AU2014230822B2 - Heat-stable Respiratory Syncytial Virus prefusion F protein oligomers and their use in immunological compositions - Google Patents

Heat-stable Respiratory Syncytial Virus prefusion F protein oligomers and their use in immunological compositions Download PDF

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Publication number
AU2014230822B2
AU2014230822B2 AU2014230822A AU2014230822A AU2014230822B2 AU 2014230822 B2 AU2014230822 B2 AU 2014230822B2 AU 2014230822 A AU2014230822 A AU 2014230822A AU 2014230822 A AU2014230822 A AU 2014230822A AU 2014230822 B2 AU2014230822 B2 AU 2014230822B2
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AU2014230822A1 (en
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Cornelis Alexander Maria De Haan
Bert Jan Haijema
Petrus Josephus Marie Rottier
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Mucosis BV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2014230822A 2013-03-14 2014-03-12 Heat-stable Respiratory Syncytial Virus prefusion F protein oligomers and their use in immunological compositions Ceased AU2014230822B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/828,667 US9060975B2 (en) 2013-03-14 2013-03-14 Heat-stable respiratory syncytial virus F protein oligomers and their use in immunological compositions
US13/828,667 2013-03-14
PCT/EP2014/054804 WO2014140083A1 (en) 2013-03-14 2014-03-12 Heat-stable respiratory syncytial virus prefusion f protein oligomers and their use in immunological compositions

Publications (2)

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AU2014230822A1 AU2014230822A1 (en) 2015-10-01
AU2014230822B2 true AU2014230822B2 (en) 2018-04-12

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AU2014230822A Ceased AU2014230822B2 (en) 2013-03-14 2014-03-12 Heat-stable Respiratory Syncytial Virus prefusion F protein oligomers and their use in immunological compositions

Country Status (8)

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US (2) US9060975B2 (enExample)
EP (2) EP3178840A1 (enExample)
JP (1) JP6285469B2 (enExample)
CN (2) CN107029227A (enExample)
AU (1) AU2014230822B2 (enExample)
BR (1) BR112015022617A2 (enExample)
CA (1) CA2905571A1 (enExample)
WO (1) WO2014140083A1 (enExample)

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RS60056B1 (sr) 2013-02-01 2020-04-30 Medimmune Llc Epitopi f proteina respiratornog sincicijalnog virusa
CN105189756B (zh) 2013-03-14 2021-06-11 爱默蕾大学 具有沉默突变的重组rsv、其相关疫苗和方法
SG11201803581VA (en) 2015-10-29 2018-05-30 Univ Emory Chimeric RSV, Immunogenic Compositions, and Methods of Use
MX2018012094A (es) * 2016-04-05 2019-01-10 Janssen Vaccines & Prevention Bv Proteinas f de prefusion del virus respiratorio sincicial (vrs) solubles y estabilizadas.
SG11201810078PA (en) * 2016-05-30 2018-12-28 Janssen Vaccines & Prevention Bv Stabilized pre-fusion rsv f proteins
CN108300705B (zh) * 2017-01-12 2021-10-22 厦门大学 稳定呼吸道合胞病毒融合蛋白的方法
CN110506060B (zh) 2017-03-30 2024-05-07 昆士兰大学 嵌合分子及其用途
EP3606942B1 (en) 2017-04-04 2025-06-11 University of Washington Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus f proteins and their use
WO2019063844A1 (en) * 2017-09-29 2019-04-04 Universiteit Antwerpen VACCINATION AGAINST SYNCYTIAL RESPIRATORY VIRUS
WO2019147749A2 (en) * 2018-01-29 2019-08-01 Merck Sharp & Dohme Corp. Stabilized rsv f proteins and uses thereof
CN110684747B (zh) 2018-07-06 2024-05-24 厦门大学 灭活及保存呼吸道合胞病毒的方法
US20200129446A1 (en) 2018-10-29 2020-04-30 University Of Iowa Research Foundation Respiratory syncytial virus (rsv) polyanhydride nanoparticle vaccine
KR102725189B1 (ko) * 2018-11-01 2024-10-31 에스케이바이오사이언스(주) 재조합 호흡기 세포융합 바이러스 f 단백질 및 이를 포함하는 백신 조성물
CN109694400A (zh) * 2019-01-31 2019-04-30 苏州高泓利康生物科技有限公司 一种表达呼吸道合胞病毒f蛋白及其制备方法
JP7657727B2 (ja) 2019-04-02 2025-04-07 サノフイ 抗原性多量体呼吸器合胞体ウイルスポリペプチド
CN110054668B (zh) * 2019-04-25 2021-09-10 北京交通大学 一种呼吸道合胞病毒融合前f蛋白及其应用
JP7818504B2 (ja) 2019-09-04 2026-02-20 ユニヴァーシティ オブ ワシントン パラミクソウイルスおよび／またはニューモウイルスのｆタンパク質を提示する自己組織化タンパク質ナノ構造体ならびにその使用
CN111303245B (zh) * 2020-02-21 2023-06-27 成都奥达生物科技有限公司 一种抗合胞病毒膜融合抑制剂
US20230173055A1 (en) * 2020-04-22 2023-06-08 POSTECH Research and Business Development Foundation Influenza virus surface protein-derived recombinant hemagglutinin protein forming trimer, and use thereof
US20230174591A1 (en) * 2020-05-19 2023-06-08 National Research Council Of Canada Use of Human Resistin as a Trimerization Partner for Expression of Trimeric Proteins
CN112480217B (zh) * 2020-11-30 2022-04-08 广州阿格纳生物医药制造有限公司 基于SARS-CoV-2的S抗原蛋白的疫苗和组合物
IL322502A (en) * 2023-02-03 2025-09-01 Novavax Inc RSV F vaccine formulations
WO2024192698A1 (zh) * 2023-03-22 2024-09-26 中科牧维(南京)生物科技有限公司 靶向人呼吸道合胞病毒融合糖蛋白的多肽拮抗剂
AU2024287014A1 (en) * 2023-06-07 2026-01-22 Sichuan Clover Biopharmaceuticals, Inc. Rsv vaccine composition, method and use thereof
CN117886902B (zh) * 2023-12-21 2024-11-26 易康生物(苏州)有限公司 改良的呼吸道合胞病毒融合f蛋白突变体及其应用
CN121221753A (zh) * 2025-02-14 2025-12-30 北京悦康科创医药科技股份有限公司 一种膜融合抑制多肽在抗肺病毒科病毒感染中的应用
CN120329390A (zh) * 2025-03-03 2025-07-18 中国医学科学院医学生物学研究所 基于异源三聚体基序的蛋白的改造及应用

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WO2010149743A2 (en) * 2009-06-24 2010-12-29 Id Biomedical Corporation Of Quebec Vaccine
WO2011008974A2 (en) * 2009-07-15 2011-01-20 Novartis Ag Rsv f protein compositions and methods for making same
WO2012158613A1 (en) * 2011-05-13 2012-11-22 Novartis Ag Pre-fusion rsv f antigens

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EP1997830A1 (en) 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV specific binding molecules and means for producing them
PL2445526T3 (pl) 2009-06-24 2017-08-31 Glaxosmithkline Biologicals S.A. Rekombinowane antygeny rsv
US8568726B2 (en) 2009-10-06 2013-10-29 Medimmune Limited RSV specific binding molecule
JP6069295B2 (ja) 2011-03-22 2017-02-01 ミュコシス ベー．フェー． 免疫組成物、免疫組成物の製造方法、疾患の治療剤または予防剤、組み替えポリペプチド、核酸配列、ベクターおよび宿主細胞

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WO2010149743A2 (en) * 2009-06-24 2010-12-29 Id Biomedical Corporation Of Quebec Vaccine
WO2011008974A2 (en) * 2009-07-15 2011-01-20 Novartis Ag Rsv f protein compositions and methods for making same
WO2012158613A1 (en) * 2011-05-13 2012-11-22 Novartis Ag Pre-fusion rsv f antigens

Non-Patent Citations (1)

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Also Published As

Publication number Publication date
AU2014230822A1 (en) 2015-10-01
CN105246910A (zh) 2016-01-13
US20140271696A1 (en) 2014-09-18
BR112015022617A2 (pt) 2017-10-31
CA2905571A1 (en) 2014-09-18
US9060975B2 (en) 2015-06-23
JP2016510983A (ja) 2016-04-14
CN107029227A (zh) 2017-08-11
WO2014140083A1 (en) 2014-09-18
EP2970393A1 (en) 2016-01-20
JP6285469B2 (ja) 2018-02-28
EP2970393B1 (en) 2017-01-11
USRE47471E1 (en) 2019-07-02
EP3178840A1 (en) 2017-06-14

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