AU2014227754B2 - Encoded nanopore sensor for multiplex nucleic acids detection - Google Patents

Encoded nanopore sensor for multiplex nucleic acids detection Download PDF

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Publication number
AU2014227754B2
AU2014227754B2 AU2014227754A AU2014227754A AU2014227754B2 AU 2014227754 B2 AU2014227754 B2 AU 2014227754B2 AU 2014227754 A AU2014227754 A AU 2014227754A AU 2014227754 A AU2014227754 A AU 2014227754A AU 2014227754 B2 AU2014227754 B2 AU 2014227754B2
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probe
nucleic acid
target nucleic
probe molecule
nanopore
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AU2014227754A1 (en
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Li-qun GU
Xinyue ZHANG
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University of Missouri–St. Louis
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University of Missouri-Columbia
University of Missouri–St. Louis
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nanotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
AU2014227754A 2013-03-15 2014-03-14 Encoded nanopore sensor for multiplex nucleic acids detection Active AU2014227754B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361788589P 2013-03-15 2013-03-15
US61/788,589 2013-03-15
PCT/US2014/028528 WO2014144217A1 (en) 2013-03-15 2014-03-14 Encoded nanopore sensor for multiplex nucleic acids detection

Publications (2)

Publication Number Publication Date
AU2014227754A1 AU2014227754A1 (en) 2015-10-01
AU2014227754B2 true AU2014227754B2 (en) 2018-03-01

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AU2014227754A Active AU2014227754B2 (en) 2013-03-15 2014-03-14 Encoded nanopore sensor for multiplex nucleic acids detection

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US (2) US9732379B2 (enExample)
EP (1) EP2971118B1 (enExample)
JP (1) JP2016517275A (enExample)
AU (1) AU2014227754B2 (enExample)
CA (1) CA2906007C (enExample)
WO (1) WO2014144217A1 (enExample)

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US11034996B2 (en) 2018-03-02 2021-06-15 The Curators Of The University Of Missouri Nucleic acid sequence and capture by formation of an abasic site-derived cross-link
WO2019243421A1 (en) * 2018-06-21 2019-12-26 F. Hoffmann-La Roche Ag Tunneling junctions for sequencing
JP7239965B2 (ja) * 2018-06-26 2023-03-15 国立大学法人東京農工大学 ２種以上の特定オリゴヌクレオチドの有無を判定する判定方法、並びに、前記判定方法を用いて検査対象が小細胞肺がん、胆管がんに罹患している又はそのリスクを有することを判定する方法
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CN112795628B (zh) * 2021-02-05 2024-02-23 南京邮电大学 基于固态纳米孔传感器的miRNA检测方法、检测探针及试剂盒
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Also Published As

Publication number Publication date
US20180002742A1 (en) 2018-01-04
CA2906007C (en) 2022-06-21
US9732379B2 (en) 2017-08-15
EP2971118A1 (en) 2016-01-20
JP2016517275A (ja) 2016-06-16
WO2014144217A1 (en) 2014-09-18
AU2014227754A1 (en) 2015-10-01
US20140309129A1 (en) 2014-10-16
EP2971118A4 (en) 2016-11-16
EP2971118B1 (en) 2019-10-02
CA2906007A1 (en) 2014-09-18

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