AU2014229424B2 - Markers associated with Wnt inhibitors - Google Patents

Markers associated with Wnt inhibitors Download PDF

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Publication number
AU2014229424B2
AU2014229424B2 AU2014229424A AU2014229424A AU2014229424B2 AU 2014229424 B2 AU2014229424 B2 AU 2014229424B2 AU 2014229424 A AU2014229424 A AU 2014229424A AU 2014229424 A AU2014229424 A AU 2014229424A AU 2014229424 B2 AU2014229424 B2 AU 2014229424B2
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Australia
Prior art keywords
patient
wnt inhibitor
biomarker
expression
cancer
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AU2014229424A
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AU2014229424A1 (en
Inventor
Jianwei Che
Jennifer Harris
Mindy HSIN-I HSIEH
Jie Li
Jun Liu
Nicholas Ng
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Novartis AG
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Novartis AG
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    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57557—Immunoassay; Biospecific binding assay; Materials therefor for cancer of other specific parts of the body, e.g. brain
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    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
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    • C12Q2600/00—Oligonucleotides characterized by their use
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2014229424A 2013-03-11 2014-03-10 Markers associated with Wnt inhibitors Ceased AU2014229424B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361776334P 2013-03-11 2013-03-11
US61/776,334 2013-03-11
PCT/IB2014/059585 WO2014141038A2 (en) 2013-03-11 2014-03-10 Markers associated with wnt inhibitors

Publications (2)

Publication Number Publication Date
AU2014229424A1 AU2014229424A1 (en) 2015-08-20
AU2014229424B2 true AU2014229424B2 (en) 2017-03-02

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AU2014229424A Ceased AU2014229424B2 (en) 2013-03-11 2014-03-10 Markers associated with Wnt inhibitors

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US (1) US10422007B2 (enExample)
EP (1) EP2972372B1 (enExample)
JP (1) JP6445984B2 (enExample)
KR (1) KR102194746B1 (enExample)
CN (1) CN105190313B (enExample)
AU (1) AU2014229424B2 (enExample)
BR (1) BR112015019567A8 (enExample)
CA (1) CA2903976C (enExample)
CL (1) CL2015002572A1 (enExample)
DK (1) DK2972372T3 (enExample)
ES (1) ES2681618T3 (enExample)
HU (1) HUE039776T2 (enExample)
IL (1) IL240794A (enExample)
MA (1) MA38395B1 (enExample)
MX (1) MX2015012534A (enExample)
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RU (2) RU2663701C2 (enExample)
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SI (1) SI2972372T1 (enExample)
TN (1) TN2015000325A1 (enExample)
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WO2017167150A1 (zh) * 2016-03-31 2017-10-05 苏州云轩医药科技有限公司 一种3-氟吡啶杂环化合物及其应用
CN106434968B (zh) * 2016-11-18 2019-10-22 北京致成生物医学科技有限公司 Ccdc168作为标记物在检测胰腺癌试剂中的应用
TWI846703B (zh) 2018-06-19 2024-07-01 日商武田藥品工業股份有限公司 癌症治療方法
EP4671385A3 (en) * 2018-08-07 2026-03-18 Torqur AG Treatment of squamous cell carcinoma
US12195804B2 (en) 2018-08-07 2025-01-14 Board Of Regents, The University Of Texas System Treatment of squamous cell carcinoma
WO2022013328A1 (en) * 2020-07-15 2022-01-20 Université Libre de Bruxelles Method for determining sensitivity to an antineoplastic agent
CN116808027B (zh) * 2023-05-30 2025-08-29 重庆医科大学附属第一医院 化合物或其盐在制备抑制wnt7a基因活性的制剂中的应用

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ES2681618T3 (es) 2018-09-14
RU2015138688A (ru) 2017-04-17
MX2015012534A (es) 2016-01-12
TN2015000325A1 (en) 2017-01-03
RU2017141378A (ru) 2019-02-14
US10422007B2 (en) 2019-09-24
US20160024587A1 (en) 2016-01-28
PL2972372T3 (pl) 2018-09-28
SI2972372T1 (sl) 2018-09-28
CA2903976C (en) 2022-02-15
RU2017141378A3 (enExample) 2020-12-15
CN105190313B (zh) 2018-06-19
RU2663701C2 (ru) 2018-08-08
CA2903976A1 (en) 2014-09-18
IL240794A0 (en) 2015-10-29
HK1212771A1 (en) 2016-06-17
TW201439328A (zh) 2014-10-16
TWI582239B (zh) 2017-05-11
JP6445984B2 (ja) 2018-12-26
IL240794A (en) 2017-09-28
BR112015019567A2 (pt) 2017-07-18
MA38395A1 (fr) 2018-02-28
MA38395B1 (fr) 2018-09-28
AU2014229424A1 (en) 2015-08-20
ZA201505227B (en) 2016-03-30
KR20150127611A (ko) 2015-11-17
EP2972372B1 (en) 2018-04-25
SG11201505873VA (en) 2015-09-29
JP2016513456A (ja) 2016-05-16
PH12015501778A1 (en) 2015-12-07
EP2972372A2 (en) 2016-01-20
WO2014141038A3 (en) 2014-11-27
CN105190313A (zh) 2015-12-23
WO2014141038A2 (en) 2014-09-18
KR102194746B1 (ko) 2020-12-24
DK2972372T3 (en) 2018-07-30
CL2015002572A1 (es) 2016-03-28
HUE039776T2 (hu) 2019-02-28
PT2972372T (pt) 2018-07-31
BR112015019567A8 (pt) 2019-11-26

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