AU2013246867B2 - Fluidically integrated rotary bead beater - Google Patents

Fluidically integrated rotary bead beater Download PDF

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Publication number
AU2013246867B2
AU2013246867B2 AU2013246867A AU2013246867A AU2013246867B2 AU 2013246867 B2 AU2013246867 B2 AU 2013246867B2 AU 2013246867 A AU2013246867 A AU 2013246867A AU 2013246867 A AU2013246867 A AU 2013246867A AU 2013246867 B2 AU2013246867 B2 AU 2013246867B2
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AU
Australia
Prior art keywords
enclosed chamber
sample
rotary element
fluidic
pct
Prior art date
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Active
Application number
AU2013246867A
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English (en)
Other versions
AU2013246867A8 (en
AU2013246867A1 (en
Inventor
Rafael BRU GIBERT
Jordi Carrera Fabra
Anna Comenges Casas
Ricard MARTIN BLANCO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qiagen GmbH
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Qiagen GmbH
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Filing date
Publication date
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Publication of AU2013246867A1 publication Critical patent/AU2013246867A1/en
Publication of AU2013246867A8 publication Critical patent/AU2013246867A8/en
Application granted granted Critical
Publication of AU2013246867B2 publication Critical patent/AU2013246867B2/en
Assigned to QIAGEN GMBH reassignment QIAGEN GMBH Request for Assignment Assignors: STAT-DIAGNOSTICA & INNOVATION, S.L.
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/07—Stirrers characterised by their mounting on the shaft
    • B01F27/072—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis
    • B01F27/0721—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis parallel with respect to the rotating axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/09—Stirrers characterised by the mounting of the stirrers with respect to the receptacle
    • B01F27/092—Stirrers characterised by the mounting of the stirrers with respect to the receptacle occupying substantially the whole interior space of the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/112—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades
    • B01F27/1121—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades pin-shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/112—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades
    • B01F27/1125—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades with vanes or blades extending parallel or oblique to the stirrer axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/115—Stirrers characterised by the configuration of the stirrers comprising discs or disc-like elements essentially perpendicular to the stirrer shaft axis
    • B01F27/1155—Stirrers characterised by the configuration of the stirrers comprising discs or disc-like elements essentially perpendicular to the stirrer shaft axis with interconnected discs, forming open frameworks or cages
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/23—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis
    • B01F27/231—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis with a variable orientation during mixing operation, e.g. with tiltable rotor axis
    • B01F27/2311—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis with a variable orientation during mixing operation, e.g. with tiltable rotor axis the orientation of the rotating shaft being adjustable in the interior of the receptacle, e.g. by tilting the stirrer shaft during the mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/83—Mixing plants specially adapted for mixing in combination with disintegrating operations
    • B01F33/8305—Devices with one shaft, provided with mixing and milling tools, e.g. using balls or rollers as working tools; Devices with two or more tools rotating about the same axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/836—Mixing plants; Combinations of mixers combining mixing with other treatments
    • B01F33/8361—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating
    • B01F33/83613—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating by grinding or milling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C17/00—Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
    • B02C17/16—Mills in which a fixed container houses stirring means tumbling the charge
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/06—Hydrolysis; Cell lysis; Extraction of intracellular or cell wall material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C12N1/066—Lysis of microorganisms by physical processes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/02—Apparatus for enzymology or microbiology with agitation means; with heat exchange means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2866—Grinding or homogeneising
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S366/00—Agitating
    • Y10S366/605—Paint mixer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Sustainable Development (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Accessories For Mixers (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Centrifugal Separators (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2013246867A 2012-04-11 2013-04-11 Fluidically integrated rotary bead beater Active AU2013246867B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261622858P 2012-04-11 2012-04-11
US61/622,858 2012-04-11
US13/836,741 US9304066B2 (en) 2012-04-11 2013-03-15 Fluidically integrated rotary bead beader
US13/836,741 2013-03-15
PCT/EP2013/057625 WO2013153176A1 (en) 2012-04-11 2013-04-11 Fluidically integrated rotary bead beater

Publications (3)

Publication Number Publication Date
AU2013246867A1 AU2013246867A1 (en) 2014-10-30
AU2013246867A8 AU2013246867A8 (en) 2014-12-11
AU2013246867B2 true AU2013246867B2 (en) 2018-01-18

Family

ID=48325599

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013246867A Active AU2013246867B2 (en) 2012-04-11 2013-04-11 Fluidically integrated rotary bead beater

Country Status (14)

Country Link
US (1) US9304066B2 (enExample)
EP (1) EP2836294B1 (enExample)
JP (2) JP5931275B2 (enExample)
KR (1) KR102251762B1 (enExample)
CN (1) CN104703683B (enExample)
AU (1) AU2013246867B2 (enExample)
BR (1) BR112014025389B1 (enExample)
CA (1) CA2870220C (enExample)
DK (1) DK2836294T3 (enExample)
ES (1) ES2647942T3 (enExample)
IN (1) IN2014KN02333A (enExample)
RU (1) RU2638854C2 (enExample)
WO (1) WO2013153176A1 (enExample)
ZA (1) ZA201500087B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201612404A2 (tr) * 2016-09-01 2018-03-21 Arcelik As Bi̇r çirpici ve kullanildiği stand mi̇kseri̇
JP6590779B2 (ja) * 2016-10-21 2019-10-16 株式会社三共 遊技機
CA3119162A1 (en) * 2018-11-13 2020-05-22 SPEX SamplePrep, LLC Improved sample grinder
US20240287622A1 (en) * 2021-06-22 2024-08-29 Janus-I Science Inc. Method for broad analysis of microorganisms and drug-resistance determinants in samples from a subject and devices therefor

Citations (8)

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US5074474A (en) * 1987-07-10 1991-12-24 Veb Berlin-Kosmetik Method and equipment for producing bioactive suspensions
CN2250810Y (zh) * 1996-02-07 1997-04-02 化学工业部上海化工研究院 细胞破碎机
US6235501B1 (en) * 1995-02-14 2001-05-22 Bio101, Inc. Method for isolation DNA
US20040200909A1 (en) * 1999-05-28 2004-10-14 Cepheid Apparatus and method for cell disruption
US6942169B2 (en) * 2001-06-06 2005-09-13 Integrated Sensing Systems Micromachined lysing device and method for performing cell lysis
US20100009349A1 (en) * 2005-12-30 2010-01-14 Hollaender Vera Method for Treating a Biological Sample
US20100331522A1 (en) * 2009-06-26 2010-12-30 Bruce Irvine Capture and elution of bio-analytes via beads that are used to disrupt specimens
US20110070589A1 (en) * 2009-09-21 2011-03-24 Phillip Belgrader Magnetic lysis method and device

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DE3765316D1 (de) 1986-06-20 1990-11-08 Inoue Mfg Apparat zum dispergieren und mahlen.
JPH0598589A (ja) 1991-10-01 1993-04-20 Oji Paper Co Ltd セルロース粒子微細繊維状粉砕物の製造方法
AU656843B2 (en) 1992-03-30 1995-02-16 Kubota Corporation Vertical pulverizer
DE4307083B4 (de) 1993-03-06 2007-07-12 Zoz Maschinenbau Gmbh Vorrichtung zur Feinstmahlung von Feststoffen
US5593097A (en) 1994-06-10 1997-01-14 Eastman Kodak Company Micro media mill and method of its use
DE19504540B4 (de) 1995-02-11 2005-02-10 Zoz Maschinenbau Gmbh Vorrichtung zum Beschicken oder Entleeren eines Behälters, insbesondere eines mit Mahlkörpern diskontinuierlich arbeitenden Mahlaggregats
EP0752274A1 (en) 1995-07-07 1997-01-08 MAZZONI LB FOOD S.r.l. Agitator mill for grinding solid particles in general and particularly solid particles dispersed in a continuous liped phase
DE19613366A1 (de) 1996-04-03 1997-10-09 Goldschmidt Ag Th Vorrichtung zur Behandlung von Suspensionen
DE19635500B4 (de) 1996-09-03 2008-01-10 Zoz Gmbh Vorrichtung zur Hochenergie- und/oder Feinstmahlung von Feststoffen und Verfahren zu dessen Betrieb
EP0881951B1 (en) 1996-11-22 2002-05-22 Toyo Ink Manufacturing Co., Ltd. Dispersing apparatus
RU2246982C1 (ru) * 2003-09-12 2005-02-27 Общество с ограниченной ответственностью "Росток" Ультразвуковое устройство
AU2005327546A1 (en) * 2005-02-15 2006-08-24 The United States Of America, As Represented By The Secretary Of The Navy Composition and process for preparing chromium-zirconium coatings on metal substrates

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5074474A (en) * 1987-07-10 1991-12-24 Veb Berlin-Kosmetik Method and equipment for producing bioactive suspensions
US6235501B1 (en) * 1995-02-14 2001-05-22 Bio101, Inc. Method for isolation DNA
CN2250810Y (zh) * 1996-02-07 1997-04-02 化学工业部上海化工研究院 细胞破碎机
US20040200909A1 (en) * 1999-05-28 2004-10-14 Cepheid Apparatus and method for cell disruption
US6942169B2 (en) * 2001-06-06 2005-09-13 Integrated Sensing Systems Micromachined lysing device and method for performing cell lysis
US20100009349A1 (en) * 2005-12-30 2010-01-14 Hollaender Vera Method for Treating a Biological Sample
US20100331522A1 (en) * 2009-06-26 2010-12-30 Bruce Irvine Capture and elution of bio-analytes via beads that are used to disrupt specimens
US20110070589A1 (en) * 2009-09-21 2011-03-24 Phillip Belgrader Magnetic lysis method and device

Also Published As

Publication number Publication date
AU2013246867A8 (en) 2014-12-11
ZA201500087B (en) 2017-07-26
EP2836294A1 (en) 2015-02-18
DK2836294T3 (en) 2017-12-04
CN104703683A (zh) 2015-06-10
WO2013153176A1 (en) 2013-10-17
BR112014025389A2 (pt) 2018-04-10
BR112014025389B1 (pt) 2021-06-01
ES2647942T3 (es) 2017-12-27
JP2016075703A (ja) 2016-05-12
IN2014KN02333A (enExample) 2015-05-01
KR102251762B1 (ko) 2021-05-17
RU2014141794A (ru) 2016-05-27
KR20150023248A (ko) 2015-03-05
US20130280710A1 (en) 2013-10-24
AU2013246867A1 (en) 2014-10-30
CN104703683B (zh) 2017-04-12
RU2638854C2 (ru) 2017-12-18
US9304066B2 (en) 2016-04-05
JP2015515629A (ja) 2015-05-28
EP2836294B1 (en) 2017-09-20
JP5931275B2 (ja) 2016-06-08
CA2870220A1 (en) 2013-10-17
CA2870220C (en) 2019-08-27

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