AU2013271737A1 - Methods for making fully human bispecific antibodies using a common light chain - Google Patents
Methods for making fully human bispecific antibodies using a common light chain Download PDFInfo
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- AU2013271737A1 AU2013271737A1 AU2013271737A AU2013271737A AU2013271737A1 AU 2013271737 A1 AU2013271737 A1 AU 2013271737A1 AU 2013271737 A AU2013271737 A AU 2013271737A AU 2013271737 A AU2013271737 A AU 2013271737A AU 2013271737 A1 AU2013271737 A1 AU 2013271737A1
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
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- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US13/488,628 US20130045492A1 (en) | 2010-02-08 | 2012-06-05 | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US13/488,628 | 2012-06-05 | ||
| PCT/US2013/044257 WO2013184761A1 (en) | 2012-06-05 | 2013-06-05 | Methods for making fully human bispecific antibodies using a common light chain |
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| AU2013271737A1 true AU2013271737A1 (en) | 2015-01-22 |
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| AU2013271737A Abandoned AU2013271737A1 (en) | 2012-06-05 | 2013-06-05 | Methods for making fully human bispecific antibodies using a common light chain |
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| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| US20120021409A1 (en) | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| MX378870B (es) | 2010-02-08 | 2025-03-11 | Regeneron Pharma | Raton de cadena ligera comun. |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| RU2664473C2 (ru) | 2012-03-16 | 2018-08-17 | Регенерон Фармасьютикалз, Инк. | ОТЛИЧНЫЕ ОТ ЧЕЛОВЕКА ЖИВОТНЫЕ, ЭКСПРЕССИРУЮЩИЕ ЧУВСТВИТЕЛЬНЫЕ К pН ПОСЛЕДОВАТЕЛЬНОСТИ ИММУНОГЛОБУЛИНОВ |
| JP2015512245A (ja) | 2012-03-16 | 2015-04-27 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ｐＨ依存性の結合特徴を有する抗原結合タンパク質を産生するマウス |
| CN107840890A (zh) | 2012-03-16 | 2018-03-27 | 瑞泽恩制药公司 | 组氨酸工程改造的轻链抗体和用于生成所述抗体的经基因修饰的非人动物 |
| CA2871068C (en) | 2012-04-20 | 2022-06-14 | Merus B.V. | Methods and means for the production of ig-like molecules |
| TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
| MX2015012540A (es) * | 2013-03-13 | 2016-04-19 | Regeneron Pharma | Ratón de cadena ligera común. |
| TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| PL3699198T3 (pl) | 2014-11-17 | 2025-06-23 | Regeneron Pharmaceuticals, Inc. | Sposoby leczenia nowotworów z wykorzystaniem dwuswoistego przeciwciała cd3xcd20 |
| HUE049650T2 (hu) * | 2014-11-20 | 2020-11-30 | Hoffmann La Roche | Közös könnyûláncok és alkalmazási eljárások |
| EP3023437A1 (en) * | 2014-11-20 | 2016-05-25 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| WO2016161010A2 (en) | 2015-03-30 | 2016-10-06 | Regeneron Pharmaceuticals, Inc. | Heavy chain constant regions with reduced binding to fc gamma receptors |
| CA2984010A1 (en) | 2015-05-12 | 2016-11-17 | Regeneron Pharmaceuticals, Inc. | Multimeric protein purity determination |
| MX2018003403A (es) * | 2015-09-23 | 2018-05-28 | Regeneron Pharma | Anticuerpos biespecificos anti-cd3 optimizados y sus usos. |
| TWI752920B (zh) | 2015-10-12 | 2022-01-21 | 美商再生元醫藥公司 | 活化瘦素受體的抗原結合蛋白 |
| AU2017206785C1 (en) | 2016-01-13 | 2023-09-07 | Regeneron Pharmaceuticals, Inc. | Rodents having an engineered heavy chain diversity region |
| DK3773713T3 (da) | 2018-04-06 | 2025-08-18 | Regeneron Pharma | Leptinreceptoragonistantistof til anvendelse i forøgelse af knoglemasse hos et individ, der lider af metabolisk dysfunktion eller hypoleptinæmI |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| PT3844189T (pt) | 2018-08-31 | 2025-01-29 | Regeneron Pharma | Estratégia de dosagem que mitiga a síndrome de libertação de citocinas para anticorpos bisepecíficos contra cd3/c20 |
| JP2022507485A (ja) * | 2018-11-16 | 2022-01-18 | ヴァーチュオウソウ ビンコ，インク． | Ｃｄ３８抗体とｉｃａｍ１抗体およびそれらの使用 |
| EP3927153A1 (en) | 2019-02-22 | 2021-12-29 | Regeneron Pharmaceuticals, Inc. | Rodents having genetically modified sodium channels and methods of use thereof |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| WO2022056276A1 (en) | 2020-09-11 | 2022-03-17 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| IL303626A (en) | 2020-12-16 | 2023-08-01 | Regeneron Pharma | Mice expressing humanized fc alpha receptors |
| WO2022140219A1 (en) | 2020-12-23 | 2022-06-30 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
| CA3197426A1 (en) | 2020-12-23 | 2022-06-30 | Regeneron Pharmaceuticals, Inc. | Methods for obtaining antibodies that bind transmembrane proteins and cells that produce the same |
| CN118496357A (zh) * | 2023-02-15 | 2024-08-16 | 康源博创生物科技(北京)有限公司 | 一种多肽以及包含其作为轻链的抗体 |
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| ES2146572T3 (es) * | 1988-09-06 | 2000-08-16 | Xoma Technology Ltd | Elementos de expresion genica y la produccion de anticuerpos quimericos de raton-ser humano. |
| US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| EP0754225A4 (en) * | 1993-04-26 | 2001-01-31 | Genpharm Int | HETEROLOGIC ANTIBODY-PRODUCING TRANSGENIC NON-HUMAN ANIMALS |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| CA2491864C (en) * | 2001-07-12 | 2012-09-11 | Jefferson Foote | Super humanized antibodies |
| PT1652920E (pt) * | 2001-10-01 | 2010-11-08 | Deutsches Krebsforsch | Processo para a produção de bibliotecas de proteínas e para a selecção de proteínas a partir da mesma |
| US20050095712A1 (en) * | 2002-01-17 | 2005-05-05 | Alberto Martin | Mutations caused by activation-induced cytidine deaminase |
| CA2489467C (en) * | 2002-06-14 | 2015-02-24 | Immunomedics, Inc. | Humanized monoclonal antibody hpam4 |
| CN101962408A (zh) * | 2002-07-12 | 2011-02-02 | 杰斐逊·富特 | 超人源化抗体 |
| RU2731084C2 (ru) * | 2008-06-27 | 2020-08-28 | Мерюс Н.В. | Продуцирующие антитела млекопитающие, не являющиеся человеком |
| MX378870B (es) * | 2010-02-08 | 2025-03-11 | Regeneron Pharma | Raton de cadena ligera comun. |
| DK3572517T3 (da) * | 2011-08-05 | 2021-06-14 | Regeneron Pharma | Humaniserede, universelle letkæde-mus |
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- 2013-06-05 KR KR20147036869A patent/KR20150023535A/ko not_active Withdrawn
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| SG11201407644UA (en) | 2014-12-30 |
| RU2014153674A (ru) | 2016-07-27 |
| JP2015525071A (ja) | 2015-09-03 |
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| IL235781A0 (en) | 2015-01-29 |
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| EP2854523A1 (en) | 2015-04-08 |
| KR20150023535A (ko) | 2015-03-05 |
| SG10201609535TA (en) | 2017-01-27 |
| CN104582476A (zh) | 2015-04-29 |
| MX2014014891A (es) | 2015-06-17 |
| CA2874846A1 (en) | 2013-12-12 |
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