AU2012368815B2 - A composition and use thereof in the treatment of anal rhagades - Google Patents
A composition and use thereof in the treatment of anal rhagades Download PDFInfo
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- AU2012368815B2 AU2012368815B2 AU2012368815A AU2012368815A AU2012368815B2 AU 2012368815 B2 AU2012368815 B2 AU 2012368815B2 AU 2012368815 A AU2012368815 A AU 2012368815A AU 2012368815 A AU2012368815 A AU 2012368815A AU 2012368815 B2 AU2012368815 B2 AU 2012368815B2
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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PCT/IT2012/000027 WO2013114410A1 (en) | 2012-01-30 | 2012-01-30 | A composition and use thereof in the treatment of anal rhagades |
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CN105848730B (zh) | 2013-12-24 | 2019-12-13 | 宝洁公司 | 提供增强的护肤活性物质渗透的化妆品组合物和方法 |
ITRM20150163A1 (it) * | 2015-04-17 | 2016-10-17 | Uniderm Farm S R L | Composizioni farmaceutiche per il trattamento delle ragadi anali |
US10117826B2 (en) | 2016-03-31 | 2018-11-06 | Peter Angia Pham | Bodily lubricating and moisturizing compositions containing plant mucilage |
US10835504B2 (en) | 2018-04-18 | 2020-11-17 | G&S Laboratories, Inc. | Compositions to treat anal itch |
WO2020022991A2 (en) * | 2018-05-02 | 2020-01-30 | Montero Gida Sanayi Ve Ticaret Anonim Sirketi | Topical compositions for stretch marks on the skin |
RU2771015C2 (ru) * | 2020-09-25 | 2022-04-25 | Общество с ограниченной ответственностью "ФАРМКОММ" | Фармацевтическая композиция в виде мази для лечения геморроя |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994004163A1 (en) * | 1992-08-21 | 1994-03-03 | Alpha-Beta Technology, Inc. | Novel glucan preparation |
WO1998046205A1 (fr) * | 1997-04-16 | 1998-10-22 | Laboratoires Serobiologiques (Societe Anonyme) | Utilisation d'une fraction proteique extraite de graines d'hibiscus esculentus en cosmetique |
JP2004051533A (ja) * | 2002-07-19 | 2004-02-19 | Ichimaru Pharcos Co Ltd | ヒアルロン酸合成促進剤 |
US6956120B2 (en) * | 2000-11-09 | 2005-10-18 | Yasushi Onaka | β-1.3-1.6 glucan (Aureobasidium medium) |
US20060093657A1 (en) * | 2004-11-04 | 2006-05-04 | Biofarmitalia S.P.A. | Patch containing a substance selected from tars having reducing characteristics in dermatology |
DE202007004856U1 (de) * | 2007-04-01 | 2007-06-06 | Rühle, Wilfried, Dipl.-Ing. | CHM Anti Aging Komplex |
US20090202664A1 (en) * | 2008-02-11 | 2009-08-13 | Svetislav Mikalacki | Herbal cream or oil for the treatment hemorroids and wounds |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6379719B1 (en) * | 1998-04-08 | 2002-04-30 | Laboratories Serobiologiques (Societe Anonyme) | Use of at least one protein fraction extracted from Hibiscus esculentus seeds and cosmetic composition containing such a fraction |
CN1233469A (zh) * | 1998-04-28 | 1999-11-03 | 王京杭 | 组织修复促进剂 |
JP2002204687A (ja) * | 2000-11-09 | 2002-07-23 | Onaka Yasushi | β−1.3−1.6グルカン(アウレオバシジウム培養液)の医療、保健、福祉、食品および各種産業分野での応用 |
JP2003104832A (ja) * | 2001-09-28 | 2003-04-09 | Chifure Keshohin:Kk | 皮膚外用剤 |
PL1622627T3 (pl) * | 2003-05-02 | 2013-11-29 | Ceapro Inc | Kompozycje farmaceutyczne zawierające zbożowy BETA(1-3)BETA(1-4)-glukan |
RU2277920C2 (ru) * | 2004-02-24 | 2006-06-20 | Государственное Учреждение "Пятигорский Государственный Научно-Исследовательский Институт Курортологии Министерства Здравоохранения Российской Федерации" | Способ лечения детей, больных хроническим вирусным гепатитом, с применением сульфидных ванн и слабоуглекислой минеральной водой |
JP5048935B2 (ja) * | 2005-08-24 | 2012-10-17 | 株式会社ヤクルト本社 | 保湿剤 |
CN101095482B (zh) * | 2007-07-05 | 2012-02-15 | 中国科学院长春应用化学研究所 | 制备膳食纤维食品用大麦麦麸或燕麦麦麸的制法 |
ITUD20100112A1 (it) * | 2010-06-09 | 2011-12-10 | Farma Derma S R L | Preparazione per uso vaginale e rettale e relativo procedimento di produzione |
CN102084963A (zh) * | 2010-09-29 | 2011-06-08 | 吉林省农业机械研究院 | 一种制备燕麦麦麸膳食纤维食品的方法 |
-
2012
- 2012-01-30 AU AU2012368815A patent/AU2012368815B2/en active Active
- 2012-01-30 CN CN201280068454.1A patent/CN104114177A/zh active Pending
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- 2012-01-30 SI SI201230046T patent/SI2646039T1/sl unknown
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- 2012-01-30 US US14/359,504 patent/US9345747B2/en active Active
- 2012-01-30 WO PCT/IT2012/000027 patent/WO2013114410A1/en active Application Filing
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2013
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-
2014
- 2014-06-26 HR HRP20140594AT patent/HRP20140594T1/hr unknown
- 2014-07-16 ZA ZA2014/05208A patent/ZA201405208B/en unknown
- 2014-07-30 IL IL233875A patent/IL233875A/en active IP Right Grant
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994004163A1 (en) * | 1992-08-21 | 1994-03-03 | Alpha-Beta Technology, Inc. | Novel glucan preparation |
WO1998046205A1 (fr) * | 1997-04-16 | 1998-10-22 | Laboratoires Serobiologiques (Societe Anonyme) | Utilisation d'une fraction proteique extraite de graines d'hibiscus esculentus en cosmetique |
US6956120B2 (en) * | 2000-11-09 | 2005-10-18 | Yasushi Onaka | β-1.3-1.6 glucan (Aureobasidium medium) |
JP2004051533A (ja) * | 2002-07-19 | 2004-02-19 | Ichimaru Pharcos Co Ltd | ヒアルロン酸合成促進剤 |
US20060093657A1 (en) * | 2004-11-04 | 2006-05-04 | Biofarmitalia S.P.A. | Patch containing a substance selected from tars having reducing characteristics in dermatology |
DE202007004856U1 (de) * | 2007-04-01 | 2007-06-06 | Rühle, Wilfried, Dipl.-Ing. | CHM Anti Aging Komplex |
US20090202664A1 (en) * | 2008-02-11 | 2009-08-13 | Svetislav Mikalacki | Herbal cream or oil for the treatment hemorroids and wounds |
Non-Patent Citations (1)
Title |
---|
BRYANT L A ET AL, JOURNAL OF FOOD SCIENCE, (19880101), vol. 53, no. 3, pages 810 - 816 * |
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