AU2013264966A1 - Dinuceloside polyphosphates for the treatment of pain - Google Patents
Dinuceloside polyphosphates for the treatment of pain Download PDFInfo
- Publication number
- AU2013264966A1 AU2013264966A1 AU2013264966A AU2013264966A AU2013264966A1 AU 2013264966 A1 AU2013264966 A1 AU 2013264966A1 AU 2013264966 A AU2013264966 A AU 2013264966A AU 2013264966 A AU2013264966 A AU 2013264966A AU 2013264966 A1 AU2013264966 A1 AU 2013264966A1
- Authority
- AU
- Australia
- Prior art keywords
- pain
- dinucleoside polyphosphate
- polyphosphate analogue
- analogue
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
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- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Biotechnology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201209244A GB201209244D0 (en) | 2012-05-25 | 2012-05-25 | Compositions |
| GB1209244.1 | 2012-05-25 | ||
| PCT/GB2013/051377 WO2013175231A1 (en) | 2012-05-25 | 2013-05-24 | Dinuceloside polyphosphates for the treatment of pain |
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| JP (1) | JP2015517565A (enExample) |
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| GB (1) | GB201209244D0 (enExample) |
| HK (1) | HK1203054A1 (enExample) |
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| CN103665043B (zh) | 2012-08-30 | 2017-11-10 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药及其在医药上的应用 |
| GB201320962D0 (en) * | 2013-11-27 | 2014-01-08 | Globalacorn Ltd | Compositions |
| WO2017209267A1 (ja) * | 2016-06-03 | 2017-12-07 | 塩野義製薬株式会社 | プリン誘導体 |
| AU2019235887B2 (en) | 2018-03-15 | 2025-07-03 | Danmir Therapeutics, Llc | 3",5"-dialkoxybenzoyl-3'-amino-3'-deoxyadenosine-5'-triphosphates and pharmaceutical uses thereof |
| US20230000063A1 (en) * | 2019-12-13 | 2023-01-05 | Chugai Seiyaku Kabushiki Kaisha | System for detecting extracellular purinergic receptor ligand, and non-human animal having the system introduced thereinto |
| US20230032473A1 (en) * | 2021-07-23 | 2023-02-02 | Wisconsin Alumni Research Foundation | Nad(h) nanoparticles and methods of use |
| CN114685588B (zh) * | 2022-05-05 | 2024-03-29 | 江苏申基生物科技有限公司 | 一种含开环核苷结构的起始加帽寡核苷酸引物 |
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| US5049550A (en) * | 1987-11-05 | 1991-09-17 | Worcester Foundation For Experimental Biology | Diadenosine 5', 5'"-p1, p4,-tetraphosphate analogs as antithrombotic agents |
| JP2783880B2 (ja) * | 1989-11-24 | 1998-08-06 | 富士レビオ株式会社 | 心臓病治療剤 |
| US5635160A (en) * | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
| US5837861A (en) * | 1997-02-10 | 1998-11-17 | Inspire Pharmaceuticals, Inc. | Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency |
| US5681823A (en) * | 1996-05-02 | 1997-10-28 | Prp Inc. | P1, P4 -dithio-P2 -P3 -monochloromethylene 5', 5'"-diadenosine P1, P4 -tetraphosphate as antithrombotic agent |
| US6462028B2 (en) * | 1997-07-25 | 2002-10-08 | Inspire Pharmaceuticals, Inc. | Method of promoting cervical and vaginal secretions |
| AR034635A1 (es) * | 2001-06-25 | 2004-03-03 | Inspire Pharmaceuticals Inc | Lubricacion de las articulaciones con agonistas del receptor purinergico p2y |
| CN1612739A (zh) * | 2001-11-06 | 2005-05-04 | 印斯拜尔药品股份有限公司 | 治疗或预防炎性疾病的方法 |
| EP1348466A3 (en) * | 2002-02-01 | 2003-10-29 | Inspire Pharmaceuticals, Inc. | Method for treating pain with adenosine-tetraphosphates |
| FR2842424A1 (fr) * | 2002-07-22 | 2004-01-23 | Univ Paris 7 Denis Diderot | Utilisation du nad ou de l'un de ses analogues, substrat des mono-adp-ribosyl tranferases, pour la preparation d'un medicament destine au traitement des pathologies liees aux recepteurs purinergiques |
| GB0502250D0 (en) * | 2005-02-03 | 2005-03-09 | Ic Vec Ltd | Use |
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| CA2913313A1 (en) | 2013-11-28 |
| US20150119352A1 (en) | 2015-04-30 |
| JP2015517565A (ja) | 2015-06-22 |
| EP2854821A1 (en) | 2015-04-08 |
| GB201209244D0 (en) | 2012-07-04 |
| HK1203054A1 (en) | 2015-10-16 |
| WO2013175231A1 (en) | 2013-11-28 |
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| HB | Alteration of name in register |
Owner name: LOZOVAYA, N. Free format text: FORMER NAME(S): GLOBALACORN LTD. Owner name: BURNASHEV, N. Free format text: FORMER NAME(S): GLOBALACORN LTD. Owner name: GINIATULLIN, R. Free format text: FORMER NAME(S): GLOBALACORN LTD. Owner name: MILLER, A. Free format text: FORMER NAME(S): GLOBALACORN LTD. |
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| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |