AU2013224421B2 - 8 - substituted 2 -amino - [1,2,4] triazolo [1, 5 -a] pyrazines as Syk tryrosine kinase inhibitors and GCN2 serin kinase inhibitors - Google Patents

8 - substituted 2 -amino - [1,2,4] triazolo [1, 5 -a] pyrazines as Syk tryrosine kinase inhibitors and GCN2 serin kinase inhibitors Download PDF

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Publication number
AU2013224421B2
AU2013224421B2 AU2013224421A AU2013224421A AU2013224421B2 AU 2013224421 B2 AU2013224421 B2 AU 2013224421B2 AU 2013224421 A AU2013224421 A AU 2013224421A AU 2013224421 A AU2013224421 A AU 2013224421A AU 2013224421 B2 AU2013224421 B2 AU 2013224421B2
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Prior art keywords
triazolo
pyrazin
dmso
nmr
mhz
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Ceased
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AU2013224421A
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AU2013224421A1 (en
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Lars Burgdorf
Carl Deutsch
Daniel Kuhn
Tatjana Ross
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Merck Patent GmbH
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Merck Patent GmbH
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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AU2013224421A 2012-02-21 2013-01-22 8 - substituted 2 -amino - [1,2,4] triazolo [1, 5 -a] pyrazines as Syk tryrosine kinase inhibitors and GCN2 serin kinase inhibitors Ceased AU2013224421B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12001153 2012-02-21
EP12001153.1 2012-02-21
PCT/EP2013/000189 WO2013124026A1 (en) 2012-02-21 2013-01-22 8 - substituted 2 -amino - [1,2,4] triazolo [1, 5 -a] pyrazines as syk tryrosine kinase inhibitors and gcn2 serin kinase inhibitors

Publications (2)

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AU2013224421A1 AU2013224421A1 (en) 2014-10-02
AU2013224421B2 true AU2013224421B2 (en) 2017-03-02

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AU2013224421A Ceased AU2013224421B2 (en) 2012-02-21 2013-01-22 8 - substituted 2 -amino - [1,2,4] triazolo [1, 5 -a] pyrazines as Syk tryrosine kinase inhibitors and GCN2 serin kinase inhibitors

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US (1) US9120804B2 (cg-RX-API-DMAC7.html)
EP (1) EP2817310B1 (cg-RX-API-DMAC7.html)
JP (2) JP6479476B2 (cg-RX-API-DMAC7.html)
CN (1) CN104114557B (cg-RX-API-DMAC7.html)
AR (1) AR090104A1 (cg-RX-API-DMAC7.html)
AU (1) AU2013224421B2 (cg-RX-API-DMAC7.html)
CA (1) CA2863723C (cg-RX-API-DMAC7.html)
ES (1) ES2674451T3 (cg-RX-API-DMAC7.html)
IL (1) IL233982A (cg-RX-API-DMAC7.html)
TW (1) TW201339165A (cg-RX-API-DMAC7.html)
WO (1) WO2013124026A1 (cg-RX-API-DMAC7.html)

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US9120804B2 (en) * 2012-02-21 2015-09-01 Merck Patent Gmbh 8-substituted 2-amino-[1,2,4] triazolo [1, 5-A] pyrazines as Syk tryrosine kinase inhibitors and GCN2 serin kinase inhibitors
NO2699580T3 (cg-RX-API-DMAC7.html) 2014-01-24 2018-02-24
US9901439B2 (en) * 2014-10-06 2018-02-27 Mark A. Anton Gore-Tex covered breast implants to minimize capsular reaction and infection while reducing palpability
EP3448522B1 (en) * 2016-04-29 2021-01-20 Iomet Pharma Ltd. Novel substituted imidazopyridine compounds as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan-2,3-dioxygenase
RS61996B1 (sr) 2016-12-22 2021-07-30 Calithera Biosciences Inc Kompozicije i postupci za inhibiranje aktivnosti arginaze
GB201709456D0 (en) * 2017-06-14 2017-07-26 Ucb Biopharma Sprl Therapeutic agents
KR20200115620A (ko) 2018-01-29 2020-10-07 메르크 파텐트 게엠베하 Gcn2 억제제 및 이의 용도
MX2020007799A (es) 2018-01-29 2020-09-18 Merck Patent Gmbh Inhibidores de cinasa no derrepresible de control de aminoacido general 2 (gcn2) y sus usos.
CA3089240A1 (en) * 2018-02-07 2019-08-15 Insmed Incorporated Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating anca associated vasculitides
KR102738945B1 (ko) 2018-03-01 2024-12-04 아스트라제네카 에이비이 (2s)-n-｛(1s)-1-시아노-2-[4-(3-메틸-2-옥소-2,3-디하이드로-1,3-벤족사졸-5-일)페닐]에틸｝-1,4-옥사제판-2-카복스아미드를 포함하는 약학 조성물
WO2019187942A1 (ja) * 2018-03-27 2019-10-03 本田技研工業株式会社 フッ化物イオン二次電池用正極活物質、当該活物質を用いた正極、およびフッ化物イオン二次電池、並びに当該活物質の製造方法
EP3556760A1 (en) * 2018-04-19 2019-10-23 F. Hoffmann-La Roche AG Spiro compounds
CN119751456A (zh) 2018-04-16 2025-04-04 C4医药公司 螺环化合物
EP3578561A1 (en) 2018-06-04 2019-12-11 F. Hoffmann-La Roche AG Spiro compounds
AU2019306532A1 (en) 2018-07-17 2021-03-04 Insmed Incorporated Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating Lupus Nephritis
BR112021018168B1 (pt) 2019-03-21 2023-11-28 Onxeo Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
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