AU2013364043B2 - Anti-NTB-A antibodies and related compositions and methods - Google Patents

Anti-NTB-A antibodies and related compositions and methods Download PDF

Info

Publication number
AU2013364043B2
AU2013364043B2 AU2013364043A AU2013364043A AU2013364043B2 AU 2013364043 B2 AU2013364043 B2 AU 2013364043B2 AU 2013364043 A AU2013364043 A AU 2013364043A AU 2013364043 A AU2013364043 A AU 2013364043A AU 2013364043 B2 AU2013364043 B2 AU 2013364043B2
Authority
AU
Australia
Prior art keywords
antibody
seq
ntb
amino acid
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013364043A
Other languages
English (en)
Other versions
AU2013364043A1 (en
Inventor
Che-Leung Law
Tim Lewis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seagen Inc
Original Assignee
Seagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seagen Inc filed Critical Seagen Inc
Publication of AU2013364043A1 publication Critical patent/AU2013364043A1/en
Application granted granted Critical
Publication of AU2013364043B2 publication Critical patent/AU2013364043B2/en
Assigned to SEAGEN INC. reassignment SEAGEN INC. Request to Amend Deed and Register Assignors: SEATTLE GENETICS, INC.
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2013364043A 2012-12-21 2013-12-20 Anti-NTB-A antibodies and related compositions and methods Ceased AU2013364043B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261745239P 2012-12-21 2012-12-21
US61/745,239 2012-12-21
PCT/US2013/077264 WO2014100740A1 (en) 2012-12-21 2013-12-20 Anti-ntb-a antibodies and related compositions and methods

Publications (2)

Publication Number Publication Date
AU2013364043A1 AU2013364043A1 (en) 2015-06-18
AU2013364043B2 true AU2013364043B2 (en) 2018-01-04

Family

ID=50979291

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013364043A Ceased AU2013364043B2 (en) 2012-12-21 2013-12-20 Anti-NTB-A antibodies and related compositions and methods

Country Status (10)

Country Link
US (4) US9708404B2 (enExample)
EP (1) EP2934585B1 (enExample)
JP (4) JP6449777B2 (enExample)
CN (2) CN107880126B (enExample)
AU (1) AU2013364043B2 (enExample)
CA (1) CA2893977C (enExample)
EA (1) EA031025B1 (enExample)
HK (1) HK1216850A1 (enExample)
IL (2) IL239211B (enExample)
WO (1) WO2014100740A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101842114A (zh) * 2007-08-02 2010-09-22 阿雷斯托生物科学股份有限公司 治疗和诊断纤维化、肿瘤侵入、血管生成和转移的方法和组合物
AU2013364043B2 (en) * 2012-12-21 2018-01-04 Seagen Inc. Anti-NTB-A antibodies and related compositions and methods
US9732154B2 (en) 2014-02-28 2017-08-15 Janssen Biotech, Inc. Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
US9603927B2 (en) 2014-02-28 2017-03-28 Janssen Biotech, Inc. Combination therapies with anti-CD38 antibodies
JP2017534251A (ja) * 2014-09-09 2017-11-24 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム Ａｇｒ２およびその受容体ｃ４．４ａに対する遮断モノクローナル抗体
CA2944085C (en) 2014-09-16 2018-04-10 Ease Charm Limited Anti-egfr antibody and uses of same
ES2881575T3 (es) * 2014-09-30 2021-11-29 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts / Univ Heidelberg Moléculas de unión, especialmente anticuerpos, que se unen a L1CAM (CD171)
AU2015339012B2 (en) * 2014-10-31 2020-11-05 Abbvie Biotherapeutics Inc. Anti-CS1 antibodies and antibody drug conjugates
UA123697C2 (uk) 2014-12-04 2021-05-19 Янссен Байотек, Інк. Спосіб лікування гострого мієлоїдного лейкозу шляхом застосування антитіла до cd38
AU2016264725B2 (en) 2015-05-20 2021-05-27 Janssen Biotech, Inc. Anti-CD38 antibodies for treatment of light chain amyloidosis and other CD38-positive hematological malignancies
US20170044265A1 (en) * 2015-06-24 2017-02-16 Janssen Biotech, Inc. Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38
PT3316909T (pt) * 2015-06-30 2023-11-22 Seattle Genetics Inc Anticorpos anti-ntb-a e composições e métodos relacionados
SI3370770T1 (sl) 2015-11-03 2021-03-31 Janssen Biotech, Inc. Subkutane formulacije protiteles proti CD38 in njihove uporabe
EP3703749A1 (en) 2017-10-31 2020-09-09 Janssen Biotech, Inc. Methods of treating high risk multiple myeloma
US12037410B2 (en) * 2018-02-13 2024-07-16 Precision Biologics, Inc. Methods and compositions for targeting Treg cells
CA3143087A1 (en) 2019-07-03 2021-01-07 Arnima BISHT Antibodies and methods of use
CN114650843B (zh) * 2019-10-04 2025-04-01 Tae生命科学有限责任公司 包括fc突变和位点特异性缀合性质的抗体组合物
WO2021111005A1 (en) 2019-12-06 2021-06-10 Thoas Fioretos Novel agents and uses thereof
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110141204A1 (en) * 2009-12-15 2011-06-16 Xerox Corporation Print Head Having a Polymer Layer to Facilitate Assembly of the Print Head

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5515508A (en) 1993-12-17 1996-05-07 Taligent, Inc. Client server system and method of operation including a dynamically configurable protocol stack
WO1996036361A1 (en) 1995-05-18 1996-11-21 The Regents Of The University Of Michigan Dna binding antibodies
MA24512A1 (fr) 1996-01-17 1998-12-31 Univ Vermont And State Agrienl Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose
WO2001053466A1 (en) 1999-12-23 2001-07-26 Hyseq, Inc. Methods and materials relating to semaphorin-like polypeptides and polynucleotides
JP2003521903A (ja) 2000-01-25 2003-07-22 ハイセック，インコーポレーテッド Ｃｄ８４様ポリペプチドおよびポリヌクレオチドに関する方法と材料
WO2001079454A1 (en) 2000-04-13 2001-10-25 Smithkline Beecham Corporation Novel compounds
WO2001090304A2 (en) 2000-05-19 2001-11-29 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
US6464770B1 (en) 2000-08-08 2002-10-15 Advanced Minerals Corporation Perlite products with controlled particle size distribution
AU2002216610A1 (en) 2000-09-01 2002-04-02 Genentech Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7795412B2 (en) 2000-09-15 2010-09-14 Genentech, Inc. Nucleic acids encoding PRO6308 polypeptides and related vectors and host cells
US20030180888A1 (en) 2000-11-03 2003-09-25 Millennium Pharmaceuticals, Inc. CD2000 and CD2001 molecules, and uses thereof
EP1223218A1 (en) 2000-11-03 2002-07-17 Millennium Pharmaceuticals, Inc. CD2000 and CD2001 molecules and uses thereof
US7892730B2 (en) 2000-12-22 2011-02-22 Sagres Discovery, Inc. Compositions and methods for cancer
CA2440618A1 (en) 2001-03-12 2002-09-19 Incyte Genomics, Inc. Immunoglobulin superfamily proteins
DE60235985D1 (de) 2001-07-19 2010-05-27 Innate Pharma Ntb-a, ein oberflächenmolekül impliziert in der aktivität natürlicher killerzellen (nk)
MXPA04001986A (es) 2001-08-29 2004-06-07 Genentech Inc Composiciones y metodos para el tratamiento de enfermedades relacionadas a la inmunidad.
US20060194265A1 (en) 2001-10-23 2006-08-31 Morris David W Novel therapeutic targets in cancer
EP1483407A4 (en) 2002-02-14 2006-11-15 Nuvelo Inc THERAPEUTIC AND DIAGNOSTIC METHODS
EP1572130A4 (en) 2002-07-08 2008-07-02 Genentech Inc COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNEAL DISEASES
DK1545613T3 (da) 2002-07-31 2011-11-14 Seattle Genetics Inc Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
WO2004016733A2 (en) 2002-08-16 2004-02-26 Agensys, Inc. Nucleic acid and corresponding protein entitled 251p5g2 useful in treatment and detection of cancer
WO2004080148A2 (en) 2002-10-02 2004-09-23 Nuvelo, Inc. Novel nucleic acids and polypeptides
WO2005019258A2 (en) 2003-08-11 2005-03-03 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
PL2489364T3 (pl) 2003-11-06 2015-06-30 Seattle Genetics Inc Związki monometylowaliny zdolne do sprzęgania do przeciwciał
US20080299042A1 (en) 2004-04-30 2008-12-04 Biogen Idec Ma Inc. Membrane Associated Molecules
EA016357B1 (ru) 2004-07-30 2012-04-30 Ринат Ньюросайенс Корп. Антитела, направленные против бета-амилоидного пептида, и способы их применения
WO2007008603A1 (en) 2005-07-07 2007-01-18 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus
WO2007008848A2 (en) 2005-07-07 2007-01-18 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
NZ566982A (en) * 2005-09-26 2011-06-30 Medarex Inc Duocarmycin drug conjugates
TW200823237A (en) * 2006-08-28 2008-06-01 Nuvelo Inc Antibodies to NTB-A
EP2206590A4 (en) * 2007-10-03 2014-02-12 Boada Germans Sa HAND CUTTING TOOL FOR CERAMIC
AR068723A1 (es) * 2007-10-05 2009-12-02 Glaxo Group Ltd Proteina que se une a antigenos que se une a il-23 humana y sus usos
PT2211904T (pt) 2007-10-19 2016-11-02 Seattle Genetics Inc Agentes de ligação a cd19 e seus usos
JP2012500815A (ja) 2008-08-29 2012-01-12 シムフォゲン・アクティーゼルスカブ 抗ｃｄ５抗体
CN102333859B (zh) * 2008-09-16 2015-04-22 三井化学株式会社 由来自植物的原料生产乳酸的方法及生产乳酸的细菌
EP2414393A1 (en) 2009-04-01 2012-02-08 Glaxo Group Limited Anti-il-23 immunoglobulins
PH12011502602A1 (en) 2009-06-17 2012-11-12 Abbvie Biotherapeutics Inc Anti-vegf antibodies and their uses
US8221753B2 (en) 2009-09-30 2012-07-17 Tracon Pharmaceuticals, Inc. Endoglin antibodies
WO2011086197A1 (en) 2010-01-18 2011-07-21 Novo Nordisk Health Care Ag Purification of blood coagulation factors
UA108227C2 (xx) * 2010-03-03 2015-04-10 Антигензв'язуючий білок
EP2558493B1 (en) 2010-04-15 2019-09-18 Progenics Pharmaceuticals, Inc. Antibodies for the treatment of clostridium difficile-associated infection and disease
US9243057B2 (en) * 2010-08-31 2016-01-26 The Regents Of The University Of California Antibodies for botulinum neurotoxins
EP3318633A1 (en) * 2010-11-17 2018-05-09 Chugai Seiyaku Kabushiki Kaisha Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii
EP2643350A4 (en) 2010-11-22 2015-01-07 Innate Pharma Sa TREATMENTS WITH NK CELL MODULATION AND METHOD FOR THE TREATMENT OF HEMATOLOGICAL MALIGNOMES
PH12014500089A1 (en) 2011-07-11 2014-02-17 Ichnos Sciences SA Antibodies that bind to ox40 and their uses
US8790651B2 (en) * 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
AU2013364043B2 (en) 2012-12-21 2018-01-04 Seagen Inc. Anti-NTB-A antibodies and related compositions and methods
EP2824112B1 (en) * 2013-07-10 2016-12-21 Miltenyi Biotec GmbH Method for inducing proliferation of Natural Killer cells by mobile nanomatrices
PT3316909T (pt) * 2015-06-30 2023-11-22 Seattle Genetics Inc Anticorpos anti-ntb-a e composições e métodos relacionados

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110141204A1 (en) * 2009-12-15 2011-06-16 Xerox Corporation Print Head Having a Polymer Layer to Facilitate Assembly of the Print Head

Also Published As

Publication number Publication date
IL239211A0 (en) 2015-07-30
JP2020055870A (ja) 2020-04-09
EP2934585A4 (en) 2016-07-13
CA2893977A1 (en) 2014-06-26
CN107880126A (zh) 2018-04-06
HK1216850A1 (zh) 2016-12-09
JP6817674B2 (ja) 2021-01-20
US20190375841A1 (en) 2019-12-12
JP2022066565A (ja) 2022-04-28
IL239211B (en) 2020-08-31
WO2014100740A1 (en) 2014-06-26
JP2019014752A (ja) 2019-01-31
EA201591191A1 (ru) 2015-11-30
AU2013364043A1 (en) 2015-06-18
US20150376276A1 (en) 2015-12-31
US9708404B2 (en) 2017-07-18
JP6449777B2 (ja) 2019-01-09
CN105188749B (zh) 2017-12-19
CA2893977C (en) 2024-02-13
CN105188749A (zh) 2015-12-23
US20230105802A1 (en) 2023-04-06
JP2016503067A (ja) 2016-02-01
CN107880126B (zh) 2021-03-30
IL271305B (en) 2021-01-31
IL271305A (en) 2020-01-30
US10435468B2 (en) 2019-10-08
EA031025B1 (ru) 2018-11-30
EP2934585B1 (en) 2018-06-13
EP2934585A1 (en) 2015-10-28
US20170320944A1 (en) 2017-11-09

Similar Documents

Publication Publication Date Title
US20230105802A1 (en) Anti-ntb-a antibodies and related compositions and methods
US20230218776A1 (en) Anti-ntb-a antibodies and related compositions and methods
US20210047404A1 (en) Cd33 antibodies and use of same to treat cancer
CA2986796C (en) Anti-ntb-a antibodies and related compositions and methods
HK1253306B (en) Anti-ntb-a antibodies and related compositions and methods
HK1206750B (en) Cd33 antibodies and use of same to treat cancer

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
HB Alteration of name in register

Owner name: SEAGEN INC.

Free format text: FORMER NAME(S): SEATTLE GENETICS, INC.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired