AU2013285364B2 - Mutant fragments of OspA and methods and uses relating thereto - Google Patents

Mutant fragments of OspA and methods and uses relating thereto Download PDF

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Publication number
AU2013285364B2
AU2013285364B2 AU2013285364A AU2013285364A AU2013285364B2 AU 2013285364 B2 AU2013285364 B2 AU 2013285364B2 AU 2013285364 A AU2013285364 A AU 2013285364A AU 2013285364 A AU2013285364 A AU 2013285364A AU 2013285364 B2 AU2013285364 B2 AU 2013285364B2
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Prior art keywords
ospa
seq
disulfide bond
fragment
borrelia
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AU2013285364A1 (en
Inventor
Par Comstedt
Brigitte Grohmann
Markus Hanner
Urban Lundberg
Andreas Meinke
Christoph Reinisch
Robert Schlegl
Wolfgang Schuler
Benjamin Wizel
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Valneva Austria GmbH
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Valneva Austria GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0225—Spirochetes, e.g. Treponema, Leptospira, Borrelia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1207—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018—Lipids, e.g. in lipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2013285364A 2012-07-06 2013-07-08 Mutant fragments of OspA and methods and uses relating thereto Active AU2013285364B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017218974A AU2017218974C1 (en) 2012-07-06 2017-08-22 Mutant fragments of OspA and methods and uses relating thereto

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261668627P 2012-07-06 2012-07-06
US61/668,627 2012-07-06
US13/802,991 2013-03-14
US13/802,991 US8986704B2 (en) 2012-07-06 2013-03-14 Mutant fragments of OspA and methods and uses relating thereto
PCT/EP2013/064403 WO2014006226A1 (en) 2012-07-06 2013-07-08 MUTANT FRAGMENTS OF OspA AND METHODS AND USES RELATING THERETO

Related Child Applications (1)

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AU2017218974A Division AU2017218974C1 (en) 2012-07-06 2017-08-22 Mutant fragments of OspA and methods and uses relating thereto

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AU2013285364A1 AU2013285364A1 (en) 2015-01-29
AU2013285364B2 true AU2013285364B2 (en) 2017-06-15

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EP (3) EP2869839B1 (enExample)
JP (1) JP6276258B2 (enExample)
KR (2) KR102190981B1 (enExample)
CN (2) CN104487084B (enExample)
AU (2) AU2013285364B2 (enExample)
CA (1) CA2876541C (enExample)
CY (1) CY1120772T1 (enExample)
DK (1) DK2869839T3 (enExample)
EA (2) EA201991059A1 (enExample)
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HR (1) HRP20181689T1 (enExample)
HU (1) HUE041286T2 (enExample)
LT (1) LT2869839T (enExample)
MX (2) MX364623B (enExample)
NZ (2) NZ733026A (enExample)
PL (1) PL2869839T3 (enExample)
PT (1) PT2869839T (enExample)
RS (1) RS57847B1 (enExample)
SI (1) SI2869839T1 (enExample)
SM (1) SMT201800557T1 (enExample)
TR (1) TR201815419T4 (enExample)
WO (1) WO2014006226A1 (enExample)
ZA (1) ZA201409222B (enExample)

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HRP20191086T1 (hr) * 2014-01-09 2019-11-01 Valneva Austria Gmbh Mutantni ospa fragmenti i postupci i uporabe koji se na njih odnose
AU2015281021B9 (en) * 2014-06-27 2019-03-28 Ube Corporation Salt of halogen-substituted heterocyclic compound
WO2016022958A2 (en) * 2014-08-07 2016-02-11 The Trustees Of Columbia University In The City Of New York Tick-associated virus sequences and uses thereof
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US12018054B2 (en) 2017-04-13 2024-06-25 Valneva Austria Gmbh Multivalent OspA polypeptides and methods and uses relating thereto
KR20190001421U (ko) 2019-05-26 2019-06-13 이준형 노크형 내부 수납식 칫솔
CN110483624B (zh) * 2019-08-22 2021-02-09 中国疾病预防控制中心传染病预防控制所 伽氏疏螺旋体OspA蛋白C端肽段及其应用
CN111269919B (zh) * 2020-03-19 2021-07-13 四川农业大学 玉米基因ZmLIP2及其应用
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US9926343B2 (en) 2018-03-27
CN107602676B (zh) 2021-06-04
HK1209370A1 (en) 2016-04-01
EA201991059A1 (ru) 2020-01-31
EP3360568A1 (en) 2018-08-15
CY1120772T1 (el) 2019-12-11
US20170107263A1 (en) 2017-04-20
HK1257893A1 (en) 2019-11-01
EP3689372A1 (en) 2020-08-05
US11466058B2 (en) 2022-10-11
US20220185851A1 (en) 2022-06-16
KR102393038B1 (ko) 2022-04-29
US20140010835A1 (en) 2014-01-09
AU2013285364A1 (en) 2015-01-29
DK2869839T3 (en) 2018-10-15
EA033007B1 (ru) 2019-08-30
CN104487084B (zh) 2017-09-22
HRP20181689T1 (hr) 2018-12-28
US12195501B2 (en) 2025-01-14
EA201590162A1 (ru) 2015-06-30
MX391136B (es) 2025-03-21
PL2869839T3 (pl) 2018-12-31
AU2017218974C1 (en) 2020-02-20
US20170101446A1 (en) 2017-04-13
US8986704B2 (en) 2015-03-24
SMT201800557T1 (it) 2018-11-09
ES2688883T3 (es) 2018-11-07
AU2017218974A1 (en) 2017-09-07
CA2876541A1 (en) 2014-01-09
CN104487084A (zh) 2015-04-01
HK1207982A1 (en) 2016-02-19
JP2015522270A (ja) 2015-08-06
US20150250865A1 (en) 2015-09-10
SI2869839T1 (sl) 2018-11-30
CA2876541C (en) 2022-03-01
TR201815419T4 (tr) 2018-11-21
KR20200141096A (ko) 2020-12-17
US20150232517A1 (en) 2015-08-20
EP2869839A1 (en) 2015-05-13
RS57847B1 (sr) 2018-12-31
EP3360568B1 (en) 2020-03-04
ZA201409222B (en) 2016-08-31
US20230295245A1 (en) 2023-09-21
EP2869839B1 (en) 2018-09-05
KR20150036191A (ko) 2015-04-07
AU2017218974B2 (en) 2019-05-30
HK1248244A1 (zh) 2018-10-12
US10544194B2 (en) 2020-01-28
MX2015000013A (es) 2015-06-04
US20200239525A1 (en) 2020-07-30
US11208439B2 (en) 2021-12-28
ES2800873T3 (es) 2021-01-04
PT2869839T (pt) 2018-11-12
KR102190981B1 (ko) 2020-12-15
MX364623B (es) 2019-05-03
JP6276258B2 (ja) 2018-02-07
CN107602676A (zh) 2018-01-19
NZ703597A (en) 2017-06-30
US20180327460A1 (en) 2018-11-15
NZ733026A (en) 2019-09-27
HUE041286T2 (hu) 2019-05-28
WO2014006226A1 (en) 2014-01-09
LT2869839T (lt) 2018-11-12

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