AU2014224976B2 - 9-(aryl or heteroaryl)-2-(pyrazolyl, pyrrolidinyl or cyclopentyl)aminopurine derivatives as anticancer agents - Google Patents

9-(aryl or heteroaryl)-2-(pyrazolyl, pyrrolidinyl or cyclopentyl)aminopurine derivatives as anticancer agents Download PDF

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Publication number
AU2014224976B2
AU2014224976B2 AU2014224976A AU2014224976A AU2014224976B2 AU 2014224976 B2 AU2014224976 B2 AU 2014224976B2 AU 2014224976 A AU2014224976 A AU 2014224976A AU 2014224976 A AU2014224976 A AU 2014224976A AU 2014224976 B2 AU2014224976 B2 AU 2014224976B2
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denotes
phet1
pyrazol
disease
formula
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AU2014224976A1 (en
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Michael Busch
Dieter Dorsch
Guenter Hoelzemann
Oliver Poeschke
Jeyaprakashnarayanan SEENISAMY
Ansgar Wegener
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Merck Patent GmbH
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Merck Patent GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
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    • A61P35/00—Antineoplastic agents
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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AU2014224976A 2013-03-05 2014-02-11 9-(aryl or heteroaryl)-2-(pyrazolyl, pyrrolidinyl or cyclopentyl)aminopurine derivatives as anticancer agents Ceased AU2014224976B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13001111.7 2013-03-05
EP13001111 2013-03-05
PCT/EP2014/000371 WO2014135245A1 (en) 2013-03-05 2014-02-11 9-(aryl or heteroaryl)-2-(pyrazolyl, pyrrolidinyl or cyclopentyl)aminopurine derivatives as anticancer agents

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AU2014224976A1 AU2014224976A1 (en) 2015-10-22
AU2014224976B2 true AU2014224976B2 (en) 2017-09-28

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EP (1) EP2964648B1 (enExample)
JP (1) JP6409007B2 (enExample)
CN (1) CN105026397B (enExample)
AR (1) AR094981A1 (enExample)
AU (1) AU2014224976B2 (enExample)
CA (1) CA2903901A1 (enExample)
ES (1) ES2614872T3 (enExample)
IL (1) IL240876B (enExample)
WO (1) WO2014135245A1 (enExample)

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US9617266B2 (en) 2017-04-11
AU2014224976A1 (en) 2015-10-22
WO2014135245A1 (en) 2014-09-12
EP2964648B1 (en) 2016-11-16
IL240876B (en) 2019-09-26
IL240876A0 (en) 2015-10-29
EP2964648A1 (en) 2016-01-13
CN105026397B (zh) 2017-06-30
CA2903901A1 (en) 2014-09-12
JP2016510045A (ja) 2016-04-04
ES2614872T3 (es) 2017-06-02
CN105026397A (zh) 2015-11-04
US20160002242A1 (en) 2016-01-07
JP6409007B2 (ja) 2018-10-17
AR094981A1 (es) 2015-09-09

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