AU2012353651B2 - Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis - Google Patents

Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis Download PDF

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Publication number
AU2012353651B2
AU2012353651B2 AU2012353651A AU2012353651A AU2012353651B2 AU 2012353651 B2 AU2012353651 B2 AU 2012353651B2 AU 2012353651 A AU2012353651 A AU 2012353651A AU 2012353651 A AU2012353651 A AU 2012353651A AU 2012353651 B2 AU2012353651 B2 AU 2012353651B2
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cancer
alkyl
group
compound
phenyl
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AU2012353651A
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AU2012353651A1 (en
Inventor
Kevin FRANKOWSKI
Sui Huang
Juan Jose Marugan
John Norton
Samarjit Patnaik
Frank J. Schoenen
Noel Southall
Steven Titus
Chen Wang
Wei Zheng
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University of Kansas
Northwestern University
United States Department of Health and Human Services
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University of Kansas
Northwestern University
Government of the United States of America
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2012353651A 2011-12-16 2012-12-17 Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis Active AU2012353651B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017276258A AU2017276258B2 (en) 2011-12-16 2017-12-13 Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161576780P 2011-12-16 2011-12-16
US61/576,780 2011-12-16
PCT/US2012/070155 WO2013090912A1 (en) 2011-12-16 2012-12-17 Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis

Related Child Applications (1)

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AU2017276258A Division AU2017276258B2 (en) 2011-12-16 2017-12-13 Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis

Publications (2)

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AU2012353651A1 AU2012353651A1 (en) 2014-07-10
AU2012353651B2 true AU2012353651B2 (en) 2017-09-14

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AU2017276258A Active AU2017276258B2 (en) 2011-12-16 2017-12-13 Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis

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US (2) US9663521B2 (enExample)
EP (1) EP2791142B1 (enExample)
JP (2) JP6463130B2 (enExample)
AU (2) AU2012353651B2 (enExample)
CA (1) CA2859370C (enExample)
ES (1) ES2748590T3 (enExample)
WO (1) WO2013090912A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9663521B2 (en) * 2011-12-16 2017-05-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis
MY195016A (en) 2014-08-04 2023-01-03 Nuevolution As Optionally Fused Heterocyclyl-Substituted Derivatives of Pyrimidine Useful for The Treatment of Inflammatory, Metabolic, Oncologic and Autoimmune Diseases
US9877966B1 (en) * 2015-08-10 2018-01-30 Eugene J. Oliva Combination therapy for the inhibition of metastasis and tumorigenesis
US11241436B2 (en) 2017-01-25 2022-02-08 Northwestern University Autophagy inducers for treatment of CNS conditions
CA3100211A1 (en) * 2018-05-15 2019-11-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Formulations and methods for the prevention and treatment of tumor metastasis and tumorigenesis
AU2020405446A1 (en) 2019-12-20 2022-05-26 Nuevolution A/S Compounds active towards nuclear receptors
BR112022012205A2 (pt) 2019-12-20 2022-09-13 Nuevolution As Compostos ativos para receptores nucleares
CA3174252A1 (en) 2020-03-31 2021-10-07 Nuevolution A/S Compounds active towards nuclear receptors
JP7713954B2 (ja) 2020-03-31 2025-07-28 ヌエヴォリューション・アクティーゼルスカブ 核内受容体に対して活性な化合物
US20260028342A1 (en) * 2022-07-29 2026-01-29 The University Of North Carolina At Chapel Hill Enhancing antimetastasis activity using targeted protein degradation

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WO2009042294A2 (en) * 2007-08-10 2009-04-02 Burnham Institute For Medical Research Tissue-nonspecific alkaline phosphatase (tnap) activators and uses thereof
US20090163545A1 (en) * 2007-12-21 2009-06-25 University Of Rochester Method For Altering The Lifespan Of Eukaryotic Organisms
WO2011046646A2 (en) * 2009-07-10 2011-04-21 Microbiotix, Inc. Inhibitors of filovirus entry into host cells

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US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
GB9604361D0 (en) 1996-02-29 1996-05-01 Pharmacia Spa 4-Substituted pyrrolopyrimidine compounds as tyrosine kinase inhibitors
US7863444B2 (en) 1997-03-19 2011-01-04 Abbott Laboratories 4-aminopyrrolopyrimidines as kinase inhibitors
US6664252B2 (en) 1999-12-02 2003-12-16 Osi Pharmaceuticals, Inc. 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
WO2003000187A2 (en) 2001-06-21 2003-01-03 Ariad Pharmaceuticals, Inc. Novel pyrazolo-and pyrrolo-pyrimidines and uses thereof
US9663521B2 (en) * 2011-12-16 2017-05-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis
JP6681070B2 (ja) * 2015-11-19 2020-04-15 国立大学法人 岡山大学 光ファイバ装置及びセンサシステム

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WO2009042294A2 (en) * 2007-08-10 2009-04-02 Burnham Institute For Medical Research Tissue-nonspecific alkaline phosphatase (tnap) activators and uses thereof
US20090163545A1 (en) * 2007-12-21 2009-06-25 University Of Rochester Method For Altering The Lifespan Of Eukaryotic Organisms
WO2011046646A2 (en) * 2009-07-10 2011-04-21 Microbiotix, Inc. Inhibitors of filovirus entry into host cells

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Abou El Ella, D.A. et al., Bioorganic and Medicinal Chemistry, 2008, vol 16, page 2391-2402 *
Ali, A.S. et al. ‘New derivatives of pyrrolo[3,2-e][1,2,4]triazolo[1,5-c]pyrimidines’ Egyptian Journal of Pharmaceutical Sciences, 1992, vol 33, page 473-484 *
Basyouni, WM et al., ‘Pyrrolo[2,3-d]pyrimidines. Part 2. Synthesis of some new pyrrolo[2,3-d]pyrimidin-4-amines and other related derivatives with molluscicidal properties’ Journal of Chemical Research, Synopses, 1996. Iss 3 page 127 *
CAS Registry Number: 578701-79-8. STN entry date: 04 Sep 2003, Chemical Name:4H-Pyrrolo[2,3-d]pyrimidin-4-imine, 3-[2-(3,4-diethoxyphenyl)ethyl]-3,7-dihydro-5,6-diphenyl-7-(phenylmethyl)- *
CAS Registry Number: 627053-04-7. STN entry date: 15 Dec 2003, Chemical Name:4H-Pyrrolo[2,3-d]pyrimidin-4-imine, 3,7-dihydro-3-butyl-5,6-diphenyl-7-(phenylmethyl)- *
CAS Registry Number: 627053-67-2. STN entry date: 15 Dec 2003, Chemical Name:4H-Pyrrolo[2,3-d]pyrimidin-4-imine, 3,7-dihydro-3-(2-methylpropyl)-5,6-diphenyl-7-(phenylmethyl)- *
CAS Registry Number: 627053-77-4. STN entry date: 15 Dec 2003, Chemical Name: 4H-Pyrrolo[2,3-d]pyrimidin-4-imine, 3-[2-(3,4-dimethoxyphenyl)ethyl]-7-(2-furanylmethyl)-3,7-dihydro-5,6-diphenyl- *
CAS Registry Number: 627053-79-6. STN entry date: 15 Dec 2003, Chemical Name: 4H-Pyrrolo[2,3-d]pyrimidin-4-imine, 3-[2-(3,4-diethoxyphenyl)ethyl]-7-(2-furanylmethyl)-3,7-dihydro-5,6-diphenyl- *
CAS Registry Number: 727999-82-8. STN entry date: 18 Aug 2004, Chemical Name:4H-Pyrrolo[2,3-d]pyrimidin-4-imine, 7-(2-furanylmethyl)-3,7-dihydro-3-[3-(4-morpholinyl)propyl]-5,6-diphenyl- *
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CAS Registry Number: 831246-08-3. STN entry date: 15 Feb 2005, Chemical Name: 4H-Pyrrolo[2,3-d]pyrimidin-4-imine, 3,7-dihydro-3-[2-(4-morpholinyl)ethyl]-5,6-diphenyl-7-(phenylmethyl)- *
El-Bayouki, K.A.M. et al., 'Synthesis of new pyrrole and pyrrolo[2,3-d]pyrimidine derivatives of potential antioxidant activity', 2010, Collection of Czechoslovak Chemical Communications, vol 72, page 813-834 *

Also Published As

Publication number Publication date
US9663521B2 (en) 2017-05-30
AU2017276258B2 (en) 2019-10-03
JP2015502367A (ja) 2015-01-22
US20170260192A1 (en) 2017-09-14
EP2791142A1 (en) 2014-10-22
CA2859370A1 (en) 2013-06-20
ES2748590T3 (es) 2020-03-17
US20140323438A1 (en) 2014-10-30
JP2017200921A (ja) 2017-11-09
AU2017276258A1 (en) 2018-01-18
AU2012353651A1 (en) 2014-07-10
JP6463130B2 (ja) 2019-01-30
JP6726640B2 (ja) 2020-07-22
CA2859370C (en) 2021-01-26
EP2791142B1 (en) 2019-07-03
US10301314B2 (en) 2019-05-28
WO2013090912A1 (en) 2013-06-20

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