AU2013277290A1 - Bioreactor cartridge and system - Google Patents
Bioreactor cartridge and system Download PDFInfo
- Publication number
- AU2013277290A1 AU2013277290A1 AU2013277290A AU2013277290A AU2013277290A1 AU 2013277290 A1 AU2013277290 A1 AU 2013277290A1 AU 2013277290 A AU2013277290 A AU 2013277290A AU 2013277290 A AU2013277290 A AU 2013277290A AU 2013277290 A1 AU2013277290 A1 AU 2013277290A1
- Authority
- AU
- Australia
- Prior art keywords
- media
- flow
- inlet
- bioreactor
- flow channels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000012010 growth Effects 0.000 claims abstract description 54
- 238000011144 upstream manufacturing Methods 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims description 22
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 18
- 239000001301 oxygen Substances 0.000 claims description 18
- 229910052760 oxygen Inorganic materials 0.000 claims description 18
- 238000006213 oxygenation reaction Methods 0.000 claims description 12
- 230000003750 conditioning effect Effects 0.000 claims description 10
- 238000003306 harvesting Methods 0.000 claims description 8
- 238000012544 monitoring process Methods 0.000 claims description 7
- 239000011159 matrix material Substances 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 235000016709 nutrition Nutrition 0.000 claims description 4
- 235000015097 nutrients Nutrition 0.000 claims 1
- 238000005086 pumping Methods 0.000 abstract description 7
- 210000004027 cell Anatomy 0.000 description 54
- 239000010410 layer Substances 0.000 description 15
- 210000004443 dendritic cell Anatomy 0.000 description 9
- 239000000463 material Substances 0.000 description 7
- 239000012530 fluid Substances 0.000 description 6
- 230000010261 cell growth Effects 0.000 description 5
- 239000004926 polymethyl methacrylate Substances 0.000 description 5
- 230000003466 anti-cipated effect Effects 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 238000004364 calculation method Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 239000004793 Polystyrene Substances 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 230000000254 damaging effect Effects 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 239000012737 fresh medium Substances 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 238000003466 welding Methods 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010067306 Fibronectins Proteins 0.000 description 2
- 102000016359 Fibronectins Human genes 0.000 description 2
- 101150099047 apip gene Proteins 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 238000010899 nucleation Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000002572 peristaltic effect Effects 0.000 description 2
- 238000004382 potting Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 229920000260 silastic Polymers 0.000 description 2
- VGVRFARTWVJNQC-UHFFFAOYSA-N 2-(2,4-dichlorophenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(Cl)C=C1Cl VGVRFARTWVJNQC-UHFFFAOYSA-N 0.000 description 1
- 239000002028 Biomass Substances 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 108010085895 Laminin Proteins 0.000 description 1
- 102000016611 Proteoglycans Human genes 0.000 description 1
- 108010067787 Proteoglycans Proteins 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000005276 aerator Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000010364 biochemical engineering Methods 0.000 description 1
- 239000010796 biological waste Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- -1 for example Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000011194 good manufacturing practice Methods 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000013028 medium composition Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000246 remedial effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 150000004756 silanes Chemical class 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/10—Hollow fibers or tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/14—Scaffolds; Matrices
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Clinical Laboratory Science (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261662859P | 2012-06-21 | 2012-06-21 | |
| US61/662,859 | 2012-06-21 | ||
| US201361808954P | 2013-04-05 | 2013-04-05 | |
| US61/808,954 | 2013-04-05 | ||
| PCT/US2013/046391 WO2013192221A1 (en) | 2012-06-21 | 2013-06-18 | Bioreactor cartridge and system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2013277290A1 true AU2013277290A1 (en) | 2015-01-22 |
Family
ID=49769305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013277290A Abandoned AU2013277290A1 (en) | 2012-06-21 | 2013-06-18 | Bioreactor cartridge and system |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20150322397A1 (enExample) |
| EP (1) | EP2864469A4 (enExample) |
| JP (1) | JP2015519922A (enExample) |
| AU (1) | AU2013277290A1 (enExample) |
| CA (1) | CA2877739A1 (enExample) |
| NZ (1) | NZ704003A (enExample) |
| WO (1) | WO2013192221A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6354219B2 (ja) * | 2014-03-11 | 2018-07-11 | 株式会社Ihi | 細胞培養装置 |
| US11377651B2 (en) * | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| IL305121A (en) | 2015-06-23 | 2023-10-01 | Univ Texas | Methods and apparatus for growing cell populations for cell therapy |
| US11186810B2 (en) | 2016-03-16 | 2021-11-30 | Shimadzu Corporation | Cell culture vessel |
| US11566217B2 (en) * | 2019-08-13 | 2023-01-31 | Flaskworks, Llc | Duty cycle for cell culture systems |
| CN110898644B (zh) * | 2019-12-05 | 2020-07-24 | 浙江创世纪环保科技有限公司 | 一种生物除臭箱 |
| WO2021212124A1 (en) * | 2020-04-17 | 2021-10-21 | Multiply Labs Inc. | System, method, and apparatus facilitating automated modular manufacture of cell therapy |
| US11981884B2 (en) * | 2022-10-17 | 2024-05-14 | Upside Foods, Inc. | Pipe-based bioreactors for producing comestible meat products and methods of using the same |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19919241A1 (de) * | 1999-04-28 | 2000-11-02 | Creavis Tech & Innovation Gmbh | 3D Zellträgersystem für Zell-, Gewebe- und Organkulturen |
| AUPQ319199A0 (en) * | 1999-09-30 | 1999-10-28 | Unisearch Limited | Method and apparatus for culturing cells |
| US7358079B2 (en) * | 1999-12-17 | 2008-04-15 | Bayer Technology Services Gmbh | Flow cell array and the utilization thereof for multianalyte determination |
| US20070122904A1 (en) * | 2000-09-29 | 2007-05-31 | Unisearch Limited | Method and apparatus for culturing cells |
| US20020187546A1 (en) * | 2001-06-08 | 2002-12-12 | Jacek Rozga | Multi-channel packed bed bioreactor |
| DE10335130A1 (de) * | 2003-07-31 | 2005-02-24 | Blue Membranes Gmbh | Immobilisierung von Katalysatoren auf porösen Körpern auf Kohlenstoffbasis |
| US20060229735A1 (en) * | 2004-10-15 | 2006-10-12 | The Cleveland Clinic Foundation | Device for tissue engineering |
| US8951784B2 (en) * | 2005-12-14 | 2015-02-10 | Sepragen Corporation | Cell culture bioreactor |
| EP2010642B1 (en) * | 2006-04-12 | 2019-05-22 | Quorus Biotech (Proprietary) Limited | Bioreactor |
| WO2009017765A1 (en) * | 2007-07-30 | 2009-02-05 | Peter Florez | Disposable mini-bioreactor device and method |
| DE102008029307A1 (de) * | 2008-06-20 | 2009-12-24 | Bayer Technology Services Gmbh | Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen |
| US9228579B2 (en) * | 2008-12-19 | 2016-01-05 | Stobbe Tech A/S | Method and device for industrial biolayer cultivation |
-
2013
- 2013-06-18 EP EP13806774.9A patent/EP2864469A4/en not_active Withdrawn
- 2013-06-18 WO PCT/US2013/046391 patent/WO2013192221A1/en not_active Ceased
- 2013-06-18 NZ NZ704003A patent/NZ704003A/en not_active IP Right Cessation
- 2013-06-18 AU AU2013277290A patent/AU2013277290A1/en not_active Abandoned
- 2013-06-18 US US14/410,085 patent/US20150322397A1/en not_active Abandoned
- 2013-06-18 JP JP2015518521A patent/JP2015519922A/ja active Pending
- 2013-06-18 CA CA2877739A patent/CA2877739A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150322397A1 (en) | 2015-11-12 |
| EP2864469A4 (en) | 2016-05-18 |
| EP2864469A1 (en) | 2015-04-29 |
| NZ704003A (en) | 2017-02-24 |
| JP2015519922A (ja) | 2015-07-16 |
| CA2877739A1 (en) | 2013-12-27 |
| WO2013192221A1 (en) | 2013-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HB | Alteration of name in register |
Owner name: NEOSTEM ONCOLOGY, LLC Free format text: FORMER NAME(S): NEOSTEM ONCOLOGY, LLC |
|
| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |