AU2014230096C1 - Use of linagliptin in cardio- and renoprotective antidiabetic therapy - Google Patents

Use of linagliptin in cardio- and renoprotective antidiabetic therapy Download PDF

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Publication number
AU2014230096C1
AU2014230096C1 AU2014230096A AU2014230096A AU2014230096C1 AU 2014230096 C1 AU2014230096 C1 AU 2014230096C1 AU 2014230096 A AU2014230096 A AU 2014230096A AU 2014230096 A AU2014230096 A AU 2014230096A AU 2014230096 C1 AU2014230096 C1 AU 2014230096C1
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disease
renal
patient
risk
patients
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AU2014230096A
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AU2014230096B2 (en
AU2014230096A1 (en
Inventor
Odd-Erik JOHANSEN
Thomas Klein
Maximilian VON EYNATTEN
Hans-Juergen Woerle
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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Priority to AU2019203445A priority Critical patent/AU2019203445A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2014230096A 2013-03-15 2014-03-14 Use of linagliptin in cardio- and renoprotective antidiabetic therapy Active AU2014230096C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2019203445A AU2019203445A1 (en) 2013-03-15 2019-05-16 Use of linagliptin in cardio- and renoprotective antidiabetic therapy

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP13159624.9 2013-03-15
EP13159624 2013-03-15
EP13177311 2013-07-19
EP13177311.1 2013-07-19
PCT/EP2014/055113 WO2014140284A1 (en) 2013-03-15 2014-03-14 Use of linagliptin in cardio- and renoprotective antidiabetic therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2019203445A Division AU2019203445A1 (en) 2013-03-15 2019-05-16 Use of linagliptin in cardio- and renoprotective antidiabetic therapy

Publications (3)

Publication Number Publication Date
AU2014230096A1 AU2014230096A1 (en) 2015-08-06
AU2014230096B2 AU2014230096B2 (en) 2019-02-21
AU2014230096C1 true AU2014230096C1 (en) 2019-08-29

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AU2014230096A Active AU2014230096C1 (en) 2013-03-15 2014-03-14 Use of linagliptin in cardio- and renoprotective antidiabetic therapy
AU2019203445A Abandoned AU2019203445A1 (en) 2013-03-15 2019-05-16 Use of linagliptin in cardio- and renoprotective antidiabetic therapy

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AU2019203445A Abandoned AU2019203445A1 (en) 2013-03-15 2019-05-16 Use of linagliptin in cardio- and renoprotective antidiabetic therapy

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US (9) US20140274889A1 (enExample)
EP (4) EP4364796A3 (enExample)
JP (4) JP2016510795A (enExample)
KR (2) KR20210099201A (enExample)
CN (2) CN110075098A (enExample)
AU (2) AU2014230096C1 (enExample)
BR (1) BR112015020209A2 (enExample)
CA (1) CA2903577C (enExample)
CL (1) CL2015002369A1 (enExample)
EA (1) EA037712B1 (enExample)
IL (1) IL240064A0 (enExample)
MX (2) MX2015011466A (enExample)
PH (1) PH12015502042B1 (enExample)
WO (1) WO2014140284A1 (enExample)

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US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
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US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
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US20130303462A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
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EP3468562A1 (en) * 2016-06-10 2019-04-17 Boehringer Ingelheim International GmbH Combinations of linagliptin and metformin
US20210299129A1 (en) * 2018-07-17 2021-09-30 Boehringer Ingelheim International Gmbh Cardiosafe Antidiabetic Therapy
MX2021000554A (es) * 2018-07-17 2021-03-29 Boehringer Ingelheim Int Tratamiento antidiabetico cardiovascular y renal seguro.
CN111333626B (zh) * 2018-12-18 2022-10-18 武汉人福创新药物研发中心有限公司 苯基吡咯烷类化合物及其用途
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EP4364796A2 (en) 2024-05-08
CL2015002369A1 (es) 2016-02-19
PH12015502042A1 (en) 2016-01-18
EP2968344A1 (en) 2016-01-20
EP3409279A1 (en) 2018-12-05
JP2016510795A (ja) 2016-04-11
NZ710249A (en) 2021-04-30
KR20210099201A (ko) 2021-08-11
IL240064A0 (en) 2015-09-24
US20190192523A1 (en) 2019-06-27
US20170065596A1 (en) 2017-03-09
JP2021095409A (ja) 2021-06-24
US20160089373A1 (en) 2016-03-31
EP4364796A3 (en) 2024-07-24
MX2015011466A (es) 2016-01-22
US20240033270A1 (en) 2024-02-01
EA201500934A1 (ru) 2016-03-31
EA037712B1 (ru) 2021-05-13
US20250025470A1 (en) 2025-01-23
AU2019203445A1 (en) 2019-06-06
CA2903577A1 (en) 2014-09-18
JP2025115998A (ja) 2025-08-07
US20180263990A1 (en) 2018-09-20
EP3744327A1 (en) 2020-12-02
KR20150128726A (ko) 2015-11-18
CA2903577C (en) 2023-10-17
AU2014230096B2 (en) 2019-02-21
BR112015020209A2 (pt) 2017-07-18
CN110075098A (zh) 2019-08-02
CN105188706A (zh) 2015-12-23
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JP2019112409A (ja) 2019-07-11
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