AU2013279748B2 - Conjugate of a photosensitiser and chitosan and uses thereof - Google Patents
Conjugate of a photosensitiser and chitosan and uses thereof Download PDFInfo
- Publication number
- AU2013279748B2 AU2013279748B2 AU2013279748A AU2013279748A AU2013279748B2 AU 2013279748 B2 AU2013279748 B2 AU 2013279748B2 AU 2013279748 A AU2013279748 A AU 2013279748A AU 2013279748 A AU2013279748 A AU 2013279748A AU 2013279748 B2 AU2013279748 B2 AU 2013279748B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- pct
- cell
- molecule
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 CC(c(cc1)ccc1C(C(C=C1)=NC1=C(C1=CC[C@](C(c2ccccc2)=C2N=C3C=C2)N1)c1ccccc1)=C(CC1)*C1=C3c1ccccc1)=O Chemical compound CC(c(cc1)ccc1C(C(C=C1)=NC1=C(C1=CC[C@](C(c2ccccc2)=C2N=C3C=C2)N1)c1ccccc1)=C(CC1)*C1=C3c1ccccc1)=O 0.000 description 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1208548.6A GB201208548D0 (en) | 2012-05-15 | 2012-05-15 | Compound and method |
| GB1208548.6 | 2012-05-15 | ||
| PCT/EP2013/059968 WO2013189663A1 (en) | 2012-05-15 | 2013-05-14 | Conjugate of a photosensitiser and chitosan and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2013279748A1 AU2013279748A1 (en) | 2014-11-20 |
| AU2013279748B2 true AU2013279748B2 (en) | 2018-08-02 |
Family
ID=46458880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013279748A Ceased AU2013279748B2 (en) | 2012-05-15 | 2013-05-14 | Conjugate of a photosensitiser and chitosan and uses thereof |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US9901636B2 (https=) |
| EP (1) | EP2849791B1 (https=) |
| JP (1) | JP6456284B2 (https=) |
| KR (2) | KR102269861B1 (https=) |
| CN (1) | CN104780941B (https=) |
| AU (1) | AU2013279748B2 (https=) |
| BR (1) | BR112014028315B1 (https=) |
| CA (1) | CA2873259C (https=) |
| DK (1) | DK2849791T3 (https=) |
| ES (1) | ES2682762T3 (https=) |
| GB (1) | GB201208548D0 (https=) |
| HR (1) | HRP20181276T1 (https=) |
| HU (1) | HUE039725T2 (https=) |
| IN (1) | IN2014DN09418A (https=) |
| MX (1) | MX362237B (https=) |
| NZ (1) | NZ630582A (https=) |
| PL (1) | PL2849791T3 (https=) |
| PT (1) | PT2849791T (https=) |
| RU (1) | RU2675830C2 (https=) |
| SG (1) | SG11201407603YA (https=) |
| SI (1) | SI2849791T1 (https=) |
| WO (1) | WO2013189663A1 (https=) |
| ZA (1) | ZA201408406B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9905911D0 (en) | 1999-03-15 | 1999-05-05 | Photocure As | Method |
| US10973896B2 (en) | 2014-04-11 | 2021-04-13 | Pci Biotech As | Treatment or prevention of melanoma using photochemical internalization of a melanoma antigen |
| WO2016030529A1 (en) * | 2014-08-28 | 2016-03-03 | Pci Biotech As | Compound and method |
| CN104650259A (zh) * | 2015-01-23 | 2015-05-27 | 广西大学 | 一种纳米孔壳聚糖四(4-磺酸基苯基)金属卟啉微球及其制备方法和使用方法 |
| GB201503776D0 (en) | 2015-03-05 | 2015-04-22 | Pci Biotech As | Compound and method |
| GB201511159D0 (en) | 2015-06-24 | 2015-08-05 | Univ Nottingham | Controlled cell delivery vehicle and treatment of tumours |
| EP3433422B1 (en) | 2016-03-22 | 2020-11-18 | Åbo Akademi University | Polysaccharide derivatives as optical brightening agents |
| KR20190013289A (ko) * | 2017-08-01 | 2019-02-11 | 순천대학교 산학협력단 | 수용성 키토산을 포함하는 나노광증감제 |
| GB201801169D0 (en) | 2018-01-24 | 2018-03-07 | Pci Biotech As | Method |
| CN108892743A (zh) * | 2018-05-28 | 2018-11-27 | 南京工业大学 | 用于光动力抗菌的纳米光敏剂，其制备方法及应用 |
| GB202101726D0 (en) | 2021-02-08 | 2021-03-24 | Pci Biotech As | Method |
| CN115399328B (zh) * | 2021-05-27 | 2024-03-22 | 中国科学院化学研究所 | 一种多糖基杀菌材料及其制备方法和应用 |
| GB202115451D0 (en) | 2021-10-27 | 2021-12-08 | Pci Biotech As | Method |
| CN117285662A (zh) * | 2022-06-15 | 2023-12-26 | 南京仁为医药科技有限公司 | 一种壳聚糖双吡啶季铵盐及其制备方法 |
| GB202301312D0 (en) | 2023-01-30 | 2023-03-15 | Pci Biotech As | Method and product |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996007432A1 (en) * | 1994-09-08 | 1996-03-14 | Radiumhospitalets Forskningsstiftelse | Transfer of molecules into the cytosol of cells |
| WO2008130181A1 (en) * | 2007-04-23 | 2008-10-30 | Korea Institute Of Science And Technology | Novel photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9905911D0 (en) * | 1999-03-15 | 1999-05-05 | Photocure As | Method |
| US20020022032A1 (en) | 1999-04-23 | 2002-02-21 | Curry Patrick Mark | Immuno-adjuvant PDT treatment of metastatic tumors |
| GB0018527D0 (en) * | 2000-07-27 | 2000-09-13 | Photocure Asa | Composition |
| JP2002241307A (ja) * | 2001-02-19 | 2002-08-28 | Yasuhiko Tabata | 光増感剤を含有する超音波治療用活性酸素発生剤 |
| GB0121023D0 (en) | 2001-08-30 | 2001-10-24 | Norwegian Radium Hospital Res | Compound |
| GB0415663D0 (en) | 2004-07-13 | 2004-08-18 | Psimei Pharmaceuticals Plc | Compound |
| EP1888115A2 (en) | 2005-05-16 | 2008-02-20 | Universite De Geneve | Compounds for photochemotherapy |
| JP4287411B2 (ja) * | 2005-07-01 | 2009-07-01 | 株式会社東芝 | 仮想メモリシステムおよび仮想記憶方法 |
| CN101024087A (zh) * | 2007-03-28 | 2007-08-29 | 长沙理工大学 | 壳聚糖－多肽－卟啉纳米药物载体及其制备和应用 |
| KR20090047872A (ko) | 2007-11-08 | 2009-05-13 | 인제대학교 산학협력단 | 신규 카보하이드레이트 복합 클로린 화합물 및 이의제조방법 |
| WO2009077908A1 (en) | 2007-12-14 | 2009-06-25 | University Of Lausanne | Colloidal particle comprising multivalent cyclic anions |
| KR101076717B1 (ko) | 2008-11-07 | 2011-10-26 | 재단법인대구경북과학기술원 | 광역학 치료용 나노구조체 및 그 제조방법 |
| US20100129432A1 (en) | 2008-11-25 | 2010-05-27 | Taipei Medical University | Microorganism-killing combination |
| KR100918811B1 (ko) | 2009-04-29 | 2009-09-25 | 다이아텍코리아 주식회사 | 클로린 ｅ６-엽산 결합 화합물 및 키토산을 함유하는 암 치료용 약학적 조성물 |
| WO2010126179A1 (ko) | 2009-04-29 | 2010-11-04 | 다이아텍코리아 주식회사 | 클로린 e6-엽산 결합 화합물 및 키토산을 함유하는 암 치료용 약학적 조성물 |
| CN102573910B (zh) * | 2009-06-12 | 2015-08-26 | 鹿特丹伊拉斯谟大学医疗中心 | 用于癌症光动力学治疗的靶向纳米光药物 |
| GB0914287D0 (en) | 2009-08-14 | 2009-09-30 | Pci Biotech As | Compositions |
| KR101228106B1 (ko) | 2010-01-21 | 2013-02-01 | 광주과학기술원 | 피부투과도, 세포유입 및 종양전달성이 증가된 나노운반체 |
| KR101250150B1 (ko) * | 2010-10-29 | 2013-04-04 | 가톨릭대학교 산학협력단 | 광역학치료를 위한 고분자-광응답제 접합체 및 이의 제조방법 |
-
2012
- 2012-05-15 GB GBGB1208548.6A patent/GB201208548D0/en not_active Ceased
-
2013
- 2013-05-14 US US14/401,215 patent/US9901636B2/en not_active Expired - Fee Related
- 2013-05-14 DK DK13725109.6T patent/DK2849791T3/en active
- 2013-05-14 SG SG11201407603YA patent/SG11201407603YA/en unknown
- 2013-05-14 RU RU2014150569A patent/RU2675830C2/ru active
- 2013-05-14 NZ NZ630582A patent/NZ630582A/en not_active IP Right Cessation
- 2013-05-14 SI SI201331125T patent/SI2849791T1/sl unknown
- 2013-05-14 ES ES13725109.6T patent/ES2682762T3/es active Active
- 2013-05-14 PT PT13725109T patent/PT2849791T/pt unknown
- 2013-05-14 EP EP13725109.6A patent/EP2849791B1/en active Active
- 2013-05-14 KR KR1020207019532A patent/KR102269861B1/ko not_active Expired - Fee Related
- 2013-05-14 HR HRP20181276TT patent/HRP20181276T1/hr unknown
- 2013-05-14 MX MX2014013516A patent/MX362237B/es active IP Right Grant
- 2013-05-14 KR KR1020147035218A patent/KR20150013803A/ko not_active Ceased
- 2013-05-14 BR BR112014028315-0A patent/BR112014028315B1/pt not_active IP Right Cessation
- 2013-05-14 CA CA2873259A patent/CA2873259C/en active Active
- 2013-05-14 WO PCT/EP2013/059968 patent/WO2013189663A1/en not_active Ceased
- 2013-05-14 CN CN201380037602.8A patent/CN104780941B/zh active Active
- 2013-05-14 IN IN9418DEN2014 patent/IN2014DN09418A/en unknown
- 2013-05-14 HU HUE13725109A patent/HUE039725T2/hu unknown
- 2013-05-14 PL PL13725109T patent/PL2849791T3/pl unknown
- 2013-05-14 JP JP2015512042A patent/JP6456284B2/ja not_active Expired - Fee Related
- 2013-05-14 AU AU2013279748A patent/AU2013279748B2/en not_active Ceased
-
2014
- 2014-11-17 ZA ZA2014/08406A patent/ZA201408406B/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996007432A1 (en) * | 1994-09-08 | 1996-03-14 | Radiumhospitalets Forskningsstiftelse | Transfer of molecules into the cytosol of cells |
| WO2008130181A1 (en) * | 2007-04-23 | 2008-10-30 | Korea Institute Of Science And Technology | Novel photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2013279748B2 (en) | Conjugate of a photosensitiser and chitosan and uses thereof | |
| Jiang et al. | Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer | |
| Wei et al. | NIR-light triggered dual-cascade targeting core-shell nanoparticles enhanced photodynamic therapy and immunotherapy | |
| Zhang et al. | Light-triggered theranostic liposomes for tumor diagnosis and combined photodynamic and hypoxia-activated prodrug therapy | |
| Khandare et al. | Novel polymeric prodrug with multivalent components for cancer therapy | |
| Maruani et al. | Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic | |
| Wen et al. | Utilizing viral nanoparticle/dendron hybrid conjugates in photodynamic therapy for dual delivery to macrophages and cancer cells | |
| KR20220010525A (ko) | 보론산 에스테르 전구약물 및 그의 용도 | |
| JPWO2005095494A1 (ja) | 新規水溶性フラーレン、その製造方法およびそれを含む活性酸素発生剤 | |
| JP2015155442A (ja) | 化合物及び生物学的材料並びにそれらの使用 | |
| Gaware et al. | Endosome targeting meso-tetraphenylchlorin–chitosan nanoconjugates for photochemical internalization | |
| Wu et al. | Near-infrared light-initiated upconversion nanoplatform with tumor microenvironment responsiveness for improved photodynamic therapy | |
| EP4077404A1 (en) | Hyaluronic acid derivatives | |
| CN116637185A (zh) | 一种适用于肿瘤靶向光动力治疗的核酸适体偶联药物及其制备方法和用途 | |
| US10561730B2 (en) | Plant virus particles for delivery of photosensitive agents | |
| KR101138438B1 (ko) | 스피루리나로부터 클로로필 ａ 및 광민감제 제조방법 | |
| US20250304545A1 (en) | Water-soluble heterocyclyl polymethine chromophores | |
| JP2011518891A (ja) | クロリンｅ６−葉酸結合化合物およびキトサンを含有する癌治療用薬学的組成物 | |
| HK1203850B (en) | Conjugate of a photosensitiser and chitosan and uses thereof | |
| KR101106756B1 (ko) | 스피루리나로부터 클로로필 ａ 및 광민감제 제조방법 | |
| KR101138437B1 (ko) | 스피루리나로부터 클로로필 ａ 및 광민감제 제조방법 | |
| KR102266865B1 (ko) | 지방산을 유효성분으로 포함하는 수용성 광감작제 결합체 및 이의 제조방법 | |
| KR20120016573A (ko) | 스피루리나로부터 클로로필 ａ 및 광민감제 제조방법 | |
| Fernandez-Megia | Synthesis of multi-functional dendrimers for targeted delivery of nucleic acids |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |