul Processed ratite carotid arteries as xenogeneic small bore vascular grafts
US7126039B2 (en) 2001-03-21 2006-10-24 Geron Corporation Animal tissue with carbohydrate antigens compatible for human transplantation
US6933103B1 (en) 2001-03-21 2005-08-23 Brennen Medical, Inc. Biocompatible tissue for therapeutic use and method of making same
AU2002242538B2 (en) 2001-03-21 2007-06-28 Geron Corporation Animal tissue with carbohydrate antigens compatible for human transplantation
WO2002088351A1 (en) 2001-04-30 2002-11-07 Rbc Biotechnology, Inc. Modified organs and cells for xenotransplantation
CA2446362A1 (en) 2001-05-07 2002-11-14 Crosscart, Inc. Submucosal xenografts
WO2002092791A1 (en) 2001-05-14 2002-11-21 Stell Tissues or organs for use in xenotransplantation
GB2375771A (en) 2001-05-24 2002-11-27 Univ Leeds Decellularisation of tissue implant material
US7087089B2 (en) 2001-06-28 2006-08-08 Cook Biotech Incorporated Graft prosthesis devices containing renal capsule collagen
TWI284665B (en) 2001-08-17 2007-08-01 Univ Nat Cheng Kung Fabrication method of the porous collagen matrix
EP1436401A4 (en) 2001-09-27 2006-06-14 Timothy Albert Holton STEM-LOOP VECTOR SYSTEM
WO2003032735A1 (en) 2001-10-18 2003-04-24 Lifecell Corporation Remodeling of tissues and organs
AU2002364596A1 (en) 2001-12-21 2003-07-15 Immerge Biotherapeutics, Inc. Knockout swine and methods for making the same
EP1465986A4 (en) 2001-12-29 2005-01-26 Woo Suk Hwang GFP-TRANSFECTED CLONING PIG, GT-KNOCKOUT CLONING PIG, AND METHOD FOR THE MANUFACTURE THEREOF
US7628996B2 (en) 2002-02-22 2009-12-08 Intracel Resources Llc Sterile immunogenic non-tumorigenic tumor cell compositions and methods
CA2480912A1 (en) 2002-04-05 2003-10-23 Novozymes North America, Inc. Improvement of strength and abrasion resistance of durable press finished cellulosic materials
NZ536563A (en) 2002-05-02 2008-03-28 Purdue Research Foundation Vascularization enhanced graft constructs
AUPS242702A0 (en) 2002-05-21 2002-06-13 Colltech Australia Limited Improved method for the extraction and purification of collagen
US6835385B2 (en) 2002-06-14 2004-12-28 Carol J. Buck Compositions and methods for softening, thinning and removing hyperkeratotic tissue
WO2004003178A2 (en) 2002-06-28 2004-01-08 Cardio, Inc. Decellularized tissue
US7547522B2 (en) 2002-08-14 2009-06-16 Immerge Biotherapeutics, Inc. Method to enrich for α(1,3)-galactosyltransferase null pig cells
EP1534819B1 (en) 2002-08-21 2009-12-09 Revivicor, Inc. Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase
US20040037735A1 (en) 2002-08-23 2004-02-26 Depaula Carl Alexander Allograft tissue purification process for cleaning bone
JP4490268B2 (ja) 2002-08-28 2010-06-23 学校法人近畿大学 システインプロテアーゼ処理コラーゲンの製造方法およびシステインプロテアーゼ処理コラーゲン
JP3658385B2 (ja) 2002-09-20 2005-06-08 佳宏 高見 皮膚の無細胞化方法、該方法による無細胞化真皮マトリックス及びその製造方法並びに該マトリックスを用いた複合培養皮膚
US7402319B2 (en) 2002-09-27 2008-07-22 Board Of Regents, The University Of Texas System Cell-free tissue replacement for tissue engineering
WO2004047622A2 (en) 2002-11-26 2004-06-10 Crosscart, Inc. Substantially non-immunogenic injectable collagen
US20040187877A1 (en) * 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of liver tissue
US20040191226A1 (en) 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of body wall
US7118901B2 (en) 2002-12-18 2006-10-10 Roche Diagnostics Operations, Inc. Recombinant bovine pancreatic desoxyribonuclease I with high specific activity
US20040176855A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
US20040175366A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
US7067298B2 (en) 2003-03-31 2006-06-27 Ambion, Inc. Compositions and methods of using a synthetic Dnase I
EP1639083A4 (en) 2003-06-06 2008-05-28 Univ Pittsburgh GENE OF CMP-N-ACETYLNEURAMIC ACID HYDROXYLASE FROM PIG
US20050013870A1 (en) 2003-07-17 2005-01-20 Toby Freyman Decellularized extracellular matrix of conditioned body tissues and uses thereof
WO2005009134A1 (en) 2003-07-21 2005-02-03 Lifecell Corporation ACELLULAR TISSUE MATRICES MADE FROM GALACTOSE α-1,3-GALACTOSE-DEFICIENT TISSUE
AU2004290006A1 (en) 2003-11-05 2005-05-26 University Of Pittsburgh Porcine isogloboside 3 synthase protein, cDNA, genomic organization, and regulatory region
AU2004316293A1 (en) 2003-11-21 2005-09-09 Revivicor, Inc. Use of interfering RNA in the production of transgenic animals
US20050186286A1 (en) 2004-02-25 2005-08-25 Yoshihiro Takami Skin decellularization method, acellular dermal matrix and production method therefore employing said decellularization method, and composite cultured skin employing said matrix
CA2857051A1 (en) 2004-03-17 2005-09-29 David Ayares Tissue products derived from animals lacking any expression of functional alpha 1,3 galactosyltransferase
AU2005243169A1 (en) 2004-05-07 2005-11-24 University Of Pittsburgh Of The Commonwealth System Of Higher Education Porcine Forssman synthetase protein, cDNA, genomic organization, and regulatory region
US20050266390A1 (en) 2004-06-01 2005-12-01 Yuichiro Ueda Processes for removing cells and cell debris from tissue and tissue constructs used in transplantation and tissue reconstruction
US20060073592A1 (en) 2004-10-06 2006-04-06 Wendell Sun Methods of storing tissue matrices
WO2006074373A2 (en) 2005-01-06 2006-07-13 Crosscart, Inc. Immunochemically modified and sterilized xenografts and allografts
AU2006227711A1 (en) 2005-03-16 2006-09-28 Musculoskeletal Transplant Foundation Soft tissue processing
US20100112543A1 (en) 2005-03-16 2010-05-06 Manh-Dan Ngo Processing soft tissue, methods and compositions related thereto
ES2384721T3 (es) 2005-08-26 2012-07-11 Regents Of The University Of Minnesota Descelularización y recelularización de órganos y tejidos
JP5002805B2 (ja) 2005-10-14 2012-08-15 財団法人ヒューマンサイエンス振興財団 生物由来スキャフォールドの作製方法
GB0606231D0 (en) 2006-03-29 2006-05-10 Univ Leeds Improvements relating to decellurisation of tissue matrices for bladder implantation
US20070248575A1 (en) 2006-04-19 2007-10-25 Jerome Connor Bone graft composition
JP5050197B2 (ja) 2006-07-31 2012-10-17 財団法人ヒューマンサイエンス振興財団 生物由来スキャフォールドの作製方法
EP2076279B1 (en) 2006-10-06 2014-08-27 Anthrogenesis Corporation Native (telopeptide) placental collagen compositions
US8956411B2 (en) 2006-11-16 2015-02-17 University Of Leeds Preparation of tissue for meniscal implantation
CA2684011A1 (en) 2007-04-16 2008-10-23 Tissue Science Laboratories Plc Decellularised collagen-containing matrix for guided tissue regeneration
WO2008125851A2 (en) 2007-04-16 2008-10-23 Tissue Science Laboratories Plc Vascular implant
KR20100005105A (ko) 2007-05-06 2010-01-13 민병현 세포외 기질 지지체를 이용한 연골질환 치료용 조성물
US20080306610A1 (en) 2007-06-07 2008-12-11 Zimmer Orthobiologics, Inc. Tissue processing for nonimmunogenic implants
US20100296969A1 (en) 2007-06-12 2010-11-25 Musculoskeletal Transplant Foundation Process for sterilizing acellular soft tissue under vacuum
WO2008154623A2 (en) 2007-06-12 2008-12-18 Musculoskeletal Transplant Foundation Process for sterilizing acellular soft tissue with irradiation
EP3473260B1 (en) 2007-07-10 2020-09-23 LifeCell Corporation Acellular tissue matrix compositions for tissue repair
CZ301086B6 (cs) 2007-10-17 2009-11-04 Bio-Skin, A. S. Sterilní autologní, allogenní nebo xenogenní implantát a zpusob jeho výroby
TWI353845B (en) 2008-03-19 2011-12-11 Food Industry Res & Dev Inst Process for preparing peptide products for promoti
GB0807868D0 (en) 2008-04-30 2008-06-04 Knight David P Cartilage repair material and a method for the preparation thereof
AU2009256193B2 (en) 2008-06-06 2015-04-23 Lifecell Corporation Elastase treatment of tissue matrices
ES2553762T3 (es) 2009-02-18 2015-12-11 Cormatrix Cardiovascular, Inc. Composiciones y métodos para prevenir la arritmia cardiaca
US9155323B2 (en) 2009-05-15 2015-10-13 Siebte Pmi Verwaltungs Gmbh Aqueous process for preparing protein isolate and hydrolyzed protein from an oilseed
US8198408B2 (en) 2009-07-27 2012-06-12 National Cheng Kung University Method for preparing porous collagen matrices
WO2011019361A1 (en) 2009-08-11 2011-02-17 Tissue Banks International Acellular dermal allografts and method of preparation
EP2538988B1 (en) 2010-02-26 2019-01-30 DeCell Technologies Inc. Methods for tissue decellularization
GB2482166A (en) 2010-07-22 2012-01-25 Tissue Science Lablratories Ltd Manufacture of collagenous material from use in therapy from collagen particles
US10207025B2 (en) 2011-04-28 2019-02-19 Lifecell Corporation Method for enzymatic treatment of tissue products
US9238793B2 (en) 2011-04-28 2016-01-19 Lifecell Corporation Method for enzymatic treatment of tissue products
US20130122583A1 (en) 2011-11-10 2013-05-16 Celxcel Pty Ltd Sterilization process

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000047131A1 (en) * 1999-02-11 2000-08-17 Crosscart, Inc. Proteoglycan-reduced soft tissue xenografts
US6267786B1 (en) * 1999-02-11 2001-07-31 Crosscart, Inc. Proteoglycan-reduced soft tissue xenografts
WO2006095342A2 (en) * 2005-03-07 2006-09-14 Technion Research & Development Foundation Ltd. Natural tissue-derived decellularized matrix and methods of generating and using same
US20120276213A1 (en) * 2011-04-28 2012-11-01 Lifecell Corporation Method for enzymatic treatment of tissue products
US20130236439A1 (en) * 2012-03-08 2013-09-12 Lifecell Corporation Enzyme-activated collagen and tissue matrices

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