AU2014290618B2 - Derivatives of N-urea substituted amino acids as formyl peptide receptor modulators - Google Patents

Derivatives of N-urea substituted amino acids as formyl peptide receptor modulators Download PDF

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Publication number
AU2014290618B2
AU2014290618B2 AU2014290618A AU2014290618A AU2014290618B2 AU 2014290618 B2 AU2014290618 B2 AU 2014290618B2 AU 2014290618 A AU2014290618 A AU 2014290618A AU 2014290618 A AU2014290618 A AU 2014290618A AU 2014290618 B2 AU2014290618 B2 AU 2014290618B2
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AU
Australia
Prior art keywords
groups
optionally substituted
amino
alkyl
carbamoyl
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AU2014290618A
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AU2014290618A1 (en
Inventor
Richard L. Beard
John E. Donello
Tien T. Duong
Michael E. Garst
Veena Viswanath
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Allergan Inc
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Allergan Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2014290618A 2013-07-16 2014-07-10 Derivatives of N-urea substituted amino acids as formyl peptide receptor modulators Active AU2014290618B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361846787P 2013-07-16 2013-07-16
US61/846,787 2013-07-16
PCT/US2014/046203 WO2015009545A1 (en) 2013-07-16 2014-07-10 Derivatives of n-urea substituted amino acids as formyl peptide receptor modulators

Publications (2)

Publication Number Publication Date
AU2014290618A1 AU2014290618A1 (en) 2016-02-18
AU2014290618B2 true AU2014290618B2 (en) 2018-04-05

Family

ID=51230227

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014290618A Active AU2014290618B2 (en) 2013-07-16 2014-07-10 Derivatives of N-urea substituted amino acids as formyl peptide receptor modulators

Country Status (11)

Country Link
US (1) US9428549B2 (en - :~:text=Arcing in an AC power system is detected,in its amplitude synchronized to the power waveform)
EP (1) EP3022174B1 (en - :~:text=Arcing in an AC power system is detected,in its amplitude synchronized to the power waveform)
JP (1) JP6653253B2 (en - :~:text=Arcing in an AC power system is detected,in its amplitude synchronized to the power waveform)
KR (1) KR102313757B1 (en - :~:text=Arcing in an AC power system is detected,in its amplitude synchronized to the power waveform)
CN (1) CN105377814B (en - :~:text=Arcing in an AC power system is detected,in its amplitude synchronized to the power waveform)
AU (1) AU2014290618B2 (en - :~:text=Arcing in an AC power system is detected,in its amplitude synchronized to the power waveform)
CA (1) CA2917811C (en - :~:text=Arcing in an AC power system is detected,in its amplitude synchronized to the power waveform)
DK (1) DK3022174T3 (en - :~:text=Arcing in an AC power system is detected,in its amplitude synchronized to the power waveform)
ES (1) ES2708571T3 (en - :~:text=Arcing in an AC power system is detected,in its amplitude synchronized to the power waveform)
RU (1) RU2696581C2 (en - :~:text=Arcing in an AC power system is detected,in its amplitude synchronized to the power waveform)
WO (1) WO2015009545A1 (en - :~:text=Arcing in an AC power system is detected,in its amplitude synchronized to the power waveform)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014010042B1 (pt) 2011-10-26 2022-03-03 Allergan, Inc Derivados de amida de aminoácidos n-ureia substituídos como moduladores de receptor tipo receptor de peptídeo formila 1 (fprl-1)
CA3114477A1 (en) 2013-03-06 2014-09-12 Allergan, Inc. Use of agonists of formyl peptide receptor 2 for treating dermatological diseases
JP6496728B2 (ja) 2013-11-21 2019-04-03 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ ホルミルペプチド受容体の調節因子としてのカルバミン酸フェニル誘導体
EA030474B1 (ru) 2013-11-28 2018-08-31 Киорин Фармасьютикал Ко., Лтд. Производные мочевины или их фармакологически приемлемые соли
US9663457B2 (en) 2014-04-09 2017-05-30 Allergan, Inc. Carbamoyl hydrazine derivatives as formyl peptide modulators
US10301269B2 (en) 2014-05-21 2019-05-28 Allergan, Inc. Imidazole derivatives as formyl peptide receptor modulators
JP6746614B2 (ja) 2015-05-27 2020-08-26 杏林製薬株式会社 ウレア誘導体、またはその薬理学的に許容される塩
PE20180234A1 (es) 2015-05-27 2018-01-31 Kyorin Seiyaku Kk Derivado de urea o sal farmacologicamente aceptable del mismo
US20200079729A1 (en) * 2015-08-05 2020-03-12 Allergan, Inc. Phenyl urea analogs as formyl peptide receptor 1 (fpr1) selective agonists
BR112020017744A2 (pt) 2018-03-05 2020-12-22 Bristol-Myers Squibb Company Agonistas do receptor do peptídeo fenilpirrolidinona formila 2

Citations (1)

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Publication number Priority date Publication date Assignee Title
US20130109866A1 (en) * 2011-10-26 2013-05-02 Allergan, Inc. Amide derivatives of n-urea substituted amino acids as formyl peptide receptor like-1 (fprl-1) receptor modulators

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FR2533210A1 (fr) 1982-09-17 1984-03-23 Lyon I Universite Claude Edulcorants de synthese
US5284828A (en) * 1990-05-14 1994-02-08 Fujisawa Pharmaceutical Co. Ltd. Peptide compound and its preparation
JP3387948B2 (ja) 1992-12-04 2003-03-17 富山化学工業株式会社 新規なフェニルアラニン誘導体またはその塩
US20030009022A1 (en) * 1993-03-31 2003-01-09 Cadus Pharmaceutical Corporation Methods and compositions for identifying receptor effectors
JP2968842B2 (ja) * 1994-02-09 1999-11-02 塩野義製薬株式会社 カルバモイルメチルウレア誘導体
EP0739903B1 (en) * 1994-02-09 2002-01-23 Shionogi & Co., Ltd. Carbamoylmethylurea derivative
US6423689B1 (en) * 1997-12-22 2002-07-23 Warner-Lambert Company Peptidyl calcium channel blockers
AU4572999A (en) * 1998-06-18 2000-01-05 Sepracor, Inc. Tetrapeptides, analogs and peptidomimetics which bind selectively mammalian opioid receptors
WO2003082314A2 (en) * 2002-04-03 2003-10-09 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with n-formyl peptide receptor like 1 (fprl1)
WO2005047899A2 (en) * 2003-11-07 2005-05-26 Acadia Pharmaceuticals Inc. Use of the lipoxin receptor, fprl1, as a tool for identifying compounds effective in the treatment of pain and inflammation
WO2010134014A1 (en) * 2009-05-18 2010-11-25 Actelion Pharmaceuticals Ltd Bridged spiro [2.4] heptane derivatives as alx receptor and/or fprl2 agonists
AU2011336973A1 (en) * 2010-12-03 2013-07-11 Allergan, Inc. Pharmaceutical compositions comprising 3,4- dihydroisoquinolin-2(1 H)-yl-3-phenylurea derivatives having formyl peptide receptor like-1 (FPRL-1) agonist or antagonist activity
US8541577B2 (en) * 2011-11-10 2013-09-24 Allergan, Inc. Aryl urea derivatives as N-formyl peptide receptors like-1 (FPRL-1) receptor modulators
US8735622B2 (en) * 2011-11-30 2014-05-27 The Regents Of The University Of Colorado, A Body Corporate Histone demethylase inhibitors and methods for using the same
BR122017004254B1 (pt) * 2013-03-06 2021-04-13 Allergan, Inc. Uso de agonistas de receptor de formil peptídeo 2 para tratar doenças inflamatórias oculares
CA3114477A1 (en) * 2013-03-06 2014-09-12 Allergan, Inc. Use of agonists of formyl peptide receptor 2 for treating dermatological diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130109866A1 (en) * 2011-10-26 2013-05-02 Allergan, Inc. Amide derivatives of n-urea substituted amino acids as formyl peptide receptor like-1 (fprl-1) receptor modulators

Also Published As

Publication number Publication date
EP3022174B1 (en) 2018-09-05
CA2917811C (en) 2021-08-31
JP6653253B2 (ja) 2020-02-26
CN105377814B (zh) 2018-04-03
RU2016104844A (ru) 2017-08-21
KR20160031007A (ko) 2016-03-21
CA2917811A1 (en) 2015-01-22
EP3022174A1 (en) 2016-05-25
ES2708571T3 (es) 2019-04-10
JP2016529235A (ja) 2016-09-23
AU2014290618A1 (en) 2016-02-18
DK3022174T3 (da) 2019-01-02
CN105377814A (zh) 2016-03-02
KR102313757B1 (ko) 2021-10-18
US20150025021A1 (en) 2015-01-22
US9428549B2 (en) 2016-08-30
RU2696581C2 (ru) 2019-08-05
WO2015009545A1 (en) 2015-01-22

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AU2014290618B2 (en) Derivatives of N-urea substituted amino acids as formyl peptide receptor modulators
AU2012336013B2 (en) Aryl urea derivatives as N-formyl peptide receptor like-1 (FPRL-1) receptor modulators
US9868700B2 (en) Carbamoyl hydrazine derivatives as formyl peptide modulators
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