AU2013358591B2 - Pyrimido [4,5-b]quinoline-4,5 (3H,10H)-diones as nonsense mutation suppressors - Google Patents

Pyrimido [4,5-b]quinoline-4,5 (3H,10H)-diones as nonsense mutation suppressors Download PDF

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Publication number
AU2013358591B2
AU2013358591B2 AU2013358591A AU2013358591A AU2013358591B2 AU 2013358591 B2 AU2013358591 B2 AU 2013358591B2 AU 2013358591 A AU2013358591 A AU 2013358591A AU 2013358591 A AU2013358591 A AU 2013358591A AU 2013358591 B2 AU2013358591 B2 AU 2013358591B2
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quinoline
dione
methyl
amino
4alkyl
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Ceased
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AU2013358591A
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AU2013358591A1 (en
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Edgar Jacoby
Juergen Reinhardt
Niko Schmiedeberg
Carsten Spanka
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Novartis AG
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Novartis AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Inorganic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2013358591A 2012-12-13 2013-12-12 Pyrimido [4,5-b]quinoline-4,5 (3H,10H)-diones as nonsense mutation suppressors Ceased AU2013358591B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261736748P 2012-12-13 2012-12-13
US61/736,748 2012-12-13
PCT/IB2013/060859 WO2014091446A1 (en) 2012-12-13 2013-12-12 Pyrimido [4,5-b]quinoline-4,5 (3h,10h)-diones as nonsense mutation suppressors

Publications (2)

Publication Number Publication Date
AU2013358591A1 AU2013358591A1 (en) 2015-05-28
AU2013358591B2 true AU2013358591B2 (en) 2016-08-25

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AU2013358591A Ceased AU2013358591B2 (en) 2012-12-13 2013-12-12 Pyrimido [4,5-b]quinoline-4,5 (3H,10H)-diones as nonsense mutation suppressors

Country Status (24)

Country Link
US (2) US9649314B2 (enExample)
EP (1) EP2931282B1 (enExample)
JP (1) JP6076498B2 (enExample)
KR (1) KR101760586B1 (enExample)
CN (2) CN107569487A (enExample)
AP (1) AP2015008441A0 (enExample)
AU (1) AU2013358591B2 (enExample)
BR (1) BR112015013535A2 (enExample)
CA (1) CA2890692A1 (enExample)
CL (1) CL2015001610A1 (enExample)
CR (1) CR20150314A (enExample)
CU (1) CU20150061A7 (enExample)
EA (1) EA028673B1 (enExample)
ES (1) ES2709034T3 (enExample)
HK (1) HK1209637A1 (enExample)
IL (1) IL239244A0 (enExample)
IN (1) IN2015DN03998A (enExample)
MA (1) MA38157A1 (enExample)
MX (1) MX363437B (enExample)
PE (1) PE20151062A1 (enExample)
PH (1) PH12015501216A1 (enExample)
SG (1) SG11201503684WA (enExample)
TN (1) TN2015000262A1 (enExample)
WO (1) WO2014091446A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX363437B (es) 2012-12-13 2019-03-22 Novartis Ag Pirimido-4,5-b]-quinolina-4,5 (3h,10h)-dionas como supresoras de mutacion sin sentido.
WO2015186062A1 (en) * 2014-06-03 2015-12-10 Novartis Ag PYRIMIDO[4,5-b]QUINOLINE-4,5(3H,10H)-DIONE DERIVATIVES
EP3152207B1 (en) 2014-06-03 2019-05-08 Novartis AG Pyridopyrimidinedione derivatives as suppressors of non-sens mutations
CA2950724A1 (en) * 2014-06-03 2015-12-10 Novartis Ag Naphthyridinedione derivatives
US10960018B2 (en) * 2016-04-15 2021-03-30 The Uab Research Foundation Methods and compounds for stimulating read-through of premature termination codons
WO2019173437A1 (en) * 2018-03-06 2019-09-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Positive allosteric modulators of dopamine 1 receptor and method of use thereof
WO2019225625A1 (ja) * 2018-05-23 2019-11-28 京都薬品工業株式会社 リードスルー誘導剤およびその医薬用途
AU2021341508A1 (en) 2020-09-10 2023-05-25 Precirix N.V. Antibody fragment against fap
CN117242060B (zh) 2021-01-13 2026-07-17 蒙特罗莎治疗股份有限公司 异吲哚啉酮化合物
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
AU2023264245A1 (en) 2022-05-02 2024-12-19 Precirix N.V. Pre-targeting
WO2024194607A1 (en) 2023-03-17 2024-09-26 Tay Therapeutics Limited Pyrimido[4,5-b][1,5]naphthyridine-4,5(3h,10h)-dione derivatives for the treatment of diseases associated with ptc mutations, such as e.g. cancer

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2884170B2 (ja) * 1989-08-24 1999-04-19 株式会社フジモト・ブラザーズ ５−デアザフラビン系化合物を有効成分とする制癌剤
WO1996028444A1 (en) 1995-03-15 1996-09-19 Pfizer Inc. 5,10-DIHYDROPYRIMIDO[4,5-b]QUINOLIN-4(1H)-ONE TYROSINE KINASE INHIBITORS
US6468990B1 (en) 1999-05-17 2002-10-22 Queen's University At Kingston Method of inhibiting binding of nerve growth factor to p75 NTR receptor
WO2004078163A2 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
WO2004006906A2 (en) 2002-07-15 2004-01-22 Combinatorx, Incorporated Methods for the treatment of neoplasms
EP4101846B1 (en) 2003-04-11 2023-08-02 PTC Therapeutics, Inc. 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
HUE031643T2 (en) 2006-04-03 2017-07-28 Technion Res & Dev Foundation New aminoglycosides and their applications in the treatment of genetic disorders
US20080090845A1 (en) 2006-08-23 2008-04-17 Neurogen Corporation Haloalkyl-substituted pyrimidinone derivatives
AU2008345225A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
EP2422817A1 (en) 2010-07-29 2012-02-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Flavin-nucleic acid ligand conjugates
JP5877200B2 (ja) 2010-08-05 2016-03-02 ユニヴェルシテ ドゥ ドロワ エ サンテ ドゥ リール ナンセンス突然変異による疾患の治療に有用な化合物及びその化合物を含む医薬組成物
MX363437B (es) 2012-12-13 2019-03-22 Novartis Ag Pirimido-4,5-b]-quinolina-4,5 (3h,10h)-dionas como supresoras de mutacion sin sentido.

Non-Patent Citations (24)

* Cited by examiner, † Cited by third party
Title
CAS Registry Number 883958-36-9; STN Entry Date 12 May 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclohexyl-10-methyl-3-phenyl- *
CAS Registry Number 883962-24-1; STN Entry Date 12 May 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cycloheptyl-2-cyclohexyl-10-methyl- *
CAS Registry Number 883962-27-4; STN Entry Date 12 May 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cycloheptyl-10-methyl-2-pentyl- *
CAS Registry Number 883962-30-9; STN Entry Date 12 May 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cycloheptyl-10-methyl-2-propyl- *
CAS Registry Number 896599-57-8; STN Entry Date 28 Jul 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cyclohexyl-2-(2-furanyl)-10-methyl- *
CAS Registry Number 896835-70-4; STN Entry Date 28 Jul 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cycloheptyl-2-ethyl-10-methyl- *
CAS Registry Number 898913-99-0; STN Entry Date 06 Aug 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cyclopentyl-10-methyl-2-(2-methylphenyl)- *
CAS Registry Number 898916-50-2; STN Entry Date 06 Aug 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cyclopentyl-2-ethyl-10-methyl- *
CAS Registry Number 898918-28-0; STN Entry Date 06 Aug 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cyclopentyl-10-methyl-2-(1-methylethyl)- *
CAS Registry Number 898920-22-4; STN Entry Date 06 Aug 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cyclopentyl-10-methyl-2-(2-thienyl)- *
CAS Registry Number 898921-75-0; STN Entry Date 06 Aug 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-(3,5-dimethylphenyl)-2-ethyl-10-methyl- *
CAS Registry Number 898923-07-4; STN Entry Date 06 Aug 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 10-methyl-3-phenyl-2-propyl- *
CAS Registry Number 898924-26-0; STN Entry Date 06 Aug 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cyclohexyl-10-methyl-2-(2-methylphenyl)- *
CAS Registry Number 899383-20-1; STN Entry Date 07 Aug 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cycloheptyl-10-methyl-2-(3,4,5-trimethoxyphenyl)- *
CAS Registry Number 899392-31-5; STN Entry Date 07 Aug 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cyclohexyl-2-(4-methoxyphenyl)-10-methyl- *
CAS Registry Number 899399-83-8; STN Entry Date 07 Aug 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cyclohexyl-2-(2,4-dichlorophenyl)-10-methyl- *
CAS Registry Number 899403-25-9; STN Entry Date 07 Aug 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cyclopentyl-10-methyl-2-(3,4,5-trimethoxyphenyl)- *
CAS Registry Number 899404-28-5; STN Entry Date 07 Aug 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-(3,5-dimethylphenyl)-10-methyl-2-propyl- *
CAS Registry Number 899407-21-7; STN Entry Date 07 Aug 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione,3-cyclopentyl-2-(4-methoxyphenyl)-10-methyl- *
CAS Registry Number 900273-38-3; STN Entry Date 10 Aug 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cyclopentyl-2-[4-(1,1-dimethylethyl)phenyl]-10-methyl- *
CAS Registry Number 900291-66-9; STN Entry Date 10 Aug 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cyclohexyl-10-methyl-2-(2-thienyl)- *
CAS Registry Number 904209-64-9; STN Entry Date 24 Aug 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclohexyl-3-cyclopentyl-10-methyl- *
CAS Registry Number 904509-55-3; STN Entry Date 25 Aug 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-(2-chlorophenyl)-3-cyclopentyl-10-methyl- *
CAS Registry Number 904516-17-2; STN Entry Date 25 Aug 2006; Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cyclopentyl-2-(2-fluorophenyl)-10-methyl- *

Also Published As

Publication number Publication date
KR101760586B1 (ko) 2017-07-21
IN2015DN03998A (enExample) 2015-10-02
EA201591105A1 (ru) 2015-10-30
HK1209637A1 (en) 2016-04-08
EA028673B1 (ru) 2017-12-29
EP2931282B1 (en) 2018-10-31
IL239244A0 (en) 2015-07-30
KR20150092306A (ko) 2015-08-12
JP2016503003A (ja) 2016-02-01
AP2015008441A0 (en) 2015-05-31
ES2709034T3 (es) 2019-04-12
EP2931282A1 (en) 2015-10-21
TN2015000262A1 (en) 2016-10-03
PH12015501216A1 (en) 2015-08-17
MX363437B (es) 2019-03-22
MA38157A1 (fr) 2016-12-30
US20170266189A1 (en) 2017-09-21
CN107569487A (zh) 2018-01-12
CL2015001610A1 (es) 2015-08-07
WO2014091446A1 (en) 2014-06-19
US9649314B2 (en) 2017-05-16
SG11201503684WA (en) 2015-06-29
CA2890692A1 (en) 2014-06-19
US20150335646A1 (en) 2015-11-26
CU20150061A7 (es) 2015-12-23
MX2015007562A (es) 2015-10-14
CN104837490A (zh) 2015-08-12
CR20150314A (es) 2015-08-10
PE20151062A1 (es) 2015-08-05
AU2013358591A1 (en) 2015-05-28
BR112015013535A2 (pt) 2017-07-11
CN104837490B (zh) 2017-10-03
JP6076498B2 (ja) 2017-02-08

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