CA2906007C - Encoded nanopore sensor for multiplex nucleic acids detection - Google Patents
Encoded nanopore sensor for multiplex nucleic acids detection Download PDFInfo
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- CA2906007C CA2906007C CA2906007A CA2906007A CA2906007C CA 2906007 C CA2906007 C CA 2906007C CA 2906007 A CA2906007 A CA 2906007A CA 2906007 A CA2906007 A CA 2906007A CA 2906007 C CA2906007 C CA 2906007C
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
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| CN105102627B (zh) * | 2013-03-15 | 2018-10-19 | 纽约哥伦比亚大学理事会 | 用于检测样品中多种预定化合物的方法 |
| US11098348B2 (en) | 2015-02-02 | 2021-08-24 | Ontera Inc. | Nanopore detection of target polynucleotides from sample background |
| EP3303620A1 (en) | 2015-06-02 | 2018-04-11 | Nanopore Diagnostics LLC | Nucleic acid detection |
| WO2018093976A1 (en) * | 2016-11-16 | 2018-05-24 | Nanopore Diagnostics, Llc | Analysis of nucleic acids using probe with non-linear tag |
| US11034996B2 (en) | 2018-03-02 | 2021-06-15 | The Curators Of The University Of Missouri | Nucleic acid sequence and capture by formation of an abasic site-derived cross-link |
| JP7377222B2 (ja) * | 2018-06-21 | 2023-11-09 | エフ． ホフマン－ラ ロシュ アーゲー | 配列決定のためのトンネル接合部 |
| JP7239965B2 (ja) * | 2018-06-26 | 2023-03-15 | 国立大学法人東京農工大学 | ２種以上の特定オリゴヌクレオチドの有無を判定する判定方法、並びに、前記判定方法を用いて検査対象が小細胞肺がん、胆管がんに罹患している又はそのリスクを有することを判定する方法 |
| JP7344786B2 (ja) * | 2019-12-19 | 2023-09-14 | 株式会社日立製作所 | 溶液中の任意のｄｎａ配列を同定する方法 |
| CN112795628B (zh) * | 2021-02-05 | 2024-02-23 | 南京邮电大学 | 基于固态纳米孔传感器的miRNA检测方法、检测探针及试剂盒 |
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| EP0304845A3 (en) * | 1987-08-28 | 1991-03-06 | Profile Diagnostic Sciences Inc. | Method and kit for assaying gene expressions |
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| US20040152084A1 (en) * | 2003-01-31 | 2004-08-05 | Slattum Paul M. | Compounds and processes for single-pot attachment of a label to nucleic acid |
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| EP1161563A2 (en) * | 1999-03-15 | 2001-12-12 | PE Corporation (NY) | Probe/mobility modifier complexes for multiplex nucleic acid detection |
| JP2003527075A (ja) * | 1999-03-25 | 2003-09-16 | ハイセック，インコーポレーテッド | ハイブリダイゼーションによる配列分析のための、溶液ベースの方法 |
| DE60025739T2 (de) | 1999-09-07 | 2006-08-31 | The Regents Of The University Of California, Oakland | Verfahren um die anwesenheit von doppelsträngiger dns in einer probe nachzuweisen |
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| AU2002365421A1 (en) | 2001-07-10 | 2003-09-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for detecting the activation state of the multiple proteins in single cells |
| JP2005517900A (ja) * | 2001-11-21 | 2005-06-16 | アプレラ コーポレイション | デジタルアッセイ |
| US20050019784A1 (en) | 2002-05-20 | 2005-01-27 | Xing Su | Method and apparatus for nucleic acid sequencing and identification |
| ATE469135T1 (de) | 2002-05-30 | 2010-06-15 | Scripps Research Inst | Kupferkatalysierte ligierung von aziden und acetylenen |
| EP1648914A4 (en) | 2003-07-31 | 2009-12-16 | Regulus Therapeutics Inc | OLIGOMERIC COMPOUNDS AND COMPOSITIONS USEFUL FOR MODULATING SMALL NON-CODING RNA |
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| EP1784754A4 (en) | 2004-08-13 | 2009-05-27 | Harvard College | OPTI-NANOPORE DNA READING PLATFORM WITH ULTRAHOLE THROUGHPUT |
| KR101159072B1 (ko) | 2005-01-20 | 2012-06-25 | 삼성전자주식회사 | 나노포어를 이용한 생분자의 분리방법 |
| KR100707198B1 (ko) | 2005-06-27 | 2007-04-13 | 삼성전자주식회사 | 나노포어 및 핵산에 비특이적으로 결합하는 물질을 이용한고감도 핵산 검출 방법 |
| WO2007041621A2 (en) | 2005-10-03 | 2007-04-12 | Xingsheng Sean Ling | Hybridization assisted nanopore sequencing |
| KR100730350B1 (ko) | 2005-10-17 | 2007-06-19 | 삼성전자주식회사 | 표면처리된 나노포어를 이용한 ｄｎａ 검출방법 및검출장치 |
| EP1954838B1 (en) | 2005-11-14 | 2014-02-26 | Life Technologies Corporation | Coded molecules for detecting target analytes |
| WO2007117832A2 (en) | 2006-03-12 | 2007-10-18 | Applera Corporation | Methods of detecting target nucleic acids |
| US8314220B2 (en) | 2007-01-26 | 2012-11-20 | Agilent Technologies, Inc. | Methods compositions, and kits for detection of microRNA |
| WO2008097190A1 (en) | 2007-02-05 | 2008-08-14 | Agency For Science, Technology And Research | Methods of electrically detecting a nucleic acid by means of an electrode pair |
| AU2008236694B2 (en) | 2007-04-04 | 2014-01-23 | The Regents Of The University Of California | Compositions, devices, systems, and methods for using a nanopore |
| EP2158476B8 (en) | 2007-05-08 | 2019-10-09 | Trustees of Boston University | Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof |
| GB0713143D0 (en) | 2007-07-06 | 2007-08-15 | Ucl Business Plc | Nucleic acid detection method |
| EP2205765B1 (en) | 2007-10-02 | 2012-09-12 | President and Fellows of Harvard College | Capture, recapture, and trapping of molecules with a nanopore |
| US20090181390A1 (en) | 2008-01-11 | 2009-07-16 | Signosis, Inc. A California Corporation | High throughput detection of micrornas and use for disease diagnosis |
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| EP2107040B1 (en) | 2008-03-31 | 2011-10-26 | Sony Deutschland Gmbh | A method of fabricating a membrane having a tapered pore |
| US9447152B2 (en) | 2008-07-07 | 2016-09-20 | Oxford Nanopore Technologies Limited | Base-detecting pore |
| US20100099198A1 (en) | 2008-07-11 | 2010-04-22 | Board Of Regents, The University Of Texas System | Apparatus and system for pattern recognition sensing for biomolecules |
| US20100148126A1 (en) | 2008-11-26 | 2010-06-17 | Board Of Regents, The University Of Texas System | Genomic sequencing using modified protein pores and ionic liquids |
| US20110003703A1 (en) | 2009-07-01 | 2011-01-06 | Charles Ma | Nucleic Acid Hybridization and Detection Using Enzymatic Reactions on a Microarray |
| US9416409B2 (en) | 2009-07-31 | 2016-08-16 | Ibis Biosciences, Inc. | Capture primers and capture sequence linked solid supports for molecular diagnostic tests |
| WO2011028494A2 (en) | 2009-08-24 | 2011-03-10 | Trustees Of Boston University | Label-free sensing of pna-dna complexes using nanopores |
| US8324914B2 (en) | 2010-02-08 | 2012-12-04 | Genia Technologies, Inc. | Systems and methods for characterizing a molecule |
| WO2011103424A2 (en) | 2010-02-19 | 2011-08-25 | The Trustees Of The University Of Pennsylvania | High-resolution analysis devices and related methods |
| WO2011106583A1 (en) * | 2010-02-26 | 2011-09-01 | Ventana Medical Systems, Inc. | Polytag probes |
| CA2795042A1 (en) * | 2010-03-30 | 2011-10-13 | Trustees Of Boston University | Tools and method for nanopores unzipping-dependent nucleic acid sequencing |
| JP6016792B2 (ja) | 2010-07-14 | 2016-10-26 | ザ キュレイターズ オブ ザ ユニバーシティ オブ ミズーリ | ナノポア促進型の核酸の単分子検出 |
| US10443096B2 (en) * | 2010-12-17 | 2019-10-15 | The Trustees Of Columbia University In The City Of New York | DNA sequencing by synthesis using modified nucleotides and nanopore detection |
| AU2013220156B2 (en) | 2012-02-15 | 2018-08-09 | Oxford Nanopore Technologies Limited | Aptamer method |
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| US20140309129A1 (en) | 2014-10-16 |
| JP2016517275A (ja) | 2016-06-16 |
| WO2014144217A1 (en) | 2014-09-18 |
| AU2014227754B2 (en) | 2018-03-01 |
| EP2971118A1 (en) | 2016-01-20 |
| AU2014227754A1 (en) | 2015-10-01 |
| EP2971118A4 (en) | 2016-11-16 |
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| CA2906007A1 (en) | 2014-09-18 |
| US20180002742A1 (en) | 2018-01-04 |
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