AU2014248081B2 - Microporous zirconium silicate and diuretics for the reduction of potassium and treatment of chronic kidney and/or chronic heart disease - Google Patents
Microporous zirconium silicate and diuretics for the reduction of potassium and treatment of chronic kidney and/or chronic heart disease Download PDFInfo
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- AU2014248081B2 AU2014248081B2 AU2014248081A AU2014248081A AU2014248081B2 AU 2014248081 B2 AU2014248081 B2 AU 2014248081B2 AU 2014248081 A AU2014248081 A AU 2014248081A AU 2014248081 A AU2014248081 A AU 2014248081A AU 2014248081 B2 AU2014248081 B2 AU 2014248081B2
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- potassium
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- ion
- crystals
- sodium
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- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 title claims abstract description 40
- 239000002934 diuretic Substances 0.000 title claims abstract description 26
- 229910052700 potassium Inorganic materials 0.000 title claims description 130
- 239000011591 potassium Substances 0.000 title claims description 126
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 title claims description 125
- 238000011282 treatment Methods 0.000 title abstract description 83
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 60
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- CBTCHTJSGLCFMY-UHFFFAOYSA-N disodium;2,2,4,4,6,6-hexahydroxy-1,3,5,2,4,6-trioxatrisilinane;zirconium Chemical compound [Na+].[Na+].[Zr].O[Si]1(O)O[Si](O)(O)O[Si](O)(O)O1 CBTCHTJSGLCFMY-UHFFFAOYSA-N 0.000 claims description 10
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- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 claims description 8
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- OGHBATFHNDZKSO-UHFFFAOYSA-N propan-2-olate Chemical compound CC(C)[O-] OGHBATFHNDZKSO-UHFFFAOYSA-N 0.000 description 1
- CCTFOFUMSKSGRK-UHFFFAOYSA-N propan-2-olate;tin(4+) Chemical compound [Sn+4].CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-] CCTFOFUMSKSGRK-UHFFFAOYSA-N 0.000 description 1
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- 229910000026 rubidium carbonate Inorganic materials 0.000 description 1
- NCCSSGKUIKYAJD-UHFFFAOYSA-N rubidium(1+) Chemical compound [Rb+] NCCSSGKUIKYAJD-UHFFFAOYSA-N 0.000 description 1
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- IEXRMSFAVATTJX-UHFFFAOYSA-N tetrachlorogermane Chemical compound Cl[Ge](Cl)(Cl)Cl IEXRMSFAVATTJX-UHFFFAOYSA-N 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 150000004897 thiazines Chemical class 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- AGHANLSBXUWXTB-UHFFFAOYSA-N tienilic acid Chemical compound ClC1=C(Cl)C(OCC(=O)O)=CC=C1C(=O)C1=CC=CS1 AGHANLSBXUWXTB-UHFFFAOYSA-N 0.000 description 1
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C01B39/00—Compounds having molecular sieve and base-exchange properties, e.g. crystalline zeolites; Their preparation; After-treatment, e.g. ion-exchange or dealumination
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US61/930,331 | 2014-01-22 | ||
| PCT/US2014/032815 WO2014165670A1 (en) | 2013-04-05 | 2014-04-03 | Microporous zirconium silicate and diuretics for the reduction of potassium and treatment of chronic kidney and/or chronic heart disease |
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| AU2014248081A1 AU2014248081A1 (en) | 2015-11-12 |
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| SMT201900037T1 (it) | 2011-02-11 | 2019-02-28 | Zs Pharma Inc | Uso di un silicato di zirconio per il trattamento di iperkaliemia |
| US9592253B1 (en) | 2015-10-14 | 2017-03-14 | ZS Pharma, Inc. | Extended use zirconium silicate compositions and methods of use thereof |
| CN114917247B (zh) * | 2022-05-18 | 2024-01-26 | 广东省疾病预防控制中心 | 纳米二氧化钛在防治肾损伤中的应用 |
| CN117776193A (zh) * | 2023-12-25 | 2024-03-29 | 杭州国瑞生物科技有限公司 | 一种环硅酸锆钠zs-9的制备方法及其应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6159505A (en) * | 1996-01-24 | 2000-12-12 | Piper; Edwina M. | Compositions for the treatment of migraine, containing potassium, magnesium and pyridoxine |
| US20040105895A1 (en) * | 2001-02-06 | 2004-06-03 | Ash Stephen R | Monovalent-selective cation exchangers as oral sorbent therapy |
| US20100104527A1 (en) * | 2008-08-22 | 2010-04-29 | Relypsa, Inc. | Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties |
| US20120213847A1 (en) * | 2011-02-11 | 2012-08-23 | ZS Pharma, Inc. | Microporous zirconium silicate for the treatment of hyperkalemia |
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| US5891417A (en) | 1997-04-08 | 1999-04-06 | Uop Llc | Zirconium silicate and zirconium germanate molecular sieves and process using the same |
| US5888472A (en) | 1997-04-08 | 1999-03-30 | Uop Llc | Zirconium silicate molecular sieves and process using the same |
| US6099737A (en) | 1999-03-29 | 2000-08-08 | Uop Llc | Process for removing toxins from blood using zirconium metallate or titanium metallate compositions |
| US6332985B1 (en) | 1999-03-29 | 2001-12-25 | Uop Llc | Process for removing toxins from bodily fluids using zirconium or titanium microporous compositions |
| EP1307270A1 (en) * | 2000-07-12 | 2003-05-07 | Uop Llc | Process for removing toxins from bodily fluids using zirconium or titanium microporous compositions |
| US6579460B1 (en) * | 2001-03-13 | 2003-06-17 | Uop Llc | Process and composition for removing toxins from bodily fluids |
| CN103919792B (zh) | 2008-08-22 | 2018-03-09 | 瑞立普萨公司 | 交联阳离子交换聚合物、组合物及在治疗方法高钾血症中的应用 |
| US20120070468A1 (en) * | 2010-09-16 | 2012-03-22 | Uop Llc | Removal of toxins from gastrointestinal fluids |
| MX2015000381A (es) * | 2012-07-11 | 2015-11-23 | Zs Pharma Inc | Silicato de zirconio microporoso para el tratamiento de la hipercalemia en pacientes hipercalcemicos y composiciones con calcio mejoradas para el tratamiento de la hipercalemia. |
| KR102184602B1 (ko) * | 2012-10-22 | 2020-11-30 | 제트에스 파마, 인코포레이티드 | 고칼륨혈증의 치료를 위한 미세다공성 지르코늄 실리케이트 |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6159505A (en) * | 1996-01-24 | 2000-12-12 | Piper; Edwina M. | Compositions for the treatment of migraine, containing potassium, magnesium and pyridoxine |
| US20040105895A1 (en) * | 2001-02-06 | 2004-06-03 | Ash Stephen R | Monovalent-selective cation exchangers as oral sorbent therapy |
| US20100104527A1 (en) * | 2008-08-22 | 2010-04-29 | Relypsa, Inc. | Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties |
| US20120213847A1 (en) * | 2011-02-11 | 2012-08-23 | ZS Pharma, Inc. | Microporous zirconium silicate for the treatment of hyperkalemia |
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| CA2908641C (en) | 2022-10-18 |
| EP2981272A1 (en) | 2016-02-10 |
| IL241926B (en) | 2020-10-29 |
| MX2015014055A (es) | 2015-12-15 |
| CL2015002951A1 (es) | 2016-11-11 |
| FI2981272T3 (fi) | 2023-05-03 |
| HUE061862T2 (hu) | 2023-08-28 |
| EP2981272A4 (en) | 2016-12-07 |
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| CN105473151B (zh) | 2018-09-18 |
| DK2981272T3 (da) | 2023-05-01 |
| US10695366B2 (en) | 2020-06-30 |
| BR112015025438B1 (pt) | 2022-06-07 |
| JP2016515624A (ja) | 2016-05-30 |
| HK1221177A1 (en) | 2017-05-26 |
| AU2014248081A1 (en) | 2015-11-12 |
| PH12015502301A1 (en) | 2016-02-10 |
| US20180271902A1 (en) | 2018-09-27 |
| ES2943007T3 (es) | 2023-06-08 |
| KR102308673B1 (ko) | 2021-10-01 |
| CN105473151A (zh) | 2016-04-06 |
| CA2908641A1 (en) | 2014-10-09 |
| PL2981272T3 (pl) | 2023-05-29 |
| ZA201507666B (en) | 2019-09-25 |
| PT2981272T (pt) | 2023-05-03 |
| BR112015025438A2 (pt) | 2017-07-18 |
| TW201521746A (zh) | 2015-06-16 |
| US20160051584A1 (en) | 2016-02-25 |
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