AU2014205120B2 - Model-based personalization scheme of an artificial pancreas for type I diabetes applications - Google Patents
Model-based personalization scheme of an artificial pancreas for type I diabetes applications Download PDFInfo
- Publication number
- AU2014205120B2 AU2014205120B2 AU2014205120A AU2014205120A AU2014205120B2 AU 2014205120 B2 AU2014205120 B2 AU 2014205120B2 AU 2014205120 A AU2014205120 A AU 2014205120A AU 2014205120 A AU2014205120 A AU 2014205120A AU 2014205120 B2 AU2014205120 B2 AU 2014205120B2
- Authority
- AU
- Australia
- Prior art keywords
- controller
- insulin
- subject
- model
- basal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
- A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic using feedback of body parameters, e.g. blood sugar or pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/022—Artificial gland structures using bioreactors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
- A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic using feedback of body parameters, e.g. blood sugar or pressure
- A61M2005/1726—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic using feedback of body parameters, e.g. blood sugar or pressure the body parameters being measured at, or proximate to, the infusion site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
Landscapes
- Health & Medical Sciences (AREA)
- Transplantation (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- External Artificial Organs (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361751941P | 2013-01-14 | 2013-01-14 | |
| US61/751,941 | 2013-01-14 | ||
| PCT/US2014/011360 WO2014110538A1 (en) | 2013-01-14 | 2014-01-13 | Model-based personalization scheme of an artificial pancreas for type i diabetes applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2014205120A1 AU2014205120A1 (en) | 2015-07-23 |
| AU2014205120B2 true AU2014205120B2 (en) | 2019-10-17 |
Family
ID=51167293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014205120A Active AU2014205120B2 (en) | 2013-01-14 | 2014-01-13 | Model-based personalization scheme of an artificial pancreas for type I diabetes applications |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US10413664B2 (enExample) |
| EP (1) | EP2943149B1 (enExample) |
| JP (2) | JP2016506775A (enExample) |
| KR (1) | KR102211352B1 (enExample) |
| AU (1) | AU2014205120B2 (enExample) |
| CA (1) | CA2897189C (enExample) |
| WO (2) | WO2014109898A1 (enExample) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7972296B2 (en) | 2007-10-10 | 2011-07-05 | Optiscan Biomedical Corporation | Fluid component analysis system and method for glucose monitoring and control |
| US8417311B2 (en) | 2008-09-12 | 2013-04-09 | Optiscan Biomedical Corporation | Fluid component analysis system and method for glucose monitoring and control |
| US7959598B2 (en) | 2008-08-20 | 2011-06-14 | Asante Solutions, Inc. | Infusion pump systems and methods |
| US9292010B2 (en) * | 2012-11-05 | 2016-03-22 | Rockwell Automation Technologies, Inc. | Online integration of model-based optimization and model-less control |
| WO2014109898A1 (en) * | 2013-01-14 | 2014-07-17 | The Regents Of University Of California | Model-based personalization scheme of an artificial pancreas for type i diabetes applications |
| WO2014172467A1 (en) | 2013-04-16 | 2014-10-23 | Smartloop Llc | Discretionary insulin delivery systems and methods |
| US9561324B2 (en) | 2013-07-19 | 2017-02-07 | Bigfoot Biomedical, Inc. | Infusion pump system and method |
| GB2523989B (en) | 2014-01-30 | 2020-07-29 | Insulet Netherlands B V | Therapeutic product delivery system and method of pairing |
| CN104749954B (zh) * | 2015-02-08 | 2017-04-12 | 北京化工大学 | 基于内模控制策略的智能灰箱控制系统装置及控制方法 |
| CA2977053C (en) | 2015-02-18 | 2023-08-01 | Insulet Corporation | Fluid delivery and infusion devices, and methods of use thereof |
| EP3374905A1 (en) | 2016-01-13 | 2018-09-19 | Bigfoot Biomedical, Inc. | User interface for diabetes management system |
| HK1256995A1 (zh) | 2016-01-14 | 2019-10-11 | Bigfoot Biomedical, Inc. | 药物输送设备、系统和方法中的阻塞解决方案 |
| EP4545005A3 (en) | 2016-01-14 | 2025-07-02 | Insulet Corporation | Adjusting insulin delivery rates |
| US12383166B2 (en) | 2016-05-23 | 2025-08-12 | Insulet Corporation | Insulin delivery system and methods with risk-based set points |
| WO2018058041A1 (en) | 2016-09-23 | 2018-03-29 | Insulet Corporation | Fluid delivery device with sensor |
| AU2017376111B2 (en) | 2016-12-12 | 2023-02-02 | Bigfoot Biomedical, Inc. | Alarms and alerts for medication delivery devices and related systems and methods |
| US10583250B2 (en) | 2017-01-13 | 2020-03-10 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| EP4708311A3 (en) | 2017-01-13 | 2026-05-20 | Insulet Corporation | METHODS, SYSTEMS AND DEVICES FOR INSULIN ADMINISTRATION |
| EP4708310A3 (en) | 2017-01-13 | 2026-05-06 | Insulet Corporation | Insulin delivery methods, systems and devices |
| US10758675B2 (en) | 2017-01-13 | 2020-09-01 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| US10881793B2 (en) | 2017-01-13 | 2021-01-05 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| US10500334B2 (en) | 2017-01-13 | 2019-12-10 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| EP3398558A1 (en) | 2017-05-02 | 2018-11-07 | Carlo Andretta | In body perfusion system |
| CA3059985C (en) | 2017-05-05 | 2023-08-08 | Eli Lilly And Company | Closed loop control of physiological glucose |
| US12653426B2 (en) | 2017-07-13 | 2026-06-16 | Bigfoot Biomedical, Inc. | Multi-scale display of blood glucose information |
| EP4765154A2 (en) | 2017-08-02 | 2026-06-24 | Diabeloop | Closed-loop blood glucose control systems and methods |
| JP7133625B2 (ja) | 2017-12-21 | 2022-09-08 | イーライ リリー アンド カンパニー | 生理的グルコースの閉ループ制御 |
| USD928199S1 (en) | 2018-04-02 | 2021-08-17 | Bigfoot Biomedical, Inc. | Medication delivery device with icons |
| US11565043B2 (en) | 2018-05-04 | 2023-01-31 | Insulet Corporation | Safety constraints for a control algorithm based drug delivery system |
| US12562251B1 (en) | 2018-05-09 | 2026-02-24 | Bigfoot Biomedical, Inc. | Computing architecture for assuring the provenance of medication therapy related parameters, and related systems, methods and devices |
| CN112313754A (zh) | 2018-06-22 | 2021-02-02 | 伊莱利利公司 | 胰岛素和普兰林肽输送系统、方法和设备 |
| US11147922B2 (en) * | 2018-07-13 | 2021-10-19 | Iowa State University Research Foundation, Inc. | Feedback predictive control approach for processes with time delay in the manipulated variable |
| CN109116738B (zh) * | 2018-09-27 | 2021-04-13 | 杭州电子科技大学 | 一种工业加热炉的二自由度内模控制分析方法 |
| AU2019347755B2 (en) | 2018-09-28 | 2023-02-02 | Insulet Corporation | Activity mode for artificial pancreas system |
| WO2020077223A1 (en) | 2018-10-11 | 2020-04-16 | Insulet Corporation | Event detection for drug delivery system |
| USD920343S1 (en) | 2019-01-09 | 2021-05-25 | Bigfoot Biomedical, Inc. | Display screen or portion thereof with graphical user interface associated with insulin delivery |
| KR102788429B1 (ko) | 2019-05-02 | 2025-03-27 | 삼성전자주식회사 | 개인화된 생체 정보 보정 장치 및 방법 |
| US11801344B2 (en) | 2019-09-13 | 2023-10-31 | Insulet Corporation | Blood glucose rate of change modulation of meal and correction insulin bolus quantity |
| US11935637B2 (en) | 2019-09-27 | 2024-03-19 | Insulet Corporation | Onboarding and total daily insulin adaptivity |
| EP4354455B1 (en) | 2019-12-06 | 2025-10-29 | Insulet Corporation | Techniques and devices providing adaptivity and personalization in diabetes treatment |
| US11833329B2 (en) | 2019-12-20 | 2023-12-05 | Insulet Corporation | Techniques for improved automatic drug delivery performance using delivery tendencies from past delivery history and use patterns |
| WO2021141941A1 (en) | 2020-01-06 | 2021-07-15 | Insulet Corporation | Prediction of meal and/or exercise events based on persistent residuals |
| WO2021158580A1 (en) | 2020-02-03 | 2021-08-12 | Insulet Corporation | Use of fuzzy logic in predicting user behavior affecting blood glucose concentration |
| US11551802B2 (en) | 2020-02-11 | 2023-01-10 | Insulet Corporation | Early meal detection and calorie intake detection |
| US11986630B2 (en) | 2020-02-12 | 2024-05-21 | Insulet Corporation | Dual hormone delivery system for reducing impending hypoglycemia and/or hyperglycemia risk |
| US11547800B2 (en) | 2020-02-12 | 2023-01-10 | Insulet Corporation | User parameter dependent cost function for personalized reduction of hypoglycemia and/or hyperglycemia in a closed loop artificial pancreas system |
| US11324889B2 (en) | 2020-02-14 | 2022-05-10 | Insulet Corporation | Compensation for missing readings from a glucose monitor in an automated insulin delivery system |
| US12495994B2 (en) | 2020-02-20 | 2025-12-16 | Insulet Corporation | Meal bolus subcategories in model based insulin therapy |
| US11607493B2 (en) | 2020-04-06 | 2023-03-21 | Insulet Corporation | Initial total daily insulin setting for user onboarding |
| US12121700B2 (en) | 2020-07-22 | 2024-10-22 | Insulet Corporation | Open-loop insulin delivery basal parameters based on insulin delivery records |
| US11684716B2 (en) | 2020-07-31 | 2023-06-27 | Insulet Corporation | Techniques to reduce risk of occlusions in drug delivery systems |
| US12569619B2 (en) | 2020-09-21 | 2026-03-10 | Insulet Corporation | Techniques for determining automated insulin delivery dosages |
| US12115351B2 (en) | 2020-09-30 | 2024-10-15 | Insulet Corporation | Secure wireless communications between a glucose monitor and other devices |
| EP4696344A3 (en) | 2020-09-30 | 2026-04-15 | Insulet Corporation | Drug delivery device with integrated optical-based glucose monitor |
| CN112398401B (zh) * | 2020-10-29 | 2022-03-29 | 上海大学 | 一种基于参数失配的低开关频率多步模型预测控制方法 |
| EP4285376A1 (en) | 2021-01-29 | 2023-12-06 | Insulet Corporation | Techniques and devices that adapt basal profiles for drug delivery applications |
| US11160925B1 (en) | 2021-01-29 | 2021-11-02 | Insulet Corporation | Automatic drug delivery system for delivery of a GLP-1 therapeutic |
| US12636435B2 (en) | 2021-02-26 | 2026-05-26 | Insulet Corporation | Techniques for optimizing usage of an automatic drug delivery system |
| US11904140B2 (en) | 2021-03-10 | 2024-02-20 | Insulet Corporation | Adaptable asymmetric medicament cost component in a control system for medicament delivery |
| WO2022192482A1 (en) | 2021-03-10 | 2022-09-15 | Insulet Corporation | A medicament delivery device with an adjustable and piecewise analyte level cost component to address persistent positive analyte level excursions |
| US20220331520A1 (en) * | 2021-04-20 | 2022-10-20 | Insulet Corporation | Automatic drug delivery system for individuals with type-2 diabetes |
| US12592306B2 (en) | 2021-04-28 | 2026-03-31 | Insulet Corporation | Devices and methods for initialization of drug delivery devices using measured analyte sensor information |
| US20220351820A1 (en) * | 2021-05-01 | 2022-11-03 | Christopher Richard Wilson | Method for determining glucose-dependent insulin sensitivity factors |
| US12496398B2 (en) | 2021-05-28 | 2025-12-16 | Insulet Corporation | Threshold based automatic glucose control response |
| EP4101482A1 (en) | 2021-06-07 | 2022-12-14 | Insulet Corporation | Exercise safety prediction based on physiological conditions |
| US12514980B2 (en) | 2021-06-30 | 2026-01-06 | Insulet Corporation | Adjustment of medicament delivery by a medicament delivery device based on menstrual cycle phase |
| US12521486B2 (en) | 2021-07-16 | 2026-01-13 | Insulet Corporation | Method for modification of insulin delivery during pregnancy in automatic insulin delivery systems |
| US12653949B2 (en) | 2021-07-29 | 2026-06-16 | Insulet Corporation | Adaptation of medicament delivery in response to user stress load |
| EP4409581A1 (en) | 2021-09-27 | 2024-08-07 | Insulet Corporation | Techniques enabling adaptation of parameters in aid systems by user input |
| CN116020006B (zh) * | 2021-10-25 | 2025-12-23 | 上海移宇科技股份有限公司 | 闭环人工胰腺胰岛素输注控制系统 |
| CN116020007B (zh) * | 2021-10-25 | 2025-11-25 | 上海移宇科技股份有限公司 | 闭环人工胰腺胰岛素输注控制系统 |
| WO2023070245A1 (en) * | 2021-10-25 | 2023-05-04 | Medtrum Technologies Inc. | Closed-loop artificial pancreas insulin infusion control system |
| US11439754B1 (en) | 2021-12-01 | 2022-09-13 | Insulet Corporation | Optimizing embedded formulations for drug delivery |
| WO2023150737A1 (en) | 2022-02-07 | 2023-08-10 | Insulet Corporation | Techniques for determining medication correction factors in automatic medication delivery systems |
| EP4243030A1 (en) | 2022-03-09 | 2023-09-13 | Insulet Corporation | Adjusting medicament delivery parameters in an open loop medicament delivery mode |
| EP4511843A1 (en) | 2022-04-21 | 2025-02-26 | Insulet Corporation | Insulin adaptation and safety monitoring for sick day management |
| KR20250129777A (ko) | 2023-01-06 | 2025-08-29 | 인슐렛 코포레이션 | 후속 자동 안전 제약 완화를 갖는 자동으로 또는 수동으로 개시되는 음식 볼러스 전달 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120123234A1 (en) * | 2009-02-26 | 2012-05-17 | Eran Atlas | Method and system for automatic monitoring of diabetes related treatments |
Family Cites Families (12)
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|---|---|---|---|---|
| US7806886B2 (en) * | 1999-06-03 | 2010-10-05 | Medtronic Minimed, Inc. | Apparatus and method for controlling insulin infusion with state variable feedback |
| AU2001291189A1 (en) * | 2000-09-22 | 2002-04-02 | Knobbe, Lim And Buckingham | Method and apparatus for real-time estimation and control of pysiological parameters |
| US7460130B2 (en) * | 2000-09-26 | 2008-12-02 | Advantage 3D Llc | Method and system for generation, storage and distribution of omni-directional object views |
| US6544212B2 (en) * | 2001-07-31 | 2003-04-08 | Roche Diagnostics Corporation | Diabetes management system |
| US8114023B2 (en) * | 2006-07-28 | 2012-02-14 | Legacy Emanuel Hospital & Health Center | Analyte sensing and response system |
| EP2166946B1 (en) * | 2007-06-21 | 2019-11-20 | University Of Virginia Patent Foundation | Lqg artificial pancreas control system and related method |
| GR1007310B (el) * | 2009-03-09 | 2011-06-10 | Αχιλλεας Τσουκαλης | Εμφυτευσιμος βιοαισθητηρας με αυτοματη βαθμονομηση |
| US8880164B2 (en) * | 2009-04-20 | 2014-11-04 | University of Technology, Sydney Ultimo | Method and system for determining a variation in a metabolic function and managing the variation accordingly |
| EP4325520A3 (en) * | 2009-05-29 | 2024-05-15 | University Of Virginia Patent Foundation | System coordinator and modular architecture for open-loop and closed-loop control of diabetes |
| US8762070B2 (en) * | 2010-02-11 | 2014-06-24 | Regents Of The University Of California | Systems, devices and methods to deliver biological factors or drugs to a subject |
| US9907909B2 (en) * | 2012-12-20 | 2018-03-06 | Animas Corporation | Method and system for a hybrid control-to-target and control-to-range model predictive control of an artificial pancreas |
| WO2014109898A1 (en) * | 2013-01-14 | 2014-07-17 | The Regents Of University Of California | Model-based personalization scheme of an artificial pancreas for type i diabetes applications |
-
2013
- 2013-12-22 WO PCT/US2013/077363 patent/WO2014109898A1/en not_active Ceased
-
2014
- 2014-01-13 AU AU2014205120A patent/AU2014205120B2/en active Active
- 2014-01-13 WO PCT/US2014/011360 patent/WO2014110538A1/en not_active Ceased
- 2014-01-13 KR KR1020157021705A patent/KR102211352B1/ko active Active
- 2014-01-13 JP JP2015552868A patent/JP2016506775A/ja not_active Withdrawn
- 2014-01-13 CA CA2897189A patent/CA2897189C/en active Active
- 2014-01-13 EP EP14737937.4A patent/EP2943149B1/en active Active
-
2015
- 2015-07-06 US US14/792,524 patent/US10413664B2/en active Active
-
2018
- 2018-12-06 JP JP2018228853A patent/JP6914907B2/ja active Active
-
2019
- 2019-09-17 US US16/574,076 patent/US11197955B2/en active Active
-
2021
- 2021-12-14 US US17/549,935 patent/US12102796B2/en active Active
-
2024
- 2024-07-15 US US18/773,448 patent/US20240366873A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120123234A1 (en) * | 2009-02-26 | 2012-05-17 | Eran Atlas | Method and system for automatic monitoring of diabetes related treatments |
Non-Patent Citations (2)
| Title |
|---|
| Alessia Tagliavini, "Development and evaluation of pid controllers for glucose control in people with type 1 diabetes mellitus", (20120716), URL: http://tesi.cab.unipd.it/40204/, (20160708) * |
| VAN HEUSDEN, K. ET AL., "Control-Relevant Models for Glucose Control Using A Priori Patient Characteristics", IEEE TRANS. BIO. ENG., (2012), vol. 59, pages 1839 - 1849 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20150306314A1 (en) | 2015-10-29 |
| JP6914907B2 (ja) | 2021-08-04 |
| EP2943149B1 (en) | 2020-09-30 |
| JP2016506775A (ja) | 2016-03-07 |
| CA2897189A1 (en) | 2014-07-17 |
| US10413664B2 (en) | 2019-09-17 |
| KR20150108862A (ko) | 2015-09-30 |
| CA2897189C (en) | 2017-09-05 |
| EP2943149A1 (en) | 2015-11-18 |
| JP2019055258A (ja) | 2019-04-11 |
| WO2014109898A1 (en) | 2014-07-17 |
| US20220105270A1 (en) | 2022-04-07 |
| US20240366873A1 (en) | 2024-11-07 |
| US11197955B2 (en) | 2021-12-14 |
| US12102796B2 (en) | 2024-10-01 |
| AU2014205120A1 (en) | 2015-07-23 |
| WO2014110538A1 (en) | 2014-07-17 |
| US20200078516A1 (en) | 2020-03-12 |
| KR102211352B1 (ko) | 2021-02-03 |
| EP2943149A4 (en) | 2016-08-17 |
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