AU2013279512A1 - N-alkyltriazole compounds as LPAR antagonists - Google Patents

N-alkyltriazole compounds as LPAR antagonists Download PDF

Info

Publication number
AU2013279512A1
AU2013279512A1 AU2013279512A AU2013279512A AU2013279512A1 AU 2013279512 A1 AU2013279512 A1 AU 2013279512A1 AU 2013279512 A AU2013279512 A AU 2013279512A AU 2013279512 A AU2013279512 A AU 2013279512A AU 2013279512 A1 AU2013279512 A1 AU 2013279512A1
Authority
AU
Australia
Prior art keywords
phenyl
methyl
triazol
biphenyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2013279512A
Other languages
English (en)
Inventor
Stephen Deems Gabriel
Matthew Michael Hamilton
Matthew C. Lucas
Yimin Qian
Achyutharao Sidduri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48628667&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2013279512(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU2013279512A1 publication Critical patent/AU2013279512A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AU2013279512A 2012-06-20 2013-06-17 N-alkyltriazole compounds as LPAR antagonists Abandoned AU2013279512A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261661961P 2012-06-20 2012-06-20
US61/661,961 2012-06-20
PCT/EP2013/062461 WO2013189864A1 (en) 2012-06-20 2013-06-17 N-alkyltriazole compounds as lpar antagonists

Publications (1)

Publication Number Publication Date
AU2013279512A1 true AU2013279512A1 (en) 2014-10-16

Family

ID=48628667

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013279512A Abandoned AU2013279512A1 (en) 2012-06-20 2013-06-17 N-alkyltriazole compounds as LPAR antagonists

Country Status (22)

Country Link
US (1) US9321738B2 (enExample)
EP (1) EP2864300A1 (enExample)
JP (1) JP2015520202A (enExample)
KR (1) KR20150021057A (enExample)
CN (1) CN104411692A (enExample)
AU (1) AU2013279512A1 (enExample)
BR (1) BR112014030685A2 (enExample)
CA (1) CA2869541A1 (enExample)
CL (1) CL2014003243A1 (enExample)
CO (1) CO7131358A2 (enExample)
CR (1) CR20140525A (enExample)
EA (1) EA201492285A1 (enExample)
HK (1) HK1206342A1 (enExample)
IL (1) IL236088A0 (enExample)
IN (1) IN2014DN09348A (enExample)
MA (1) MA37764A1 (enExample)
MX (1) MX2014014710A (enExample)
PE (1) PE20142448A1 (enExample)
PH (1) PH12014502789A1 (enExample)
SG (1) SG11201407220YA (enExample)
UA (1) UA109868C2 (enExample)
WO (1) WO2013189864A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012296662A1 (en) 2011-08-15 2014-03-27 Intermune, Inc. Lysophosphatidic acid receptor antagonists
JP2015520203A (ja) * 2012-06-20 2015-07-16 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｌｐａｒ拮抗薬としてのｎ−アリールトリアゾール化合物
US10000459B2 (en) 2013-03-15 2018-06-19 Epigen Biosciences, Inc. Heterocyclic compounds useful in the treatment of disease
AU2015281021B9 (en) 2014-06-27 2019-03-28 Ube Corporation Salt of halogen-substituted heterocyclic compound
AR108838A1 (es) * 2016-06-21 2018-10-03 Bristol Myers Squibb Co Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa
KR102698386B1 (ko) 2017-12-19 2024-08-22 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 피라졸 n-연결된 카르바모일 시클로헥실 산
WO2019126103A1 (en) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Cyclohexyl acid pyrazole azoles as lpa antagonists
CN112074515B (zh) 2017-12-19 2025-01-10 百时美施贵宝公司 作为lpa拮抗剂的环己基酸异噁唑唑类
JP7202383B2 (ja) 2017-12-19 2023-01-11 ブリストル－マイヤーズ スクイブ カンパニー Ｌｐａアンタゴニストとしてのピラゾールｏ－架橋カルバモイルシクロヘキシル酸
TW202017918A (zh) * 2017-12-19 2020-05-16 美商必治妥美雅史谷比公司 作為lpa拮抗劑之環己基酸三唑吖
JP7526096B2 (ja) * 2017-12-19 2024-07-31 ブリストル－マイヤーズ スクイブ カンパニー Ｌｐａアンタゴニストとしてのシクロヘキシル酸イソキサゾールアジン
KR102697358B1 (ko) 2017-12-19 2024-08-20 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 이속사졸 o-연결된 카르바모일 시클로헥실 산
EP3728210B1 (en) 2017-12-19 2026-02-11 Bristol-Myers Squibb Company Isoxazole n-linked carbamoyl cyclohexyl acids as lpa antagonists
US10662172B2 (en) * 2017-12-19 2020-05-26 Bristol-Myers Squibb Company Triazole N-linked carbamoyl cyclohexyl acids as LPA antagonists
KR20200100713A (ko) * 2017-12-19 2020-08-26 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 시클로헥실 산 트리아졸 아졸
US11312706B2 (en) 2017-12-19 2022-04-26 Bristol-Myers Squibb Company Cyclohexyl acid pyrazole azines as LPA antagonists
IL297802A (en) * 2017-12-29 2022-12-01 Biomarin Pharm Inc Glycolate oxidase inhibitors to treat the disease
ES2946657T3 (es) * 2018-09-18 2023-07-24 Bristol Myers Squibb Co Acidos ciclopentílicos como antagonistas de LPA
ES2948793T3 (es) * 2018-09-18 2023-09-19 Bristol Myers Squibb Co Acidos cicloheptílicos como antagonistas de LPA
CN113366000A (zh) * 2018-09-18 2021-09-07 百时美施贵宝公司 作为lpa拮抗剂的氧杂双环酸
EP4058144A1 (en) 2019-11-15 2022-09-21 Gilead Sciences, Inc. Triazole carbamate pyridyl sulfonamides as lpa receptor antagonists and uses thereof
TWI843503B (zh) 2020-06-03 2024-05-21 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
KR102913125B1 (ko) 2020-06-03 2026-01-20 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제 및 이의 용도
CA3218917A1 (en) 2021-05-11 2022-11-17 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
WO2022241023A1 (en) 2021-05-13 2022-11-17 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
KR20240115978A (ko) 2021-12-08 2024-07-26 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제 및 이의 용도
AR128613A1 (es) 2022-02-25 2024-05-29 Lhotse Bio Inc Compuestos y composiciones para el tratamiento de afecciones asociadas con la actividad del receptor de lpa

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200827346A (en) 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
GB2466121B (en) * 2008-12-15 2010-12-08 Amira Pharmaceuticals Inc Antagonists of lysophosphatidic acid receptors
GB2470833B (en) * 2009-06-03 2011-06-01 Amira Pharmaceuticals Inc Polycyclic antagonists of lysophosphatidic acid receptors
US20110065695A1 (en) 2009-09-11 2011-03-17 Jeremy Beauchamp Use of aminodihydrothiazines for the treatment or prevention of diabetes
GB2474748B (en) * 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
WO2011159550A2 (en) * 2010-06-14 2011-12-22 Amidra Pharmaceuticals, Inc. Lysophosphatidic acid receptor antagonist and uses thereof
WO2011159633A1 (en) 2010-06-15 2011-12-22 Amira Pharmaceuticals, Inc. Inhalable formulations of lysophosphatdic acid receptor antagonists
PH12013501136A1 (en) * 2010-12-07 2013-07-08 Amira Pharmaceuticals Inc Lysophosphatidic acid receptor antagonists and uses thereof
WO2012138648A1 (en) * 2011-04-06 2012-10-11 Irm Llc Compositions and methods for modulating lpa receptors
AU2012296662A1 (en) * 2011-08-15 2014-03-27 Intermune, Inc. Lysophosphatidic acid receptor antagonists

Also Published As

Publication number Publication date
IN2014DN09348A (enExample) 2015-07-17
CO7131358A2 (es) 2014-12-01
CA2869541A1 (en) 2013-12-27
PE20142448A1 (es) 2015-01-28
CL2014003243A1 (es) 2015-03-20
PH12014502789A1 (en) 2015-02-09
EA201492285A1 (ru) 2015-04-30
CR20140525A (es) 2015-01-12
MX2014014710A (es) 2015-03-04
SG11201407220YA (en) 2014-12-30
UA109868C2 (ru) 2015-10-12
IL236088A0 (en) 2015-02-01
KR20150021057A (ko) 2015-02-27
HK1206342A1 (en) 2016-01-08
JP2015520202A (ja) 2015-07-16
BR112014030685A2 (pt) 2017-06-27
EP2864300A1 (en) 2015-04-29
US9321738B2 (en) 2016-04-26
CN104411692A (zh) 2015-03-11
MA37764A1 (fr) 2016-01-29
WO2013189864A1 (en) 2013-12-27
US20150133511A1 (en) 2015-05-14

Similar Documents

Publication Publication Date Title
AU2013279512A1 (en) N-alkyltriazole compounds as LPAR antagonists
JP2015520203A (ja) Ｌｐａｒ拮抗薬としてのｎ−アリールトリアゾール化合物
CA2724077C (en) Amide compound
CN104822680B (zh) 咪唑并吡啶化合物
AU2013279510A1 (en) Substituted pyrazole compounds as LPAR antagonists
US20100266714A1 (en) P2x3 receptor antagonists for treatment of pain
US11020395B2 (en) Cycloalkyl substituted triazole compounds as agonists of the APJ receptor
US20020052370A1 (en) Cyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
JP2023552793A (ja) 心不全の処置のための、ｒｘｆｐ１モデュレーターとしての４－（２－フルオロ－４－メトキシ－５－３－（（（１－メチルシクロブチル）メチル）カルバモイル）ビシクロ［２．２．１］ヘプタン－２－イル）カルバモイル）フェノキシ）－１－メチルシクロヘキサン－１－カルボン酸誘導体及び類似化合物
TW202108587A (zh) Jak抑制劑
JP4585522B2 (ja) ブラジキニン拮抗物質又は逆作用物質としてのアルファ−ヒドロキシアミド
CA2877184A1 (en) Lpar-substituted cyanopyrazole compounds
JP2007501790A (ja) スルホニル置換ｎ−（ビアリールメチル）アミノシクロプロパンカルボキサミド
US11807624B2 (en) Substituted pyrimidinones as agonists of the APJ receptor
US7816380B2 (en) 1-hydroxycycloalkanecarboxamide derivatives
JP2023179389A (ja) 医薬組成物
ZA200300121B (en) Cyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase.

Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted