BR112015019567A8 - inibidor de wnt, seu uso e métodos para prognosticar sensibilidade ao mesmo, e composição farmacêutica - Google Patents

inibidor de wnt, seu uso e métodos para prognosticar sensibilidade ao mesmo, e composição farmacêutica Download PDF

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Publication number
BR112015019567A8
BR112015019567A8 BR112015019567A BR112015019567A BR112015019567A8 BR 112015019567 A8 BR112015019567 A8 BR 112015019567A8 BR 112015019567 A BR112015019567 A BR 112015019567A BR 112015019567 A BR112015019567 A BR 112015019567A BR 112015019567 A8 BR112015019567 A8 BR 112015019567A8
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Brazil
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methods
wnt inhibitor
pharmaceutical composition
sensitivity
wnt
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BR112015019567A
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English (en)
Portuguese (pt)
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BR112015019567A2 (pt
Inventor
Hsieh Hsin-I
Harris Jennifer
Che Jianwei
Li Jie
Liu Jun
Ng Nicholas
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Novartis Ag
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Publication of BR112015019567A2 publication Critical patent/BR112015019567A2/pt
Publication of BR112015019567A8 publication Critical patent/BR112015019567A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
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  • Biotechnology (AREA)
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  • Urology & Nephrology (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR112015019567A 2013-03-11 2014-03-10 inibidor de wnt, seu uso e métodos para prognosticar sensibilidade ao mesmo, e composição farmacêutica BR112015019567A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361776334P 2013-03-11 2013-03-11
PCT/IB2014/059585 WO2014141038A2 (en) 2013-03-11 2014-03-10 Markers associated with wnt inhibitors

Publications (2)

Publication Number Publication Date
BR112015019567A2 BR112015019567A2 (pt) 2017-07-18
BR112015019567A8 true BR112015019567A8 (pt) 2019-11-26

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BR112015019567A BR112015019567A8 (pt) 2013-03-11 2014-03-10 inibidor de wnt, seu uso e métodos para prognosticar sensibilidade ao mesmo, e composição farmacêutica

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US (1) US10422007B2 (enExample)
EP (1) EP2972372B1 (enExample)
JP (1) JP6445984B2 (enExample)
KR (1) KR102194746B1 (enExample)
CN (1) CN105190313B (enExample)
AU (1) AU2014229424B2 (enExample)
BR (1) BR112015019567A8 (enExample)
CA (1) CA2903976C (enExample)
CL (1) CL2015002572A1 (enExample)
DK (1) DK2972372T3 (enExample)
ES (1) ES2681618T3 (enExample)
HU (1) HUE039776T2 (enExample)
IL (1) IL240794A (enExample)
MA (1) MA38395B1 (enExample)
MX (1) MX2015012534A (enExample)
PH (1) PH12015501778A1 (enExample)
PL (1) PL2972372T3 (enExample)
PT (1) PT2972372T (enExample)
RU (2) RU2017141378A (enExample)
SG (1) SG11201505873VA (enExample)
SI (1) SI2972372T1 (enExample)
TN (1) TN2015000325A1 (enExample)
TW (1) TWI582239B (enExample)
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DE202015106125U1 (de) * 2015-10-23 2016-10-27 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Monoterpenhaltige Zusammensetzung zur Behandlung von Tumor- und/oder Krebserkrankungen
CN105617359A (zh) * 2015-12-31 2016-06-01 中国科学院成都生物研究所 Wnt信号通路蛋白Frzb在制备抗肝癌药中的应用
WO2017167150A1 (zh) * 2016-03-31 2017-10-05 苏州云轩医药科技有限公司 一种3-氟吡啶杂环化合物及其应用
CN106434968B (zh) * 2016-11-18 2019-10-22 北京致成生物医学科技有限公司 Ccdc168作为标记物在检测胰腺癌试剂中的应用
TWI846703B (zh) 2018-06-19 2024-07-01 日商武田藥品工業股份有限公司 癌症治療方法
WO2020030708A1 (en) * 2018-08-07 2020-02-13 Piqur Therapeutics Ag Treatment of squamous cell carcinoma
US12195804B2 (en) 2018-08-07 2025-01-14 Board Of Regents, The University Of Texas System Treatment of squamous cell carcinoma
EP4182479A1 (en) * 2020-07-15 2023-05-24 Université Libre de Bruxelles Method for determining sensitivity to an antineoplastic agent
CN116808027B (zh) * 2023-05-30 2025-08-29 重庆医科大学附属第一医院 化合物或其盐在制备抑制wnt7a基因活性的制剂中的应用

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SG11201505873VA (en) 2015-09-29
PH12015501778A1 (en) 2015-12-07
PL2972372T3 (pl) 2018-09-28
CA2903976C (en) 2022-02-15
RU2663701C2 (ru) 2018-08-08
TW201439328A (zh) 2014-10-16
MA38395A1 (fr) 2018-02-28
WO2014141038A2 (en) 2014-09-18
CA2903976A1 (en) 2014-09-18
CL2015002572A1 (es) 2016-03-28
KR102194746B1 (ko) 2020-12-24
RU2017141378A (ru) 2019-02-14
CN105190313A (zh) 2015-12-23
HK1212771A1 (en) 2016-06-17
KR20150127611A (ko) 2015-11-17
CN105190313B (zh) 2018-06-19
EP2972372A2 (en) 2016-01-20
MX2015012534A (es) 2016-01-12
ZA201505227B (en) 2016-03-30
HUE039776T2 (hu) 2019-02-28
AU2014229424A1 (en) 2015-08-20
ES2681618T3 (es) 2018-09-14
BR112015019567A2 (pt) 2017-07-18
IL240794A (en) 2017-09-28
TWI582239B (zh) 2017-05-11
PT2972372T (pt) 2018-07-31
AU2014229424B2 (en) 2017-03-02
TN2015000325A1 (en) 2017-01-03
SI2972372T1 (sl) 2018-09-28
JP6445984B2 (ja) 2018-12-26
WO2014141038A3 (en) 2014-11-27
MA38395B1 (fr) 2018-09-28
IL240794A0 (en) 2015-10-29
DK2972372T3 (en) 2018-07-30
US20160024587A1 (en) 2016-01-28
US10422007B2 (en) 2019-09-24
RU2017141378A3 (enExample) 2020-12-15
JP2016513456A (ja) 2016-05-16
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